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Naproxen Sodium

Anaprox DS 550mg Tablet

Anaprox DS 550mg tablet is an immediate-release form of naproxen sodium, a nonsteroidal anti-inflammatory drug or NSAID. This FDA-approved drug is primarily used to manage pain and inflammation associated with various conditions such as ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, and menstrual pain. This drug reduces inflammation by inhibiting the production of prostaglandins. These substances contribute to inflammation in the body. Anaprox DS should be taken as directed by a healthcare provider, with considerations for special dosages in children and elderly due to different absorption rates. Important to note are the potential side effects ranging from common digestive disturbances to serious cardiovascular and gastrointestinal risks. In case of an overdose or if you notice any serious side effects like chest pain, bleeding, or more, contact your doctor immediately.

Product Overview

Anaprox DS 550mg tablets are a form of naproxen sodium, classified under nonsteroidal anti-inflammatory drugs (NSAIDs). This medication is primarily used to address moderate to severe pain and reduce inflammation in various medical conditions. It is effective against chronic illnesses like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and polyarticular juvenile idiopathic arthritis in children. It also provides relief from acute pain conditions such as menstrual cramps, tendonitis, bursitis, and acute gout attacks.

The standard adult dose for chronic conditions like arthritis is 550 mg twice daily, which may be adjusted based on efficacy and tolerance. For acute conditions, the initial dose may be higher, followed by lower maintenance doses. Special considerations are given to individuals over 65 or those with kidney or liver issues, where dosages are carefully adjusted to prevent accumulation and potential toxicity.

While Anaprox DS is effective in pain management, it carries risks of significant side effects. Common adverse reactions include gastrointestinal upset, heartburn, and nausea. More severe risks involve cardiovascular events like heart attack and stroke, particularly in long-term users or those with existing heart conditions. It may also lead to serious gastrointestinal issues such as ulcers and bleeding, especially in older adults or those taking certain other medications. Patients are advised to take this medicine with food or antacids to mitigate stomach upset and not to lie down immediately after ingestion to avoid esophageal discomfort. It’s crucial for users to follow their healthcare provider’s instructions closely and discuss any potential interactions with other medications they are taking.

Uses of Anaprox DS 550mg Tablet

This medication helps alleviate pain and inflammation in various medical conditions. It is approved for treating:

  • Ankylosing Spondylitis (It is a type of arthritis that usually affects the spine)
  • Polyarticular Juvenile Idiopathic Arthritis (a type of arthritis in children that impacts one or more joints)
  • Menstrual period pain
  • Osteoarthritis (a condition where joint tissue deteriorates)
  • Tendonitis (inflammation of the tendons)
  • Rheumatoid Arthritis (It is a kind of autoimmune disease that affects the joints)
  • Bursitis (inflammation of fluid-filled sacs around the joints)
  • Gout (a condition caused by excessive uric acid in the body)

How to Use Anaprox DS?


Anaprox DS comes in the form of immediate-release tablets and has the strength of:

  • 550 mg

Recommended Dosage for Different Patients

Dosage for Rheumatoid Arthritis, Osteoarthritis, & Ankylosing Spondylitis

  • For Adults (18 Years & Older)
    • Typical Dosage: 550 mg taken twice daily.
    • Maximum Dosage: Up to 1,650 mg per day, recommended for a short period (no more than 6 months).
  • For Children (ages 0 to 17 years): A safe and effective dosage for individuals under 18 years has not been established.
  • Special Dosage Considerations for Adults Over 65 Years: Your body may process this medication more slowly. To prevent too much of the drug from accumulating in your body, which can be harmful, your primary caregiver may start you on a lower dose.

Dosage for Polyarticular Juvenile Idiopathic Arthritis

  • For Children (2 to 17 Years)
    • Children in this age range typically take the oral suspension form of this medication (a liquid mixture).
    • The dosage is determined by your child’s weight and should be administered twice daily, with doses evenly spaced throughout the day.
  • For Children (ages 0 to 23 months): An effective and safe dosage for children younger than two years has not been established.

Dosage for Bursitis, Tendonitis, & Menstrual Pain

  • For Adults (18 Years & Older)
    • Initial Dose: 550 mg taken every 12 hours as needed.
    • Maximum Daily Dose on Day 1: Up to 1,375 mg.
    • For subsequent days, the daily dose should not exceed 1,100 mg.
  • For Children (0 to 17 Years): An effective and safe dosage for individuals under 18 years has not been established.
  • Special Dosage Considerations for Adults Over 65 Years: Your body may process this medication more slowly. To prevent too much of the drug from accumulating in your body, which can be harmful, your doctor can begin you on a lower dose at the beginning of treatment.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • If using an over-the-counter product, carefully read all instructions on the package.
  • If prescribed by your doctor, read the Medication Guide provided by your pharmacist before starting Anaprox DS and each time you get a refill.
  • Consult your primary caregiver or pharmacist if you have any questions.
  • Take Anaprox DS orally as your doctor directs, usually two or three times a day with a full glass of water (8 ounces or 240 milliliters).
  • Avoid lying down for at least 10 minutes after taking the medication.
  • To prevent stomach upset, take the medication with food, milk, or an antacid.
  • The doses depend on the specific medical condition & how you respond to treatment.
  • Use the lowest effective dose for the short duration, which is needed to minimize the risk of stomach bleeding and other side effects.
  • Follow your doctor’s instructions or the package label closely regarding dosage. Do not increase your dose or take it more often than advised.
  • For chronic conditions like arthritis, continue taking the medication as your doctor has instructed.
  • It may take up to two weeks of regular use to experience the full benefits of certain conditions, such as arthritis.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Anaprox DS Work?

Anaprox DS is part of a category of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs work by reducing pain, inflammation (swelling and damage), and fever. Anaprox DS may decrease swelling by lowering levels of prostaglandin, a hormone-like substance that typically causes inflammation. After taking a dose of Anaprox DS, the drug can remain active in your body for up to 4 days. The frequency of doses depends on the specific condition being treated—you may need to take a dose every 6 to 12 hours or up to twice a day. Generally, you will continue taking the medication until your symptoms resolve. The appropriate dosage for your condition will be determined by your doctor. Once you stop taking Anaprox DS, it should be completely eliminated from your body in about 4 days. If you have any questions about how long Anaprox DS lasts in your system, consult your doctor or pharmacist.

Important Safety Information

Side Effects

Common side effects of Anaprox DS oral tablet may include:

  • Nausea and vomiting
  • Diarrhea
  • Gas
  • Stomach pain
  • Heartburn
  • Dizziness
  • Constipation

Serious side effects of Anaprox DS oral tablet may include:

  • Shortness of breath or trouble breathing
  • High blood pressure
  • Weakness in one part or side of your body
  • Chest pain
  • Swelling of the throat or face
  • Trouble speaking
  • Ulcers & bleeding in your intestines & stomach, including symptoms like:
    • Bloody vomit
    • Unusual swelling of your legs, arms, feet, and hands or weight gain
    • Asthma attacks in people who have asthma
    • Sticky stool and black
    • Stomach pain
    • Yellowing of your skin or the whites of your eyes
    • Blisters or skin rash with fever
    • Weakness, lethargy, or fatigue (low energy), which can be caused by less red blood cell count
    • Blood in your stool

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • High Blood Pressure Warning: Anaprox DS can cause an increase in blood pressure or even worsen existing high blood pressure. It may also reduce the effectiveness of medications for high blood pressure. Monitoring your blood pressure regularly while taking Anaprox DS is important.
  • Water Retention and Swelling Warning: Certain forms of this medication contain additional salt. If you are monitoring your salt intake, discuss with your doctor which formulation of Anaprox DS is appropriate for you.
  • Asthma Warning: Anaprox DS can trigger an asthma attack. If you have asthma that reacts to aspirin or other NSAIDs, you should avoid using Anaprox DS.
  • Allergic Reaction Warning: Anaprox DS can cause severe allergic reactions. If you have ever had an allergic reaction to Anaprox DS, do not take it again, as repeating exposure could be life-threatening. Symptoms of an allergic reaction may include:
    • Difficulty breathing
    • Swelling of your throat or tongue
    • Hives
  • Alcohol Interaction Warning: Consuming alcohol while taking Anaprox DS increases your risk of developing stomach ulcers and bleeding.
  • Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS): Anaprox DS can cause a serious condition known as DRESS. This condition may develop 2 to 6 weeks after starting the medication and can be life-threatening. Symptoms of DRESS may include:
    • Skin rash
    • Fever
    • Swollen lymph glands
    • Organ damage, such as liver failure
  • Serious Skin Reactions Warning: Anaprox DS may cause life-threatening allergic reactions known as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Both conditions can severely damage your skin or internal organs and may lead to death. If you experience any of the following symptoms while taking Anaprox DS, contact your doctor immediately:
    • Skin rash
    • Hives
    • Sores in your mouth
    • Blistering or peeling skin
  • Harm to a Fetus Warning: Anaprox DS can cause harm to a fetus if taken after 20 weeks of pregnancy. If you are pregnant or planning to become pregnant, inform your doctor before starting this medication.

Boxed Warning

FDA Warnings: This drug carries boxed warnings, which are the most serious kind of warning issued by the Food & Drug Administration or FDA. These warnings inform doctors and patients about potential dangerous effects of the drug.

  • Heart Disease Risk: Anaprox DS may increase the risk of heart disease. Using this drug long-term or in high doses can heighten this risk. People with existing heart disease and risk factors, such as high blood pressure, are at an increased risk of experiencing this side effect. Anaprox DS should not be used for pain relief before or after heart bypass surgery as it could raise your risk of heart attack and stroke.
  • Risk of Ulcers and Bleeding: Anaprox DS can cause ulcers & bleeding in your stomach (including intestinal). This can occur at any time during treatment, sometimes without any warning symptoms, and can be life-threatening. The risk is higher if you are older than 65 years.


  • Risk of Heart Attack or Stroke: Anaprox DS can increase the risk of a fatal heart stroke or attack, even if you don’t have any risk factors. Don’t use this medication just after or before heart bypass surgery (coronary artery bypass graft also called CABG).
  • Stomach or Intestinal Bleeding: Anaprox DS may cause intestinal or stomach bleeding, which may be fatal. These conditions can happen without warning, particularly in older adults.
  • Allergies and Reactions: Do not use Anaprox DS if you are allergic to it or if you have had a severe allergic reaction and an asthma attack after taking another NSAID or even aspirin.
  • Use in Children: Consult a doctor before giving Anaprox DS to a child under 12 years old.
  • Health Conditions: Before using Anaprox DS, ask a primary caregiver or pharmacist if it is safe for you, especially if you have:
    • Heart disease, diabetes, high blood pressure, if you smoke, or high cholesterol
    • A history of heart stroke, attack, or blood clot
    • Stomach ulcers or bleeding
    • Asthma
    • Liver or kidney disease
    • Fluid retention
    • If you are taking aspirin to prevent heart stroke or attack

Other Important Precautions

  • For People with Stomach Problems: If you have a history of ulcers or intestinal or stomach bleeding, Anaprox DS can increase your risk of further stomach or intestinal bleeding.
  • For People with Kidney Disease: Long-term use of Anaprox DS can lead to kidney damage. If you have serious kidney disease, you should not take this medication.
  • For Pregnant People: There is limited research on how Anaprox DS affects a fetus during pregnancy. There are concerns that it could harm the fetus. The FDA advises against using Anaprox DS from the 20th week of pregnancy onward due to potential risks like reduced amniotic fluid. If you are pregnant or planning to become pregnant, discuss this with your doctor before taking Anaprox DS.
  • For People Who Are Breastfeeding: Anaprox DS can pass into breast milk & may also cause side effects in a breastfeeding child. It is recommended not to breastfeed while taking this medication.
  • For Older Adults: If you are over the age of 65, be cautious when using Anaprox DS. Your body may process this drug more slowly. At the beginning of your treatment, your doctor might start you on a lower dose to prevent the drug from accumulating too much in your system, which can be dangerous.
  • For Children: The safety and effectiveness of Anaprox DS have not been established for children under the age of 2 years.


Anaprox DS should not be used in the following situations:

  • Hypersensitivity: It is contraindicated in patients with a known hypersensitivity to Anaprox DS.
  • History of Allergic Reactions: It is contraindicated in patients who have experienced asthma attacks, urticaria (hives), or allergic-type reactions after taking other NSAIDs or even aspirin.
  • Peri-operative Pain in CABG Surgery: It is contraindicated for treating peri-operative pain in the context of coronary artery bypass graft (CABG) surgery.
  • Active Peptic Ulceration: It is contraindicated in patients with active peptic ulcers.

Missed Dose

  • Since Anaprox DS is typically taken as needed, you might not be on a regular dosing schedule.
  • If you miss a dose and it’s almost time for your next dose, just skip the missed dose. 
  • Do not take two doses at the same time.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


If you suspect an overdose of Anaprox DS, seek emergency help immediately. Symptoms of an overdose may include:

  • Restlessness
  • Confusion about identity, place, and time
  • Bleeding under the skin
  • Sleepiness
  • Muscle tremors

Take immediate medical attention to address these symptoms effectively.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]


  • Keep this medication out of the reach of children and pets to ensure safety.
  • Store Anaprox DS at room temperature, ideally between 20 & 25 degrees Celsius (68 & 77 degrees Fahrenheit).
  • Protect the medication from moisture. Keep the container tightly closed to prevent it from contamination.
  • Avoid exposing the medication to extreme heat, as it may affect its efficacy.
  • Safely dispose of any unused medication after the expiration date to prevent accidental use or environmental harm.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Anaprox DS Interactions

Prescription Anaprox DS oral tablets may interact with other vitamins, drugs, or herbs you may be taking. An interaction occurs when another substance affects how a medicine works, which can be harmful or stop the drug from being effective. To minimize the risk of interactions, it is important for your doctor to manage all your medications meticulously. Make sure to inform your doctor about all medications, vitamins, or herbs you’re currently taking. If you want to know how Anaprox DS might interact with something else you’re taking, consult with your doctor or pharmacist. Below are examples of drugs that can cause interactions with Anaprox DS.

  • Antidepressant Drugs: Using selective serotonin reuptake inhibitors (SSRIs) along with Anaprox DS can increase your risk of stomach and intestinal bleeding. Examples of SSRIs that can interact with Anaprox DS include:
    • Fluoxetine (Prozac)
    • Paroxetine (Brisdelle, Paxil)
    • Citalopram (Celexa)
    • Fluvoxamine (Luvox)
  • Blood Pressure Drugs: Anaprox DS may reduce the effectiveness of your blood pressure medications. Additionally, if you are older than 65 years, combining Anaprox DS with certain blood pressure medications could harm your kidneys. Examples of blood pressure drugs that can interact with Anaprox DS include:
    • Angiotensin II Receptor Blockers: like losartan (Cozaar) & Diovan (valsartan)
    • Angiotensin-Converting Enzyme (ACE) Inhibitors: such as Zestril (lisinopril)
    • Diuretics: such as furosemide (Lasix) and hydrochlorothiazide 
    • Beta-Blockers: such as metoprolol tartrate (Lopressor) and propranolol (Inderal LA)
  • Heartburn Drugs and Stomach Protectants: Using medications that treat heartburn or protect the stomach alongside Anaprox DS can slow down the pain-relieving effects of Anaprox DS. Examples of these medications include:
    • Magnesium oxide
    • Aluminum hydroxide
    • Sucralfate (Carafate)
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Taking Anaprox DS with other NSAIDs can heighten your risk of stomach and intestinal bleeding. Examples of NSAIDs that can interact with Anaprox DS include:
    • Ketoprofen
    • Diclofenac (Cambia)
    • Ibuprofen (Motrin, Advil)
    • Aspirin (Bufferin, Bayer)
    • Flurbiprofen
    • Etodolac
    • Ketorolac
  • Cholestyramine: If you take cholestyramine (Prevalite) along with Anaprox DS, your body may absorb Anaprox DS more slowly than normal. This could delay the effectiveness of Anaprox DS in relieving your symptoms.
  • Lithium: Taking Anaprox DS with lithium (Lithobid) can increase the lithium levels in your body to potentially dangerous levels.
  • Methotrexate: If you take methotrexate (Trexall) together with Anaprox DS, it can result in dangerously high levels of methotrexate in your body, which can be harmful.
  • Warfarin: Using warfarin (Jantoven) in conjunction with Anaprox DS heightens your risk of experiencing stomach and intestinal bleeding.

[Note: This isn’t a complete list, and there could be other drugs that interact with Anaprox DS. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Anaprox DS Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

How often can you take Anaprox DS?

The recommended initial dose for Anaprox DS (naproxen sodium) tablets is 550 mg. After the first dose, you should take 550 mg every twelve hours or 275 mg (half of a 550 mg tablet) every six to eight hours as needed. The total amount of naproxen sodium you take on the first day should not exceed 1375 mg, which is equivalent to two and a half tablets.

Is Anaprox DS the same as Aleve?

Anaprox DS and Aleve are not the same, although both contain the active ingredient naproxen. Anaprox DS contains a higher dosage of naproxen per pill compared to Aleve. Anaprox DS is used for treating acute pain, chronic pain, and inflammatory conditions and should be taken under a doctor’s supervision. On the other hand, Aleve contains naproxen sodium and is typically used for temporary relief of minor aches, pains, and fever reduction.

What foods should you avoid while taking Anaprox DS?

While taking Anaprox DS, it’s important to avoid certain foods & beverages to reduce the risk of side effects. Specifically:

  • Alcohol: Avoid drinking alcohol as it can significantly increase the risk of intestinal bleeding.
  • Salty Foods: Consuming food items that are high in salt can exacerbate stomach upset and other gastrointestinal issues associated with Anaprox DS.
  • Grapefruit: This fruit and its juice may interact with naproxen and lead to increased side effects.
  • Caffeine: Caffeine can also aggravate stomach upset, so it is advisable to limit intake while taking Anaprox DS.

Is Naproxen sodium 550 mg a painkiller?

Yes, Naproxen sodium 550 mg is a painkiller. It helps in relieving pain from various conditions, including muscle aches, headaches, menstrual cramps, tendonitis, and dental pain. Additionally, it helps reduce pain, swelling, and joint stiffness associated with arthritis, bursitis, and gout attacks. Naproxen sodium falls under the category of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs).

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