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Bupropion XL

Bupropion XL

Bupropion XL is an FDA-approved prescription antidepressant primarily used to treat depression & seasonal affective disorder. It comes in the form of a tablet and is available in strengths of 150 mg and 300 mg. It is typically indicated for use in adults, and pediatric patients should consult a licensed healthcare provider to determine usage and dosage. You should not use this medication in conjunction with MAOIs or following the abrupt discontinuation of alcohol or sedatives. This medication modifies brain neurotransmitter levels, specifically dopamine and norepinephrine, to help improve mood and emotional regulation. For a safe and efficient use of the medication. You can buy Bupropion online from reputable sources. 

Product Overview

Bupropion XL is an extended-release antidepressant primarily used to treat depression and seasonal affective disorder. It modifies brain neurotransmitter levels, specifically dopamine and norepinephrine, to help improve mood and emotional regulation. Available in 150 mg & 300 mg tablet forms, the medication is typically prescribed at an initial dose of 150 mg once daily, potentially adjusted based on individual response but not exceeding 300 mg daily. It is also used to aid in smoking cessation, starting at 150 mg daily. 

This medication is intended for adult use, and a healthcare provider must strictly supervise any pediatric applications. The tablets should be swallowed whole to maintain effective release and absorption. Patients are advised to maintain a consistent dosing schedule to optimize the therapeutic effects. Common side effects of Bupropion XL include constipation, dizziness, dry mouth, and sleep disturbances. More severe reactions, such as seizures and significant mood changes, necessitate immediate medical attention. 

Bupropion should not be used in conjunction with MAO inhibitors or following the abrupt discontinuation of alcohol or sedatives. Interaction with drugs like digoxin and linezolid should be managed under close medical supervision. For storage, Bupropion XL should be kept at a controlled room temperature, away from excessive heat, light, and moisture, and out of the reach of children and pets. Patients should discuss any side effects or concerns with their physician or healthcare provider to ensure safe and effective use of the medication. Regular follow-ups and adherence to the prescribed dosage are crucial for managing the condition effectively.

What Are the Uses of Bupropion XL?

It is used to treat:

  • Depression
  • Seasonal affective disorder

What Are the Forms & Strengths of Bupropion XL?

Bupropion XL comes in the form of a tablet with the following strengths:

  • 150 mg
  • 300 mg

What Are the Recommended Dosage of Bupropion XL?

For Depression

Extended-release Tablets

  • Adults 
    • Aplenzin: Initially, 174 mg once daily in the morning. Your doctor may make dosage adjustments as required. However, the dosage should not exceed more than 522 mg daily. 
    • Forviro XL: 450 mg once daily
    • Welbutrin XL: Initially, 150 mg once in the morning daily. Your doctor may make dosage adjustments as required. However, the dose should not exceed more than 300 mg daily. 
  • Children- The doctor will determine the usage and dosage. 

Sustained-release Tablets

  • Adults: The initial recommended dose is 150 mg twice daily in the morning. Your doctor may adjust your dosage as required. However, the dosage typically does not exceed 200 mg twice daily, with a gap of at least eight hours. 
  • Children: Usage and dosage is determined by your doctor. 


  • Adults: Initially, the recommended dosage is 100 mg twice daily. Your doctor may make dosage adjustments as required. However, the dosage should not exceed 100 mg thrice daily, taken at least six hours apart. 
  • Children: Your doctor will determine the usage and dosage.
For Seasonal Affective Disorder 
  • Adults:
    • Aplenzin: Initially, take 174 mg once daily in the morning. Your doctor may make dosage adjustments as required. However, the dosage should not exceed 522 mg daily.
    • Wellbutrin XL: The initial dosage is 150 mg once daily in the morning. Your doctor may make dosage adjustments as required. However, your daily dosage should not exceed 300 mg.
  • Children: Your doctor will determine the usage and dosage. 
To Quit Smoking
  • Adults: 150 mg is taken once daily for the first three days. Your doctor may make dosage adjustments if required. However, the dose should not exceed 300 mg daily. 
  • Children: Your doctor will determine the usage and dosage. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Bupropion XL?

  • Before starting to take Bupropion, you should carefully read and follow the instructions for use in the patient information leaflet that came with your prescription or that your pharmacist gave you. 
  • If you don’t understand any part of the leaflet or have any questions or concerns about medication use, consult your doctor. 
  • Bupropion is available in the form of a tablet and a long-acting tablet to be taken orally by mouth.
  • The regular tablet is taken thrice daily, with each dose at least six hours apart, or four times daily, with each dose at least four hours apart. 
  • The sustained-release tablets are typically taken two times daily with a gap of at least eight hours between doses. 
  • The extended-release tablet of Bupropion is typically taken once daily in the morning. Each dose should be taken 24 hours apart. 
  • Your doctor will initially prescribe you a low dose of Bupropion, which will gradually increase based on your body’s response to treatment & the condition being treated. 
  • Take Bupropion exactly as directed by your doctor. 
  • Do not take it more or less than prescribed, more frequently, or in larger quantities, as it can cause unwanted side effects. 
  • If Bupropion upsets your stomach, you should take it with food. 
  • Swallow the long-acting tablets whole. You should not try to chew, crush, or break them. 
  • You should not abruptly stop taking this medication without consulting your doctor. When you decide to discontinue taking this medication, you should tell your doctor, and they will help you gradually taper off the medication. 
  • If you experience difficulty sleeping or staying asleep, you should not use this medication too close to bedtime. 
  • Take this medication around the same time every day to help you remember to take it and maintain consistency in dosage.
  • It may take around a month or even longer for you to feel the full benefit of this medication. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Bupropion XL Work?

Bupropion is an antidepressant medicine that works by influencing certain neurotransmitters in the brain, specifically dopamine and norepinephrine. It helps restore the balance of these natural substances, which play a crucial role in mood regulation and overall brain function. 

Important Safety Information for Using Bupropion XL

What Are the Side Effects of Bupropion XL?

Like every other medication, Bupropion may also cause side effects in some people. These side effects don’t usually require medical attention and may disappear within a few days as the body gets used to the medication. But if these symptoms persist or worsen, you should immediately tell your healthcare provider or doctor. The common side effects caused by Bupropion are as follows: 

  • Constipation
  • Dizziness
  • Dry mouth
  • Headache
  • Nausea
  • Restlessness
  • Sore throat
  • Trouble sleeping

In some rare cases, Bupropion may cause serious side effects in some people. These symptoms require immediate medical attention. Call your doctor immediately if you experience any of the following side effects. The following serious side effects of Bupropion XL should be immediately treated, or else it could be fatal. 

  • Suicidal thoughts & mood or behavioral changes
  • Severe allergic reactions: Itchy skin, hives, skin rash, swelling, shortness of breath and angina (chest pain)
  • Severe skin reactions: Painful rash, fever, fluid-filled blisters, sore throat, peeling skin
  • Manic episodes: Angry or very happy mood, very high or low energy, problems with sleep
  • Seizures
  • Vision problems: Vision changes, eye pain, swelling or redness in or around the eye

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Bupropion XL? 

  • Do not take this medication if you have seizures, an eating disorder, or suddenly stopped using alcohol or sedatives. Do not take two medicines that contain Bupropion simultaneously. 
  • You should not use Bupropion within fourteen days before or after you have used an MAO inhibitor such as linezolid, methylene blue injection, phenelzine, isocarboxazid, rasagiline, selegiline, or tranylcypromine. 
  • Some young adults have suicidal thoughts and behaviors while starting treatment with this medication. You should closely monitor your symptoms and report any new or worsening symptoms to your doctor. 
  • Even if you are an adult aged more than 24 years or if you do not have a mental illness and are using Bupropion to treat some other condition, you may still notice unexpected changes in your mental health. You may become suicidal, especially in the initial days of treatment and any time dosage adjustment is made. 
  • Bupropion may cause seizures, particularly in patients with specific medical conditions or when using certain drugs. Share your complete medical history with your doctor and all the medications you are taking to treat the condition. 
  • This medication may cause mild pupillary dilation, which may cause an episode of angle-closure glaucoma in some individuals. 

What Are the FDA Boxed Warning for Bupropion XL?

For Children, Teenagers, and Young Adults (up to 24 years):

  • Antidepressants like Bupropion can increase suicidal thoughts and behaviors in children, teenagers, and young adults during clinical studies.
  • This risk should be weighed against the benefits of treating depression.
  • Bupropion is generally not recommended for children under 18, except in specific cases a doctor determines.

For All Ages:

  • Discuss the potential risks & benefits of antidepressants with your doctor before starting treatment.
  • Depression & other mental illnesses increase the risk of suicide, especially at the start of treatment or during dose changes.
  • This risk is higher if you or your family have a history of bipolar disorder, mania, or suicide attempts.

Mental Health Monitoring:

  • Bupropion may cause unexpected changes in mental health, including increased suicidal thoughts or actions, especially at treatment start or during dose adjustments.
  • Let your doctor know if you experience new or worsening depression, suicidal thoughts, extreme worry, agitation, panic attacks, trouble sleeping, aggressive behavior, irritability, impulsivity, severe restlessness, or abnormal excitement.

Regular Check-Ups:

  • Regular doctor visits are essential, especially at the beginning of treatment.
  • Always read the patient information leaflet provided with your prescription and ask your doctor or pharmacist any questions.
  • For more information, visit the FDA website or the manufacturer’s site.
  • Always talk to your doctor about the risks & benefits of Bupropion.

What Are the Bupropion XL Precautions?

  • Before taking this medication, let your doctor or healthcare provider know if you have an allergy to Bupropion, any other medication, or any other active or inactive ingredient in the product. Ask your pharmacist, physician, or healthcare provider for the complete list of the ingredients. 
  • Before taking Bupropion, tell your doctor about all the medications you are taking, including prescription and non-prescription medications, over-the-counter drugs, and herbal supplements you may be taking, especially if you are using or have stopped using MAO inhibitors within the past 14 days. Your doctor is most likely not to recommend you take this medication. 
  • Let your doctor know if you have or ever had any seizures or eating disorders known as anorexia nervosa or bulimia. Also, tell them if you consume large amounts of alcohol or take sedatives and plan to stop these suddenly. These conditions and sudden changes in alcohol or sedative use can increase the risk of seizures when taking Bupropion, so your doctor will likely advise against using this medication in such cases.
  • Tell your doctor if you consume large amounts of alcohol, use marijuana (cannabis), or overuse prescription medications. Also, tell them if you have a history of the following conditions: 
    • A head injury 
    • High blood pressure
    • Tumor in the brain or spine
    • Liver disease 
    • Kidney disease 
    • Heart failure
  • Tell your doctor if you are pregnant, planning to get pregnant, or if you suspect a pregnancy before or while you are receiving treatment with Bupropion. Tell your doctor if you get pregnant while you are using this medication. 
  • This medication may cause drowsiness. You should not drive, operate heavy machinery, or do anything that requires alertness and clear vision unless you can do it safely. 
  • Consult a licensed healthcare provider to discuss the safe use of alcoholic beverages while you are using Bupropion. Consuming large amounts of alcohol can cause unwanted side effects and make your condition worse. 
  • This medication may cause a rise in your blood pressure levels. Your doctor may check your blood pressure before taking Bupropion and on a regular basis while you are using this medication, especially if you are taking nicotine replacement therapy. 
  • This medication may cause angle-closure glaucoma. Ask your doctor about having an eye examination before you start taking Bupropion. If you experience vision changes, eye pain, nausea or vomiting, redness or swelling in or around your eyes, immediately call your doctor or seek prompt medical attention. 
  • While taking Bupropion to stop smoking, some individuals have reported symptoms such as hostility, changes in behavior, depressed mood, and suicidal thoughts and behavior. The role of this medication in causing these mood changes is not clear since patients who quit smoking with or without medications may experience mental health changes due to nicotine withdrawal. However, some of these symptoms occurred in individuals who were taking this medication and continued to smoke. Some people had these symptoms when they initially started using Bupropion, and others developed them after several weeks of treatment or after stopping taking this medication. These symptoms have also occurred in people who don’t have a history of mental illness and have worsened in people who already have a mental illness. Tell your doctor and healthcare provider if you have or have ever had bipolar disorder, depression, schizophrenia, or other mental illness. 
  • If you experience any of the following symptoms, you should discontinue taking Bupropion and immediately call your doctor: new or worsening symptoms, suicidal thoughts or actions, agitation, anxiety, panic attacks, restlessness, angry or violent behavior, mania, angry or violent behavior, acting dangerously, restlessness, hallucinations, abnormal thoughts or sensations, feeling that people are against you, confusion, or any other sudden or abnormal changes in behavior. Ensure that your family member or caretaker knows that your symptoms may be severe so they can call your doctor if you cannot seek treatment by yourself. Your doctor will monitor your symptoms closely until you get better.

What Are the Contraindications of Bupropion XL?

Bupropion XL is contraindicated for use in patients who have:

  • Existing or prior diagnosis of anorexia nervosa or bulimia
  • Seizure disorder
  • Undergoing abrupt discontinuation of alcohol, barbiturates, benzodiazepines, and antiepileptic drugs
  • Using MAOIs 
  • Known hypersensitivity to Bupropion or any other ingredient present in the product
  • Anaphylactoid/anaphylactic reactions and Stevens-Johnson Syndrome 

What If You Missed a Dose of Bupropion XL?

  • To get the best results from your medication, you should maintain consistency in dosage and take it around the same time every day. 
  • If you have missed a Bupropion dose, you should take it as soon as possible. 
  • However, if it is almost time for your next dose, you may omit the missed dose and continue taking it according to your regular medication dosing schedule. 
  • You should only take one medication at a time. Do not take double or extra doses of the same medication to make up for the missed dose. 
  • You can try setting a medication reminder on your phone to prevent missing doses. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Bupropion XL?

You should not take Bupropion more than the recommended dose as it can lead to unwelcome side effects. Symptoms of a medication overdose may include loss of consciousness, hallucinations, fever, and muscle pain. One of the biggest causes of concern is seizures, which happen in 33.33% of Bupropion overdose cases. If you suspect an overdose, you should immediately seek medical assistance. You can call your doctor, poison control helpline, or 911. You can also head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Bupropion XL?

  • You should keep Bupropion XL in its original container tightly closed at a controlled room temperature, away from direct sunlight, excess heat, and moisture. 
  • Keep all medications, including Bupropion, in a safe place, away from the sight and reach of children and pets, as many medications are not child-resistant, and young children cannot open them easily. 
  • Do not keep medications that are outdated or no longer needed. Discard them safely. 
  • Do not pour unwanted medications down the drain, flush them down the toilet, or throw them in the household garbage bin. 
  • Dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them.
  • The best way to eliminate outdated or no longer needed medications is to give them to the medicine take-back program.
  • To learn more about properly discarding unwanted medications, consult your healthcare provider, pharmacist, or local waste disposal company.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Bupropion XL?

Although some medications should not be used together, there are times when two different medications might be used simultaneously, even if an interaction could occur. In these cases, your doctor may need to change the dose or take other precautions. Your healthcare professional needs to know if you are taking any of the medicines listed below. The following interactions are selected for their potential significance and are not necessarily all-inclusive.

  • Aripiprazole Lauroxil
  • Bromopride
  • Digoxin
  • Eliglustat
  • Furazolidone
  • Iproniazid
  • Isavuconazonium Sulfate
  • Isocarboxazid
  • Linezolid
  • Lofexidine
  • Methylene Blue
  • Metoprolol
  • Moclobemide
  • Nialamide
  • Nirmatrelvir
  • Ozanimod
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • St John’s Wort
  • Tipranavir
  • Tranylcypromine

What Are the Other Bupropion XL Interactions?

Some medications should not be used at or around the time of eating certain foods since interactions may occur. Consuming tobacco products or alcohol with certain medications may also lead to interactions to occur. Using this medication with any of the following is not recommended, but it may be unavoidable in some cases. Your doctor may change your dosage or how frequently you use this medication or give you specific instructions about the use of alcohol, tobacco, or food if you use them together. 

  • Ethanol

[Note: This isn’t a complete list, and there could be other drugs that interact with Bupropion XL. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Bupropion XL Alternatives?

Patients look for substitutes for Bupropion when the medication does not suit them, or they do not get the desired result. The choice of medicine is based on various factors, such as the patient’s age, medical condition, needs, and potential side effects. The medications listed below are primarily antidepressants, like Bupropion XL.

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Bupropion XL Cost & Coupons

The cost of Bupropion XL can vary depending on factors such as health insurance coverage & pharmacy pricing. Many individuals find that their insurance plans do not cover the cost of Bupropion XL for uses such as weight loss or smoking cessation, resulting in high out-of-pocket expenses. To help manage these costs, some turn to services like Polar Bear Meds, which offers Bupropion XL from Canada for customers in the USA. Additionally, new customers can use the coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

What are the long-term effects of using Bupropion XL for depression and seasonal affective disorder?

Long-term use of Bupropion XL is generally considered safe for managing depression and seasonal affective disorder when monitored by a healthcare professional. However, people should be aware of potential risks such as the possibility of dependence, changes in mood or behavior, and the rare but serious risk of developing seizures. Regular follow-ups with your doctor are crucial to assess the effectiveness and adjust dosages as necessary.

How does Bupropion XL interact with other medications used for mental health disorders?

Bupropion XL can interact with various drugs, including other antipsychotics, antidepressants, and medications used to treat anxiety. It is crucial not to use Bupropion XL within two weeks of taking MAO inhibitors due to the risk of severe interactions. Always inform your doctor about all the medications you are currently taking to ensure safe combinations and avoid potential interactions.

Can Bupropion XL be used alongside nicotine replacement therapy to quit smoking?

Yes, Bupropion XL is often prescribed to aid in smoking cessation and can be used concurrently with nicotine replacement therapies. However, people should consult with their healthcare provider to adjust dosages appropriately and monitor for high blood pressure, which can occur when combining these treatments.

What should be done if serious side effects or symptoms occur while taking Bupropion XL?

If you experience severe side effects such as suicidal thoughts, significant changes in mood or behavior, or symptoms of an allergic reaction, seek immediate medical attention. These symptoms can indicate serious conditions that require prompt treatment. Regular mental health monitoring and immediate communication with your healthcare provider are crucial for managing these risks effectively.

Our Guarantee

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