
Leflunomide


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Arava (leflunomide) is an FDA-approved medication primarily used to treat rheumatoid arthritis (RA) in adults. It functions as a disease-modifying antirheumatic drug (DMARD) that suppresses the immune system to reduce inflammation and prevent joint damage. Available in tablet form, Arava is prescribed in various dosages and may also be used off-label for psoriatic arthritis and juvenile idiopathic arthritis (JIA). Monitoring liver function and blood cells is essential during treatment due to potential serious side effects, including liver damage and lowered immunity. You can buy Arava (leflunomide) online from Canada with a valid prescription from your doctor.
Arava, known generically as leflunomide, is an essential treatment for adults with active rheumatoid arthritis (RA), an autoimmune disorder that primarily affects the joints. As a disease-modifying antirheumatic drug (DMARD), Arava helps to diminish the overactive immune responses, thereby reducing inflammation and tissue damage in RA patients. It is available in tablet forms of 10 mg, 20 mg, and 100 mg strengths.
The typical treatment regimen starts with a higher loading dose to rapidly achieve effective drug levels, followed by a maintenance dose tailored to individual patient needs based on their liver and bone marrow function. While Arava is primarily used for RA, it also finds off-label use in managing psoriatic arthritis and juvenile idiopathic arthritis, offering broader therapeutic applications.
Arava treatment requires careful monitoring due to its potential to cause significant side effects, such as liver enzyme elevations and severe infections. Regular blood tests are crucial to check liver function and blood cell counts. Given its risks, Arava is not advised during pregnancy, and both men and women should use effective contraception during and after treatment as specified by healthcare guidelines. Engaging and informed discussions with healthcare providers are vital to optimize treatment outcomes with Arava.
Arava comes in the form of tablets that you take by mouth and is available in these three following strengths:
The dosage of Arava prescribed by your doctor will vary based on several personal health factors. These include your risk for liver or bone marrow issues, how your body reacts to the medication, and any other health conditions you might have. Initially, when you start treatment with Arava, your doctor might prescribe a higher dose for the first three days—this is known as a loading dose. This higher dose helps to quickly increase the level of Arava in your body, allowing the medication to start acting more swiftly.
After this initial phase, your doctor will adjust your dose to a smaller, daily amount that suits your specific needs. The goal is to find the lowest possible dose that still effectively manages your condition. It's crucial to follow the dosage instructions provided by your doctor, as they will tailor the amount based on your individual response to the treatment and your medical profile.
Dosage for Rheumatoid Arthritis
[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they'll customize your dosage accordingly.]
Arava is a medication used for treating arthritis, and there are several important steps and checks involved in its use to ensure safety and effectiveness:
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They'll adjust it as needed over time.]
Arava works by targeting rheumatoid arthritis (RA) at its source—the immune system. In RA, the immune system mistakenly attacks the joints and other healthy tissues, causing inflammation and symptoms like pain and swelling. Over time, this inflammation can damage tissues and worsen symptoms. Arava belongs to a class of medications known as disease-modifying anti-rheumatic drugs (DMARDs), which help control this overactive immune response and reduce inflammation.
While traditional DMARDs like Arava are chemical-based, newer DMARDs, known as biologics, are made from living cells and target specific parts of the immune system more precisely. By reducing inflammation, Arava can help alleviate symptoms of RA, prevent further joint damage, and maintain your ability to perform daily activities. It’s important to discuss with your doctor how Arava fits into your overall treatment plan and how it can help manage your condition effectively.
Arava can lead to both mild and serious side effects. While the list provided here includes some common reactions to the medication, it's not exhaustive. For a more comprehensive understanding of what you might experience while taking Arava, or for advice on managing any side effects, please consult with your doctor or pharmacist. If you find that certain side effects are particularly troublesome, your doctor might suggest discontinuing Arava. Should this occur, your doctor can provide you with an alternative treatment plan that includes a method to help your body eliminate Arava more quickly.
Common Side Effects of Arava: Like all medications, it can cause side effects. These side effects are usually temporary and may last only a few days to weeks. However, if they persist, become bothersome, or feel intense, it's important to talk to your doctor or pharmacist. Here’s what you might experience while taking Arava:
Serious Side Effects of Arava: It can sometimes cause serious side effects as well. So, it’s crucial to be aware of these so you can get help quickly if they occur. Always contact your doctor immediately if you experience any serious side effects, and call 911 or your local emergency services if symptoms seem life-threatening. Here’s a detailed look at some potential serious side effects from taking Arava:
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Arava (leflunomide) comes with the highest level of warnings from the Food and Drug Administration (FDA), known as boxed warnings. These warnings are issued to highlight potential dangerous effects associated with the medication.
Liver Health Concerns: Arava can also lead to serious liver problems, which in some cases may be fatal. This risk increases if you combine Arava with other medications that can harm the liver, like acetaminophen. If you have existing severe liver disease, you should not use Arava. Your doctor will conduct liver function tests before and during your treatment to monitor for signs of liver damage. Symptoms of liver problems may include nausea, unusual bleeding or bruising, fatigue, pain in the upper right abdomen, yellowing of the skin or the whites of your eyes, dark urine, or flu-like symptoms. If you experience liver issues while on Arava, your doctor will stop the treatment and may provide a specific treatment to quickly clear the drug's byproducts from your body.
Before you start taking Arava, it's crucial to discuss your complete health history with your doctor. This medication may not be suitable for everyone, especially if you have certain health conditions.
Pregnancy and Breastfeeding: Arava is harmful if used during pregnancy or while trying to conceive and can cause serious harm to an unborn baby. It is essential to use effective birth control before, during, and for two years after stopping Arava. The drug's safety during breastfeeding has not been established, and it could potentially harm a nursing child.
If you happen to forget a dose of Arava, take it as soon as you remember. However, if your next scheduled dose is near, just skip the missed dose and continue with your regular dosing schedule. Do not take extra doses to make up for the missed one. If you're worried about missing doses, consider setting reminders using your phone, a reminder app, or a kitchen timer to help keep you on track.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Taking more Arava than prescribed can be dangerous and lead to severe side effects. Never exceed the dosage your doctor has recommended. Symptoms of an overdose might include diarrhea, abdominal pain, a drop in white or red blood cells, and elevated liver enzymes. If you suspect an overdose, contact your doctor immediately for advice. You can also reach out to the American Association of Poison Control Centers at 800-222-1222 for immediate guidance. If your symptoms feel life-threatening, call 911 or head to the nearest emergency room without delay.
[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Arava should be kept at room temperature, around 77°F (25°C). Make sure to store the tablets in a tightly closed container to protect them from light. If you find yourself with leftover Arava after your treatment is complete, it's crucial to dispose of the medication correctly. This is not just to ensure safety and prevent accidental ingestion by children or pets, but also to avoid environmental contamination. Proper disposal of medications like Arava helps maintain safety in your home and community.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Arava can potentially interact with a variety of other medications, as well as vitamins, herbs, and supplements. While no specific interactions with foods have been reported, it's important to be aware that interactions can vary in their effects. Some may reduce the effectiveness of Arava, while others could increase side effects or cause new ones.
Before starting Arava, it’s crucial to discuss all medications you're currently taking with your doctor and pharmacist. This includes anything from prescription drugs to over-the-counter products, as well as any supplements or herbal remedies. By sharing this information, your healthcare providers can help you avoid any harmful interactions.
Warfarin: Combining Arava with warfarin, a blood thinner, might lower your INR, which is a measure of how quickly your blood clots. A lower INR means your blood clots faster, which can be risky. If you are on both medications, your doctor will need to monitor your INR levels closely to adjust the dosage as necessary.
If you’re concerned about how other drugs might interact with Arava, or if you experience any unusual symptoms, don’t hesitate to consult your healthcare team for guidance. They can provide detailed information and support to ensure your treatment is both safe and effective.
Arava is a medication used for treating certain autoimmune conditions, and while it doesn't interact with many common substances, there are still some important considerations to keep in mind:
Alcohol: Drinking alcohol can be harmful to your liver, and since Arava can also cause significant liver damage, it’s best to avoid alcohol to protect your liver health. If you're unsure about alcohol consumption while on Arava, it's a good idea to discuss this with your doctor.
Herbs and Supplements: No specific herbs or supplements have been reported to interact directly with Arava, but it's still wise to consult with your doctor or pharmacist before starting any new herbal or dietary supplements. They can help ensure that nothing you take will interfere with Arava's effectiveness or cause adverse effects.
Foods: There are no specific foods known to interact with Arava, so you generally don’t need to change your diet while on this medication. However, if you have any concerns about your diet or specific foods, discussing them with your doctor can provide personalized advice.
Lab Tests: Arava is not known to affect the results of lab tests. Nevertheless, your doctor will likely conduct regular tests to monitor your liver function and blood cell counts, both during and after your treatment, to ensure Arava is safe and effective for you. If you're worried about how Arava might affect any upcoming lab tests, make sure to talk to your doctor.
Vaccines: Because Arava can weaken your immune system, you should avoid receiving live vaccines while taking it. Live vaccines contain a weakened form of the germ they aim to protect against, which could be harmful while on Arava. Since Arava’s effects can linger in the body for up to two years after stopping treatment, consult with your doctor before getting any live vaccines during this time.
[Note: This isn't a complete list, and there could be other drugs that interact with Arava. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
There are several alternatives to Arava available for treating rheumatoid arthritis (RA), and finding the right one can depend on your specific health needs. These alternatives might work better for some individuals and can be used alone or alongside other treatments. For instance, some common alternatives include other disease-modifying antirheumatic drugs (DMARDs) or biologic agents, which target specific parts of the immune system to reduce inflammation and prevent joint damage. Examples of other drugs that may be used for RA include:
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

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