Insulin Glulisine 

Apidra 

Apidra is FDA-approved for improving glycemic control in patients with type 1 and type 2 diabetes mellitus. It is typically used alongside an intermediate or long-acting insulin to manage blood sugar levels. Apidra (Insulin glulisine) comes in vials, cartridges, or an Apidra insulin pen. The medication dosage depends upon the patient’s condition, needs, and response to treatment. It is administered as a mealtime insulin within 15 before starting a meal or within 15 minutes of starting a meal. You should not use Apidra if you have hypersensitivity to the medication or if you have severe hypoglycemia. Taking this medicine, having a proper diet, and regular exercise can help you lead a healthy and long life. 

Product Overview

Apidra is the brand name of insulin glulisine, a rapid-acting insulin analog used to improve glycemic control in adults and children (6 years and older) with type 1 or type 2 diabetes. This medication helps regulate blood sugar levels and is typically used alongside long-acting basal insulin. Each Apidra product, whether in vials, cartridges or the Apidra SoloSTAR insulin pen, contains insulin glulisine as the main active ingredient, which works by facilitating the absorption of glucose into cells, reducing sugar production in the liver, and inhibiting the release of stored glucose into the bloodstream.

The recommended dosage of Apidra varies depending on individual needs and may require adjustments during periods of stress, illness, or changes in lifestyle. It is administered as a subcutaneous injection 15 minutes before or after starting a meal. The injection sites include the abdomen, buttocks, upper arm, or thigh, with a different site chosen for each injection to minimize the risk of injection site reactions. Common side effects of Apidra include hypoglycemia, allergic reactions, injection site reactions, and weight gain. 

It is essential to monitor blood sugar levels regularly while taking Apidra and to follow proper storage guidelines to maintain its effectiveness. In case of a missed dose, taking the prescribed dose as soon as possible is essential unless it is almost time for the next dose. In case of an overdose, seek medical assistance immediately. Insulin glulisine (the generic name for Apidra) should be stored in the refrigerator or at room temperature for up to 28 days.

What Are the Uses of Apidra?

It is prescribed for treating the following conditions:

• Type 1 and type 2 diabetes mellitus (adults)
• Type 1 diabetes (children four years old and above)
• Diabetic ketoacidosis
• Diabetic coma
• Nonketotic hyperosmolar syndrome 
• Acidosis 

[Note: Do not take Apidra without consulting your doctor. They will determine whether you need this medication based on your conditions.]

What Are the Forms & Strengths of Apidra?

Apidra comes in the following forms and strengths: 

• Prefilled Apidra SoloStar Pen: 3 ml
• Vial: 10 ml

What Is the Recommended Dosage for Apidra?

Diabetes dosages are based on the patient’s age, weight, medication form, and severity of the medical condition for which they are using insulin. If you use an Apidra insulin pen, your doctor will prescribe a loading dose and gradually increase the dosage on the basis of your response to the treatment. The following sections included only the average doses of the Apidra for type 1 and 2 diabetes. In case your dosage schedule is different from the others, do not change it without consulting a medical expert.  

• Adults: The recommended daily dosage ranges between 0.5-1 unit per kilogram of body weight daily. 
• Children: Children may require 0.8 to 1.2 units of insulin per kilogram of body weight daily when administered via injection under the skin.
• Subcutaneous Injection: It is essential to inject it within 15 minutes before starting a meal or within 20 minutes after starting a meal. 
• Continuous Subcutaneous Injection: When setting up the insulin pump for the first time, use the same daily dose as your previous treatment plan. 
• Intravenous Administration: Insulin should be used at concentrations between 0.05-1 unit/mL when administered through an IV with infusion systems that use PVC bags. The insulin remains stable only in a solution of 0.9% saltwater (normal saline).

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Apidra?

Before using insulin pens, carefully read the prescribing information for Apidra. Doing so will avoid potential risks that may arise from the incorrect administration. Here are some important steps on how to use Apidra:

• Consult a professional to learn insulin administration. They will show you how to inject the dose properly. Make sure to follow your doctor’s instructions for the safe and effective use of the medication.
• Inject the insulin 15 minutes before starting a meal or within 15 minutes after starting the meal. 
• Check the insulin for discoloration or particles. If it has changed appearance, do not use it. Safely discard it and get a new insulin from your pharmacist. 
• Before administration, clean the injection spot with rubbing alcohol. 
• Apidra pens are injected subcutaneously (under the skin), especially in the abdomen, buttocks, upper arm, or front thigh. 
• Do not inject into skin that is torn, damaged, red, swollen, itchy, or if it has stretch marks. 
• Do not inject cold insulin, as it may be painful. The insulin that is in use may be kept at room temperature. 
• If you take insulin intravenously, visit the nearest clinic, as it is injected through professionals only. 
• If you use an insulin pump, do not dilute or mix insulin glulisine with other insulin. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Apidra Work?

Insulin glulisine is a rapid-acting insulin that works within 10 to 15 minutes after injection, peaks in about 1 hour, and works for 2 to 4 hours after injection. When used as a mealtime insulin, Apidra should be injected within 15 minutes before starting a meal or within 20 minutes. It has a shorter duration of action compared to naturally occurring human insulin. It works by reducing blood sugar levels in the body. It inhibits glucose production by the liver and helps glucose get absorbed in the bloodstream so your body can utilize it for energy. 

Important Safety Information for Using Apidra

What Are the Side Effects of Apidra?

Common Side Effects: Insulin glulisine (the generic name for Apidra) can have some common reactions. The majority of patients experience these effects, but they do not require any immediate medical attention. While they stay for a few days or weeks, it is important to keep a check on them. As soon as these side effects start bothering you or intensify, reach out to your healthcare provider. Some of the common side effects of Apidra may include: 

• Hypoglycemia: Taking too much insulin can make your sugar levels go down drastically. This is usually known as hypoglycemia. This side effect is very common in patients using Apidra and can be treated by eating reliable forms of sugar. 
• Allergic Reaction: This medication contains some inactive ingredients or active components that can interact with your body, causing mild allergic reactions. However, these effects will disappear on their own without requiring special medical attention. Some of the signs of an allergic reaction may include itching, rash, or redness. 
• Injection Site Reactions: Such side effects occur when the immune system responds to the injection’s components. Its symptoms may include discoloration, redness, pain, or itching around the injection site. Cold compresses can help alleviate the discomfort.
• Lipodystrophy: In this condition, you may experience loss of fat tissues, usually indicated as lumps or small dents in the skin. When you administer insulin under the skin, it can either cause lipoatrophy (loss of fat) or lipohypertrophy (build-up of fat). 
• Weight Gain: When you take excess insulin, your body absorbs the excess glucose in the form of fat. If your glucose levels are not controlled and the levels are too high, it can lead to weight gain.    
• Upper Respiratory Tract Infection: This infection affects the upper part of the body, such as the nose, throat, or sinuses. It happens due to rapid fluctuations in blood glucose levels that affect the immune system. As a result, you become prone to infections. Its symptoms are similar to those of the common flu. 

Serious Side Effects: This medication contains certain components that can cause severe risks in patients with certain medical problems. Therefore, if you notice anything suspicious during your treatment with Apidra, contact your doctor right away.  Some of its serious side effects may include:

• Severe Hypersensitivity: Apidra ingredients may cause severe allergic reactions in certain patients due to their medical conditions. To avoid such reactions, inform your doctor beforehand about the products you are using or if you have any allergic reactions to the medication. 
• Severe Hypoglycemia: While mild hypoglycemia can be treated at home, severe cases can cause life-threatening situations. If your blood sugar levels drop drastically, seek medical assistance. Its symptoms may include:
  • Anxiety
  • Confusion
  • Shakiness
  • Seizures
  • Fainting
  • Difficulty speaking
  • Excessive sweating
  • Fatigue 
• Hypokalemia: Insulin glulisine can move the potassium levels from the blood to the cells, leading to low potassium levels in the blood. This can be life-threatening if not managed adequately. Symptoms of hypokalemia may include:
  • Cramps
  • Muscle weakness
  • Irregular heartbeats
• Peripheral Edema: It refers to the swelling that develops in the extremities (arm or leg). This occurs when insulin impacts your body’s ability to handle sodium and water. As a result, it causes fluid build-up in the tissues. Therefore, if you take Apidra, closely monitor your fluid intake and discuss any swelling with a medical expert.

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

What Are the Warnings for Apidra?

Like all medications, misusing this insulin can cause several risks. These complications can be avoided if you are aware of the following warnings:

• Do not share your Apidra insulin cartridges or needles with others, as infection may spread from one person to another. 
• The most common side effect of Apidra is hypoglycemia, which may become life-threatening if not treated. Look for signs and symptoms of severe low blood sugar levels. 
• Apidra may cause hypokalemia, which, if not treated, can further cause ventricular arrhythmia, respiratory paralysis, and ultimately death. 
• Patients have also reported accidental mixups between insulin products, causing severe complications. To avoid such errors, always consult a medical professional and check the insulin label before each use.
• Using thiazolidinediones, PPAR gamma agonists, with Apidra can cause dose-related fluid retention. As a result, patients can even experience heart failure or worsen the condition. Beware of the signs and symptoms of heart failure, and if it develops, seek immediate medical assistance.
• Patients using an insulin pump should check the product before using it, as any malfunction or degradation of the insulin can lead to hyperglycemia and ketoacidosis. 

What Are the Precautions for Apidra?

When considering treatment with Apidra insulin cartridges or pens, you must know about the risks the medication can cause. Any mistake can lead to adverse side effects. Therefore, it is necessary to follow the below precautions. Doing so may prevent potential complications:

• Patients’ blood sugar levels should be carefully monitored while receiving treatment with Apidra. 
• Before using Apidra, let your doctor know if you have known hypersensitivity to insulin glulisine or any inactive ingredient in the medication. 
• Avoid consuming alcohol alongside Apidra, as it may lower your blood sugar levels and make your condition worse. 
• Consult your doctor before use if you think you are pregnant, are breastfeeding a baby, or are planning to get pregnant. 
• Apidra should be used with caution in patients who have had or currently have problems related to their kidneys, liver, or heart.
• You should continue to exercise regularly and maintain a nutritious, balanced diet along with Apidra.
• Rotate your injection spots to prevent lipodystrophy each time you inject the medication.
• Before using the insulin, check it for any change in appearance. Do not use it if it appears to be cloudy, discolored, or has particles in it. 
• Only start, stop, or change insulin after consulting your doctor. 
• During your treatment with Apidra cartridge pens, frequently check your blood sugar levels. This step ensures that your diabetes is under control. 
• Remember that Apidra does not cure diabetes; it only helps control the condition.  
• If you become unconscious after using this medication, tell your doctor. They will adjust the dosage of Apidra or other medicines you may be taking.
• When traveling, always bring sugary food or drink with you. This helps control your blood sugar levels during episodes of hypoglycemia. 
• If your eyesight is becoming weak during treatment with Apidra, inform your healthcare provider. 
• When using this medication, frequently check your kidney, heart, blood pressure, eyes, or feet. 
• Do not skip meals when taking this insulin.
• Avoid driving or using any heavy machinery until you know how the medication may affect you. 

What Are the Contraindications of Apidra?

Apidra is contraindicated for use in patients: 

• During episodes of hypoglycemia
• Who have hypersensitivity to Apidra, insulin glulisine, or other Apidra ingredients.

What If You Miss a Dose of Apidra?

• To control blood sugar levels, taking your medication on time is essential. 
• If you have missed a dose of Apidra, check your blood sugar levels and take it accordingly. 
• You may skip it if it is normal, but if it is high, taking the prescribed dose as soon as possible is essential. 
• If it is almost time for your next dose, you may skip the missed dose and take the next dose as per schedule. 
• Do not take two doses of the same medication to compensate for the missed dose.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much Apidra?

Taking Apidra more than recommended may cause hypoglycemia and hypokalemia. Symptoms of an overdose may include dizziness, confusion, headache, and loss of consciousness. If the person has overdosed on the medication and is unconscious, having seizures, or can’t be woken up, immediately seek medical assistance. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How To Store Apidra?

To maintain the safety and effectiveness of your Apidra cartridge pens, you need to follow the below storage instructions:

• You may store unopened Apidra in the refrigerator between 2- 8°C. When kept this way, you can use it till the expiration date. 
• You can also keep Apidra at a cool room temperature and use it within 28 days. 
• Do not freeze the medication. Safely discard the frozen insulin and get a new one from your pharmacist. 
• You may store opened Apidra vials at cool room temperature, away from direct sunlight, excess heat, and moisture. 
• Keep the medication at room temperature and use it within 28 days. Do not freeze the pen, and remove the needle before storing it. 
• Keep the medication in a safe place, away from the sight and reach of children.  
• Dispose of the insulin cartridges or needles in a sharps container. 
• Ask a medical practitioner how to discard the product safely without damaging the surrounding environment.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Are the Apidra Interactions?

Drug alternatives occur when you take two or more drugs together. These interactions can either increase the risk of developing adverse side effects or impact how the medication may work on your body. As a result, these interactions may lower the effect of the drug. Therefore, if you are considering treatment with Apidra insulin pens, be cautious of the following interactions:

• ACE Inhibitors
• Alcohol
• Atypical Antipsychotics
• Beta-Blockers
• Clarithromycin
• Inhaled Corticosteroids
• Oral Corticosteroids
• Danazol
• Diabetes Medications
• Disopyramide
• Diuretics
• Epinephrine
• Estrogens
• Glucagon
• Hepatitis C Antivirals
• HIV Protease Inhibitors 
• Isoniazid
• Lanreotide
• Mifepristone
• Monoamine Oxidase Inhibitors
• Octreotide
• Oral Contraceptives
• Pasireotide
• Pegvisomant
• Progestins
• Quinine
• Quinolone Antibiotics 
• Selective Serotonin Reuptake Inhibitors
• Somatostatin
• Somatropin
• Sulfamethoxazole
• Sunitinib
• Tacrolimus
• Testosterone
• Thyroid Replacement Hormones

What Are the Other Apidra Interactions?

Other than the above-mentioned drugs, inulin glulisine may interact with certain diseases. Patients with specific medical conditions must be extra cautious if they have the following diseases. To avoid any serious complications, inform your doctor beforehand about your existing problems. They will adjust your dosage accordingly. These medical problems are as follows:

• Renal or liver problems
• Hypoglycemia
• Hypokalemia

[Note: This isn’t a complete list, and there could be other drugs that interact with Apidra. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

What Are the Apidra Alternatives?

Drug alternatives are convenient for patients to switch from one treatment to another. They usually opt for different drugs: 

• When these people are not achieving the results they are aiming for, 
• When they have certain medical problems that may interact with Apidra or 
• When the medication is not under their budget

These reasons influence their choice, making them choose different drugs. However, it is important to note that these decisions should only be made under medical supervision. Your doctor will monitor your condition & prescribe the Apidra insulin dosage accordingly. Some of the popular drugs that can be taken in place of insulin glulisine include:

• Humulin R (insulin R)
• Novolog (insulin aspart)
• Humalog (insulin lispro)
• Toujeo (insulin glargine)
• Levemir (insulin detemir)
• Tresiba (insulin degludec)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Apidra Cost & Coupons

Many factors, including pricing, influence Apidra’s cost. Diabetes medications are not the ones that can be availed at low prices. To manage the high-end costs of these drugs, people use their health insurance plans. However, not all medications are covered by medical insurance. Here, Polar Bear Meds come to the rescue. With their affordable medications, you can buy Apidra online without compromising the quality. Moreover, if you reside in the US, you save extra dollars by using their coupon codes.  

Frequently Asked Questions 

Is it necessary to refrigerate Apidra?

Yes, it is important to keep your insulins in the refrigerator as long as they are not opened or used. However, ensure that you are not freezing the medication, as cold insulin can irritate the skin and cause pain during administration. 

What is the fast-acting nature of Apidra insulin?

Only one mealtime insulin is approved for use within 15 minutes before or within 20 minutes after a meal begins, called Apidra SoloSTAR. Apidra is the only mealtime insulin approved for use within 15 or 20 minutes after starting a meal.

How long does Apidra take to act?

A rapid-acting insulin analog called Apidra has been shown to improve glycemic control in patients with diabetes, both adults and children. Apidra’s use during mealtime should be performed within 15 minutes after starting a meal or 20 minutes after starting a meal if used between meals.

Is Apidra a regular insulin?

No, Apidra is not a regular insulin. It is a fast-acting insulin that starts working within 15 minutes and controls blood sugar levels after meals. On the other hand, regular insulin takes much more time to show its effects, usually 30 minutes.

Is Apidra and Lantus the same?

No, these two medications are not the same. While both are insulin-based medications that help manage glycemic control, their onset of action varies. Apidra takes 15 minutes to start working after administration, and the duration of action of Apidra insulin lasts about 3 to 5 hours to manage sudden spikes in blood sugar levels during mealtime. On the other hand, Lantus is a long-acting insulin that starts working within 1-2 hours but provides a steady insulin release for long-term glucose management in the blood.  

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