Bosutinib
Bosulif Tablets
Bosulif (bosutinib) is an FDA-approved specialized medication classified as a tyrosine kinase inhibitor, designed to treat Philadelphia chromosome-positive chronic myelogenous leukemia in certain adults and children. This type of leukemia is marked by an abnormal chromosome that drives the disease. Bosulif is administered orally, available in tablets or capsules, making it convenient for patients as it can be taken once daily. It is a recommended treatment option for adult patients who meet specific criteria. So, if you want to buy Bosulif to treat leukemia, you must get your doctor’s prescription first.
Product Overview
Bosulif, known by its generic name bosutinib, is a critical medication in the battle against Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML). Approved by the FDA, it serves as a tyrosine kinase inhibitor that targets certain proteins involved in the proliferation of leukemia cells. Suitable for adults and children over the age of one, Bosulif is particularly valuable for patients who have either not responded to prior treatments or cannot tolerate them.
The drug comes in tablet and capsule forms, offering various dosages, including 100mg, 400mg, and 500mg for tablets and 50mg and 100mg for capsules. For effective treatment, adults typically take 400 mg daily for newly diagnosed cases and 500 mg daily for chronic, accelerated, or blast phases. At the same time, children’s doses are calculated based on body surface area. Administering Bosulif involves precise guidelines to maximize its efficacy while minimizing side effects. Patients are highly advised to take this medication with food to enhance absorption and mitigate gastrointestinal discomfort.
Bosulif tablets should be swallowed whole without breaking or crushing to avoid direct contact with the drug’s contents, which could be harmful. It is also important to avoid intake of grapefruit or its juice, which can affect the drug’s effectiveness, and to be cautious with other medications that might interact with Bosulif, especially those that influence the CYP3A4 enzyme system. However, patients must be aware of the several side effects, which range from diarrhea, rash, and fatigue to more severe reactions like liver damage and heart disease. Regular consultations with a healthcare giver are crucial to monitor the patient’s response to the drug and adjust dosages or treatment plans as necessary.
Uses of Bosulif Tablets
Bosulif is approved to treat:
- Adults & children 1 year and older with a type of leukemia called Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in its chronic phase. This includes those who are newly diagnosed who have not responded well or cannot tolerate other treatments.
- Adults with more advanced stages of this leukemia, such as the accelerated or blast phases, especially if previous treatments haven’t worked or were not tolerated.
How to Use the Bosulif Tablets?
Dosage
Bosulif is available in tablet and capsule form with the following strengths:
Tablets:
- 100mg
- 400mg,
- 500mg
Capsules:
- 50mg
- 100mg
Recommended Dosage for Different Patients
Usual Dose for Adults
- For newly diagnosed cases: Take 400 mg orally once a day.
- For chronic, accelerated, or blast phases: Take 500 mg orally once a day.
Usual Dose for Children
- For newly diagnosed cases: Take 300 mg/m2 orally once a day.
- For chronic phase cases that show resistance or intolerance to previous therapies, Take 400 mg/m2 orally once a day.
[Note: Remember these recommendations mentioned above may vary depending on person to person. Discuss it with your doctor or pharmacist, and they’ll customize your Bosulif Tablets dosage accordingly.]
How to Take It?
- Take Bosulif with food to help with absorption and reduce stomach discomfort.
- Swallow the tablet whole; do not crush, chew, or break it. If a tablet is accidentally crushed or broken, wash any contact areas on your skin with soap and water immediately. Consult your pharmacist on how to dispose of a broken pill properly.
- If you cannot swallow the capsules whole, wear gloves and carefully open the necessary number of Bosulif capsules. Mix the contents with room-temperature applesauce or yogurt (refer to product instructions for detailed guidance). Do not mix with other foods. Consume the mixture immediately without chewing, and do not save any for later use. Ensure this is taken with a full meal.
- When administering Bosulif to a child, wear gloves to handle the capsules or tablets. The dosage may need adjustment as the child grows, as directed by a physician.
- Avoid taking Bosulif within 2 hours of consuming antacids or H2 blocker medications. Discuss with your doctor or pharmacist if you are on Proton Pump Inhibitors (PPIs).
- Steer clear of grapefruit or its juice and any supplements containing grapefruit extract during your treatment.
- Your dosage may require adjustments due to factors like toxicity or if you have kidney or liver issues.
[Note: Your doctor will decide the right Bosulif Tablets dose for you based on your condition, following guidelines & studies on the drug. They’ll adjust it as needed over time.]
How Do the Bosulif Tablets Work?
Bosulif is a targeted medication that specifically blocks the function of BCR-ABL kinase, a protein that is often overproduced in cells affected by chronic myelogenous leukemia (CML). By targeting this protein, Bosulif helps to stop or slow down the growth of CML cells. Additionally, Bosulif affects other proteins in the Src family of kinases, such as Src, Lyn, and Hck, further affecting the progression of the disease. This drug is part of a group of medications known as tyrosine kinase inhibitors, which are designed to interfere with specific pathways crucial for the survival and proliferation of cancer cells.
Important Safety Information
Side Effects
Common side effects of Bosulif tablets include:
- Diarrhea
- Rash
- Fatigue
- Fever
- Nausea
- Vomiting
- High liver enzyme levels in the blood
- Headache
- Low blood cell counts
- High creatinine levels in the blood
- Respiratory tract infection
Mild side effects of Bosulif tablets include:
- Itching
- Dizziness
- Fluid buildup or swelling
- Constipation
- Shortness of breath
- Lower appetite
- Cough
- Joint pain
- Back pain
Serious side effects of Bosulif tablets include:
- Liver Damage
- Heart Disease
- Stomach pain
[Note: This above list may not cover all possible side effects of Bosulif tablets. Always consult your healthcare giver or doctor for medical advice about side effects.]
Warnings
Gastrointestinal: Bosulif may cause severe diarrhea and other gastrointestinal issues. If you experience intolerable gastrointestinal side effects, inform your doctor. Depending on your situation, they may need to pause your treatment, adjust your dosage, or stop the medication altogether.
Risk of Infection and Bleeding: Bosulif can lead to myelosuppression, a condition where the bone marrow produces fewer blood cells necessary for fighting infections and aiding in blood clotting. This can make you more susceptible to infections and increase your tendency to bleed easily. Contact your doctor immediately if you notice unusual bruising, bleeding, or signs of infection like fever, chills, or body aches.
Liver Health Concerns: There is an increased risk of liver problems when taking Bosulif. Stop using this medication & seek immediate medical help if you experience signs such as fever, shortness of breath, easy bruising or bleeding, jaundice (yellowing of the eyes or skin), blood in your stools, swelling, rapid weight gain, or severe and ongoing vomiting, stomach pain, or diarrhea. Your doctor will regularly check your liver enzymes, especially during the first three months of treatment and after that, as needed.
Fluid Retention and Heart Issues: Bosulif may cause fluid retention or heart problems. Report any symptoms such as swelling, rapid weight gain, shortness of breath, changes in heart rate, weak pulse, or fainting to your doctor. Additionally, Bosulif can increase the risk of kidney toxicity. Your doctor may assess your kidney function before and during your treatment.
Precautions
Allergies: Before taking bosutinib, inform your doctor, pharmacist, or healthcare giver if you have any allergies, including to bosutinib itself. This medication may contain other inactive ingredients that can trigger allergic reactions or other issues. For more information on these ingredients, consult your pharmacist.
Medical History: It’s important to discuss your medical history with your healthcare provider before using bosutinib, particularly if you have liver disease or kidney disease. These conditions can affect how the medication works and your overall treatment plan.
Effects on Alertness and Coordination: Bosutinib may cause dizziness. Consuming alcohol or using marijuana (cannabis) can intensify this dizziness. Avoid driving, using machinery, or performing any tasks that need alertness until you are certain you can perform them safely. Alcohol can also increase your risk of severe liver problems, so it’s advisable to avoid alcoholic beverages & discuss marijuana use with your doctor.
Pre-Surgical Considerations: Inform your doctor or dentist about all the medications you are using currently, including prescription & non-prescription drugs and several herbal products, before undergoing any surgery.
Immunizations and Infections: Notify your healthcare professional that you are using bosutinib before receiving any immunizations/vaccinations. It’s also crucial to avoid contact with individuals who have recently received live vaccines, such as the flu vaccine administered through the nose.
Injury Prevention: To reduce the risk of cuts, bruises, or injuries, be cautious when using sharp objects like razors and nail cutters. Avoid participating in contact sports, games, or other activities that could lead to injury.
Other Important Precautions
Pregnancy: Women who are pregnant or might become pregnant should avoid handling this medication or breathing the dust from the tablets or capsules, as bosutinib can be absorbed through the skin and lungs and may harm an unborn baby. If you are pregnant or planning to become pregnant, do not use bosutinib. A pregnancy test should be conducted before starting this medication. Discuss reliable forms of birth control to use during treatment & for 2 weeks after the final dose. If you become pregnant while using bosutinib, contact your doctor immediately to understand the risks and benefits of continuing the medication.
Breastfeeding: It is unknown if bosutinib passes into breast milk. Due to several risks to the infant, breastfeeding is not recommended while using this medication & for 2 weeks after the last dose. Consult your doctor before breastfeeding.
Missed Dose
- If you miss taking a dose of Bosulif (bosutinib) and more than 12 hours have passed, do not take the missed dose.
- Continue with your regular dosing schedule & take the next dose at its scheduled time.
- Avoid taking two doses simultaneously to compensate for the missed one.
- Keep track of your dosing times to help ensure consistent medication intake, which is crucial for effective treatment.
- Set reminders or alarms if you find it challenging to remember your medication schedule.
- If you frequently miss doses, discuss with your healthcare provider for additional strategies or adjustments to your treatment plan.
[Note: If you missed a Bosulif tablet dose and are unsure when to take the next dose, immediately consult your doctor or pharmacist.]
Overdose
If someone overdoses on Bosulif tablets and experiences severe symptoms like unconsciousness or difficulty breathing, immediately call 911. For other overdose symptoms, contact a poison control center without delay. Residents in the US should reach out to their local poison control center for prompt assistance.
[Note: If you consumed more than the recommended Bosulif tablets dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]
Storage
- Keep Bosulif tablets at a controlled room temperature between 20°C-25°C (68°F-77°F).
- Short-term excursions are permissible between 15°C to 30°C (59°F to 86°F).
- Store the tablets in a dry or wet-free place away from direct sunlight.
- Keep the tablets in their original container with the lid tightly closed to prevent moisture entry.
[Note: Discuss with your healthcare professional or doctor the proper disposal of unused Bosulif tablets and any questions you may have regarding their storage.]
Bosulif Interactions
When taking Bosulif, it’s important to be cautious about using other medications concurrently, as some can interfere with its effectiveness or exacerbate side effects. Always discuss all medications you’re taking with your healthcare provider, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Here are some key interactions to be aware of:
Medications Influencing the CYP3A4 Enzyme: Bosulif’s metabolism involves a key enzyme known as CYP3A4. Interactions occur when other drugs affect the activity of this enzyme, potentially altering Bosulif levels in your body, which could either increase toxicity or reduce its efficacy. Drugs known to interfere with CYP3A4 include:
- Antifungals like ketoconazole and fluconazole may elevate Bosulif levels.
- Antibiotics such as rifampin and clarithromycin could also alter Bosulif concentrations.
Interaction with Proton Pump Inhibitors (PPIs): The concomitant use of Bosulif and proton pump inhibitors (PPIs) is not recommended. PPIs, which are commonly used to treat conditions like heartburn, indigestion, and GERD, can decrease the absorption of Bosulif, reducing its effectiveness. PPIs include:
- Lansoprazole (Prevacid)
- Pantoprazole (Protonix)
- Omeprazole (Prilosec)
- Rabeprazole (Aciphex)
- Esomeprazole (Nexium)
- Dexlansoprazole (Dexilant)
Herbs and Supplements: Certain supplements, particularly those containing grapefruit extract, can increase Bosulif levels, leading to a higher risk of adverse effects. Before starting treatment, ensure your doctor is aware of any supplements you are taking, especially those with grapefruit.
Food Interactions: Bosulif can also react with grapefruit or grapefruit juice. Consuming these while on Bosulif may raise the drug’s levels in your body, increasing the likelihood of side effects. If grapefruit is a regular part of your diet, discuss possible risks with your doctor to determine the best approach.
[Note: This is not a complete list, and there could be other drugs that may interact with Bosulif tablets. Make sure to tell your doctor or pharmacist about any prescription, over-the-counter medicines, & herbal products you’re currently taking.]
Bosulif Alternatives
[Note: Your doctor will choose what’s the best alternative medication for you. Don’t use any of these alternative medicines without consulting your healthcare giver. Taking them by yourself can cause very serious side effects.]
Frequently Asked Questions
Does Bosulif cause heart problems?
Bosulif, a medication used in certain medical treatments, has been associated with potential cardiovascular issues. Specifically, it may lead to serious heart-related complications, including heart failure and a reduction in blood flow to the heart, potentially resulting in a heart attack. Patients must be active for symptoms indicative of such problems. Suppose you experience any signs such as shortness of breath, unexpected weight gain, chest pain, or noticeable swelling in the hands, ankles, or feet. In that case, it is imperative to seek immediate medical attention. These symptoms could indicate fluid retention, where the body accumulates excessive fluid, further exacerbating the risk of heart complications.
Can Bosulif cause hair loss?
Based on clinical studies, hair loss is not a commonly reported side effect among individuals taking Bosulif to treat chronic myeloid leukemia (CML). However, it is important to note that while Bosulif itself is not typically associated with hair loss, other medications used to manage CML, such as Gleevec (imatinib), have been known to cause this issue. Therefore, if you experience hair loss while on treatment, it may be linked to other medications or factors, and discussing these symptoms with your healthcare provider is advisable.
Is Bosulif effective?
Bosulif has been found to be an effective treatment option in medical studies, particularly for reducing the proportion of white blood cells that contain the Philadelphia chromosome. This chromosome is a genetic abnormality associated with certain types of leukemia, and the ability of Bosulif to target these cells plays a crucial role in the management of the disease. The effectiveness of this medication highlights its importance in the treatment regimen for patients affected by this specific chromosomal alteration.
What is the indication of bosutinib tablets?
Bosutinib, sold under Bosulif, is an anticancer medication that inhibits specific proteins in cancer cells. By targeting these proteins, bosutinib effectively halts the proliferation of cancer cells, thereby impeding the progression of the disease. Primarily, it is prescribed for the treatment of chronic myelogenous leukemia (CML), a type of cancer that affects the bone marrow & the blood. However, its use is not limited to this indication alone. For potential additional uses or any inquiries regarding your treatment, it is advisable to consult your healthcare provider or pharmacist. This ensures you receive tailored advice and information about your specific health needs.
How is Bosulif administered?
Bosulif is administered orally as part of its recommended treatment protocol. Patients are advised to take the prescribed dosage once daily, which should be taken alongside food to enhance absorption and reduce potential gastrointestinal discomfort. The tablets must be swallowed whole; they should not be altered in any way, such as by cutting, crushing, breaking, or chewing. This ensures the medication’s effectiveness and prevents any unintended release or absorption of the drug. Treatment with Bosulif should be continued consistently until there are signs of disease progression or if the patient experiences intolerance to the therapy. At this point, a healthcare provider should be consulted for possible adjustments to the treatment plan.
What strength are bosutinib tablets?
Bosutinib tablets are available in three different dosage strengths, each formulated as film-coated tablets. The specific dosages are:
Bosulif 100 mg: Each film-coated tablet contains 100 milligrams of bosutinib in the form of monohydrate.
Bosulif 400 mg: Each film-coated tablet includes 400 milligrams of bosutinib, also in monohydrate form.
Bosulif 500 mg: This highest dosage strength contains 500 milligrams of bosutinib per film-coated tablet, similarly presented as monohydrate.
These tablets are tailored to meet varying therapeutic needs and dosing requirements prescribed by healthcare professionals.
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