Apo-Varenicline

Apo-Varenicline is a prescription medication that contains varenicline tartrate, a proven smoking cessation aid. It reduces nicotine cravings and withdrawal symptoms. It works by partially stimulating the nicotine receptors in the brain while blocking nicotine from attaching, making smoking less rewarding and helping users stay smoke-free. This medication is typically available in strengths such as 0.5 mg and 1 mg oral tablets.

It is taken orally, usually once or twice daily with a full glass of water after eating, as directed by your healthcare provider. Apo-Varenicline is suitable for adult smokers who are motivated to quit smoking. It is not recommended for use in children and adolescents less than 18 years of age. Treatment generally begins one week before the planned quit date and follows a specific titration schedule to minimize side effects and improve results.

Similar to other medicines, Apo-Varenicline can cause certain common side effects in some people using it, which may include vivid dreams, trouble sleeping, headache, or nausea. In rare cases, users may experience changes in mood or behavior. Tell your doctor if you have any medical conditions, especially kidney issues or mental health concerns, before starting this drug. In case of overdose, seek prompt medical assistance. Store Apo-Varenicline tablets in a cool and dry place at room temperature. Follow your treatment plan & consult your doctor before discontinuing use. To quit smoking confidently with this smoking cessation aid, buy Apo-Varenicline tablets online from Canada.

It is used as:

• Smoking cessation aid

What Are the Forms & Strengths of Apo-Varenicline?

It is available in the form of oral tablets that come in the following strengths:

• 0.5mg
• 1mg

What Is the Recommended Dosage for Apo-Varenicline?

The Apo-Varenicline dosage will be different for different people. Follow your doctor’s instructions or directions given on the prescription label. The information given here only includes the average doses of Apo-Varenicline. If your doctor has recommended you use this drug at a different dose, you should not change it unless your doctor tells you otherwise.

Dosage to Stop Smoking

• Adults and Children Aged 17 Years and Above
  • Days 1-3: 0.5mg once daily
  • Days 4-7: 0.5mg twice daily
  • Days 8 to End of Treatment: 1mg twice every day
• Children Aged 16 or Less: Use of Apo-Varenicline is not recommended in individuals belonging to this age group.

[Note: Remember, these recommendations may vary from individual to individual. Discuss it with your doctor, and they will adjust your dosage accordingly.]

• Before using Apo-Varenicline 0.5 mg and 1 mg tablets, refer to the prescription label or the medication guide, if provided by your pharmacist, to understand how to use them properly. Ask your doctor if you have any questions or difficulty understanding any part of this guide.
• You should use this drug exactly as directed by your physician. Avoid taking more of it, more often, or longer than your doctor has recommended, as it can lead to unfavorable outcomes.
• While using this medicine, it is also important to participate in a stop-smoking program to make it easier for you to quit smoking.
• You should set a date on your calendar to stop smoking and begin to use Apo-Varenicline one week prior to this date.
• It is possible that your doctor may recommend that you start using Apo-Varenicline anytime and then stop smoking between 8 & 35 days of being treated with this drug.
• Your doctor may recommend that you take this medicine for twelve weeks. Your doctor may recommend you continue using this medicine for 12 more weeks, even if you have stopped smoking, to help you stay smoking-free.
• You should take Apo-Varenicline oral tablets with a full glass of water, preferably after having a meal.
• If you are motivated to stop smoking but did not succeeded in treatment with this drug previously, or if you returned to smoking after taking treatment with Apo-Varenicline, then you should talk to your doctor about whether you need another course of Varenicline treatment.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They'll adjust it as needed over time.]

Apo-Varenicline works by targeting specific receptors in the brain that nicotine usually binds to. It stimulates these receptors at a much lower level than nicotine, decreasing cravings and withdrawal symptoms. Simultaneously, it blocks nicotine from binding to these receptors, reducing the pleasure derived from smoking. It is often used alongside counseling to help people quit smoking effectively and stay off.

Common side effects of Apo-Varenicline: Similar to other medicines, Apo-Varenicline has certain commonly occurring side effects associated with its use. It is important to mention that not everyone using this drug will experience these symptoms, and most of them usually resolve on their own without the need for medical intervention. However, if you experience persistent or bothersome symptoms, report them promptly to your doctor. Common side effects of Apo-Varenicline may include:

• Abnormal dreams: This medicine can affect the brain’s neurotransmitter systems, particularly those involved in regulating sleep. This influence may cause vivid or unusual dreams and, in certain rare cases, nightmares. These disturbances are said to be due to the drug’s partial agonist activity at nicotinic receptors, which may alter sleep architecture. If you experience bothersome nightmares, you should take the drug earlier in the day or adjust your medication dosage.
• Absence of menstruation: Some females using Apo-Varenicline have reported changes in their menstrual cycles, like missed periods. The exact mechanism behind why this happens is not completely understood, but it may involve hormonal fluctuations or stress related to smoking cessation. If menstruation irregularities do occur, discuss them with your doctor to rule out other causes and determine appropriate management.
• Change in taste: Apo-Varenicline can alter taste perception, causing persistent bad taste or a change in how what you consume tastes. This side effect is thought to be due to the drug’s interaction with taste receptors and its impact on the central nervous system. To manage this side effect, you should maintain good oral hygiene and stay adequately hydrated throughout the day. If taste changes are severe, you should consult a healthcare professional.
• Diarrhea: Gastrointestinal disturbances, including diarrhea, are one of the most common side effects associated with the use of Apo-Varenicline. This occurs due to the effects of this medicine on the digestive system, possibly changing gut motility or microbiota. To manage this symptom, you should stay properly hydrated. If symptoms are persistent or severe, your doctor may adjust your dosage or suggest treatments to alleviate discomfort.
• Constipation: Some people using Apo-Varenicline may experience difficulty having bowel movements, which may be due to the drug’s impact on gastrointestinal motility. To help manage this symptom, you should increase fiber intake in your diet, stay well-hydrated, and engage in regular physical activity while using it. If constipation becomes problematic, your doctor may recommend appropriate interventions.
• Difficulty moving: Some users may experience difficulty in moving, such as stiffness or reduced coordination. These symptoms may result from the drug’s central nervous system effects, such as its influence on motor control pathways. If such issues develop, you should consult a medical provider to assess the situation and consider alternative treatments if necessary.
• Gastrointestinal side effects: Some people may have excess gas or air in their stomachs or bowels, which may manifest as bloating or flatulence. These symptoms may be due to changes in gut motility or alterations in the gut microbiome. Managing their stomachs includes dietary adjustments, including reducing their intake of gas-producing foods, and considering over-the-counter medicines after consulting with a healthcare provider.
• Joint pain or swelling: When using Apo-Varenicline for adult smokers, some people may experience joint pain or swelling. This may be due to the medicine’s impact on inflammatory pathways or as a side effect of smoking cessation itself. If you experience joint symptoms, you should consult a medical provider to determine the cause & appropriate treatment.
• Lack or loss of strength: Some people may experience reduced strength or weakness, potentially due to its effects on the central nervous system or as a withdrawal symptom during smoking cessation. Ensuring adequate nutrition, rest, and hydration can help mitigate these feelings. If weakness persists, you should consult a medical provider.
• Loss of taste: Apo-Varenicline can cause a loss of taste, making food less enjoyable. This side effect is likely due to the drug's interaction with taste receptors and its central nervous system effects. Maintaining good oral hygiene & staying hydrated may help alleviate this symptom. If the loss of taste is significant, consulting a healthcare provider is recommended.
• Muscle stiffness: Muscle stiffness or rigidity has been reported by some users of Apo-Varenicline. This may result from the drug's effects on neurotransmitter systems involved in muscle control. Engaging in gentle stretching exercises and ensuring adequate hydration can help manage stiffness. If symptoms are severe, a healthcare provider should be consulted.
• Painful menstruation: Some women may experience dysmenorrhea (painful menstruation) while taking Apo-Varenicline. This could be due to hormonal changes associated with smoking cessation or as a side effect of the medication. Over-the-counter pain relief medicines, such as ibuprofen, may help alleviate discomfort. If pain is severe or persistent, consulting a healthcare provider is advisable.
• Toothache: Some individuals taking Apo-Varenicline have reported toothaches or dental discomfort. This could be related to changes in oral hygiene habits during smoking cessation or as a side effect of the medication. Follow good oral hygiene practices to avoid this side effect.

Severe Apo-Varenicline side effects: In rare instances, Apo-Varenicline can cause certain severe side effects in some users. These adverse reactions require medical attention immediately and can become severe if not treated promptly. You should seek emergency medical attention promptly if you experience any of the serious side effects given below:

• Severe allergic reactions: This medicine can cause severe allergic reactions in some people, which can become life-threatening in certain situations. You should discontinue using Varenicline and seek medical attention if you have any of the following symptoms of a severe allergic reaction:
  • Breathing difficulties
  • Wheezing
  • Fever
  • General feeling of illness
  • Swelling under the skin of the face, mouth, tongue, lips, or throat
  • Itching, rash, or red bumps on the skin (hives)
  • Difficulty swallowing
  • Nausea or vomiting
  • Dizziness
  • Lightheadedness
  • Fainting
  • Stomach cramps
• Seizures: Some people using Apo-Varenicline have reported having seizures. There are different kinds of seizures, some of which are not easy to recognize. You should discontinue using varenicline and contact your healthcare provider if you have any of the following signs and symptoms of an active or possible seizure:
  • Stiffness in your legs or arms
  • Muscle twitching, spasms, jerking, or other kinds of uncontrolled movements
  • Feeling anxious
  • Confusion
  • Dizziness or lightheadedness
  • Falling or losing consciousness
• New or worsening heart or blood vessel problems: This medicine can cause new or worsening heart or blood vessel issues, such as heart attacks and strokes. It is mainly seen in people with existing heart or blood vessel problems. Immediately let your doctor or healthcare provider know if you notice any change in symptoms. Seek medical help promptly if you have any signs of a heart attack or stroke. These may include:
  • Pain or pressure in the chest
  • Fast or abnormal heart rate
  • Pain in your jaw, throat, back, or arm
  • Difficulty breathing
  • Upset stomach
  • Sweating
  • Vomiting
  • Dizziness
  • Sudden and severe headache
• Sleepwalking: This medicine can cause sleepwalking in some users, which can cause harm to yourself or others. You should discontinue using Apo-Varenicline and contact your physician or healthcare provider immediately if you start sleepwalking.
• Severe skin reactions: Apo-Varenicline can cause severe skin reactions such as Stevens-Johnson Syndrome, which can lead to death if left untreated. If you develop a rash, you should discontinue use and contact your healthcare provider immediately. Seek emergency help if you have any of the following symptoms:
  • Painful purple or red skin that looks burned and is peeling off
  • Flat red rash or skin blisters on the mouth, skin, nose, or genitals
  • Painful red or watery eyes
• New or worsening mental health issues: This medicine can cause or worsen your mental health issues. The risk is greater in people with a history of mental health issues. These symptoms may also happen because of nicotine withdrawal. Discontinue using this drug and seek medical help if you have any of the following symptoms:
  • Changes in mood or behavior
  • Aggression
  • Hostility
  • Agitation
  • Depressed mood
• Suicidal behavior or thoughts: Apo-Varenicline can cause suicidal thoughts or actions in some people using it. If you are having thoughts about harming yourself, contact the suicide & crisis lifeline at 988 or call 911. Immediately call your doctor if you or your caregiver notice any of the symptoms given below:
  • New or increased thoughts of self-harm
  • Attempt at suicide
  • New or worsening feelings of anxiety, depression, or other unusual mood or behavioral changes
• Angioedema: This medication can cause a rare reaction known as angioedema. Symptoms may include swelling of the lips, face, tongue, or throat. If you have this kind of swelling, discontinue using this medicine and contact your doctor. If you are experiencing difficulty breathing, seek emergency medical attention immediately.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Similar to other medicines, Apo-Varenicline has certain warnings that people should keep in mind while using it. The key points of this warning may include:

• Do not consume large amounts of alcohol while being treated with this medicine, as it can cause harm.
• Some users may experience sleepwalking while using Apo-Varenicline. It can also cause behavioral issues that may be harmful to you, other people, or property. Check with your doctor if you start sleepwalking.
• Patients who have ever had an allergic reaction to Apo-Varenicline or any of the components present in the product should not use it. Your medical provider or pharmacist can tell you about all the ingredients in this product.
• Do not share these components, as they have the same condition as you, as it may cause harm.
• You should not use this product's ingredients, such as nicotine replacement therapy like patches, gums, or nicotine inhalers. Using Apo-Varenicline and nicotine replacement therapy together may increase your risk of unwanted side effects and is unlikely to increase your chance of quitting.
• When you try to quit smoking, it is possible that you may experience nicotine withdrawal symptoms. The most common signs and symptoms of nicotine withdrawal include anxiety, depression, craving to smoke, restlessness, difficulty sleeping, reduced heart rate, trouble concentrating, weight gain, and increased appetite.
• It is not known how Apo-Varenicline can affect pregnancy or harm an unborn baby. Let your doctor or healthcare provider know beforehand if you are pregnant, plan to become pregnant, or suspect a pregnancy. You should only take this medicine while pregnant if the benefits associated with the medicine use justify its risks.
• It is still unknown whether this drug passes into breast milk. Let your healthcare provider know if you are breastfeeding a baby or plan to breastfeed while using this medicine. If you do breastfeed an infant while using Apo-Varenicline, you should be watchful for signs of seizures in your baby and feeding problems, such as spitting up more than usual.

There are some precautions that users should take before and while receiving treatment with Apo-Varenicline. For this medicine, consider the following:

• Before using Apo-Varenicline, share your medical history with your physician, especially if you have renal problems, seizures, heart or blood vessel problems, and mental health problems. This information is critical to help ensure that this medicine is safe for you to use.
• Quitting smoking may interact with certain other medicines and supplements. Tell your doctor or healthcare provider about all products you currently or plan to use, including all prescriptions, over-the-counter drugs, herbs, vitamins, and mineral supplements.
• You should visit your healthcare professional at regular intervals to check your or your child’s progress, especially during the first few weeks of using this medicine. This helps you and your doctor determine if this medicine is working as well as it should and if you require dosage adjustments.
• Your doctor may recommend that you take certain blood and urine tests while using this medicine to look for unwanted side effects.
• Apo-Varenicline can increase the risk of a heart attack in some people using it, especially those who already have heart or blood vessel-related conditions. Immediately contact your medical provider if you experience chest pain, pain in the joints when you walk, excessive sweating, or difficulty breathing.
• This drug can cause some users to feel agitation, irritability, or other abnormal behaviors. It can also cause some people to have suicidal thoughts and behavior or cause depression. If you or your caregiver notice any of these symptoms, immediately inform your doctor or healthcare professional.
• Apo-Varenicline can cause severe allergic reactions in some people using it, including angioedema, a life-threatening condition that requires prompt medical attention. Immediately call your doctor if you develop a rash, itching, hives, or chest tightness while you are using this medicine.
• You may experience severe skin reactions while using this medicine. Consult with your doctor immediately if you have peeling, blistering, red skin lesions, loosening of the skin, severe acne or rash, fever, chills, sores or ulcers on the skin while you are taking Apo-Varenicline.
• Apo-Varenicline can cause dizziness or drowsiness in some users. You should not drive, operate heavy machinery, or engage in activities that require mental alertness or clear vision unless you determine how this drug affects you.
• Let your doctor know if you have nausea or sleeping issues while using Apo-Varenicline. You may require a dosage adjustment.

To get the most out of this smoking cessation aid, you should stay consistent in dosage and try to take it around the same time each day to help you remember to take it on time. If you have missed a dose of Apo-Varenicline, you should ask your doctor or follow the instructions given below:

• You should take the dose as soon as you remember missing it unless it is almost close to your next scheduled dose.
• Avoid taking extra doses of the same drug simultaneously to make up for the missed dose, as it can cause unfavorable reactions.
• If you often forget to take your medicine on time, set a reminder on your mobile phone or mark your calendar to help you remember to take it as scheduled.
• If you still cannot determine when to take the missed dose, consult your doctor or healthcare provider for Apo-Varenicline missed dose guidance​.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

An overdose of Apo-Varenicline can cause serious health risks such as nausea, vomiting, and neuropsychiatric effects like mood changes or agitation. In severe cases, it could require medical intervention, such as dialysis. If you or someone has taken this medicine more than the prescribed dose, it is essential that you seek emergency medical attention immediately. You can call 911 or a licensed healthcare professional. You can also go to the nearest medical care center.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Similar to other medicines, you should adhere to proper Apo-Varenicline storage instructions to maintain its effectiveness and safety.

• You should keep this medicine at a controlled room temperature in its original container, tightly closed away from direct exposure to heat and light.
• Do not keep it in the bathroom, under the sink, or in other places with high humidity, as moisture can cause harm.
• Store it in a safe place such as a medication cabinet, away from the reach of children & pets, to avoid accidental consumption.
• You should not keep medicines that are outdated or no longer needed. Dispose of them in a way that does not allow anyone to come in contact with them.
• You should not throw unwanted or unused medicines into the trash, pour them into the drain, or flush them into the toilet unless instructed to do so.
• The best way to get rid of such medicines is to take them to a medicine take-back program.
• You can ask your pharmacist or a medical practitioner how to dispose of expired or unwanted medicines.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medicines and their dosing may interact with Apo-Varenicline and quitting smoking, and reduce the effectiveness of this product or cause unfavorable reactions. To prevent and manage such drug interactions, tell your doctor about all medicines you are using or plan to use alongside this drug. This includes all prescription medications, over-the-counter drugs, herbal supplements, and vitamins or minerals. If your doctor identifies any potential drug interactions, they may alter your dosage of one or both drugs or suggest another treatment option altogether. Some of the medicines that may interact with Apo-Varenicline include:

• Bupropion
• Ethanol
• Insulin
• Theophylline
• Warfarin

What Are the Other Apo-Varenicline Interactions?

Apart from medicines, Apo-Varenicline also interacts with certain food items, beverages, supplements, and herbs that you should consider.

Interaction with alcohol: You should limit your intake of alcohol while using Apo-Varenicline, as this medicine affects your ability to tolerate alcohol. Consuming both together can cause the following effects:

• Intoxication or increased drunkenness
• Unusual or aggressive behavior
• No memory of what happened

Interaction with diseases: The presence of certain medical conditions may affect the use of Apo-Varenicline. Share your complete medical and personal history with your doctor, especially if you have the following conditions:

• Angina
• Depression
• Heart attack
• Heart or blood vessel problems
• Mental problems
• Renal issues
• Seizures
• Stroke

[Note: This is not a complete list, and there may be other drugs that interact with Apo-Varenicline. Be sure to inform your doctor about any prescription, over-the-counter medications, and herbal products you are taking.]

While Apo-Varenicline is an effective smoking cessation aid, it may not be safe for everyone to use, due to contraindications, potential side effects, or personal preferences. In such cases, people look for substitutes for this drug. While there are many effective alternatives available, you should not use them without consulting a licensed healthcare professional. Some of them include:

• Bupropion
• NRT (nicotine patch)
• Nicotrol

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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