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What Is Novolin Insulin?
Novolin Insulin is a brand encompassing a range of insulin-based products, including Novolin R (Regular insulin), Novolin ge Toronto (Regular insulin), Novolin N (NPH or isophane insulin), and various preparations that blend Regular and NPH insulin.
The Novolin Insulin product line includes:
- The Novolin ge Toronto pen & vial
- Novolin ge 40/60 Penfill cartridge
- Novolin ge 30/70 Penfill cartridge
- Novolin ge 50/50 Penfill cartridge
- Novolin ge NPH penfill cartridge
Let’s delve into these products more comprehensively.
Regular Insulin
Regular insulin, also known as neutral or soluble insulin, is a short-acting insulin with an onset of approximately 30 minutes and a duration of up to 8 hours. It is administered before meals to manage the post-meal blood sugar spike.
NPH
NPH insulin, or isophane insulin, falls into the intermediate-acting category, serving to regulate blood sugar levels. Its effects typically commence within around 90 minutes and can persist for up to 24 hours. NPH insulin is produced by blending regular insulin with protamines, which are small proteins that delay insulin onset and extend its duration.
Mix (30/70, 40/60, 50/50)
In addition to providing enhanced precision in dosing and superior blood sugar control, NPH insulin can also be combined with Regular insulin (R). These two insulin types (NPH and R) are commonly administered in the same syringe for optimal therapeutic outcomes.
What Is a Novolin Pen Used For?
Novolin insulin products serve as vital treatment options for individuals diagnosed with diabetes mellitus who require insulin therapy to effectively manage elevated blood sugar levels.
NPH insulin, classified as an intermediate-acting insulin analog, offers comprehensive protection throughout the day against fluctuations in blood glucose levels. This insulin variant acts as a stabilizing force, maintaining blood sugar levels within a desired range over an extended period.
Conversely, regular insulin, characterized by its short-acting nature, expeditiously controls the surge in blood sugar following meals. It is particularly well-suited to address the immediate insulin needs during mealtime, offering swift and effective regulation.
Furthermore, it is worth noting that regular insulin holds a special significance in the management of two major diabetic complications. It is the preferred treatment for hyperosmolar hyperglycemic state, a condition marked by severe dehydration resulting from elevated blood sugar levels. Additionally, regular insulin plays a pivotal role in addressing diabetic ketoacidosis (DKA), a condition characterized by abnormal ketone levels in the urine or blood.
Dosage Guidelines for Novolin Insulin
- Individualization of Dosage: Customize and adjust Novolin 70/30 dosage based on the individual’s metabolic needs, blood glucose monitoring results, and glycemic control objectives.
- Administration Timing: Administer Novolin 70/30 subcutaneously approximately 30 minutes before a meal.
- Typical Dosing Frequency: Typically, Novolin 70/30 is prescribed for twice-daily dosing, with each dose meant to cover either two meals or one meal and a snack.
- Consideration for Changes: Be aware of potential dosage adjustments that may be necessary due to changes in physical activity, variations in meal patterns (such as macronutrient content or meal timing), shifts in hepatic or renal function, or during acute illness.
- Transitioning from Other Insulins: When transitioning from another insulin product to Novolin 70/30, it is important to recognize that dosage adjustments may be required to ensure an appropriate and effective insulin regimen.
How Does Novolin Insulin Pen Work?
Novolin pen contain insulin analogs that function similarly to naturally occurring insulin. Their primary role is to regulate blood sugar levels by managing the breakdown of carbohydrates, fats, and proteins in the body while also facilitating the absorption of sugar from the bloodstream.
Regular insulin is a fast-acting type, commencing its action within 30 minutes and maintaining its effectiveness for up to 8 hours. In contrast, insulin isophane (NPH) takes around 90 minutes to begin working and offers sustained blood sugar control for approximately 24 hours.
When used in combination, regular and NPH insulin can provide enhanced blood sugar level management. This is achieved by harnessing the rapid effects of regular insulin alongside the extended control offered by NPH insulin. This combination allows for a more precise mimicry of the natural insulin activity in the body. Consequently, it helps minimize fluctuations in blood sugar levels that can occur when using insulin analogs alone.
Warnings and Side Effects of Novolin Insulin
- Do not share Novolin pens or syringes among different patients.
- Changes in insulin regimens can lead to hyperglycemia or hypoglycemia.
- Medication errors can result in hypoglycemia.
- Hypersensitivity reactions and hypokalemia may also occur.
Novolin 70/30 Insulin Interactions
The following drug might interact with this drug: repaglinide. When your blood sugar falls too low, you will usually notice a pounding heartbeat, and this may be caused by medications that block beta-blockers (like propranolol, metoprolol, and glaucoma eye drops like timolol).
Frequently Asked Questions
Is it necessary to refrigerate Novolin 70/30 Insulin?
All unopened Novolin 70/30 should be kept in the refrigerator b/w 36°F & 46°F (2°C and 8°C). It should not be frozen. Novolin 70/30 should not be used once it has been frozen. In the event that refrigeration is not feasible, it is possible to store the unopened vial at room temperature for up to 42 days (6 weeks), provided that the temperature is kept below 77°F (25°C).
How long can a Novolin Insulin pen be kept at room temperature?
The storage parameters (unopened) of Novolin 70/30 insulin are as follows:
- Keep it at a temperature below 77°F (25°C) for up to 6 weeks.
- Keep vials away from direct light and heat as well as away from the presence of other products.
- Throw away fully used vials after 6 weeks (42 days) of use, no matter how much insulin is left in the vial.
How does Novolin Insulin differ from other insulins?
Compared to faster-acting insulins, Novolin ge NPH is a longer-acting insulin, which means that it will lower your blood sugar within 112 hours of being taken, and the effects will last for approximately 24 hours. Novolin ge NPH is often used in combination with fast-acting insulins to achieve the best results.
Can you take Novolin 70-30 more than once a day?
There is usually no need to administer more than two Novolin 70-30 injections during the day. However, you should administer one every two to three hours, depending on the type of meal you will consume. It is usually recommended to administer Novolin 70/30 insulin two times a day.
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