Perindopril/Indapamide
Aceon Plus
Aceon Plus is a combination medication used to treat hypertension or high blood pressure. It contains perindopril and indapamide, which belong to different classes of drugs. The ACE inhibitor perindopril helps widen the blood vessels, allowing smooth flow of the blood. At the same time, indapamide is a diuretic (water pill) that helps the body to excrete extra salt and fluid through urination. In addition, the medication also reduces the risk of heart attack and death in people with heart problems. This prescription drug is recommended for use in adults requiring combination therapy to maintain consistent blood pressure levels. Its tablet forms are available in different strengths, so patients planning to buy Aceon Plus online must consult a medical professional for appropriate dosage recommendations.
Product Overview
Aceon Plus is an FDA-approved medication used to manage hypertension. This prescription drug contains perindopril erbumine as its active ingredient, often combined with another drug, indapamide. Perindopril is an angiotensin-converting enzyme that effectively reduces blood pressure by widening blood vessels & improving blood flow. When this drug is paired with indapamide, a diuretic that helps eliminate extra fluid from the body, the medication works effectively in lowering blood pressure levels.
Aceon Plus is available as oral tablets in varying strengths, like 4 mg/1.25 mg, 5 mg/1.25 mg, and 8 mg/2.5 mg. Doctors usually recommend taking the medication at the same time each day for better results. It is suitable for adults and is especially beneficial for people who need combination therapy to maintain their blood pressure levels effectively.
Despite its benefits, the medication can cause various side effects like dizziness or gastrointestinal discomfort. Since these effects are temporary, they do not require immediate medical attention, but serious reactions like mood changes and unexplained muscle pain should not be overlooked, as they can cause life-threatening situations. Moreover, patients are advised to follow safety precautions before using this medication. Doing so helps avoid the risk of potential side effects. If you plan to buy Aceon Plus online, consult a medical professional.
What Is Aceon Plus Used For?
This medication is used to treat hypertension or high blood pressure.
What Forms & strengths does Aceon Plus come in?
Aceon Plus comes in the form of an oral tablets with the following strengths:
- Low Dose Tablet: 2mg/0.625mg
- High Dose Tablets: 4mg/1.25mg, 5mg/1.25mg, and 8mg/2.5mg
What Is the Recommended Dosage for Aceon Plus?
The recommended dose of Aceon Plus may vary depending on various factors like the age and severity of the medical condition. Although the following section includes the average doses of the medication, patients must consult an expert for appropriate doses.
- Initial Treatment: The typical starting dose of Aceon Plus is 2 mg/0.625 mg. This low dose is particularly suitable for the initial management of mild to moderate hypertension.
- Subsequent Therapy: For patients requiring a high dose after the initial treatment, 4mg/1.25mg or 8mg/2.5mg may be used. However, this dosage is not suitable for the starting stage due to the risk of symptomatic hypertension.
- Maintenance Dose: Doctors first start by determining the appropriate for each individual drug. Then, they fix a dose for the patient, leaving room for personalizing the dosage if needed.
[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Use Aceon Plus?
Proper administration is crucial to increase the effectiveness of the medication you are taking. If you plan to buy Aceon Plus to treat hypertension, follow the below administration steps:
- Read the medication guide & follow the instructions carefully.
- Take the medication by mouth once a day. It is usually advised to take it in the morning as Aceon causes patients to urinate.
- If you are taking the medication at bedtime, try to take it at least 4 hours before sleeping.
- Take the medicine as a whole with a glass of water.
- Do not crush, chew, or break the medicine. Doing so may release all the drugs at once, causing potential side effects.
- If you are unable to swallow the medicine, talk to a medical professional.
- Do not abruptly discontinue the medication, as it may take a few weeks to see the full benefits.
- People taking other cholesterol-lowering drugs like cholestyramine or colestipol should take Aceon Plus at least 4 hours before or after taking other drugs.
- If the condition does not improve or worsens over time, consult a medical expert.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
What Is Aceon Plus’s Mechanism of Action?
Aceon Plus is a combination of two drugs; thus, it works in two ways to lower blood pressure. Perindopril is an ACE inhibitor that blocks enzymes like angiotensin-converting enzyme, producing angiotensin II (a hormone). This hormone usually causes blood vessels to contract and blood pressure to rise. By restricting the production of ACE, perindopril helps blood vessels relax and widen, resulting in low blood pressure. At the same time, indapamide is a water pill that aids in eliminating excess salt and water from the body through urine. This fluid reduction lowers the blood volume and helps lower blood pressure.
Important Safety Information for Using Aceon Plus
What Are the Side Effects of Aceon Plus?
Common Side Effects of Aceon Plus: Like all medication, Aceon Plus can cause some common reactions. These effects are generally temporary and subside within a few days or weeks once your body adjusts to the drug’s effects. However, consult a medical professional if they become severe or bother you. Some of the common side effects of Aceon Plus may include:
- Headache: Due to fluctuations in blood pressure, many people can experience headaches. This side effect generally happens at the start of the treatment and will subside once your blood pressure levels return to normal. To manage headaches, drink plenty of water throughout the day and take over-the-counter pain relievers after asking your doctor.
- Dizziness: A drop in blood pressure can result in dizziness. This is a common side effect that happens when you stand up suddenly from a lying or sitting position. To prevent this, avoid sudden movements, stay hydrated, and take your medicines timely.
- Tiredness: Many patients can experience tiredness after taking their medication. This happens due to the drug’s effects on the body. It is a temporary side effect that lessens over time. In the meantime, take proper rest & maintain a balanced diet to support your energy levels. However, if the tiredness persists, talk to a medical expert.
- Nausea: This side effect results from changes in blood pressure levels or dehydration. It usually happens at the start of the treatment and lessens over time once your body adjusts to the effects of the medication. To prevent nausea, eat small, frequent meals and avoid spicy foods.
- Dry Cough: This is a common side effect that happens due to the mechanism of ACE inhibitors like Aceon Plus. The medication prevents the breakdown of substances like bradykinin, which accumulate in the respiratory tract. To prevent dry cough, drink plenty of water and avoid irritants, such as smoke. However, if the cough becomes severe, talk to a doctor.
- Dehydration or Electrolyte Imbalance: It occurs because of the diuretic component in the medicine, which increases urine production. Elimination of bodily fluids can further lead to electrolyte imbalance, causing dehydration. To prevent this side effect, stay hydrated and maintain a balanced diet rich in electrolytes.
- Stomach Pain: Changes in blood pressure or gastrointestinal irritation can lead to stomach pain. The pain range from mild to moderate, which can be prevented by taking the medicine with food. Moreover, avoid foods that may irritate your stomach lining. Over-the-counter pain relievers can also help reduce the discomfort.
- Loss of Appetite: Many people also lose their appetite during treatment with Aceon Plus, which generally happens due to changes in blood pressure and gastrointestinal effects. To manage this side effect, eat small, frequent meals & consume foods that are easy to digest.
- Drowsiness: Fluctuations in blood pressure can make you feel sleepy or drowsy. This is a common side effect that generally happens in the initial phase of the treatment and may subside once your blood pressure becomes stable. To manage drowsiness, maintain a healthy diet and take your medicines on time to avoid changes in blood pressure.
Serious Side Effects of Aceon Plus: This medication combines two drugs, which may cause severe reactions in certain patients. If you suspect any unusual signs after taking this drug, report them immediately to your medical provider. Some of the serious side effects of Aceon Plus may include:
- Kidney Problems: This side effect occurs in patients with existing kidney problems or those who are dehydrated. The drugs present in the medication can impact kidney functioning by altering blood flow within the kidneys. If you notice symptoms like swelling in the legs, weakness, or reduced urine, contact your doctor right away.
- High Potassium Levels: Hyperkalemia results from the use of Aceon Plus, as it affects the electrolyte balance in the body. High potassium levels can lead to serious heart rhythm problems. If you experience irregular heart rhythm, consult your medical provider.
- Fainting: A sudden drop in blood pressure can result in fainting, especially when you stand up quickly from a sitting or lying position. If you experience persistent fainting after taking this medication, reach out to a medical professional.
- Vision Changes: You may notice blurred vision or halos around lights during your treatment with Aceon Plus. This is a serious side effect that happens due to fluctuations in blood pressure or fluid levels in the eye. Watch out for any changes in your vision and report them immediately to your doctor.
- Eye Pain: A reduced blood flow or changes in fluid levels in the eye can result in eye pain. This side effect is serious and, if left untreated, can cause life-threatening situations. If you experience eye pain for a long time after taking this medication, visit your doctor immediately.
- Liver Diseases: Problems like hepatitis or jaundice can occur as a side effect of Aceon Plus. These conditions are related to the liver and happen due to the medication’s impact on liver function. Therefore, patients taking this drug are advised for regular liver function tests. If you suspect any signs like dark urine, severe fatigue, and yellowing of skin or eye, seek immediate medical assistance.
- Severe Allergic Reaction: Aceon Plus can cause severe allergic reactions like difficulty breathing or swelling on the lips, face, tongue, or throat. These effects should not be overlooked, as they can lead to severe life-threatening situations. Watch out for any of these reactions and report them directly to your doctor.
- Mood Changes: While rare, this medication can cause mood changes like depression or anxiety in certain patients. These changes may result from the medication’s impact on blood flow and brain function. If you notice any such signs, talk to a medical professional.
- Infections: People with a weakened immune system who are taking Aceon Plus are more likely to experience this side effect. This medication can affect the body’s ability to fight off infections. If you notice signs like fever, chills, or sore throat, immediately seek medical attention.
- Unexplained Muscle Pain: This side effect is related to changes in blood flow or electrolyte imbalances. While gentle stretching and taking over-the-counter can help reduce the pain, it is important to discuss this with your doctor. Doing so avoids the potential risk of complications.
- Hypotension: Aceon Plus helps reduce blood pressure, but it often results in severe low blood pressure, especially when taken in large quantities. Therefore, patients are advised always to follow their doctor’s instructions. If you notice symptoms like dizziness, fainting, and fatigue, consult your doctor right away.
- Neutropenia & Agranulocytosis: Low white blood cell count is a severe side effect of Aceon Plus that occurs due to the medication’s impact on bone marrow function. While rare, it should not be overlooked. People taking this medication should be aware of signs like frequent infections, fever, or unusual bruising. If you suspect any during your treatment, discuss them with your medical provider.
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Are There Any Warnings for Aceon Plus?
Yes, there are several warnings associated with the use of this medication. If you plan to buy Aceon Plus to treat hypertension, you must be aware of the following warnings:
- Angioedema: While rare, this medication can result in conditions like angioedema, where swelling occurs under the skin, particularly around the neck, throat, and face. This condition can become life-threatening if it causes difficulty breathing. People using this medication should consult a doctor if they notice any such signs.
- Intestinal Angioedema: Aceon Plus can also cause intestinal swelling, leading to stomach pain along with nausea and vomiting. If you experience such a condition, seek immediate medical attention and stop using the drug.
- Hypotension: This medication can severely drop your blood pressure levels, especially at the start of the treatment or when your doctor increases the dose. As a result, you can experience fainting or severe problems in patients with heart diseases.
- Surgery & Anesthesia: Perindopril/indapamide can interact with anesthesia and other surgical medications, resulting in conditions like hypotension. Therefore, doctors advise discontinuing the medication one day prior to surgery.
What Is the FDA Boxed Warning for Aceon Plus?
Boxed warnings are among the most stringent warnings issued by the FDA. These vigilant warnings alert doctors and patients about the harmful effects of a particular prescription drug. Aceon Plus also carries a boxed warning associated with its use:
- Fetal Toxicity: Pregnant women using drugs like Aceon Plus can affect the renin-angiotensin system during the second and third trimesters, harming the developing baby’s kidney function and increasing the risk of illness and death for both the baby and mother. This results in oligohydramnios, a condition where there is too little amniotic fluid, causing underdeveloped lungs and abnormal bone growth in the baby. Moreover, the baby may also experience other serious problems like an underdeveloped skull, low blood pressure, kidney failure, no urine production, or death in extreme cases. If you are taking Aceon Plus and pregnancy is detected, discontinue the medication’s use and consult a medical provider.
What Are the Aceon Plus Precautions?
If you plan to buy Aceon Plus online, you must know certain safety guidelines to prevent the risk of potential side effects. These precautions are as follows:
- If you are allergic to perindopril, indapamide, or any of the ingredients listed in the medication formulation, inform your doctor immediately. The product contains certain components that can cause severe allergic reactions.
- People with planned surgeries or other medical procedures should tell their doctor beforehand about the products they are using. This includes all prescription medications, over-the-counter drugs, and herbal supplements. This step is important, as many drugs, including Aceon Plu,s can interact with anesthesia.
- When considering treatment with this medication, share a complete medical history with your doctor to avoid the risk of potential complications. The conditions that must be informed to a medical professional include:
- Connective tissue diseases
- Diabetes Mellitus
- History of angioedema
- Kidney diseases
- Liver problems
- Aceon Plus can cause dizziness, fatigue, or headaches. Therefore, people are advised to avoid driving, using heavy machines, or engaging in activities that require a sharp mind. This effect usually happens at the start of the treatment.
- Do not use this medication with other drugs that affect the renin-angiotensin system, as it can raise the risk of low blood pressure, kidney damage, and hyperkalemia.
- Be cautious while taking Aceon Plus with medications like mTOR inhibitors or DPP-IV inhibitors, as it can raise the risk of experiencing angioedema. Always consult a professional before co-administering two or more drugs.
- This medication may affect your kidney functioning. Therefore, users must inform their doctors of the drug they are taking. This step is important as regular monitoring is required in patients with existing kidney issues.
- Aceon Plus can cause dehydration, and this risk is higher if you experience excessive sweating, diarrhea, or vomiting. Watch out for these signs and report them immediately to your doctor.
- Pregnant women or those planning to get pregnant should not use this medication, as it can harm the developing fetus.
- Breastfeeding mothers should consult a medical expert before using this medication. Discuss every risk & benefit associated with the use of this medication.
- This medication can increase potassium levels, so users should consult a medical professional. They will closely monitor each patient for any changes.
- ACE inhibitors like perindopril can cause persistent dry cough. To prevent this side effect, talk to a medical professional.
- Older patients are extremely sensitive to the effects of this medication. So, always consult a doctor; they will adjust the dosage accordingly.
- This medication can raise the levels of blood glucose, especially in diabetic patients.
What Are the Contraindications of Aceon Plus?
Do not use this medication if you fall under any of the following categories:
- People with hypersensitivity reactions to ACE inhibitors, hydrochlorothiazide, sulfonamide derivatives, or other ingredients present in this medication.
- People with a history of angioedema due to genetic reasons or earlier reactions to ACE inhibitors.
- Kidney problems
- Low Potassium Levels
- Liver issues
- Hepatic encephalopathy
- Combination with certain heart medications, causing conditions like torsade de pointes
- Genetic intolerance to galactose
- Co-administration with sacubitril/valsartan
- Co-administration with aliskiren-containing drugs in people with diabetes
What If You Miss a Dose of Aceon Plus?
- If you miss a dose of your medication, take the missed dose as soon as possible.
- However, if it is close to the time of the next dose, you can skip the previous one and follow the regular dosing schedule.
- Do not take two medicines simultaneously to make up for the missed dose.
- Use medication apps or set times on your mobile devices to avoid skipping any doses.
- If you are still unsure what to do next, talk to a medical expert.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
What Happens If You Take Too Much of Aceon Plus?
Taking more than the prescribed dose of Aceon Plus can cause various harmful effects. The most common one is hypotension. Such a condition can result in symptoms like dizziness, nausea, cramps, drowsiness, changes in urine output, and confusion. Moreover, people can also notice changes in body salt and fluid balance. If you are noticing any of these signs, seek immediate medical assistance or call 911.
[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]
How to Store Aceon Plus?
To maintain the long-term effectiveness and safety of your medication, you must keep the drug in a controlled environment. Here are some storage guidelines for Aceon Plus:
- Store the medication at a normal temperature.
- Keep the medicine in its original packaging to prevent it from being exposed to light and moisture.
- Store the medicine somewhere safe to keep it away from the reach and out of sight of children.
- Before you decide to buy Aceon Plus online from Canada, check its expiration date, as many online medical providers engage in unethical practices. This step prevents the risk of potential complications caused by expired medicines.
- Discard the product when not in use or expired.
- Ask a medical expert how to dispose of the medication safely without damaging the environment.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
What Medications Interact with Aceon Plus?
Co-administering drugs without medical guidance can result in adverse reactions. Therefore, people using Aceon Plus are advised to always consult a medical professional before combining any two or more drugs. If you plan to buy Aceon Plus online from Canada, be cautious of the drugs you are taking. Here is a list of certain drugs that can cause major drug interactions if taken with Aceon Plus:
- Aliskiren
- Allopurinol
- Aspirin
- Azilsartan
- Birth control pills containing drospirenone
- Candesartan
- Ibuprofen
- Naproxen
- Sacubitril/valsartan
[Note: This isn’t a complete list, and there could be other drugs that interact with Aceon Plus. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
What Are the Aceon Plus Alternatives?
While many drug alternatives are available in the market, people must discuss with their doctor before switching from one treatment option to another. These professionals will closely monitor each individual’s medical condition and prescribe the most suitable drug alternative accordingly. If you are looking for drug alternatives to Aceon Plus, here are some of them:
- Ramipril
- Amlodipine
- Lisinopril
- Nifedipine
- Furosemide
- Carvedilol
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Aceon Plus Cost & Coupons
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Frequently Asked Questions
Is perindopril a good blood pressure tablet?
Yes, perindopril is an effective blood pressure medication for treating high blood pressure. This medicine works by relaxing blood vessels, resulting in a smooth blood flow. It also helps lowers the risk of strokes & heart attacks. Many users find it convenient due to its once daily regimen.
Is it better to take perindopril in the morning or at night?
There is no specific timings for taking perindopril. It depends on the individual’s lifestyle and suitability when they want to take the medication. However, doctors recommend taking the medicine 30 to 60 minutes before the first meal of the day. This helps ensure that the medicine is absorbed properly and works effectively all over the day. For specific timing, consult a medical professional. They will determine the best time to suit your body’s needs.
Can you eat bananas if you take perindopril?
It is generally best to avoid eating bananas during treatment with perindopril. This is because, bananas are high in potassium and this drug can increase potassium levels in your blood. Excessive potassium levels can result in irregular heartbeat and other problems related to heart. For a personalized diet chart, talk to your medical provider.
Why combine perindopril and indapamide?
Combining perindopril and indapamide is considered beneficial as the combination offers a dual approach to managing high blood pressure. Perindopril is an ACE inhibitor that widens blood vessels, whereas indapamide is a water pill that eliminates excess salt and fluid from the body via urine. Together, these drugs provide an effective control over blood pressure levels compared to medication alone. Moreover, this combination also reduces the risk of cardiovascular problems like heart attacks and strokes. For detailed information, consult your medical provider.
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