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Actonel is an FDA-approved medication used to treat and prevent osteoporosis in postmenopausal women, men, and individuals experiencing glucocorticoid-induced osteoporosis and Paget’s disease. Its active ingredient is risedronate, a bisphosphonate medication. It is available as a tablet to be taken orally with a full glass of water on an empty stomach and comes in different dosage forms: 5 mg, 30 mg, 35 mg, 75 mg, and 150 mg. The dose of Actonel depends upon the condition it is being used to treat and how your body responds to the treatment. As with every other medicine, Actonel may cause some side effects, which usually go away on their own. You can buy Actonel online for osteoporosis at the most affordable prices. 

Product Overview

Actonel, containing the active ingredient risedronate, is a bisphosphonate medication used to manage and prevent osteoporosis in postmenopausal women, men, and those experiencing glucocorticoid-induced osteoporosis. It also treats Paget’s disease by reducing the activity of bone-resorbing cells, thereby increasing strength and bone density. 

Actonel should be taken orally on an empty stomach with a full glass of water, available in tablet forms of 5 mg, 30 mg, 35 mg, 75 mg, and 150 mg strengths. The dosage of the drug varies based on the condition being treated- from daily to monthly regimens. It is suitable for adults who can remain upright for at least 30 minutes post-administration, a requirement to prevent esophageal irritation. 

Common side effects include skin rash, stomach pain, and flu-like symptoms, with severe reactions potentially involving the esophagus and jawbone. Precautions should be taken to avoid interactions with calcium supplements and certain other medications. In case of a missed dose, skip it if close to the next scheduled time; never double the dose. For overdoses, seek immediate medical help. Actonel should be kept at room temperature, away from moisture, direct light and heat, and kept out of reach of children. Proper disposal of outdated or unwanted medication should be ensured by consulting a healthcare professional or local waste disposal company for guidance.

Uses of Actonel 

It is used to treat or prevent the following conditions:

  • Osteoporosis in postmenopausal women
  • Osteoporosis in men
  • Paget’s disease
  • Glucocorticoid-induced osteoporosis

How to Use Actonel?


Actonel comes in the form of tablets that are taken orally by mouth. It is available in the following strengths: 

  • 5 mg
  • 30 mg
  • 35 mg
  • 75 mg
  • 150 mg

Recommended Dosage for Different Patients

For treating and preventing osteoporosis after menopause

  • one 5-mg tablet taken every day
  • one 35-mg tablet taken every week
  • one 75-mg tablet taken two days consecutively once a month
  • one 150-mg tablet taken every month

For treating osteoporosis in men

  • one 35-mg tablet taken every week

For treating and preventing glucocorticoid-induced osteoporosis

  • one 5-mg tablet taken every day

For treating Paget’s disease

  • one 35-mg tablet taken every day
  • The treatment usually lasts for around two to three months.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Actonel tablets come in different strengths that are taken on different dosage schedules. 
  • The dosage of Actonel will depend on the strength of the tablet and the condition being treated. If your dosage strength changes, you will also need to change your schedule accordingly. 
  • Follow the directions for use given on your prescription label and carefully read the instructions for use.
  • Contact your doctor or a licensed healthcare professional if you have any questions or concerns. 
  • Use Actonel exactly as directed by your doctor. 
  • Actonel is usually given for only 3 to 5 years. 
  • Take the tablet on an empty stomach with a full glass of water or at least 30 minutes before you eat, drink, or take any other medication.
  • While taking Actonel tablets, do not use tea, coffee, juice, soda, or mineral water. 
  • You should not crush, chew, or break the tablet. Swallow it whole. 
  • After taking your medication, wait for at least 30 minutes before:
    • Lying down. You may sit, stand, or walk and do everyday activities like reading or watching TV while sitting. 
    • Taking your first meal or drink except for plain water. 
    • Taking any other medication including iron, calcium, vitamins, laxatives, or antacids. 
  • Take Actonel at the same time every day, on the same day every week, or month. 
  • Ensure that you maintain proper dental hygiene while using this medication. It is essential that you clean and floss your teeth on a regular basis. Let your dentist know you are using Actonel if you need to undergo a dental procedure. 
  • This medication is only a part of a complete treatment program that includes exercise, diet changes, taking calcium and vitamin supplements, and bone mineral density testing. 
  • Keep the medication at normal room temperature, away from heat, direct heat, and moisture. Store unused medications in the foil blister pack. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Actonel Work?

Actonel belongs to a class of medicati called bisphosphonates that work by slowing the activity of cells known as osteoclasts. These cells break down bone cells as new bone cells are being made in bone tissues. The medication helps increase bone tissue thickness and strength and may also help prevent bone fractures. 

Important Safety Information

Side Effects

Common side effects of Actonel may include:

  • Skin rash
  • Stomach or abdominal pain
  • Heartburn, indigestion, or diarrhea 
  • Flu-like symptoms 
  • Stomach pain 
  • Back pain, muscle pain, or joint pain 

Mild side effects of Actonel may include:

  • Back pain
  • Muscle aches
  • Fever
  • Chills 
  • Flu-like symptoms
  • Headache 
  • High blood pressure
  • Constipation
  • Indigestion
  • Diarrhea
  • Dizziness 
  • Insomnia 

Adverse side effects of Actonel may include:

  • Issues in the esophagus. Symptoms may include:
    • Irritation in the food pipe
    • Food pipe inflammation 
    • Ulcers in esophagus
    • Bleeding in the esophagus
  • Hypocalcemia. Symptoms may include:
    • Muscle spasms or twitching
    • Tingling or numbness in toes, fingers, or mouth
  • Urinary tract infection. Symptoms may include:
    • Frequent urination
    • Burning sensation
    • Dark, red, or brown-colored urine
  • Severe allergic reaction
  • Pain in joints, bones, or muscles
  • Osteonecrosis 
  • Cataracts 

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]


  • Do not take this medication if you have problems with your esophagus or low calcium levels in your body. 
  • You should not take Actonel if you cannot stand straight or sit upright for a minimum duration of thirty minutes after taking it. 
  • Actonel can cause severe problems in the esophagus or stomach. Call your doctor immediately if you have new or worsening heartburn, chest pain, or pain when swallowing. 
  • Look for symptoms of an allergic reaction, such as difficulty breathing, hives, or inflammation in your face or throat.


  • Before taking this medication, tell your doctor or healthcare provider if you are allergic to risedronate or other inactive ingredients in Actonel. 
  • Before taking risedronate, share your medical history with your doctor, especially if you have difficulty or painful swallowing, esophagus problems, low calcium levels, an inability to stand straight or sit upright for at least half an hour, severe kidney problems, or intestinal/stomach disorders. 
  • Rarely, risedronate may cause severe jawbone problems. Before taking this medication, your doctor should carefully check your mouth. 
  • To prevent jawbone problems, have regular checkups and learn to keep your mouth healthy. If you have jay pain, let your dentist and doctor know immediately. 
  • If you are going to have dental surgery, tell your doctor about all your medications, including risedronate. 
  • Let your doctor know if you think you may be pregnant or if you are planning to start a family. Do not become pregnant while taking action. This medication may stay in your body for many years. 
  • Do not take two different strengths or brands of residronate simultaneously. 
  • Avoid taking other medications at least 30 minutes after taking risedronate. This includes calcium, vitamins, iron, laxatives, and antacids. Some medications can make it harder for your body to absorb actonel. 
  • Try to quit or avoid smoking, as it can reduce your bone mineral density and elevate your risk for fractures. 
  • Consuming large amounts of alcohol is not advisable, as heavy drinking may also cause bone loss. 


The contraindications associated with Actonel are as follows:

  • Hypersensitivity to risedronate or any other inactive ingredients
  • Hypocalcemia
  • Hypercalcemia
  • Problems with esophageal muscles

Missed Dose

  • If you forget to take the medication on an empty stomach, do not take it later in the day. Skip the missed dose and take it the next morning. 
  • Do not take two doses in one day to compensate for the missed dose. 
  • When you take Actonel once a week or once per month and forget to take the medication on the scheduled dosage day, take it on an empty stomach and return to your regular weekly or monthly dosing schedule. Do not take two doses of Actonel on the same day. 
  • Call your doctor for instructions if you have missed more than two doses a month. 
  • If you are still trying to decide when to take the missed dose, call your doctor to find out when to take your next dose of the medicine.
  • To ensure that you don’t miss a dose in the future, try setting a reminder on your phone. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]


In the event of an actonel overdose, it is crucial to take prompt action. Drink plenty of water and call 911 or head to the nearest hospital if you suspect an overdose. Do not induce vomiting, and do not lie down or recline. Be vigilant for any signs of an overdose, which may include:

  • Convulsion 
  • Confusion
  • Irregular heartbeat
  • tremors
  • Muscle cramps
  • Difficulty in breathing
  • Numbness or tingling around the feet, fingertips, or mouth
  • Shortness of breath

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Store Actonel at room temperature, away from direct light, excess heat, and moisture. Do not keep it in the bathroom. 
  • Keep all medications, including Actonel, away from the sight and reach of children. 
  • Do not keep medicines that are outdated or no longer needed. Discard them safely. 
  • Do not flush the medications unless instructed to do so. 
  • Do not throw unwanted medications in wastewater or household garbage bins. 
  • Contact your healhcare provider or local waste disposal company for more information on properly discarding unwanted and expired medications. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Actonel Interactions

Interactions with the following drugs may change how Actonel works or may also increase your risk for adverse side effects. 

  • Aluminum hydroxide
  • Calcium acetate
  • Calcium carbonate
  • Calcium chloride
  • Calcium citrate
  • Calcium gluconate
  • Cimetidine 
  • Citric acid
  • Deferasirox
  • Dexlansoprazole  
  • Entecavir 
  • Famotidine 
  • Foscarnet 
  • Ibuprofen 
  • Magnesium supplement
  • Nizatidine 
  • Potassium chloride
  • Selenium 
  • Sodium bicarbonate
  • Sodium sulfate
  • Sodium zirconium cyclosilicate
  • Teriparatide
  • Voclosporin 
  • Zinc 

[Note: This isn’t a complete list, and there could be other drugs that interact with Actonel. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

Actonel Alternatives

  • Fosamax (alendronate)
  • Boniva (ibandronate)
  • Evista (raloxifene)
  • Reclast (zoledronic acid)
  • Atelvia (risedronate)
  • Prolia (denosumab)
  • Aredia (pamidronate)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How does Actonel differentiate from other osteoporosis treatments?

Actonel, containing the active ingredient risedronate, is part of the bisphosphonate class of medications. It is distinct in its dosing flexibility (daily, weekly, monthly) and its ability to treat not only postmenopausal osteoporosis but also glucocorticoid-induced osteoporosis and Paget’s disease. This versatility may be compared with medications like alendronate (Fosamax) or ibandronate (Boniva), which have different effects, dosing schedules, or approved usage.

Can Actonel be used concurrently with calcium supplements or other osteoporosis medications?

While Actonel can be part of a comprehensive osteoporosis management plan that includes calcium and vitamin D supplements, it should not be taken simultaneously as calcium supplements as it can interfere with the absorption of Actonel. It is advised to take Actonel at least 30 minutes before any other medication or supplement, including calcium, to ensure adequate absorption and efficacy.

What are the long-term effects of using Actonel for osteoporosis?

Actonel is usually prescribed for a limited duration, commonly between 3 to 5 years, due to the risks associated with the long-term use of Actonel, like atypical femoral fractures and osteonecrosis of the jaw. The decision to continue treatment beyond this period depends on individual patient risk assessments and the balance of benefits and potential harms. Monitoring bone density and reevaluating treatment necessity is critical to long-term therapy management.

Are there specific precautions that should be taken when starting treatment with Actonel?

Before beginning treatment with Actonel, patients should ensure their calcium levels are normal, as Actonel can cause hypocalcemia. It is crucial to address any issues with the esophagus, such as difficulty swallowing, before taking Actonel, as it can exacerbate or lead to new esophageal problems. Moreover, maintaining an upright position for at least 30 minutes after taking the medication is vital to prevent esophageal irritation. Patients should also discuss their dental health with their provider, as dental procedures can increase the risk of jaw problems while on Actonel therapy. 

Our Guarantee

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