Insulin Lispro

Humalog

Humalog is FDA-approved for improving glycemic control in patients with type 1 diabetes and type 2 diabetes. The prescription medication contains insulin lispro, a rapid-acting insulin that helps to lower blood sugar levels after 10-20 minutes of taking a meal and reduces the chances of severe complications of diabetes. It comes in single-use prefilled pens, cartridges, and vials that are usually prescribed along with long-acting insulin or other antidiabetic medications. The dosage of the drug depends on your age, condition, and requirements. You should talk to a licensed healthcare professional to get personalized advice and guidance regarding dosage, storage & potential risks, and benefits of using this medication. To ensure authenticity, you should buy Humalog insulin types online from trusted pharmacies.

Product Overview

Humalog insulin lispro is a prescription medication approved by the FDA containing insulin lispro, a rapid-acting (short-acting) insulin used to improve glycemic control in patients with type 1 & type 2 diabetes. Insulin lispro works by helping lower blood sugar levels post-meals, reducing the risk of serious diabetes-related complications. It is commonly prescribed alongside long-acting insulin or other antidiabetic medications to manage blood sugar effectively.

Humalog is available in several forms, including single-use, prefilled pens, cartridges, and vials. The dosage depends on individual factors such as age, condition, and specific needs. Typically, it should be injected 15 minutes prior or within 20 minutes after starting to eat. Regular blood sugar monitoring is important for optimal control. Humalog is suitable for adults and children with diabetes, as a healthcare provider prescribes. Common side effects include hypoglycemia, weight gain & injection site reactions. 

It should not be administered during episodes of hypoglycemia or by people allergic to insulin lispro. If a Humalog dose is missed, take it as soon as remembered unless it’s near the time for the next dose. Do not take two doses simultaneously to make up for a missed dose. In case of an insulin lispro overdose, seek medical attention immediately. Store Humalog at room temperature, away from heat, moisture, and direct sunlight. Unopened vials or cartridges are good until expiration, while opened products should be discarded after 28 days. Always consult your physician or pharmacist for personalized advice & guidance.

What Are the Uses of Humalog? 

It improves glycemic control in patients with type 1 and type 2 diabetes. Your doctor may also prescribe Humalog to treat the following conditions: 

• Gestational diabetes 
• Diabetic ketoacidosis 
• Hyperglycemia
• Hyperkalemia

[Note: Do not take Humalog without consulting your doctor. They will determine whether you need this medication based on your conditions.]

What Are the Forms & Strengths of Humalog?

Humalog comes in the form of a liquid solution available as: 

Form: KwikPen pen (100 IU or 200 IU/ml) 

Strength: 3 ml

Form: Tempo Pen (100 IU/ml)

Strength: 3 ml

Form: Junior KwikPen (100 IU/ml)

Strength: 3 ml

Form: Vial 

Strength: 3 ml, 10 ml

Form: Cartridges

Strength: 3 ml

What Is the Recommended Dosage of Humalog?

The dosage of Humalog to improve glycemic control in individuals with type 1 & 2 diabetes mellitus varies from person to person. It depends on a variety of factors, such as the patient’s age, the condition being treated, and tolerability. The dosage mentioned here applies to everyone, and your doctor may prescribe a dosage that is different from the one given. If they have recommended you follow a different dosage schedule, you should follow their directions and not change your dose without talking to them first. 

Type 1 Diabetes Mellitus 

• Daily dose for adults: 0.5-1 unit/kg/day in divided doses is recommended. 
• Non-obese: 0.4-0.6 units/kg/day
• Obese individuals: 0.8-1.2 units/kg/day. 
• Pediatric Patients: 0.4-1 units/kg/day for children aged 3 and above. 

For Type 2 Diabetes Mellitus 

• Starting dose: 4 units or 10% of your total daily insulin. 
• To be injected 15 minutes before or after a meal.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Humalog? 

Before administering Humalog Kwikpen, you should know how to use it properly by reading the instructions given on the prescription label, patient information leaflet, and, if available, the medication guide. If you need help understanding any part of the instructions or have any doubts or concerns regarding using insulin lispro, you should talk to your doctor beforehand. 

• The Humalog dosage is based on the medical condition & response to treatment by the patient. 
• You can inject Humalog by yourself, but if you want the insulin to be injected in the upper arm, you will need help from someone. Ensure you and your caregiver know how to inject the insulin properly. 
• Before using Humalog for the first time, your doctor will show you how to inject the insulin properly. 
• Humalog is usually given subcutaneously, under the skin of the abdomen, front thigh, buttocks, and upper arm. 
• Before injecting the insulin, ensure that you have the proper insulin in the correct dosage. Also, check the insulin for any change in appearance. 
• Do not use the insulin if there is any color change, it appears cloudy, or if it has some particles in it. 
• Do not share your injections with others, even if the needle is changed, as it may cause infection to spread from one person to another. 
• Do not reuse the needle after using it, as it may be contaminated. Always use a new needle for injecting. 
• Constantly rotate the injection spot to reduce the chances of getting thickened skin, lumps, and pits under your skin.
• Do not inject the injection where the skin is torn, damaged, red, tender, bruised, or has stretch marks. 
• Properly wash your hands before and after administering the injection. 
• Administer the injection before 15 minutes or within 20 minutes of starting a meal. 
• Avoid injecting frozen insulin, as it can be painful. The insulin you are currently using may be kept at room temperature. 
• Do not mix Humalog with other insulin or medication apart from insulin NPH (for intravenous administration). 
• Measure each medication dose very carefully, as even small changes in the amount of insulin can greatly affect blood sugar levels. 
• Select your prescribed dosage and inject the insulin into your skin as shown by your doctor or healthcare provider. 
• Do not try to adjust the dosage while injecting the insulin. 
• Pull the needle out of your skin and ensure that you have injected the complete dose of the medication. 
• Replace the cap after use. 
• Dispose of the needle in a sharps container. Do not throw it in wastewater or your household garbage bin.
• Intravenous administration of insulin lispro should only be done by a healthcare practitioner in a medical setting, as severe hypoglycemia may occur. 
• If your doctor has directed you to inject this medication with an infusion pump, you should carefully read the instructions manual and directions that come with the infusion pump. Ask your doctor if you have any questions or concerns, and keep the pump away from light and heat sources. Do not dilute or mix the insulin if you are using an insulin pump. 
• Let your doctor or healthcare professional know if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Humalog Work?

Humalog is a rapid-acting insulin that starts to affect swiftly in the body within 10-20 minutes of injection. Its mechanism of action is the same as the insulin that naturally occurs inside the body. It helps glucose absorption by the bloodstream so that our body can utilize it for energy. It suppresses the production of glucose inside the liver. 

Important Safety Information for Using Humalog

What Are the Side Effects of Humalog?

Common side effects of Humalog: Similar to other insulin medications, Humalog may cause certain temporary side effects in some people using it. These symptoms resolve on their own without any medical intervention within a couple of days or weeks. You should be aware of all the potential risks before use and discuss any queries or concerns you may have with your doctor. The list below does not include all possible side effects, and users may also experience other symptoms. Report them to your healthcare professional or doctor promptly. Common Humalog side effects include: 

• Low blood sugar: This is one of Humalog’s most common side effects. This occurs when the dose of insulin exceeds the needs of the body, leading to a drop in blood sugar levels. Humalog, a fast-acting insulin, works quickly to reduce levels of blood sugar, but if you do not consume food or engage in excessive physical activity, it can lead to hypoglycemia. Low blood sugar (hypoglycemia) symptoms may include shaking, confusion, sweating, dizziness & in severe cases, loss of consciousness. To prevent hypoglycemia, you should regularly monitor blood sugar levels. To manage low blood sugar, you should regularly intake a well-balanced diet at regular intervals and carry a reliable and quick source of glucose, such as juice or glucose tablets. If these symptoms persist or become worse, seek prompt medical attention. 

• Weight gain: Insulin, including Humalog, can help regulate glucose storage in cells. However, when too much insulin is present, it can encourage fat storage, leading to weight gain over time. To manage weight gain, patients are advised to follow a healthy, balanced diet that supports their insulin needs, along with regular physical activity. A healthcare provider can offer guidance on adjusting insulin doses to minimize this side effect, and in some cases, switching to a different type of insulin or adding other medications might help manage weight more effectively. 

• Rashes: Rashes may develop at the injection site or elsewhere in the body due to the body’s sensitivity to insulin or any of the ingredients present in the product. This can lead to redness, hives, or bumps at the injection site. To prevent rashes, you should rotate injection sites each time you inject the insulin and avoid injecting the insulin into areas that are damaged or have poor circulation. If a rash persists or worsens, or if it is accompanied by difficulty breathing or swelling, it may indicate a severe allergic reaction. 

• Itching: This common injection site reaction occurs as a result of the body’s immune system to insulin or any of its ingredients. The itching at the injection site is usually mild and may be managed with over-the-counter antihistamines or by applying a cold compress. If the itching persists or spreads to other parts of the body, you should tell your doctor or healthcare provider. To reduce the risk of itching, you should rotate injection site areas. 

• Swelling in hands and feet: Also known as edema, swelling in the hands and feet can be caused by fluid retention caused by insulin, which may be uncomfortable. In some cases, it can worsen over time. To manage the swelling, you should limit the intake of salty foods, elevate your legs, or wear compression stockings. 

• Injection site reaction: Injection site reactions, such as pain, redness, or swelling at the injection spot, may occur because of the irritation caused by the insulin itself or due to the administration procedure. To minimize the chance of having injection site reactions, you should rotate the injection sites regularly and use proper injection techniques. If the symptoms are severe, get in touch with your doctor. 

If any of these symptoms persist or cause severe discomfort, you should discuss them with your doctor. You should report any new or worsening symptoms to your doctor immediately. Your doctor has prescribed you Humalog after determining that its benefits justify the risks associated with its use. 

Serious Side Effects of Humalog: This medication can cause severe side effects in certain rare cases, which require prompt medical assistance and can become fatal if left untreated. If you experience any of the symptoms given below, you should immediately discontinue the use of Humalog and seek medical attention. Severe side effects caused by Humalog may include: 

• Severe allergic reaction: Although rare, a severe allergic reaction to Humalog is possible. Its symptoms include trouble breathing, swelling of the face, throat, or lips, a rapid heartbeat, dizziness, and anaphylaxis (a severe, life-threatening allergic response). A severe allergic reaction to Humalog can be due to the individual’s sensitivity to insulin lispro or any other ingredient in the product. To prevent an allergic reaction, tell your doctor about any known hypersensitivity to any of the ingredients listed in the product. If you experience any signs and symptoms of a severe allergic reaction, you should get emergency medical treatment immediately, as anaphylaxis can become life-threatening if not treated properly. 

• Severe hypoglycemia: This can occur when too much insulin is injected or when meals are skipped. This causes the levels of blood sugar to drop below normal. Symptoms of severe hypoglycemia include confusion, difficulty speaking, unconsciousness, seizures, and, in extreme cases, coma. The risk of having severe hypoglycemia, is higher in individuals who have irregular sleep patterns, are physically active without adjusting their insulin dose, or are on multiple daily injections without continuous glucose monitoring. To prevent hypoglycemia, you should monitor your blood sugar levels on a regular basis, follow the prescribed dosage regimen, and adjust medication dosage based on food intake, and physical activity. If an episode of hypoglycemia occurs, you should treat it by consuming fast-acting carbohydrates, such as juice, glucose tablets, or regular soda. In case of severe hypoglycemia where the individual is unconscious, glucagon injections may be necessary.

• Severe hypokalemia: This can occur when insulin is administered in high doses over a long period of time. Severe hypokalemia can lead to potassium deficiency in the bloodstream. Severe hypokalemia can cause muscle weakness, cramping, irregular heartbeat, fatigue, and even life arrhythmias. This is more likely to happen in people who have existing kidney conditions or those who are receiving other medications that affect potassium levels. To prevent hypokalemia, you should take this medication exactly as your doctor has prescribed and have regular blood tests to monitor potassium levels. If hypokalemia is suspected, seek medical care to avoid serious complications. 

• Heart failure: The risk of heart failure is higher in people who have existing cardiovascular conditions, as it may lead to symptoms like fatigue, shortness of breath & swelling in the legs & abdomen. To prevent the risk of heart failure exacerbation, you should maintain a healthy lifestyle, including controlling blood pressure, avoiding salt intake, and regularly monitoring heart health. If signs of heart failure develop, such as unexplained weight gain, swelling, or difficulty breathing, it is vital to seek medical attention immediately.

• Hyperglycemia: This occurs when there are high levels of sugar in the body, which may be due to illness, stress, or an improper diet. Its symptoms may include increased thirst or urination, fatigue, and blurred vision. If hyperglycemia is left untreated, it can cause more serious complications, such as ketoacidosis or long-term damage to the organs. To prevent this, you should follow your insulin regimen and adjust doses as required. If you experience severe or persistent high blood sugar, seek medical intervention to avoid complications. 

• Ketoacidosis: This is a potentially fatal condition that is more common in people with type 1 diabetes but can happen in type 2 diabetes as well. Its symptoms may include nausea, vomiting, abdominal pain, deep or rapid breathing, fruity-smelling breath, confusion, and even coma. This condition is typically caused by missed insulin doses or uncontrolled blood sugar levels. To prevent ketoacidosis, you should follow the prescribed insulin dose and stay hydrated. If DKA is suspected, seek immediate medical attention. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Humalog? 

There are certain warnings that you should consider while using Humalog to manage diabetes type 1 or 2. The key points of the warnings may include: 

• Do not share your Humulin with others, even if the needle changes. This includes syringes, cartridges, needles, injectable pens, and more, as they can spread infection from one person to another. 
• Do not start, stop, or change your insulin brand or dosage without consulting your doctor. 
• Do not use Humalog when the patient is having an episode of hypoglycemia. 
• Do not take Humalog (insulin lispro) with medications that belong to a class of drugs known as thiazolidinediones, as it may cause heart failure. 
• It is considered unsafe to consume alcohol alongside humalog as it may cause unwanted side effects.
• Do not drive, operate heavy machinery, or indulge in activities that require your concentration unless you determine how this medication affects you. 
• Humalog should be used with caution in patients who have conditions related to their liver, kidney, or heart. 
• Humalog should be used with caution in patients who have renal or hepatic impairment. Such patients may require dosage adjustments and careful monitoring of their condition. 
• While using subcutaneously, do not mix Humalog with any other medication or insulin apart from NPH insulin.
• When administered intravenously, Humalog should not be mixed with any insulin. 
• Hypoglycemia is the most common side effect of Humalog, which, if not treated, may become life-threatening. Its symptoms may include increased appetite, hunger, dizziness, irritability, confusion, anxiety, or shakiness. You should consume a fast-acting sugar source, such as fruit beverages, hard candy, biscuits, raisins, or non-diet soda, to quickly alleviate hypoglycemia symptoms. Your doctor or healthcare provider is most likely to recommend a glucagon injection kit if you have severe hypoglycemia. Ensure your friends, family, and caregivers know how to inject it in case of an emergency. 
• You should also be watchful for signs and symptoms of hyperglycemia (high blood sugar), including increased thirst or urination. 
• All insulins, including Humalog, may result in hypokalemia, which, if not treated, may cause respiratory paralysis, ventricular arrhythmia, and ultimately death. 
• Tell your doctor if you also take pioglitazone or rosiglitazone, taking it together with Humalog may cause heart-related problems. 

What Are the Humalog Precautions?

• Before taking Humalog, tell your doctor if you have any condition and what medications you are taking for its treatment. This includes all prescription, non-prescription, and over-the-counter medications, herbal supplements, and vitamins. 
• Before starting treatment with Humalog, tell your doctor about your medical history, especially if you have a disease related to the heart, kidneys, and liver. 
• Before taking Humalog, tell your doctor if you have an allergy to insulin lispro or any inactive ingredients in the medication. 
• Let your doctor know if you think you are pregnant, planning to get pregnant, or if you are breastfeeding a baby. You may require a dosage adjustment. 
• It is essential to monitor your blood glucose levels regularly while receiving treatment with Humalog and share the report with your doctor to help them determine the best dosage for you. 
• Constantly rotate the injection spot each time you inject the medication to avoid injection site reaction. 
• Do not inject into skin that is torn, damaged, red, swollen, or if it has stretch marks. 
• Do not use the product if it is discolored or has particles. 

What Are the Contraindications of Humalog? 

Humalog is contraindicated for use in patients: 

• During episodes of hypoglycemia
• Who have known hypersensitivity to Humalog, insulin lispro, or any of its inactive ingredients. 

What If You Miss a Dose of Humalog?

• For safe and efficient use of the medication, it is recommended that the dosage of Humalog be maintained consistently. 
• If you missed a dose of the medication, check your blood sugar levels and decide accordingly. 
• If your blood glucose levels are in the average range, you can skip the missed dose and take the next dose as scheduled. 
• If your blood sugar levels are high, you should immediately inject the prescribed dosage. 
• However, if it is time for your next dose of Humalog, you may skip the missed dose and take the medication as per your dosing schedule. 
• Do not take two doses of the same medication, as it may cause adverse effects. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Humalog?

Overdose of Humalog may cause hypoglycemia and hypokalemia, which, if not treated, can become life-threatening. Symptoms of overdose include drowsiness, sweating, and loss of consciousness. Mild symptoms of overdose may be treated by giving the patient oral glucose. But if someone has taken Humalog more than recommended and has passed out, is having seizures, or can’t be woken up, immediately call 911 or head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store Humalog?

Following proper storage guidelines is essential for ensuring the safety and efficacy of the medication. You can keep Humalog in its original packaging in the refrigerator or at a controlled room temperature, away from sunlight, moisture & excess heat.

• Keep Humalog in the original container at average room temperature, away from direct sunlight, excess heat, and moisture. 
• Do not freeze the product or use it if it is frozen, as injecting frozen insulin can be painful. 
• Safely discard the frozen insulin and get a new one from your pharmacist. 
• When unopened Humalog is kept at room temperature, it is suitable for use until its expiration date. 
• When opened, it is best recommended to use it within 28 days. 
• Throw it away after 28 days, even if any medication is left. 
• Do not keep medications that are outdated or no longer needed. 
• Do not flush the medicine unless instructed to do so. 
• Do not throw the drug in wastewater or household garbage bins. 
• For guidance on safely disposing of the medication, you can contact your healthcare provider or the local waste disposal company. 
• You should discard the needles, syringes, cartridges, and vials in a sharps disposal container. If you do not have a sharps container, use a container made of hard plastic with a tightly fitting lid to discard the used medication. 
• Keep all insulins, including Humalog, in a safe place away from the reach and sight of children. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Humalog?

Some medicines may interact with Humalog and reduce its effectiveness or cause unwanted symptoms in some users. To prevent and manage this, you should tell your doctor about all prescription & non-prescription medications, over-the-counter drugs, herbs, and vitamin supplements. Some of the potential interactions of Humalog may include: 

• Metformin
• ACE inhibitors 
• DPP-4 inhibitors
• Glucagon-like peptide agonists
• SGLT2 inhibitors 
• Sulfonylureas 
• Thiazolidinediones
• Certain antidepressants
• Antipsychotic drugs 
• Corticosteroids
• Diuretics (water pills)
• Certain cholesterol-lowering medications 
• Protease inhibitors used to treat HIV
• Oral contraceptives
• Albuterol
• Clonidine
• Reserpine
• Guanethidine
• Beta-blockers
• Angiotensin II receptor blockers 

[Note: This isn’t a complete list, and there could be other drugs that interact with Humalog. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

What Are the Other Humalog Interactions?

Certain herbs, vitamin supplements, food items & beverages may interact with Humalog and affect how it works. You should be aware of such interactions before using this medication and discuss them with your doctor if you have any queries or concerns. To prevent these interactions, your doctor may suggest that you make certain dietary or lifestyle changes while being treated with insulin lispro. 

• Alcohol interaction: Alcohol can affect the levels of blood glucose in some people with diabetes. People can experience both hypoglycemia and hyperglycemia, depending on how much and how frequently they drink. You should avoid drinking alcohol if your diabetes is not well tolerated or if you have high triglyceride levels, pancreatitis, or neuropathy. If your blood sugar levels are regulated, moderate alcohol consumption may not affect the levels of blood sugar. However, you should limit alcohol consumption and avoid consuming alcohol on an empty stomach or following exercise. 
• Disease interaction: There are some disease interactions with Humalog, namely, renal disease, liver disease, and hypokalemia. To prevent disease interactions, you should share your entire medical and family history with your doctor or healthcare provider. Based on the severity of your diabetes mellitus, your healthcare provider may recommend you change your dosage or use an alternative treatment. 

What Are the Humalog Alternatives?

While Humalog is an effective injectable insulin used to manage type 1 & type 2 diabetes mellitus, it may not be tolerable for everyone or may be contraindicated due to hypersensitivity reactions or other conditions. In such cases, people look for alternatives to Humalog. While there are many popular alternatives to this medication available on the market, you should not use them without talking to your doctor first. Based on your condition, age, tolerability, and other factors, they will help you determine the most suitable drug. Some of the substitutes for Humalog may include: 

• Ozempic (semaglutide)
• Metformin (Metformin Hydrochloride)
• Lantus (insulin glargine)
• Apidra (insulin glulisine)
• Toujeo (insulin glargine)

[Note: Your doctor will choose what’s best for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Humalog Cost & Coupons

Several factors, such as health insurance coverage, prescription duration, and the pharmacy you choose to buy Humalog online, can affect the price of obtaining it at a lower price. Many Americans discover that their health insurance coverage does not usually include insulins such as Humalog, which leads to significant out-of-pocket expenses. To manage these financial expenses, people turn to online Canadian pharmacies such as Polar Bear Meds, which enables them to buy Humalog online from Canada in the USA at a reduced cost and have it delivered to their doorstep conveniently. Additionally, first-time buyers can use the Humalog insulin pen coupons WELCOMEPB10 during checkout to get 10% off on their first order.

Frequently Asked Questions

Is Humalog short or long-acting?

Humalog is a rapid-acting (short-acting) insulin that starts to function about 15 minutes after injection & peaks in about one hour. However, it loses its effect in 2-4 hours. If needed, you should inject the medication within 15 minutes before eating or even right after a meal. 

When taking Humalog, what should I monitor?

Keeping a close eye on the sugar level in the blood is essential. Hypoglycemia is the most common adverse effect seen in patients who use insulin lispro. This is why close glucose monitoring is recommended and mandatory for all patients who have diabetes. Any changes to dosage should be done only under medical supervision.

Can you take Humalog Kwikpen without eating?

The blood sugar levels may be dangerously low if you do not eat when taking Humalog. How long does Humalog take to work? Humalog and Humalog Mix both work quickly to lower your blood sugar. Within 15 minutes after administration, the drugs begin reducing blood sugar levels.

Does Humalog insulin need to be avoided at certain times?

To use Humalog safely, you must not inject it into any areas of the skin that are thickened or have developed lumps or “pits.” Furthermore, you should not inject Humalog into areas where the skin is bruised, tender, scaly, complex, or otherwise damaged.

Can you estimate how much Humalog should lower blood sugar by 1 unit?

Generally, one unit of insulin is needed to correct a high blood sugar situation. One unit of insulin is usually required to lower the blood glucose level to 50 mg/dld. The drop in blood glucose can vary from 30 to 100 mg/dl, depending on particular insulin sensitivity and other circumstances.

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