Bilastine

Blexten

Blexten is an effective antihistamine featuring bilastine, designed to alleviate symptoms of allergic rhinitis and urticaria (hives). This medication blocks histamine, which triggers allergy symptoms, offering relief without significant drowsiness. Available in 20 mg tablets, Blexten should be taken once daily on an empty stomach for best results. It is suitable for adults and children over 12 years but should be used cautiously in elderly patients, especially those with renal issues. Common side effects include headache and nausea, while serious reactions are rare. Always consult with a healthcare provider before starting Blexten to ensure it aligns with your medical needs.

Product Overview

Blexten is a potent antihistamine containing bilastine, which is used to relieve symptoms associated with allergic rhinitis (both seasonal and perennial) and urticaria (hives). As an antihistamine, bilastine works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is renowned for its fast-acting properties and does not typically cause significant drowsiness, a common drawback of many older antihistamines. While the FDA approval status of bilastine can vary, it is widely approved and used in many countries across the globe for its efficacy and safety.

Available in a 20 mg tablet form, Blexten should be taken once daily to achieve optimal results. It is best taken on an empty stomach, either 1 hour before or 2 hours after meals, to enhance absorption. Blexten is suitable for adults and children over 12 years of age, but it should be administered with caution to elderly patients, especially those with renal impairment.

Like all medications, Blexten can cause side effects, with common ones including headache, drowsiness, and nausea. Serious but rare side effects may include allergic reactions and heart rate changes. It is important not to miss doses or overdose, as this can lead to increased side effects. Blexten should be stored at room temperature and kept away from moisture and heat. Patients should consult their healthcare provider before starting Blexten to ensure it is the proper medication for their condition, particularly considering potential interactions with other drugs or health conditions.

Uses of Blexten

• Treating allergic conditions

How to Use Blexten?

Dosage

Strengths and Forms

This medication comes in tablet forms with a dosage strength of 20 mg. 

Recommended Dosage for Different Patients

Adults and Children 12 Years and Older

• Standard Dosage: The usual dosage is 20 mg of bilastine once daily. This dosage is effective for treating symptoms of allergic rhinitis (seasonal and perennial) and urticaria (hives).

Children Under 12 Years

• Blexten is generally not recommended for children under the age of 12 due to insufficient data on safety and efficacy in this age group.

Elderly Patients

• Standard Dosage: The usual adult dosage of 20 mg once daily applies to elderly patients as well. However, caution is advised, especially in those with renal impairment, as no specific dose adjustment is typically required, but they may be more sensitive to the effects of antihistamines.

Patients with Renal Impairment

• Mild to Moderate Renal Impairment: No adjustment in the standard dosage is necessary.
• Severe Renal Impairment: The use of Blexten is not recommended in patients with severe renal impairment due to the lack of data and potential accumulation of the drug in the body.

Patients with Hepatic Impairment

• No dosage adjustment is necessary for patients with hepatic impairment alone since the kidneys primarily eliminate blasting.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

• Blexten should be taken once daily. To maximize its effectiveness, it is recommended to take Blexten on an empty stomach, ideally 1 hour before or 2 hours after meals. This helps to avoid any interference with absorption that can occur with certain foods.
• The typical dosage for adults and children 12 years of age and older is 20 mg per day. Always follow the dosage prescribed by your healthcare provider.
• Blexten comes in tablet form. Swallow the tablet whole with water without chewing or breaking it.
• Take Blexten at the same time each day to maintain an even level of the medication in your body.
• Continue taking Blexten for as long as your doctor has prescribed. Do not stop taking the medication without consulting your healthcare provider, even if you feel better.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Blexten Work?

Blexten, containing the active ingredient bilastine, is an antihistamine that relieves allergy symptoms such as sneezing, itchy and runny nose, and red, watery eyes. It works by blocking histamine, a substance in the body that is released during an allergic reaction. By inhibiting the action of histamine, Blexten effectively reduces the typical symptoms associated with allergies. This makes it an effective treatment for seasonal allergies, also known as hay fever and other allergic conditions. Blexten is known for its fast-acting properties and is taken orally, providing relief without causing significant drowsiness, a common side effect of many antihistamines.

Important Safety Information

Side Effects

Common Side Effects

• Headache
• Drowsiness
• Dizziness
• Nausea
• Fatigue
• Abdominal pain

Serious Side Effects

• Allergic Reactions: In rare cases, Blexten can cause severe allergic reactions. Symptoms might include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.
• Heart Rate Changes: There may be instances of palpitations or fast, irregular heartbeat.
• Severe Dizziness and Fainting: While mild dizziness is a common side effect, severe dizziness or fainting can be a sign of a more serious problem.
• Mental/Mood Changes: On rare occasions, there may be significant mood alterations, confusion, or hallucinations.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

• Allergic Reactions: Patients with a known allergy to bilastine or any component of Blexten should avoid taking this medication as it may cause severe allergic reactions, including anaphylaxis.
• Renal Impairment: Blexten should be used with caution in patients with severe renal impairment. The medication is primarily excreted by the kidneys, and impaired kidney function could lead to higher levels of the drug in the bloodstream, potentially increasing the risk of side effects.
• Elderly Patients: While no specific dosage adjustment is required for elderly patients, caution is advised due to the potential for decreased kidney function with age, which could affect the drug’s elimination from the body.
• Pregnancy and Breastfeeding: The safety of Blexten during pregnancy and breastfeeding has not been established. Therefore, it should only be used if the potential benefit justifies the potential risk to the fetus or infant.
• Effects on Ability to Drive and Use Machines: Although Blexten is considered a non-sedating antihistamine, patients should be aware of how they react to the drug before driving or operating machinery, as cases of drowsiness have been reported.

Precautions

• Food Interactions: Blexten should be taken on an empty stomach, either 1 hour before or 2 hours after a meal, as food can reduce the absorption of the medication and diminish its effectiveness.
• Alcohol and CNS Depressants: While Blexten itself does not typically cause drowsiness, combining it with alcohol or other central nervous system (CNS) depressants may enhance sedative effects. Patients should be cautious about using these substances together.
• Use in Children: Blexten is not recommended for children under the age of 12, as safety and efficacy have not been established for this age group.
• Lactose Intolerance: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take Blexten as it contains lactose.
• Informing Healthcare Providers: Patients undergoing allergy testing should inform their doctor about their Blexten use because antihistamines can affect the results of skin tests, leading to false negatives. It is generally recommended to stop taking antihistamines several days before testing.

Missed Dose

If you realize you’ve missed a dose shortly after it was due, take it immediately. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take an extra dose to compensate for the missed one.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdose 

An overdose might lead to pronounced sedation or drowsiness, more than what is typically expected, even though Blexten is known for being less sedating than older antihistamines. In the event of a suspected overdose, it is crucial to seek immediate medical attention. Treatment may involve symptomatic and supportive measures, depending on the severity of the symptoms and the specific conditions of the overdose.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

Storage

• Store it at room temperature (between 15°C – 30°C).
• Do not use Blexten after the expiry date stated on the carton and the blisters. The expiry date refers to the last day of that month.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Blexten Interactions

• Food Interactions: Bilastine should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. This is particularly important with high-fat meals, which can reduce the absorption of bilastine and decrease its effectiveness.
• Alcohol: While not a direct interaction, combining bilastine with alcohol can enhance drowsiness or sedation effects.
• Other CNS Depressants: Using bilastine with another central nervous system (CNS) depressants such as benzodiazepines, opioids, tricyclic antidepressants, or other sedatives can increase the risk of enhanced sedation.
• P-glycoprotein (P-gp) Inhibitors: Although not a common interaction, bilastine is a substrate of the P-gp transporter. Strong inhibitors of P-gp (like ketoconazole or itraconazole) might increase the levels of bilastine in the body, potentially increasing the risk of side effects.
• Fruit Juices: Certain fruit juices such as grapefruit, orange, and apple can decrease the absorption of bilastine, reducing its effectiveness. It’s recommended to avoid consuming these juices close to the time of taking bilastine.

[Note: This isn’t a complete list, and there could be other drugs that interact with Blexten. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Blexten Alternatives

• Claritin 24 Hour Non-Drowsy (loratadine)
• Claritin Reditabs (loratadine)
• Claritin Syrup (loratadine)
• Zyrtec (cetirizine)
• Allegra (fexofenadine)
• Benadryl (diphenhydramine)
• Xyzal (levocetirizine dihydrochloride)
• Xyzal Oral Drops (levocetirizine dihydrochloride)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can Blexten lead to drowsiness?

Blexten Tablet, an antihistamine designed for quick relief from allergies, can cause sleepiness in some individuals. If you find yourself feeling overly drowsy during the day after taking it, it is advisable to take this medication at night.

Under what circumstances should I avoid taking Blexten Tablets?

You should avoid taking Blexten if you have previously experienced an allergic reaction to it, or if you have lactose or sorbitol intolerance. Additionally, it’s not recommended for individuals with liver or kidney failure, epilepsy, or difficulty urinating. It’s also important to inform your doctor that you are taking Blexten tablets if you are scheduled for an allergy test, as it may influence the test results.

Is it safe to stop taking Blexten Tablets on my own?

You should avoid Blexten if you have experienced an allergic reaction to it or have lactose or sorbitol intolerance. Additionally, it’s not recommended for individuals with liver or kidney failure, epilepsy, or difficulty urinating. It’s also important to inform your doctor that you are taking Blexten tablets if you are scheduled for an allergy test, as it may influence the test results.

Is it safe to use Blexten Tablet in patients with prostate enlargement?

Blexten Tablet is generally not recommended for patients with prostate enlargement, as Bilastine may exacerbate urinary difficulties in such cases. Before taking this medication, it is crucial to consult with your doctor to discuss safe and appropriate treatment options.

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