Adcirca

Buy Adcirca Online from Licensed Canadian Pharmacies

Adcirca is a brand name of tadalafil that treats PAH (pulmonary arterial hypertension), a form of high blood pressure in the lung arteries, in which the vessels become narrow, stiff, and thickened. This raises pressure in the pulmonary arteries and places extra strain on the right side of the heart, which must work harder to pump blood forward.

In PAH, changes in the blood vessel walls happen because of abnormal cell growth, inflammation, and reduced nitric oxide signaling. This may cause shortness of breath, fatigue, chest pressure, dizziness, and reduced physical stamina over the period of time. All of this together can make your everyday tasks harder.

Adcirca lowers pulmonary artery pressure and reduces strain on the heart. It does not cure PAH, but when used every day as prescribed and combined with regular monitoring, it can help you walk farther, feel less short of breath with activity, and maintain daily function for a longer duration.

Drug Summary

What Is Adcirca Used For?

Adcirca (tadalafil) is approved to treat:

• Pulmonary arterial hypertension or PAH in adults.

What Are the Benefits of Adcirca?

• Improves exercise capacity (which is often measured by how far you can walk in six minutes during clinical testing.
• Offers a once-daily oral option.
• Relaxes and widens the pulmonary blood vessels, which lowers pressure in the pulmonary arteries and reduces workload on the right side of the heart.
• Slow worsening of PAH symptoms.

Adcirca Dosage for PAH (Pulmonary Arterial Hypertension)

• For Adults: The usual total dose is 40 mg (1 tablet of 40 mg or 2 tablets of 20 mg) once per day, taken orally.

Note: Do not divide your daily dose (40 mg) into multiple doses throughout the day. This is not recommended.

How Do You Take Adcirca Tablets?

To get the maximum results with Adcirca, here’s how you should take it:

• You should take this medicine as prescribed by your primary care physician.
• Take it once a day as per your daily dosing schedule.
• You may take your Adcirca with or without food.
• If you are prescribed a 20 mg tablet of Adcirca and your total daily dose is 40 mg, then take one after another. Don’t split the dose throughout the day.

How Does Adcirca Work?

Adcirca contains tadalafil, a phosphodiesterase-5 (PDE5) inhibitor. This enzyme that breaks down cGMP (cyclic guanosine monophosphate), a chemical that helps blood vessels relax.

In pulmonary arterial hypertension (PAH), the blood vessels in the lungs become narrow, tight, and stiff, which raises pressure in the pulmonary arteries and forces the right side of the heart to work harder.

Tadalafil’s mechanism, in simple terms:

1. Your body naturally makes nitric oxide, which increases cGMP inside the smooth muscle cells of blood vessels.
2. cGMP relaxes these muscles, helping the vessels open wider.
3. PDE5 normally breaks down cGMP, ending this relaxing effect.
4. Tadalfil blocks PDE5, so cGMP stays active for longer.

This helps in achieving:

• Relaxation of pulmonary vascular smooth muscles (the muscle lining lung arteries)
• Wider lung blood vessels (vasodilation)
• Lower resistance to blood flow through the lungs
• Reduced pulmonary artery pressure, easing strain on the heart
• Better oxygen delivery and improved exercise capacity

Tadalafil does not reverse existing lung-vessel damage, but it improves the signaling pathway that causes abnormal tightening of pulmonary arteries.

What Are the Side Effects of Adcirca?

Common Adcirca side effects may include:

• Headache
• Flushing (warmth or redness of the face and neck)
• Indigestion or stomach discomfort (dyspepsia)
• Muscle aches or back pain
• Nasal congestion or a runny nose
• Nausea
• Mild low blood pressure, lightheadedness, or dizziness, especially when standing up quickly

Serious side effects (rare):

• Very low blood pressure
• Loss of vision suddenly (in one or both eyes)
• Sudden decrease or loss of hearing
• Serious allergic reactions
• Priapism (a painful erection lasting more than four hours)
• Worsening shortness of breath, chest pain, or swelling of the legs (which may signal PAH progression or cardiac issues)

Note: Call your doctor if you experience any serious symptoms or unusual changes.

Adcirca Warnings

There’s no official boxed warning for Adcirca, but there are other warnings that you should consider:

• Do not use this medicine with nitrates and riociguat, as they widen blood vessels, and Adcirca does too. This may cause a dangerous drop in your blood pressure.
• People with a recent heart attack, stroke, unstable angina, or serious arrhythmias may not tolerate additional vasodilation.
• People with significant kidney or liver disease should speak with their doctor first, since the medication clears more slowly in these conditions. Your provider may alter your doses.
• Adcirca cannot be used with PDE5 inhibitors (contraindicated).
• Also, avoid using this if you’ve ever had NAION (non-arteritic anterior ischemic optic neuropathy). A sudden vision loss condition.

Take these precautions while on treatment with Adcirca 20 mg tablets:

• Share your full medical history and all the current medicines you use with your health care provider.
• Drink plenty of water.
• Report dizziness, faintness, or lightheadedness, especially when starting treatment.
• Keep all follow-up appointments.
• Stopping Adcirca without guidance can worsen PAH, so discuss any dose changes with your specialist first.

Adcirca Missed Dose

Take one missed dose of Adcirca as soon as you recall on the very same day. If it’s nearly time for your next dose (scheduled one), skip the one that you missed and resume with your regular dosing routine.

Do not double your doses. If you frequently forget doses, speak with your health care provider or set alarms.

Adcirca Overdose

Taking more Adcirca than prescribed can increase the chances of serious side effects. This includes:

• Significant drops in blood pressure
• Fainting
• Chest pain
• Persistent headache
• Visual changes
• Prolonged erections in men

If you or someone else may have taken too many tablets, call your local emergency number right away and contact the Poison Control Center at their toll-free number 1-800-222-1222.

Do not wait for severe symptoms to appear, and do not attempt to treat a suspected overdose on your own.

How to Store Adcirca

After you order Adcirca from Canada, follow these guidelines to store this medicine:

• Store the tablets at room temperature, typically up to 77°F (or up to 25°C).
• Keep the Adcirca bottle tightly closed and avoid storing it in bathrooms and near the sinks where moisture can reach.
• Do not use tablets that are chipped, discolored, or past the expiration date.
• Safely store Adcirca tablets somewhere children and pets can’t reach.
• Dispose of the unused or expired tablets as per your local disposal guidelines.

Adcirca Interactions

Adcirca interacts with several other medicines, mainly through additive blood-pressure-lowering effects and CYP3A4 metabolism.

Common interacting medications and classes include:

• Nitrostat (nitroglycerin)
• Nitrates like:
• Isosorbide dinitrate
• Isosorbide mononitrate
• Adempas (riociguat)
• Norvir (ritonavir) and other strong CYP3A4 inhibitors like:
• Nizoral (ketoconazole)
• Sporanox (itraconazole)
• Cardura (doxazosin) and other alpha-blockers, including:
• Terazosin
• Prazosin
• Tamsulosin
• Other PDE5 inhibitors like:
• Revatio (sildenafil)
• Viagra (sildenafil)
• Levitra (vardenafil)
• Staxyn (vardenafil)
• Certain blood pressure medicines and diuretics (that may increase the risk of symptomatic hypotension when combined)

Adcirca Alternatives

If Adcirca is not suitable for you, your health care provider will choose an alternative medication, including:

• Letairis (ambrisentan)
• Tracleer (bosentan)
• Opsumit (macitentan)
• Adempas (riociguat)
• Uptravi (selexipag)

For more advanced PAH:

• Remodulin (treprostinil)
• Tyvaso (treprostinil inhalation)
• Flolan (epoprostenol)

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Adcirca Cost & Coupons

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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.