Ticagrelor

Brilinta

Brilinta (Ticagrelor) is an FDA-approved medication to reduce the risk of serious cardiovascular events such as heart attacks, strokes, and death due to heart complications, particularly in adults. Brilinta contains ticagrelor, which is the active ingredient in the medication, and it is part of a group of drugs known as antiplatelets. It works as an antiplatelet drug by preventing blood clots and is taken orally in tablet form, typically twice a day, alongside low-dose aspirin. It’s available in 60 mg and 90 mg dosages, with specific regimens based on the patient’s condition. This medication is available exclusively as a brand-name drug. Critical side effects include increased bruising, shortness of breath, and potential severe bleeding. Usage should be closely monitored by a healthcare provider, mainly due to its interactions with other medications.

Product Overview

Brilinta, known generically as Ticagrelor, is an antiplatelet medication used primarily to prevent serious cardiovascular issues in adults, including heart attacks, strokes, and related deaths. It’s particularly prescribed for patients with a history of cardiovascular diseases or those who have undergone procedures like stent placement. The medication inhibits platelets from clumping together, thus reducing the likelihood of forming dangerous blood clots.

Administered orally, Brilinta is available in two strengths: 60 mg and 90 mg tablets, with the dosage varying based on the medical condition and treatment phase. Initially, a higher loading dose is used to rapidly elevate drug levels in the body, followed by a regular maintenance dose. It is essential to take Brilinta alongside aspirin, typically 75 to 100 mg daily, to enhance its efficacy. While Brilinta is effective in preventing thrombotic events, it does carry risks of side effects. Common issues include more frequent bruising and mild shortness of breath. However, it may also cause severe bleeding, which necessitates immediate medical attention. Other significant adverse effects include dyspnea and potential bradyarrhythmias. 

Drug interactions are noteworthy with Brilinta, especially with NSAIDs like ibuprofen, certain antifungal and antiviral medications, and drugs that affect heart rhythm, such as digoxin. These interactions can either increase the risk of side effects or diminish the effectiveness of the medication. Given these factors, Brilinta treatment requires careful management and consultation with healthcare professionals even before you buy Brilinta online.

What Are the Uses of Brilinta?

Brilinta is prescribed for:

• Reducing the risk of serious cardiovascular issues in adults. These issues can include heart attacks, strokes, and death due to heart-related problems.
• Preventing blood clots in individuals with acute coronary syndrome (ACS) who have had a stent placed in their heart’s blood vessels.
• Reducing the likelihood of heart attacks and strokes in people who have not previously experienced these conditions.
• Managing stroke risks in those who are either experiencing a stroke caused by a blocked vessel or a transient ischemic attack (TIA).

What Are the Forms and Strengths of Brilinta?

It comes in the form of a tablet that is taken by mouth twice a day, and it should be used in combination with aspirin. It comes in two strengths: 

• Brilinta 60 mg tablet
• Brilinta 90 mg tablet

What Is the Typical Dosage of Brilinta?

The typical dosage for Brilinta (ticagrelor) can vary based on the individual’s health condition and the specific reasons for which it’s prescribed. It’s crucial to adhere strictly to the dosage and schedule as prescribed by your healthcare provider. Here are some general guidelines regarding the typical dosing for Brilinta:

Dosage for Preventing Cardiovascular Events

Brilinta is prescribed to reduce the risk of cardiovascular events such as heart attacks or strokes, especially in individuals with acute coronary syndrome (ACS) or those who have a history of heart attacks. Here is how Brilinta is typically dosed:

• First Day of Treatment: You will start with a one-time loading dose of 180 mg. This initial high dose helps to quickly establish an adequate level of the medication in your body.
• First Year of Treatment: After the initial loading dose, you will take 90 mg of Brilinta twice daily for one year.
• Second Year and Beyond: Starting from the second year of treatment, the dosage will be reduced to 60 mg, taken twice daily. You will continue with this dosage as long as your doctor recommends.

Brilinta is taken alongside aspirin each day to enhance its effectiveness. The recommended daily dose of aspirin to be taken with Brilinta is between 75 mg and 100 mg. Always follow your doctor’s instructions regarding medication to ensure safety and effectiveness in preventing heart-related health events.

Dosage for Preventing Blood Clots After Stent Placement

Brilinta is prescribed to prevent blood clots in individuals with acute coronary syndrome (ACS) who have undergone stent placement. Here’s the recommended dosage plan for such cases:

• Initial Treatment: On the first day, you will take a one-time loading dose of 180 mg. This higher initial dose ensures that the medication starts working effectively right away.
• First Year of Treatment: Following the loading dose, you should take 90 mg of Brilinta twice daily for one year.
• Subsequent Years: From the second year of treatment onwards, the dosage is reduced to 60 mg, taken twice daily. You should continue this regimen as long as it is recommended by your doctor.

Aspirin is also recommended in combination with Brilinta, typically 75 mg to 100 mg. Always follow your doctor’s guidance regarding using these medications to optimize your treatment and prevent complications.

Dosage for Preventing Heart Attack and Stroke

Brilinta is used to prevent heart attacks and strokes in individuals diagnosed with coronary artery disease (CAD) who are at a higher risk but have not previously had a heart attack or stroke. Here is the recommended dosage:

• Ongoing Treatment: The standard dosage is 60 mg of Brilinta, taken twice daily. Continue this dosage for as long as your doctor prescribes.
• Combination with Aspirin: It is essential to take Brilinta in conjunction with aspirin each day. The advised daily aspirin dosage when used with Brilinta is between 75 mg and 100 mg.

Dosage for Preventing Stroke

Brilinta is prescribed for individuals experiencing a stroke due to a blocked blood vessel or a transient ischemic attack (TIA). Here’s the standard dosing protocol:

• • Initial Treatment: On the first day, you’ll receive a one-time loading dose of 180 mg. This higher dose ensures that the medication begins to work effectively and immediately.
  • Continuing Dosage: After the loading dose, you should take 90 mg of Brilinta twice daily for up to 30 days.

• Combination with Aspirin:

• • Loading Dose of Aspirin: On the first day, along with the initial dose of Brilinta, a loading dose of aspirin between 300 mg and 325 mg is recommended.
  • Maintenance Dose of Aspirin: Subsequently, the daily aspirin dosage should be between 75 mg and 100 mg.

[Note: These recommendations may vary from person to person. Discuss them with your doctor, and they’ll customize your dosage accordingly.]

How to Take Brilinta?

Take Amoxil exactly as prescribed by your doctor. Do not take more than the prescribed amount, do not take it more frequently, and do not take it for a longer duration than directed. Here are some key instructions for taking Amoxil correctly:

• You should take Brilinta twice a day. It can be taken with or without food, depending on your preference.
• For optimal effectiveness, try to take your doses of Brilinta approximately 12 hours apart. 
• Maintaining a routine, such as taking the medication in the morning and evening, can help keep the drug levels consistent in your body.
• If you find it difficult to swallow tablets, there are strategies that might help, which you can find in this article. Additionally, discussing with your doctor or pharmacist is advisable for further guidance on how to take the medication effectively.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Brilinta Work?

Brilinta is known generically as ticagrelor and is commonly used alongside low-dose aspirin to help prevent heart attacks and strokes in people who have a history of heart disease or stroke or who are at increased risk for these conditions due to factors like diabetes or a history of transient ischemic attack (TIA). It is also used to prevent blood clots after certain heart surgeries, such as the placement of a stent. Ticagrelor is classified as an antiplatelet drug. It works by preventing platelets in your blood from clumping together to form harmful clots. This action helps to keep the blood flowing smoothly through your body, reducing the risk of severe cardiovascular events.

What Are the Safety Guidelines for Using Brilinta?

What Are the Side Effects of Brilinta?

Common Brilinta Side Effects: Medications like Brilinta, used to prevent blood clots and protect against strokes and heart attacks, can cause common side effects. These typically last a few days to weeks. If you experience these side effects for a prolonged period, or if they become bothersome or intense, it’s crucial to consult your doctor or pharmacist to ensure your safety. The common side effects of Brilinta may include:

• Bruising more often than usual: You might notice that you bruise more easily than before, which is due to the medication’s effect on your blood’s ability to clot.
• Shortness of breath: You may experience a feeling of being unable to breathe deeply enough, which can occur even during mild exertion.

Mild Brilinta Side Effects: Brilinta, commonly used to reduce the risk of stroke and heart attack by preventing clots, can have some mild side effects. These side effects are usually temporary, and your body may adjust to them over time. However, if they continue for an extended period or become troublesome, it’s important to consult with your primary healthcare provider. The mild side effects of Brilinta may include:

• Dizziness: You may feel lightheaded or unsteady, which can happen especially when standing up quickly.
• Diarrhea: You might experience loose, watery bowel movements.
• Mild Allergic Reaction: Signs can include skin rash, itching, or slight swelling.

Adverse/Serious Brilinta Side Effects: Brilinta is a medication used to prevent blood clots, but it can also lead to serious side effects. If you experience any of the following adverse effects while taking Brilinta, contact your doctor immediately. For life-threatening side effects or if you believe you are having a medical emergency, call your local emergency number or 911 right away. Serious side effects of Brilinta may include:

• • Abnormal Bradycardia (Slow Heart Rate): This occurs when your heart rate is unusually slow, which can affect how well your body functions.
  • Major Bleeding: This may require urgent medical attention. Signs of significant bleeding include:
    • Uncontrolled bleeding from any part of the body.
    • Urine that appears pink, red, or brown.
    • Coughing up blood or black material that looks like coffee grounds.
    • Stools that are red or black in color, which can indicate bleeding in the gastrointestinal tract.

• Severe Allergic Reactions to Brilinta:

• • Swelling of the mouth, tongue, or throat: This can impede your ability to breathe or speak and requires immediate medical attention.
  • Swelling under the skin: Often noticeable in the hands, feet, eyelids, or lips.

Although rare, severe allergic reactions to Brilinta are a medical emergency. If you experience any signs of a severe allergic reaction, it is crucial to seek medical help immediately to ensure your safety and receive appropriate treatment.

[Note: Remember, this list may not cover all possible side effects. If the symptoms appear life-threatening or if you think you are having a medical emergency, call 911 right away.]

What Are the Warnings to Consider Before You Use Brilinta?

When considering the use of Brilinta, especially if you’re planning to purchase it online, it’s crucial to carefully consider the potential risks along with the benefits. This decision should be made in collaboration with your doctor. Here are some important considerations to discuss before starting Brilinta:

• Concomitant Aspirin Maintenance Dose: It is advised to use Brilinta with a maintenance dose of aspirin between 75 mg and 100 mg. Higher doses of aspirin above 100 mg after the initial loading dose may reduce the effectiveness of Brilinta.
• Dyspnea (Difficulty Breathing): Approximately 14% of patients taking Brilinta may experience dyspnea, which is generally mild to moderate and often resolves on its own during continued treatment. However, a small percentage of patients find the symptom intolerable and may need to stop using Brilinta. If dyspnea is new, prolonged, or worsens and is related to Brilinta, continued treatment without interruption is usually possible unless the symptom is intolerable.
• Discontinuation of Brilinta: Stopping Brilinta can significantly increase the risk of a heart attack, stroke, and death. If it is necessary to stop Brilinta temporarily, for example, to manage bleeding or before major surgery, it should be restarted as soon as it is safe to do so. In cases where surgery involves a significant risk of bleeding, Brilinta should ideally be stopped five days prior to the procedure and resumed once hemostasis is achieved.
• Bradyarrhythmias (Slow Heart Rhythms): Brilinta can cause slow heart rhythms, such as ventricular pauses and AV block. These conditions have been noted after the drug was approved for use. Patients with a history of certain heart rhythm disorders (like sick sinus syndrome or severe AV block) who do not have a pacemaker may face an increased risk of developing bradyarrhythmias while taking Brilinta.
• Alcohol Consumption: While there is no direct interaction identified between alcohol and Brilinta, it is important to consider the effects of heavy drinking. Consuming large amounts of alcohol can irritate the stomach lining and increase the risk of developing bleeding ulcers. Since Brilinta itself can cause bleeding as a side effect, drinking alcohol while on this medication may further heighten your risk of bleeding. Discuss with your doctor the safe amount of alcohol you can consume while taking Brilinta, if any.

What Are the Boxed Warning of Using Brilinta?

Here are some boxed warning issued by the FDA that are crucial to consider:

• Risk of Bleeding: Brilinta has a boxed warning, which is the most serious type of warning issued by the Food and Drug Administration (FDA). This warning highlights the significant risks associated with bleeding and the use of aspirin in conjunction with Brilinta. These risks are serious and require careful consideration. It is important to discuss these risks with your doctor to fully understand the implications of taking aspirin while being treated with Brilinta.

What Are the Precautions for Brilinta?

It is crucial when you buy Brilinta online to discuss your medical history with your doctor. Brilinta may not be suitable if you have certain health conditions or factors that could interact negatively with the drug. Here are specific conditions and factors to consider:

• Active Bleeding: If you are currently experiencing serious bleeding, such as bleeding in your brain or from a bleeding ulcer, Brilinta is likely not appropriate for you. The drug can increase the risk of bleeding.
• History of Brain Bleeding: If you have had bleeding in your brain in the past, Brilinta may increase your risk of bleeding problems. Make sure to inform your doctor about this history; they will likely recommend a different treatment option for your condition.
• Heart Rate Problems: Brilinta may cause your heart rate to slow down. If you already have issues with a slow heart rate, Brilinta could exacerbate this problem. It’s important to inform your doctor about any heart rate issues you have experienced or if you are currently taking medications to manage your heart rate. Your doctor will assess whether Brilinta is a safe option for you.
• Breathing Problems: Brilinta has been known to cause breathing difficulties, including shortness of breath. If you have respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD), taking Brilinta might worsen these conditions. Discuss with your doctor to determine if Brilinta is suitable for your medical needs.
• Liver Problems: If you have significant liver issues, such as cirrhosis, your body may not be able to process Brilinta effectively. This can result in higher levels of Brilinta in your bloodstream, increasing your risk of bleeding. It’s important to inform your doctor about any liver problems you have. They will likely recommend a different medication that is safer for your condition.
• Allergic Reactions: If you have previously experienced an allergic reaction to Brilinta or any of its components, your doctor will probably advise against using this medication. Be sure to discuss alternative treatments with your doctor that might be more suitable for your health needs.
• Pregnancy: The safety of Brilinta during pregnancy is not fully established. In animal studies, high doses of Brilinta were shown to harm the fetus, although these results do not always predict human outcomes. If you are pregnant or planning to become pregnant, it is crucial to consult with your doctor. They can assess whether Brilinta is the most appropriate medication for your condition during pregnancy.
• Breastfeeding: Brilinta has been found to pass into breast milk in animal studies, which may pose a risk to a nursing infant. Due to these findings, it is generally recommended not to take Brilinta if you are breastfeeding. Discuss with your doctor potential safe alternatives for feeding your child if you need to take Brilinta.

Who Should Not Use Brilinta?

Do not take Brilinta if you:

• Have a history of intracranial hemorrhage.
• Are currently experiencing active bleeding
• Have allergies to ticagrelor or any ingredients in Brilinta

What Happens If You Miss a Dose of Brilinta?

Here’s what you can do when you miss a dose of Brilinta:

• If you miss a dose of Brilinta, do not take an extra dose to catch up. Simply wait and take your next scheduled dose at the regular time. Taking an additional dose can increase your risk of serious bleeding.
• To ensure you don’t miss doses in the future, consider setting a reminder on your phone or using a medication timer. These tools can help you maintain your dosing schedule and get the full benefit of your treatment.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Overdose On Brilinta?

Do not take more Brilinta than prescribed by your doctor, as it can cause serious health issues. If you take too much, you may experience the following symptoms:

• Nausea
• Excessive bleeding
• Vomiting
• Irregular heartbeat
• Diarrhea

If you suspect an overdose, contact your doctor immediately. Alternatively, you can call your nearest emergency number or contact the American Association of Poison Control Centers for assistance.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store Brilinta Tablets?

Proper storage of Brilinta tablets is essential to maintain their effectiveness. Here are some guidelines on how to store Brilinta properly: 

• Store ticagrelor (Brilinta) at room temperature, between 59°F and 86°F (15°C and 30°C).
• Keep the medication away from light and heat.
• Do not store Brilinta in moist or damp areas, such as bathrooms.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Are the Interactions of Brilinta?

Brilinta can interact with various medications and foods, impacting its effectiveness or increasing side effects. Here’s how these interactions with medication might affect your treatment with Brilinta:

• Ibuprofen: Taking Brilinta with ibuprofen can increase your risk of bleeding, especially in the stomach, because both drugs can independently raise bleeding risks.
• Digoxin: Using Brilinta with digoxin, a heart rhythm medication, can lead to higher blood levels of digoxin due to Brilinta slowing down digoxin’s breakdown. This requires close monitoring to ensure safe digoxin levels.
• Certain Antifungal Drugs: Medications like Posaconazole, Ketoconazole, Voriconazole, and Itraconazole may increase Brilinta’s levels in your blood by slowing down its breakdown, raising the risk of bleeding. Regular monitoring for bleeding symptoms is necessary if you take these antifungals with Brilinta.
• Certain Antiviral Drugs: Similar to antifungals, antiviral drugs like Nefazodone, Nelfinavir, Ritonavir, Saquinavir, and Atazanavir can increase Brilinta’s levels and enhance bleeding risks. It’s important to monitor for signs of increased bleeding.
• Certain Seizure Drugs: Phenytoin, Carbamazepine, and Phenobarbital can reduce the effectiveness of Brilinta by accelerating its breakdown. Your doctor may suggest alternative medications to avoid this interaction.
• Certain Cholesterol Drugs: Using Brilinta with cholesterol medications like simvastatin or lovastatin can increase their levels in your blood, potentially leading to serious side effects. The dosage of these cholesterol medications needs careful management.
• Opioid Pain Relievers: Opioids can hinder the absorption of Brilinta, making it less effective. Options like injectable opioids might be considered to avoid this issue.

What Are the Other Interactions of Brilinta?

• Supplements and Herbs: While no specific interactions are noted with herbs or supplements, it’s wise to discuss any new supplements with your healthcare provider.
• Grapefruit Interaction: Consuming grapefruit or grapefruit juice can increase the levels of Brilinta in your blood, raising the risk of side effects like bleeding. Discuss with your doctor the safety of consuming grapefruit during your treatment.

[Note: This isn’t a complete list, and there could be other drugs that interact with Brilinta. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Brilinta Alternatives?

If Brilinta (ticagrelor) is not suitable for you, either due to allergies or other reasons, there are several alternative medications that can be used to prevent blood clots and reduce the risk of strokes and heart attacks. Here are some commonly prescribed alternatives to Brilinta:

• Aspirin
• Effient (prasugrel)
• Aspirin-dipyridamole ER
• Xarelto (rivaroxaban)
• Cilostazol
• Plavix (clopidogrel)
• Eliquis (apixaban)
• Lovenox (enoxaparin)
• Persantine (dipyridamole)
• Arixtra (fondaparinux)
• Aggrenox (dipyridamole/aspirin)
• Pradaxa (dabigatran)
• Jantoven (warfarin)
• Savaysa (edoxaban)
• Heparin
• Ticlopidine
• Eptifibatide

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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Frequently Asked Questions

Is Brilinta the same as Plavix?

Brilinta (ticagrelor) and Plavix (clopidogrel) are both medications used to prevent blood clots, but they are not the same. Both medications help to keep your blood from forming harmful clots, which can lead to heart attacks or strokes. While they serve a similar purpose, they have some differences:

• Dosage Frequency: Brilinta is typically taken twice a day, whereas Plavix is taken once a day.
• Combination with Aspirin: Both Brilinta and Plavix are often prescribed alongside low-dose aspirin to enhance their clot-preventing effects.

Both medications are effective at reducing the risk of blood clots, but the choice between them depends on individual health needs and the doctor’s recommendation.

When is the best time of day to take Brilinta?

You should take Brilinta at the same times each day, such as one tablet in the morning and another in the evening. Your doctor will typically also recommend taking a low-dose aspirin along with Brilinta. Aspirin is commonly used to help prevent blood clots.

Can you drink coffee while taking Brilinta?

There is no documented interaction between caffeine and Brilinta, and studies suggest that consuming caffeine is generally safe for individuals taking Brilinta. However, it’s important to consult your doctor or pharmacist for personalized advice regarding your caffeine intake while on Brilinta, including recommendations on safe amounts specific to your health condition.

Can you take Brilinta just once a day?

Brilinta is not prescribed as a once-daily medication. The standard dosing schedule for Brilinta involves taking it twice a day. In some cases, a one-time higher “loading dose” of Brilinta may be used at the start of treatment to quickly establish effective drug levels in your body. After the loading dose, you will continue with the regular twice-daily dosing.

Does shortness of breath go away with Brilinta?

Shortness of breath is a known side effect for 14% to 21% of individuals taking Brilinta, as observed in clinical trials. This side effect is usually mild and tends to improve over time as you continue taking the medication. Significantly, it does not damage the lungs. If you experience shortness of breath while taking Brilinta, discussing this with your doctor is crucial, especially if the symptom is persistent or bothersome.

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