Apriso

Apriso is an FDA-approved prescription medicine that contains mesalamine, an anti-inflammatory agent used to treat and maintain remission of ulcerative colitis. This drug is available in the form of extended-release capsules with a strength of 0.375mg. The usual recommended dosage is four capsules once daily, preferably in the morning, with or without food, exactly as a healthcare professional has prescribed. This medication is intended for use in adults and children under medical supervision. For a safe and effective use of the medicine, you should talk to your doctor beforehand and discuss with them the queries and concerns you may have regarding its usage, storage, and more. If you want to buy Apriso to treat ulcerative colitis, you can obtain it from reputable sources.

Apriso is a prescription medication that contains mesalamine, an anti-inflammatory agent used to treat and maintain remission in ulcerative colitis. Mesalamine reduces inflammation in the colon lining, helping to alleviate gastrointestinal symptoms such as diarrhea, rectal bleeding, and abdominal pain. Each Apriso capsule contains 0.375 g (375 mg) of mesalamine in an extended-release formulation. The usual dosage is four capsules (1.5 g) once daily in the morning, with or without food. This medication is intended for adults and children aged 18 years and older.

It works by releasing mesalamine gradually throughout the colon, ensuring prolonged anti-inflammatory effects. Similar to other medicines, Apriso can cause certain temporary side effects, which may include headache, nausea, diarrhea, abdominal pain, and flu-like symptoms. Rare but severe reactions, such as kidney issues or allergic responses, require immediate medical attention. Avoid Apriso if you have a known hypersensitivity to salicylates or mesalamine.

Use Apriso with caution if you have kidney or liver disease. If a dose is missed, take it as soon as possible unless it is close to the next scheduled dose. Do not double the dose. In case of an Apriso overdose, seek medical assistance immediately. Store Apriso at controlled room temperature (20-25°C) in a dry place, away from light, moisture & heat. Consult your healthcare provider before use, especially if you are pregnant, breastfeeding, or taking other medications.

It is used to treat:

• Ulcerative colitis in patients aged 18 and above and prevent it from recurring

What Are the Forms & Strengths of Apriso?

It comes in the form of extended-release capsules with the strength of:

• 0.375g

What Is the Recommended Dosage of Apriso?

The recommended dosage of Apriso may depend on factors such as the patient's age, tolerability, and needs. It may also depend on the strength and form of the medicine you are using. It may also be based on how often and longer you decide to take the medicine. The recommended dose of Apriso mentioned here is applicable to everyone. If your doctor has recommended you take this medicine in a different way, you should follow their instructions and not make dosage alterations without asking them first, as it can lead to unfavorable outcomes.

Adult Dosage for Ulcerative Colitis

• You should take four capsules orally once each day, preferably in the morning.
• You should not co-administer Apriso with antacids.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they'll customize your dosage accordingly.]

• Before taking Apriso for the first time or each time you get a refill, you should refer to the patient information leaflet and medication guide provided by your pharmacist or medical provider. If you have any questions or concerns about medication use or if you have difficulties understanding any part of the leaflet, you should ask your doctor.
• You should take Apriso extended-release capsules exactly as your doctor has instructed you. Do not take it more or less than recommended, in large quantities, or more often than prescribed.
• Apriso can affect the results of certain medical tests. Let your doctor or dentist know about all the medicines you are using, including Apriso.
• You may take Apriso with or without food.
• While being treated with Apriso, you should ensure the intake of plenty of fluids throughout the day to prevent kidney stones.
• You should swallow the extended-release capsules as a whole and avoid chewing, breaking, crushing, or opening them. Let your doctor or healthcare provider know if you have trouble swallowing the capsule.
• You should call your doctor at once if your symptoms of ulcerative colitis do not get better or if they worsen.
• While being treated with Apriso, you may require frequent certain blood tests to monitor your blood cells or kidney function.
• The capsule can pass into your stool after your body has absorbed the medicine. However, if this happens more than once or twice, let your doctor or healthcare provider know.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They'll adjust it as needed over time.]

Apriso, which contains the active ingredient mesalamine, is a medication used to treat and maintain remission in adults with ulcerative colitis. It belongs to the aminosalicylate class of drugs and functions by reducing inflammation in the colon. Apriso is available as an extended-release and delayed-release oral capsule, which means it releases the drug slowly over time and passes through the stomach before dissolving. This helps to target the medication directly to the colon, where it can effectively reduce inflammation and prevent flare-ups of ulcerative colitis.

What Are the Side Effects of Apriso?

Common side effects of Apriso: Similar to other medicines, Apriso can cause certain temporary side effects in some people using it. Most of these side effects usually resolve on their own without the need for medical intervention. However, if they persist or become bothersome, you should get in touch with a licensed healthcare professional and report any new or worsening symptoms to them. While your doctor has prescribed you to use mesalamine after determining that the benefits associated with the use of Apriso outweigh its risks, you should consult your doctor if you have any questions or concerns regarding the medicine use. Common side effects of Apriso may include:

• Headache: Headaches are one of the most common side effects of Apriso. The exact mechanism behind why this happens is not entirely understood, but it is said to be due to mesalamine’s influence on inflammatory pathways. To manage headaches, you should use over-the-counter pain relief medicines such as acetaminophen after consulting with your doctor. To prevent headaches, you should ensure proper hydration throughout the day and practice relaxation techniques. If headaches persist or become severe, you should discuss this with your physician or medical giver.
• Abdominal pain: Some people using Apriso can experience upper abdominal pain. This discomfort may be due to the medication’s effect on the gastrointestinal tract. To alleviate stomach irritation, you should take Apriso with food or a milky drink. However, it's essential to differentiate between medication-related abdominal pain and symptoms of ulcerative colitis. If the pain is persistent or worsening, consult your doctor for further evaluation.
• Nausea/vomiting: These symptoms may be due to the body’s response to mesalamine. To minimize the risk of nausea & vomiting, you should take the medicine with food and avoid lying down immediately after taking the dosage. Eating smaller, more frequent meals & avoiding greasy, rich, or spicy foods can also help. If nausea and vomiting persist, you should get in touch with your physician or healthcare provider. They may recommend anti-nausea medicines or assess the need for adjusting your treatment plan.
• Dizziness: Dizziness has been reported by some people taking Apriso capsules. While the exact cause behind why this happens is not well-defined, it could be due to the body’s adjustment to the medicine. To manage dizziness, you should rise slowly from sitting or lying down after a long time to prevent the risk of falling & injuring. Staying hydrated and avoiding sudden jerky movements can also help. If dizziness persists or interferes with your daily activities, you should consult your doctor.
• Back pain: While this is a less common side effect of Apriso, it may be related to musculoskeletal effects or referred pain. To help alleviate discomfort, you should engage in gentle stretching exercises and maintain a good posture. You can use over-the-counter pain relief medicines, but only after discussing them with your doctor. If back pain is severe or persistent, you should seek medical guidance to rule out other potential causes.
• Rash: Skin rashes can occur as a reaction to Apriso, which may be due to an allergic reaction or increased sensitivity to sunlight. To prevent rashes, you should protect your skin from excessive exposure to the sun by opting for protective clothing and applying broad-spectrum sunscreen. If you do develop a rash, you should monitor its progress. While mild rashes resolve on their own, severe, widespread rashes or rashes accompanied by other symptoms such as fever require immediate medical attention. These could indicate a more serious condition such as Stevens-Johnson syndrome.
• Abnormal liver function tests: Apriso can cause an increase in the liver enzymes, indicating liver irritation or damage, which occurs because mesalamine is metabolized in the liver. In some individuals, this can cause liver inflammation. To support liver health, you should avoid consuming alcohol and be cautious while using other medicines that can affect the liver. You should also limit your consumption of alcohol-containing medicines & beverages. If you notice significant abnormalities in liver functions, tell your doctor. They may adjust your medication dosage or recommend you consider alternative therapies.
• Cold or flu-like symptoms: Some patients report experiencing symptoms resembling a cold or flu, such as runny nose, sore throat, or fatigue, while on Apriso. These symptoms may be associated with the body's immune response to the medication. Rest, adequate hydration, and over-the-counter remedies can provide relief. However, if symptoms are severe, persistent, or accompanied by high fever, consult your healthcare provider to rule out infections or other underlying conditions.

Severe side effects of Apriso: While rare, Apriso can cause adverse symptoms in some patients belonging to certain risk groups. If you experience any of the following side effects, you should seek medical attention by calling a healthcare professional or 911. You can also go to the nearest emergency room. Serious side effects of mesalamine may include:

• Gastrointestinal bleeding: The use of mesalamine has been associated with gastrointestinal bleeding, presenting as bloody or tarry stools and vomiting blood or material resembling coffee grounds. The exact mechanism behind why this happens is not fully understood, but it may involve local irritation or ulceration of the gastrointestinal mucosa. To prevent or manage this side effect, you should monitor for signs and symptoms of bleeding, especially during the initial days of starting treatment with Apriso. If such symptoms do occur, you should seek immediate medical attention. Your doctor may recommend you discontinue using mesalamine and explore alternative treatment options.
• Mesalamine-induced acute intolerance syndrome: Some people using Apriso may experience an acute intolerance syndrome that mimics a flare-up of ulcerative colitis, characterized by symptoms such as cramping, acute abdominal pain, fever, bloody diarrhea, headache, or rash. This syndrome is believed to be caused due to a hypersensitivity reaction to mesalamine. If you notice any new or worsening symptoms, immediately report them to a healthcare professional. If a mesalamine-induced acute intolerance syndrome is diagnosed, then it is necessary to discontinue using Apriso and consider alternative treatment options.
• Increased sensitivity to light: Mesalamine can increase sensitivity to ultraviolet light, leading to severe sunburns or skin reactions. To prevent photosensitivity reactions, you should limit your exposure to direct sunlight, especially during peak hours. To protect your treated skin from excessive exposure to sunlight, you should opt for protective clothing and apply broad-spectrum sunscreen when under the sun. If severe skin reactions occur, get in touch with your doctor at once. They may recommend you adjust your dosage or discontinue taking Apriso.
• Kidney problems: Mesalamine has been associated with kidney issues, including interstitial nephritis and the formation of kidney stones. Symptoms of renal issues may include changes in urination patterns, swelling, weight gain, severe side and back pain, frequent urination, and foul-smelling, dark, or cloudy urine. To prevent kidney problems, you should ensure adequate hydration throughout the day while being treated with mesalamine. Regular monitoring of kidney function through certain blood tests is recommended. If symptoms of kidney issues arise, contact your healthcare provider promptly.
• Low white blood cell counts: Mesalamine can cause bone marrow suppression, causing decreased production of white blood cells. Its symptoms may include fever, chills, mouth or skin sores, sore throat, cough, light-headedness, and difficulty breathing. Blood tests at regular intervals to monitor blood cell counts are recommended. If you experience signs of infection or unusual bruising, seek medical attention immediately. Treatment may involve discontinuing mesalamine and initiating supportive care.
• Allergic reactions: Some individuals may have hypersensitivity to mesalamine or its components, resulting in allergic reactions such as difficulty breathing, hives, and swelling under the skin of the face, lips, tongue, or throat. Avoid mesalamine if you have known allergies to salicylates. If an allergic reaction occurs, discontinue Apriso use immediately and seek emergency medical attention.
• Liver issues: Mesalamine has been linked to liver issues, particularly in people with pre-existing liver conditions. Symptoms of hepatic issues include loss of appetite, upper abdominal pain, fatigue, easy bruising or bleeding, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes). Regular monitoring of liver function through certain blood tests is recommended. If symptoms of liver problems arise, contact your healthcare provider promptly.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• Apriso affects a substance in the bloodstream that causes tissue damage, inflammation, and diarrhea.
• You should discontinue using Apriso and get in touch with your physician if you experience severe stomach pain, bloody diarrhea, and stomach cramping.
• You should not use Apriso if you have ever had a hypersensitivity reaction to aspirin, mesalamine, sulfasalazine, or salicylates. This medication may contain certain active or inactive ingredients that can cause allergic reactions or similar problems. You should be aware of all the ingredients your medicine contains. If you do not know what ingredients your medication contains, you should get in touch with your doctor or health care provider.
• It may not be considered safe to breastfeed a baby while using mesalamine. Ask your doctor about any potential risks. If you are breastfeeding, get in touch with a healthcare professional if you notice diarrhea in the breastfeeding baby.
• You should not give Apriso to a child. This medication is not approved for use in anyone less than 18 years of age.
• During pregnancy, Apriso should be used only when the benefits outweigh the risks related with its use. Discuss the pros & cons of using this medication during pregnancy.

• Before taking Apriso, you should make sure that it is safe for you to use by sharing your complete medical history, especially if you have or have ever had hepatic disease, kidney stone or renal disease, eczema, or a blockage in your intestine or stomach.
• Before using Apriso, you should let your physician or healthcare provider know if you are pregnant, suspect you may be pregnant, or plan to become pregnant while using this drug. It is still not known if Apriso will harm an unborn fetus. However, having untreated or uncontrolled ulcerative colitis while pregnant may cause complications such as low birth weight or premature birth. The benefit of treating this condition may outweigh the potential risks to the unborn baby.
• Apriso can increase your sensitivity to the sun, especially if you have skin problems such as eczema and atopic dermatitis. While being treated with this drug, you should limit your time under the sun and avoid tanning booths and sunlamps. When you are under the sun, you should wear protective clothing and sunscreen. Let your doctor know immediately if you get sunburned or develop redness or skin blisters.
• If you plan to undergo surgery, including a dental procedure, you should let your doctor or healthcare provider know about all the products you have been using, including all herbs, supplements, and prescription or non-prescription medicines.
• Apriso may contain aspartame. If you have phenylketonuria or any other medical condition that requires you to avoid or limit aspartame or phenylalanine in your diet, you should ask your doctor or healthcare provider about safely using this medicine.
• Apriso is similar to aspirin. Children and adolescents less than 18 years of age should not take aspirin or aspirin-containing medicines such as salicylates. If you have chickenpox, flu, or an undiagnosed illness, or if you have recently recently received a vaccine. In such cases, using aspirin or aspirin-containing products raises the risk of Reye’s syndrome, a rare but severe illness.

Apriso is contraindicated for use in patients with:

• Known or suspected hypersensitivity to aminosalicylates, salicylates, or any component of Apriso capsules.
• Known renal impairment
• Known liver impairment

• If you have missed a dose of Apriso, you should take it as soon as you remember unless it is almost time to take your next dose. In that case, you can skip the missed dose and continue taking your medicine according to the regular dosing schedule.
• You should not take two doses of the same medication simultaneously to make up for the missed dose, as it can cause unwanted side effects.
• If you often forget to take your medicine at the scheduled time, you can set a reminder on your mobile phone or mark your calendar.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Consuming Apriso more than the recommended dosage can lead to severe side effects & complications such as severe stomach ache, cramping, fever, headache, bloody diarrhea, and skin rash. In extreme cases, it can cause serious conditions such as kidney damage, liver issues, or even cardiovascular issues. If you suspect an Apriso overdose, seek medical attention immediately. Call your doctor immediately or 911. You can also go to the nearest medical care center.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

• Keep mesalamine in a dark and dry place in its original packaging to keep it protected from direct exposure to sunlight, moisture, and excessive heat.
• Do not keep Apriso in the bathroom, under the sink, or in other places with high humidity and moisture can cause harm to certain medicines.
• Do not keep medications if they have passed their expiration date or are no longer required. Discard such medications in a way that does not let children, animals, and other people consume them.
• You should avoid flushing unused or unwanted medicines down the toilet, into the drain, or throwing them into the household trash unless instructed to do so by a licensed healthcare professional.
• Ask your pharmacist or healthcare provider how you should discard any medicine that you do not use.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medicines may interact with Apriso and affect how it works or cause unwanted side effects. To prevent and manage potential drug interactions, you should discuss any concerns with your doctor and tell them about medicines you use or plan to use alongside mesalamine, including all prescription medications, over-the-counter drugs, herbs, or vitamin and mineral supplements. This information is beneficial in helping your doctor identify and prevent potential Aspiro interactions. To manage such interactions, your doctor may adjust your dosage of one or both medicines or recommend using a different medication altogether. Some of the potential Aspiro interactions include:

• Aceclofenac
• Acemetacin
• Amtolmetin Guacil
• Azathioprine
• Balsalazide
• Bismuth Subsalicylate
• Bromfenac
• Bufexamac
• Celecoxib
• Choline Magnesium Trisalicylate
• Choline Salicylate
• Clonixin
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Furosemide
• Ibuprofen
• Indomethacin
• Ketoprofen
• Levoketoconazole
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Magnesium Salicylate
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Naproxen
• Nepafenac
• Niflumic Acid
• Olsalazine
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Salicylamide
• Salicylic Acid
• Tamarind
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Valdecoxib
• Varicella Virus Vaccine, Live
• Warfarin

What Are the Other Apriso Interactions?

Apart from medicines, Apriso may also interact with certain herbs, vitamin and mineral supplements, food items, and beverages. To manage this, your doctor may recommend you make certain dietary or lifestyle changes. The presence of certain medical problems can influence the safety and effectiveness of mesalamine. It's important to inform your doctor if you have any of the following conditions:

• Allergy to aminosalicylates or salicylates: You should not use Mesalamine if you are allergic to salicylates (e.g., aspirin) or aminosalicylates, as it may trigger severe hypersensitivity reactions.
• Renal disease: Use mesalamine with caution if you have kidney disease. Apriso is primarily excreted through the kidneys & impaired renal function can lead to an increased risk of adverse reactions. Regular monitoring of kidney function is recommended.
• Liver disease: Patients with liver impairment should use mesalamine cautiously, as there have been reports of hepatic failure in individuals with pre-existing liver conditions.
• Heart conditions: Mesalamine has been associated with hypersensitivity reactions affecting the heart, such as myocarditis and pericarditis. If you have a history of these conditions, inform your doctor before using Apriso.
• Skin conditions, including atopic dermatitis or eczema: Individuals with pre-existing skin conditions may have more severe photosensitivity reactions when using mesalamine. It is best recommended to avoid excessive sun exposure and use protective measures.
• Phenylketonuria: Certain forms of mesalamine, such as Aspriso extended-release capsules, contain aspartame, which may be harmful to individuals with phenylketonuria.

[Note: This isn't a complete list, and there could be other drugs that interact with Apriso. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

While Apriso is an effective medication used to treat and manage remission of ulcerative colitis, it may not be suitable for everyone due to allergies or other contraindications. If you want to take a substitute for this medication, you should consult a healthcare professional before using it. Based on your medical condition, age, and needs, they will help you determine the medication that is most suitable for you to use. Some of the most effective alternatives to Apriso may include:

• Mesalamine
• Lialda (mesalamine)
• Humira (adalimumab)
• Sulfasalazine
• Azathioprine
• Xeljanz (tofacitinib)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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