Adalimumab

Abrilada

Abrilada (adalimumab) is an FDA-approved interchangeable biosimilar to Humira. It is prescribed to alleviate pain, inflammation, and skin symptoms associated with various autoimmune disorders, including rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, hidradenitis suppurativa, ulcerative colitis, Crohn’s disease, plaque psoriasis, and uveitis. As a member of the TNF alfa inhibitors class, Abrilada effectively blocks TNF, a substance in the body that causes inflammation. Abrilada is available in multiple formats: a single-dose prefilled pen and glass syringe at doses of 40 mg per 0.8 mL, 20 mg per 0.4 mL, and 10 mg per 0.2 mL, as well as a single-dose glass vial of 40 mg per 0.8 mL. So, if you want to buy Abrilada online from Canada, you need to get a valid prescription from your doctor.

Product Overview

Abrilada (adalimumab) is a biosimilar to Humira that has received FDA approval and is used to manage and alleviate symptoms in various autoimmune disorders such as rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, hidradenitis suppurativa, ulcerative colitis, Crohn’s disease, plaque psoriasis, and uveitis. Classified as a TNF alfa inhibitor, Abrilada functions by blocking TNF, a substance in the body known to cause inflammation, thereby reducing pain, inflammation, and skin symptoms linked to these conditions. 

Available in a range of formats and strengths, Abrilada caters to different treatment needs through its single-dose prefilled Abrilada Pen, glass syringes available in doses of 40 mg per 0.8 mL, 20 mg per 0.4 mL, and 10 mg per 0.2 mL, and a single-dose glass vial at 40 mg per 0.8 mL. It is important for patients considering Abrilada to obtain a valid prescription, particularly when ordering from international sources like Canada. The medication is typically administered every two weeks, though some conditions and patient responses may necessitate weekly injections.

For optimal management of conditions treated with Abrilada, it is crucial to follow the prescribed Abrilada dosing regimen closely. This includes the initial administration phases for diseases like Crohn’s disease and ulcerative colitis that require a more aggressive dosing schedule at the start, followed by a regular maintenance dose. Patients should be thoroughly guided on the proper techniques for self-injection and must adhere strictly to their dosing schedule as directed by their healthcare provider, ensuring they understand when and how to adjust doses if necessary.

What Is Abrilada Used For? 

Abrilada is an FDA-approved medication designed to manage and treat various inflammatory conditions, such as

• Rheumatoid Arthritis
• Juvenile Idiopathic Arthritis
• Psoriatic Arthritis
• Ankylosing Spondylitis
• Hidradenitis Suppurativa
• Crohn’s Disease
• Ulcerative Colitis
• Plaque Psoriasis
• Uveitis

What Are the Forms & Strengths of Abrilada?

Abrilada is available in the following forms and strengths:

Single-dose Abrilada prefilled pen

• 40 mg per 0.8 mL

Single-dose Abrilada prefilled glass syringe

• 40 mg per 0.8 mL 
• 20 mg per 0.4 mL 
• 10 mg per 0.2 mL

Single-dose Abrilada glass vial 

• 40 mg per 0.8 mL

What Is the Recommended Dosage of Abrilada?

• Rheumatoid Arthritis Treatment for Adults

  • For adults battling rheumatoid arthritis, the standard regimen is a 40 mg injection administered bi-weekly. 
  • If you’re taking Abrilada without methotrexate, your physician might adjust your dose to 40 mg weekly or 80 mg every two weeks, based on how well you respond to treatment. 
  • Additionally, your doctor may also recommend other medications to complement your Abrilada therapy.

• Psoriatic Arthritis & Ankylosing Spondylitis Treatment for Adults

  • Individuals with psoriatic arthritis or ankylosing spondylitis typically receive a 40 mg injection every two weeks. 
  • Alongside Abrilada, your doctor may prescribe additional medications to support your treatment.

• Crohn’s Disease & Ulcerative Colitis Treatment for Adults

  • For those suffering from Crohn’s disease or ulcerative colitis, the treatment begins with an initial dose of 160 mg on the first day (which can be given as four 40 mg injections in one day or two 40 mg injections over two consecutive days). This is followed by an 80 mg dose on the fifteenth day (administered as two 40 mg injections in one day). 
  • From day 29 onward, a maintenance dose of 40 mg is given bi-weekly. 
  • Depending on your treatment response, your doctor may adjust the maintenance dose to 40 mg weekly or 80 mg every two weeks.

• Psoriasis Treatment for Adults

  • Start with an initial dose of 80 mg on day 1, administered as two 40 mg injections.
  • Follow up with 40 mg on day 8.
  • Continue with a maintenance dose of 40 mg every two weeks starting from day 22. 
  • Depending on how you respond to the treatment, your doctor might adjust the maintenance dose to either 40 mg weekly or 80 mg every two weeks.

• Uveitis Treatment for Adults

  • An initial dose of 80 mg on day 1 is given as two 40 mg injections. 
  • A follow-up dose of 40 mg on day 8.
  • A maintenance dose of 40 mg every two weeks beginning on day 22.

• Hidradenitis Suppurativa (HS) Treatment for Adults

  • An initial dose of 160 mg on day 1 can be administered as four 40 mg injections in one day or as two 40 mg injections per day over two consecutive days.
  • A subsequent dose of 80 mg on day 15 is given as two 40 mg injections.
  • A maintenance dose starting on day 29, which can be either 40 mg weekly or 80 mg every two weeks.

• Juvenile Idiopathic Arthritis (JIA) & Enthesitis-Related Arthritis (ERA) 

  • For children weighing 30 kg or more, the standard dose is 40 mg administered every two weeks.
  • For children weighing between 10 kg and less than 30 kg, the standard dose is 20 mg administered every two weeks.

• • Crohn’s Disease in Children 

• For children weighing 40 kg or more:

• • • Initial Abrilada dose: 160 mg on day 1, which can be given as four 40 mg injections in a single day or as two 40 mg injections per day across two consecutive days.
    • Second Abrilada dose: 80 mg on day 15, given as two 40 mg injections in one day.
    • Maintenance dose: 40 mg every two weeks starting from day 29. Depending on the child’s response, the doctor may adjust the maintenance dose to 40 mg weekly or 80 mg every two weeks.

• For children weighing less than 40 kg:

• • Initial Abrilada dose: 80 mg on day 1, given as two 40 mg injections in one day.
  • Second Abrilada dose: 40 mg on day 15.
  • Maintenance dose: 20 mg every two weeks starting from day 29. Depending on the child’s response, the doctor may adjust the maintenance dose to 20 mg weekly.

• • Psoriasis Treatment for Children 

• For children weighing 40 kg or more:

• • • Start with 40 mg administered weekly for the first two weeks, followed by 40 mg every two weeks thereafter.

• For children under 40 kg:

• • Start with 20 mg administered weekly for the first two weeks, followed by 20 mg every two weeks thereafter.

• Hidradenitis Suppurativa Treatment for Adolescents 

For adolescents aged 12 years and older with Hidradenitis Suppurativa (HS), weighing at least 30 kg, the treatment regimen is:

• An initial dose of 80 mg on the first day is given as two 40 mg injections.
• A follow-up dose of 40 mg on day 8.
• A maintenance dose of 40 mg every two weeks starting from day 22. Depending on the individual’s response, the doctor may adjust the maintenance dose to 40 mg weekly or 80 mg every two weeks.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Abrilada dosage accordingly.]

How Do You Inject Abrilada?

When you buy Abrilada online from Canada, you need to follow these administration guidelines associated with this:

• Administer Abrilada as a subcutaneous injection using a prefilled pen or syringe designed for one-time use.
• Adhere to the prescribed dosing schedule, which varies based on the severity and type of condition being treated, and always follow your doctor’s precise instructions.
• Learn the correct self-injection techniques from a healthcare provider to ensure safe and effective use of the medication. Seek clarification from your doctor or pharmacist if you are unsure about administering the medication.
• Avoid using Abrilada if any signs of infection are present; contact your doctor immediately for guidance.
• Prepare for each injection by cleaning the intended area of the skin with rubbing alcohol. Check the medication before use, and do not use it if the solution appears cloudy, discolored, or contains particles. In such cases, contact your pharmacist for a replacement.
• Allow the prefilled pen or syringe to reach room temperature naturally, between 15 to 30 minutes before injection. Avoid using external heat sources like microwaves or hot water to warm it.
• Do not shake the injection device, as this may damage the medication.
• Select an appropriate injection site, such as the front of your thighs or the abdomen area, avoiding a 2-inch radius around the navel. Rotate the injection site with each dose, ensuring new injection spots are at least 1 inch away from the last used spot.
• Avoid injecting into areas that are red, hard, tender, damaged, bruised, or scarred, and never inject through clothing.
• Be aware that Abrilada can weaken your immune system, increasing susceptibility to infections, some of which may be severe or life-threatening. Regular medical assessments are necessary to monitor your health.
• Use each needle and syringe only once. Dispose of them safely in a designated sharps disposal container after use.

[Note: Your doctor will decide the right Abrilada amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Adalimumab (Abrilada) Work in the Body?

Abrilada, also known as adalimumab, is a type of biological disease-modifying antirheumatic drug (DMARD). It targets and inhibits tumor necrosis factor (TNF), a protein that plays a significant role in the body’s inflammatory process. TNF is involved in various inflammatory diseases, and by blocking its action, Abrilada reduces inflammation and helps alleviate symptoms throughout the body. This reduction in inflammation can lead to a decrease in pain & swelling and can help prevent further tissue damage in diseases such as rheumatoid arthritis and psoriatic arthritis. Through this mechanism, Abrilada offers therapeutic relief and improves the quality of life for individuals suffering from these conditions.

Important Safety Information for Using Abrilada

What Are the Side Effects of Abrilada?

Common Side Effects of Abrilada: This medication can cause several common side effects that include:

• Injection Site Reaction: A common Abrilada side effect is injection site reactions. These reactions can include redness, swelling, itching, or pain when administering the injection. These symptoms are generally mild and resolve independently within a few days. Monitoring the site for severe or prolonged reactions is crucial. 
• Upper Respiratory Tract Infection: Patients receiving Abrilada may experience upper respiratory tract infections. Symptoms can include a runny or blocked nose, sore throat, cough, and general malaise. It is important to maintain good hygiene and avoid close contact with people who are sick. If you suspect an infection, seek medical advice quickly. 
• Headache: Headaches are a frequently reported side effect of Abrilada. These headaches can vary in severity and occur due to the body’s response to the medication. Managing stress, adequate hydration, and regular sleep can help alleviate this symptom. 
• Rash: Some patients on Abrilada develop skin rashes. These rashes may appear as red, itchy, or inflamed skin across various parts of the body. It’s essential to monitor the rash and seek medical advice if it spreads or worsens. Over-the-counter creams and medications may help, but always check with a healthcare provider first. 
• Sinus Inflammation: Abrilada can lead to sinus inflammation, resulting in symptoms such as a stuffy nose, facial pain, or pressure and a reduced sense of smell. Treatments for sinus inflammation include steam inhalation, nasal sprays, and staying hydrated.
• Accidental Injury: While not directly a side effect of the medication itself, patients taking Abrilada may experience accidental injuries due to general weakness or fatigue as a reaction to the treatment. It is important to take precautions such as avoiding strenuous activities until you know how Abrilada affects your body. 
• Nausea: Nausea is another side effect that can occur when taking Abrilada. Eating small, frequent meals and avoiding spicy or fatty foods can help manage this symptom. If nausea worsens or leads to vomiting, contact your healthcare provider for advice. 
• Fever: A common side effect of Abrilada is fever, which indicates an immune response possibly triggered by the medication. Patients may experience elevated body temperatures, a common occurrence when treating conditions such as rheumatoid arthritis. Managing your body temperature while undergoing treatment is crucial. 
• Swollen Glands: Abrilada can cause the lymph glands to swell, a sign that the body is fighting an infection or reacting to the medication itself. This swelling can be uncomfortable and may occur in various body parts. If you’re using Abrilada to manage rheumatoid arthritis and notice swollen glands, it’s advisable to monitor this condition closely with your healthcare team.
• Night Sweats: Those on Abrilada injections may experience night sweats, which can disrupt sleep and complicate daily life. This symptom can be intense and require changes in sleeping arrangements or nightwear.
• General Feeling of Illness: A generalized feeling of being unwell is a reported side effect of Abrilada. This nonspecific symptom can include fatigue, weakness, or a vague sense of discomfort. 
• Joint and Muscle Pain: While Abrilada alleviates the pain associated with rheumatoid arthritis, it can paradoxically cause joint and muscle pain as a side effect. 
• Easy Bruising: Patients taking Abrilada may notice that they bruise more easily. This can occur even with minor bumps or no clear cause, indicating changes in blood clotting factors or skin vulnerability. 
• Unusual Bleeding: Similar to easy bruising, unusual bleeding is a serious side effect of Abrilada. This can include bleeding gums, nosebleeds, or other bleeding that is not normal for the individual. Anyone experiencing these symptoms while using Abrilada to manage rheumatoid arthritis should seek immediate medical attention.
• Pale Skin: Pale skin may indicate anemia, another side effect of Abrilada. This condition can lead to fatigue and weakness, affecting overall health. 
• Lightheadedness: Lightheadedness or dizziness can occur as a side effect of Abrilada, potentially affecting balance and daily activities. This can be particularly challenging for patients managing rheumatoid arthritis. 

Serious Side Effects of Abrilada: When you buy Abrilada to manage rheumatoid arthritis, you can consider the following serious side effects:

• Serious Infections: Patients using Abrilada for rheumatoid arthritis should be active for signs of serious infections. These include fever, cough, muscle aches, and weight loss, as well as dark urine, chills, and vomiting. Such infections require prompt medical attention, as Abrilada can suppress the immune system, reducing its ability to combat pathogens. Regular health monitoring is essential while on this medication.
• Low Blood Cell Counts: A reduction in blood cell counts is a significant risk when taking Abrilada. Symptoms such as unrelenting fever, easy bruising or bleeding, and pale skin indicate this condition. This reduction can impair the body’s clotting and infection-fighting abilities. Immediate consultation with a healthcare provider is crucial if these symptoms occur.
• Severe Allergic Reactions: Abrilada may cause severe allergic reactions. Symptoms include rash, difficulty breathing, and swelling of the face, eyes, lips, or mouth, along with hives. These reactions can be critical and require urgent medical care. Patients should seek emergency help if they experience any of these symptoms.
• Heart Failure: Heart failure is a potential risk for patients taking Abrilada, especially those with existing heart conditions. Symptoms to watch for include shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, excessive tiredness, and sudden weight gain. These symptoms suggest potential heart failure. Regular medical check-ups are necessary to monitor heart health while using Abrilada.
• Liver Problems: Liver issues can arise as a serious side effect of Abrilada. Symptoms such as vomiting, yellowing of the skin or eyes, stomach pain, and unusual fatigue may indicate liver damage, which can be severe. Immediate medical intervention is necessary if these symptoms appear.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Abrilada? 

The answer is yes. Abrilada, which contains adalimumab, may pose serious health risks, particularly to certain groups of individuals. If you have concerns about these risks, it is important to discuss them with your healthcare provider, who may consider alternative treatment options.

• Risk of Serious Infections from Abrilada: This medication increases the likelihood of severe infections, which can sometimes be life-threatening. This risk is more pronounced in individuals who are older, are taking other immune-suppressing medications (such as methotrexate, abatacept, anakinra, or corticosteroids), or have underlying health conditions that predispose them to infections. 
• Cancer Risk Associated with Abrilada: Patients taking Abrilada or similar medications have shown a higher incidence of certain cancers, including lymphoma, leukemia, and skin cancers, during clinical trials. It is critical for your healthcare provider to assess your risk for cancer before initiating Abrilada and to monitor you during treatment. If you have a history of cancer or are at increased risk due to other conditions like COPD and a history of smoking, discuss these factors with your healthcare provider.
• Potential for Severe Allergic Reactions to Abrilada: Abrilada may cause severe allergic reactions, such as anaphylaxis, which is an emergency condition where the throat may close. Symptoms such as rashes, breathing difficulties, itching, or swelling in the face or throat require immediate medical intervention.
• Effects of Abrilada on the Nervous System: Although uncommon, Abrilada can induce or worsen conditions that affect the nervous system, such as multiple sclerosis (MS) or Guillain-Barré syndrome. Patients with pre-existing neurological conditions should inform their healthcare provider, who may monitor symptoms closely during treatment. Symptoms like numbness, tingling, muscle weakness, vision changes, or dizziness should be reported immediately to a healthcare provider.
• Abrilada’s Impact on Blood Cell Counts: Treatment with Abrilada can result in lower blood cell counts, elevating risks of bleeding and infection. Notify your healthcare provider if you experience persistent fever, easy bruising, pale skin, or unusual bleeding.
• Heart Failure and Abrilada: Patients using Abrilada have experienced new or worsening heart failure. Discuss your heart health with your healthcare provider before using Abrilada, especially if you have a history of heart failure. Be alert to symptoms like shortness of breath, swelling in your legs, ankles, or feet, irregular heartbeats, or unusual tiredness or weakness.
• Lupus-like Syndrome from Abrilada: In rare cases, Abrilada can cause a condition resembling lupus, marked by symptoms such as rashes, unusual bruising or bleeding, or increased fatigue. These symptoms should be promptly reported to your healthcare provider.

What Are the FDA Boxed Warning for Abrilada?

The product label for Abrilada includes a Boxed Warning, which is the most serious warning from the FDA. This warning is used to alert healthcare professionals and patients about the significant risks of using the medication. For Abrilada, these risks include an increased likelihood of serious infections and the potential for developing malignancies. This information is crucial for guiding treatment decisions and monitoring for adverse effects throughout the therapy period.

What Are the Abrilada Precautions?

When using Abrilada, it’s important to consider the following precautions:

• Infection Precautions: Before starting treatment with Abrilada, it’s crucial to inform your doctor if you exhibit any signs of infection, such as fever, chills, muscle aches, fatigue, cough, presence of bloody mucus, skin sores, diarrhea, painful urination, or a general feeling of being unwell.
• Age and Immunization Considerations: Abrilada is approved for specific age groups and conditions. If children are prescribed Abrilada, ensure they are up to date with all childhood immunizations prior to commencing therapy.
• Medical History Disclosure: Inform your doctor if you have a history of any of the following conditions:

• Tuberculosis, or exposure to it within your household.
• Any chronic infections.
• Cancer.
• Hepatitis B, as Abrilada, may reactivate or worsen this condition.
• Residency or travel to areas like the Ohio and Mississippi River valleys, which are prone to fungal infections such as histoplasmosis, coccidioidomycosis, or blastomycosis.
• Diabetes.
• Heart failure.
• Any neurological symptoms such as numbness, tingling, or disorders like multiple sclerosis or Guillain-Barre syndrome.
• Upcoming major surgery.
• Recent or upcoming vaccinations.

• Travel and Residential Concerns: Discuss your current living location and any recent or planned travels with your doctor to assess potential exposure to region-specific infections.

• Considerations for Older Adults: Individuals over 65 years old may face a higher risk of infections while on Abrilada. It is essential for you and your doctor to monitor for any signs of infection during treatment.

• Pregnancy and Abrilada: The effects of Abrilada on an unborn baby are unknown. If you are pregnant or planning to become pregnant, notify your doctor. Ensure that any healthcare provider who treats your newborn is aware if you used Abrilada during your pregnancy, especially before administering any vaccines to the baby.

• Breastfeeding: Breastfeeding might not be safe while using Abrilada. Discuss the risks and the best methods to feed your baby during this period with your doctor.

What If You Miss a Dose of Abrilada?

If you forget to administer your dose of Abrilada at the scheduled time, you should take the missed dose as soon as you remember. Following this, you should continue with your normal injection schedule, taking your next dose on the usual day as planned. It is important not to inject two doses at once to make up for the missed one, as this could lead to unwanted side effects. Instead, simply resume your regular dosing routine.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Abrilada?

In the event of an overdose where severe symptoms such as loss of consciousness or difficulty breathing occur, it is critical to call 911 immediately. For other overdose scenarios not presenting immediate life-threatening symptoms, contact your local poison control center without delay.

[Note: If you consumed more than the recommended dose, get medical help immediately, or call the Poison Help line at 1-800-222-1222.]

How to Store Abrilada?

When you buy Abrilada online from Canada, you can consider the following storage guidelines:  

• Keep your medicine in its original packaging until use to protect it from light.
• Store Abrilada in the refrigerator at temperatures between 36ºF to 46ºF (2ºC to 8ºC); do not freeze.
• Ensure Abrilada is stored in the refrigerator out of reach of children.
• Maintain the correct temperature for the medicine during travel, whether by car, bus, train, plane, or other transportation.
• If necessary, a single Abrilada syringe, pen, or vial may be kept at room temperature (up to 30°C) for a maximum of 30 days; always shield it from light.
• Once a syringe, pen, or vial is removed from the refrigerator and stored at room temperature, use it within 30 days or dispose of it, even if it has been returned to the refrigerator.
• Mark the date on the label when you remove the pen, syringe, or vial from the refrigerator to track how long it has been out.
• Do not use Abrilada after the expiration date or if the packaging is torn or shows signs of tampering.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Drugs Interact with Adalimumab (Abrilada)?

Major drug interactions with Abrilada (adalimumab) are:

• Abatacept
• Baricitinib
• Cabazitaxel
• Dacarbazine
• Eculizumab
• Fam-trastuzumab deruxtecan
• Ganciclovir
• Hydrocortisone
• Ibritumomab
• Leflunomide
• Measles virus vaccine
• Nadofaragene firadenovec
• Obinutuzumab
• Paclitaxel
• Quizartinib
• Radium 223 dichloride
• Sacituzumab govitecan
• Tacrolimus
• Ublituximab
• Valganciclovir
• Yellow fever vaccine
• Zanubrutinib

What Are the Other Abrilada Interactions?

Apart from drug interactions, Abrilada also has the following other interactions:

• Abrilada Disease Interactions: There are 8 disease interactions with Abrilada, which include:

• Interaction with Infections: Serious infections such as sepsis and opportunistic infections have been reported using TNF blockers like Abrilada. These infections include bacterial, mycobacterial, invasive fungal, viral, parasitic, and other opportunistic pathogens like aspergillosis, legionellosis, blastomycosis, coccidioidomycosis, histoplasmosis, listeriosis, candidiasis, pneumocystosis, and tuberculosis. It is advised not to initiate treatment with Abrilada in patients with active infections, including significant localized infections. There should be caution and close monitoring when considering using Abrilada in patients with a history of recurrent infections, underlying conditions predisposing them to infections, or those with chronic, latent, or localized infections. Discontinue administration if a patient develops a serious infection or sepsis.

• Interaction with Malignancies: Clinical trials have observed malignancies in patients receiving TNF blockers. Patients with psoriasis should be monitored for non-melanoma skin cancers (NMSCs), especially those with a history of extensive phototherapy. Reports of melanoma and Merkel cell carcinoma have been noted in patients treated with TNF blocker therapy. Periodic skin examinations are recommended for all patients, particularly for those with skin cancer risk factors. There have also been postmarketing reports of fatal hepatosplenic T-cell lymphoma (HSTCL) in patients treated with TNF blockers. Use caution in patients with a history of malignancies or in those who develop malignancies while undergoing treatment.
• Neurologic Reactions: TNF blockers, including Abrilada, have been associated with rare cases of CNS manifestations such as systemic vasculitis, seizures, new onset or exacerbation of symptoms, and radiographic evidence of central nervous system demyelinating disorders like multiple sclerosis and optic neuritis, as well as peripheral demyelinating disorders including Guillain-Barré syndrome. 

• Tuberculosis: TNF blockers can reactivate tuberculosis or cause new tuberculosis infections in patients, including those who have previously been treated for latent or active tuberculosis. Active tuberculosis cases have also occurred in patients being treated with these agents for latent tuberculosis. Patients should be screened for latent tuberculosis infection with a tuberculin skin test before starting and periodically during treatment with TNF blockers. Those testing positive should be treated according to standard medical practice before therapy with TNF blockers. 
• Congestive Heart Failure: TNF blockers have been associated with cases of worsening or new onset congestive heart failure (CHF). Adalimumab, another TNF blocker, has not been formally studied in patients with CHF but has been observed to have a higher rate of serious CHF-related adverse reactions in clinical trials of another TNF blocker. Use caution when treating patients with heart failure and monitor them closely.
• Chronic Obstructive Pulmonary Disease: In controlled trials of TNF blockers, a higher incidence of malignancies was noted among patients at higher risk for malignancies (such as those with a significant smoking history and patients treated with cyclophosphamide for Wegener’s granulomatosis) compared to controls.
• Hematologic Abnormalities: Reports of leukopenia, thrombocytopenia, neutropenia, and pancytopenia, some of which were fatal, have been associated with TNF blockers. 
• Hepatitis B: Reactivation of hepatitis B, sometimes fatal, has been associated with TNF blockers in patients previously infected with the hepatitis B virus (HBV). Screen for viral hepatitis according to published guidelines before starting therapy, and monitor patients at risk or with evidence of current or prior HBV infection for clinical and laboratory signs of hepatitis or HBV reactivation. Exercise caution in prescribing TNF blockers to patients previously infected with HBV. 

• Interaction with Herbs and Supplements: Specific interactions between Abrilada and herbal or dietary supplements have not been well-documented. However, patients should consult with their healthcare provider before starting any new herbal or dietary supplements while on Abrilada treatment, as some supplements may alter immune function or interfere with the medication’s effects.

• Interaction with Alcohol: There is no direct interaction between Abrilada and alcohol noted in the medical literature; however, excessive alcohol consumption may exacerbate serious conditions or interfere with the immune system. 

[Note: This isn’t a complete list, and there could be other drugs that interact with Abrilada. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Abrilada Alternatives?

If you are looking for alternatives to Abrilada, there are several other medications that can be used depending on the specific condition being treated. Here are some of the common alternatives:

• Psoriasis

• • Clobetasol
  • Stelara (ustekinumab)
  • Methotrexate
  • Triamcinolone
  • Ustekinumab
  • Skyrizi (risankizumab)

• For Plaque Psoriasis

• • Otezla (apremilast)
  • Skyrizi (risankizumab)
  • Tremfya (guselkumab)
  • Taltz (ixekizumab)
  • Stelara (ustekinumab)
  • Apremilast

• For Psoriatic Arthritis

• • Methotrexate
  • Otezla (apremilast)
  • Enbrel (etanercept)
  • Stelara (ustekinumab)
  • Humira (adalimumab)
  • Cimzia (certolizumab pegol)
  • Taltz (ixekizumab)

• For Ankylosing Spondylitis

• Cosentyx (secukinumab)
• Celebrex (celecoxib)
• Enbrel (etanercept)
• Prednisone
• Cimzia (certolizumab pegol)
• Diclofenac

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Abrilada Cost & Coupons

Abrilada is a reliable treatment for rheumatoid arthritis, although its retail cost can be a concern for many across the US. To counter these steep prices, numerous patients opt for services like Polar Bear Meds to access more affordable options. Additionally, the pharmacy provides valuable coupons to enhance savings. If you’re in America, Buy Abrilada online with a coupon using the code “WELCOMEPB10” to enjoy a 10% discount on your initial order. Take advantage of these budget-friendly solutions for a smooth and economical way to purchase quality medications.

Frequently Asked Questions

Is Abrilada the same as Humira?

Yes, Abrilada is essentially the same as Humira in terms of its active ingredient and its use for various conditions. It is interchangeable with Humira for the approved indications, dosage forms, strengths, and routes of administration. However, Abrilada is not approved for use in pediatric ulcerative colitis, adolescent hidradenitis suppurativa, and pediatric uveitis, which are conditions that Humira is approved to treat. This means that while Abrilada can be used in similar ways as Humira for most conditions, there are specific pediatric uses for which it has not received approval.

Does Abrilada cause weight gain?

No, Abrilada does not typically cause weight gain. The common side effects associated with Abrilada are more related to serious infections, potential liver issues, and allergic reactions. Weight gain is specifically mentioned as a potential symptom of new or worsening heart failure, a serious but uncommon side effect, rather than a direct effect of the medication itself​.

Is adalimumab a chemo drug?

No, adalimumab is not classified as a chemotherapy drug. It is a type of biological therapy, specifically a TNF inhibitor. Adalimumab targets and neutralizes TNF (tumor necrosis factor), a protein in the body that causes inflammation and can lead to joint damage in conditions like rheumatoid arthritis. This differs from chemotherapy drugs, which generally target rapidly dividing cells and are used primarily to treat cancer.

Does adalimumab affect kidneys?

Yes, adalimumab can affect the kidneys. There are documented cases where adalimumab has been associated with kidney issues such as chronic interstitial nephritis. These effects can be caused by patchy inflammation and structural changes in the kidney tissue, which might lead to kidney dysfunction or acute renal failure in some patients​. However, it’s important to note that such kidney-related side effects are relatively rare but should be considered, especially in patients with pre-existing kidney conditions or those who are particularly susceptible to kidney issues.

Is adalimumab a steroid?

No, adalimumab is not a steroid. It is a biological medicine, specifically a type of protein that works by targeting the immune system to reduce inflammation.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Abrilada online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Abrilada online to manage rheumatoid arthritis at a substantial cost, call us at 1-888-779-2193 toll-free.