Nebivolol

Bystolic 

Bystolic is a medication used to treat hypertension. It comes in tablet form with dosages ranging from 2.5mg to 20mg. The typical starting dose for hypertension is 5 mg once daily, with adjustments based on kidney and liver function. Bystolic works by blocking chemicals that bind to heart receptors, slowing the heart rate and relaxing blood vessels to lower blood pressure. Common side effects include headache, fatigue, and dizziness. It’s important to take Bystolic as prescribed and follow safety guidelines, including regular monitoring of blood pressure and heart rate.

Product Overview

Bystolic is a medication containing the active ingredient nebivolol, which is primarily used to treat hypertension (high blood pressure). Hypertension is a common condition where the force of the blood against the artery walls is too high, which results in heart disease, stroke, and other health problems if not managed properly. Nebivolol works by blocking certain receptors in the heart, slowing down the heart rate, and relaxing blood vessels, thereby reducing blood pressure.

Bystolic comes in tablet form with strengths of 2.5mg, 5mg, 10mg, and 20mg. It is typically taken once daily, with or without food, and the dosage may be adjusted based on the patient’s response and medical condition. It is suitable for adults and should be used cautiously in people with kidney or liver problems. The medication works by inhibiting the action of chemicals that stimulate the heart and blood vessels, leading to a decrease in heart rate and dilation of blood vessels.

Common side effects of Bystolic include headache, diarrhea, fatigue, dizziness, and nausea. Patients should be cautious about potential allergic reactions and heart-related issues. It is important to follow the prescribed dosage and not to stop taking the medication abruptly. If a dose is missed, it should be taken as soon as possible unless it is close to the time for the next dose. In case of overdose, immediate medical attention is required. Bystolic should be stored at room temperature, away from heat and moisture, and out of reach of children. Patients should inform their healthcare providers of all medications they are taking to avoid potential interactions.

What Are the Uses of Bystolic?

It is used to: 

• Treat hypertension

What Are the Forms & Strengths of Bystolic?

It comes in the form of a tablet and is available in the following forms: 

• 2.5mg, 5mg, 10mg, 20mg

What Are the Recommended Bystolic Dosages for Different Patients?

For Hypertension (High Blood Pressure)

• The typical starting dose is 5 mg, taken orally once per day.
• The dose may be increased every 2 weeks, but should not exceed 40 mg per day.

Dosing adjustments for people with kidney problems:

• For those with a creatinine clearance (CrCl) between 30 and 80 mL/min: The manufacturer does not provide specific dosing adjustments.
• For those with a CrCl below 30 mL/min: Start with a dose of 2.5 mg taken orally once per day, and increase the dose cautiously if needed.

For People with hepatic problems:

• Mild liver impairment (Child-Pugh Class A): The manufacturer does not provide specific dose adjustment instructions.
• Moderate liver impairment (Child-Pugh Class B): Start with 2.5 mg taken by mouth once daily. If the initial response is not adequate, the dose can be increased cautiously.
• Severe liver impairment (Child-Pugh Class C): Bystolic should not be used in this case as it is contraindicated.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Bystolic?

When you buy Bystolic online, you can consider the following guidelines while using:

• Before you start using Bystolic, you should refer to the patient information leaflet and if available medication guide. Read and understand the instructions for use carefully and if you have difficulty understanding any part of the leaflet or if you have any concerns or questions about the medication use, make sure to ask your physician or medical provider. 
• Bystolic is part of a treatment plan which may also include a healthy balanced diet, regular physical exercise, and weight management. Follow your medication, exercise routine, and diet very closely.
• Take Bystolic 2.5 mg tablet exactly as your doctor prescribes. Do not alter the dosage or duration of treatment without consulting your doctor.
• Follow the instructions on your prescription label carefully.
• Take this tablet at the same time each day, either without having a meal or after a meal. 
• Your doctor may recommend you start using Bystolic at a low dose and increase it gradually based on your condition, age, and response to treatment.  
• You should swallow the Bystolic as a whole and do not break, crush, or chew it. 
• Do not skip doses or stop taking Bystolic without your doctor’s approval. Abruptly stopping the medication can worsen your condition or lead to serious heart problems.
• Your blood pressure should be monitored regularly. Make sure to visit your doctor for check-ups.
• Inform your surgeon that you are taking Bystolic if you plan to undergo surgery.
• Continue using this medication exactly as directed by your physician, even if you feel well. If Bystolic is effective in treating your condition and does not provide you with unwanted side effects, your doctor is most likely to prescribe you to take this medication for the rest of your life. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Bystolic Work?

Bystolic (nebivolol) works by blocking certain chemicals that bind to receptors in the heart, which slows down the heart rate and allows the heart to relax between contractions. This action helps to lower blood pressure. Additionally, Bystolic uniquely relaxes blood vessels, further reducing blood pressure.

Important Safety Information

What Are the Side Effects of Bystolic?

Common Side Effects of Bystolic: Bystolic, a medication often prescribed for managing hypertension, can induce a variety of side effects. While it effectively lowers blood pressure, users may experience symptoms ranging from mild discomforts to more severe health issues. These side effects are caused by the drug’s mechanism that slows the heart rate and reduces blood vessel constriction. Common side effects of Bystolic may include: 

• Headache: Headaches caused by Bystolic are typically mild but can occasionally disrupt daily activities. This side effect arises as the body adjusts to the medication’s effects on blood circulation and nerve activity within the brain. Patients experiencing persistent headaches should consult their doctor, as adjustments to the dosage might be necessary.
• Diarrhea: Bystolic may lead to gastrointestinal disturbances such as diarrhea. This occurs because the medication can affect the digestive system’s motility and fluid balance. If diarrhea is severe or continues for an extended period, it is important to seek medical advice to prevent dehydration and possible nutrient depletion.
• Fatigue or Tiredness: Fatigue or general tiredness with Bystolic usage can result from the decreased heart rate and blood pressure, limiting the oxygen and nutrient supply to muscles and other tissues. Patients feeling unusually tired or weak should discuss these symptoms with their healthcare provider.
• Shortness of Breath: Some individuals on Bystolic might experience shortness of breath. This symptom can arise from the heart’s reduced capacity to pump blood efficiently, affecting lung function and oxygen intake. Persistent or worsening breathlessness should be addressed promptly by a medical professional.
• Dizziness or Lightheadedness: Dizziness or lightheadedness while taking Bystolic is often a result of lowered blood pressure, which can briefly impair blood flow to the brain when changing positions. It’s advisable to rise slowly from sitting or lying down to prevent or reduce this effect.
• Nausea or Upset Stomach: Nausea or an upset stomach may occur as side effects of Bystolic due to its influence on the gastrointestinal system’s nerves and muscles. Eating small, frequent meals can help mitigate nausea. If the symptom persists, consulting a healthcare provider is recommended.
• Slow Heartbeat (Bradycardia): Bystolic works by reducing the heart rate, which can sometimes become too slow, a condition known as bradycardia. Symptoms like fatigue, dizziness, or fainting may occur and should be taken seriously, as they might indicate the need for medical adjustment of the medication.
• Insomnia or Trouble Sleeping: Trouble sleeping or insomnia may develop as the body adjusts to Bystolic. This can be due to the medication’s influence on neurological pathways involved in sleep regulation. Patients struggling with sleep should consider consulting their healthcare provider for advice on managing this side effect.
• Swelling of the Legs or Feet (Edema): Edema, or swelling in the legs and feet, can occur with Bystolic due to fluid retention. This side effect may result in discomfort and mobility issues. Reducing salt intake and elevating the legs can help alleviate the swelling, but if it persists, medical consultation is advised.

Serious Side Effects of Bystolic: While effective in controlling hypertension, Bystolic, like all medications, can have serious side effects. These side effects require prompt medical assistance & may become fatal if not treated properly. If you experience any of the following symptoms, you should call your doctor immediately. These side effects include:

• • Severe Allergic Reactions: Patients taking Bystolic may experience severe allergic reactions. Symptoms could include a rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing, necessitating urgent medical intervention.
  • Reduced Blood Pressure: This medication can cause low blood pressure or hypotension. If you feel symptoms of hypotension, such as dizziness, fainting, or drowsiness, you should lie down. Call your healthcare provider immediately if you experience confusion, weakness, fatigue, or feeling lightheaded. 

• Peripheral Vascular Disease: A bystolic 2.5 mg tablet can cause PVD, also known as peripheral arterial disease, a multi-system disorder that happens when a vasospasm occurs. It can also cause your heart to pump less blood to the body, leading to blood circulation problems in the arms, legs, and intestines. 

• Heart-related Issues: Bystolic may cause heart-related side effects such as chest pain, worsening heart failure, or irregular heartbeats. These symptoms are serious and require prompt medical evaluation.
• Severe Dizziness or Fainting: This medication can sometimes lead to extremely low blood pressure, manifesting as severe dizziness or fainting spells. Such symptoms should be immediately reported to a healthcare provider.
• Breathing Problems: Individuals with asthma or other respiratory conditions might find that Bystolic exacerbates their breathing problems. Monitoring and discussion with a doctor are advised if respiratory symptoms worsen.
• Changes in Blood Sugar Levels: Bystolic can affect blood sugar levels, which is particularly significant for individuals with diabetes. Regular monitoring of blood sugar levels is recommended for diabetic patients on this medication.
• Severe Skin Reactions: Rare but serious reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, may occur with Bystolic. These conditions involve severe skin rash, peeling, and sores, and require immediate medical care.
• Swelling of the Extremities: Swelling in the arms or legs while taking Bystolic could indicate heart or circulation problems. It’s important for patients experiencing this symptom to seek medical advice quickly.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

What Are the Bystolic Warnings?

When you buy Bystolic online, you can consider the following warning associated with the medication: 

• Maintain all medical and lab appointments while taking Bystolic to monitor its effectiveness in controlling high blood pressure and to check your heart rate.
• Inform all healthcare providers and lab personnel that you are taking Bystolic.
• You should not use this medication if you have bradycardia, a condition in which your heart beats too slow, or a heart block, where the electric signals in your heart move too slow. 
• You should avoid using this medication if you have severe or worsening heart failure, which causes you to feel extreme fatigue, difficulty breathing or swelling in your legs. 
• Be aware that Bystolic can cause drowsiness and dizziness, which may vary among individuals. Avoid driving or operating heavy machinery until you know how it affects you.
• Notify your healthcare professionals before undergoing any surgery, including dental procedures, that you are on Bystolic.
• Contact your doctor for medical advice if you become pregnant while taking Bystolic. It is uncertain if Bystolic passes into breast milk, so avoid breastfeeding while on this medication.
• Note that Bystolic may worsen allergic reactions to different substances, and your allergic symptoms may not respond as effectively to epinephrine while on Bystolic.
• While Bystolic for anxiety works as a great short-term solution to address certain anxiety symptoms, you won’t be able to manage the underlying causes of your anxiety. 

What Are the Bystolic Precautions?

Bystolic, also known by its generic name nebivolol, is a beta-blocker used primarily to treat high blood pressure. When taking Bystolic, it’s important to consider several precautions:

• • Allergies: Inform your doctor or pharmacist if you are allergic to nebivolol or have any other allergies. The medication may contain inactive ingredients that can cause allergic reactions.
  • Medical History: Share your medical history with your doctor, especially if you have:
    • Heart failure
    • Kidney disease
    • Liver disease
    • Heart rhythm problems (e.g., slow heartbeat, second- or third-degree atrioventricular block)
    • Blood circulation issues (e.g., Raynaud’s disease, peripheral vascular disease)
    • Mental/mood disorders (e.g., depression)
    • Myasthenia gravis (a muscle disease)
    • Overactive thyroid (hyperthyroidism)
    • Breathing problems (e.g., asthma, chronic bronchitis, emphysema)
    • Serious allergic reactions, including those requiring epinephrine treatment
  • Dizziness: Nebivolol may cause dizziness. Avoid driving or operating machinery until you know how the medication affects you. Alcohol and marijuana can increase dizziness, so limit their use.

• Discontinuing Use: If you skip medication doses or abruptly stop taking the Bystolic 2.5 mg tablet without consulting your physician, it can cause chest pain, heart failure, or fatal heart rhythms in people with existing cardiovascular disease. You should not discontinue using nebivolol without talking to your doctor, as it can cause unwanted side effects or worsen the condition. If you plan to discontinue Bystolic, consult a licensed healthcare practitioner; they will help you gradually taper off the drug to reduce the risk of undesirable side effects. 

• • Surgery: If you are scheduled for surgery and will be given anesthesia, inform your doctor or dentist ahead of time about all the medications you use, including Bystolic.
  • Blood Sugar Levels: Nebivolol may mask the rapid heartbeat associated with low blood sugar (hypoglycemia). If you have diabetes, monitor your blood sugar levels closely and inform your doctor if you experience symptoms of high blood sugar, such as increased thirst or urination. Your doctor may suggest some adjustments in your diabetes medication, exercise program, or diet.
  • Children: Children may be more susceptible to low blood sugar while using nebivolol. Ensure they eat regularly, and inform the doctor if they cannot eat, are vomiting, or show symptoms of low blood sugar.
  • Pregnancy: Use nebivolol during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. Babies born to mothers taking this medication may need monitoring for issues like low birth weight, low blood pressure, decreased heartbeat, lowered blood sugar, and shallow breathing.
  • Breastfeeding: It is unknown if nebivolol passes into breast milk. Consult your doctor before breastfeeding.

• Medication Caution: Do not share your medications, including Bytolic, with other people, even if they have the same condition as you, as it may harm them. 

What Are Bystolic Contraindications?

Bystolic is contraindicated for use in patients who have: 

• Had a series of allergic reactions to Bystolic, nebivolol, or other ingredients present in the medication.
• Heart failure and are in the ICU or are required to use medications to maintain blood circulation. 
• Irregular heartbeat and slow heartbeat
• Have severe hepatic damage
• Serious problems in the lungs (such as asthma or emphysema) or certain heart issues. Ask your doctor what these heart problems are.

What Happens If You Miss a Dose of Bystolic?

When you forget to take the dose, follow these instructions:

• Take this medication as soon as you remember. 
• If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. 
• Do not take a double dose to make up for the missed one.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much Bystolic? 

Symptoms of an overdose may include a slow heart rate, dizziness, vomiting, difficulty breathing, or a sensation of being close to fainting. If you experience any of these symptoms, you should seek immediate medical assistance. You can call your physician, 911, or poison control helpline. You can also go to the nearest hospital if you experience severe side effects such as difficulty breathing, seizures, or loss of consciousness. 

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How Do You Store Bystolic?

When you want to store Bystolic, follow these general instructions:

• Store the medicine in a sealed container between 68°F-77°F or 20°C-25°C at room temperature, away from heat, moisture, and direct sunlight. Avoid freezing.
• While transporting from one place to another, you can expose Bystolic to temperatures between 59°F-86°F or 15°C-30°C for shorter periods of time. 
• Keep it out of children’s reach.
• Dispose of any expired or unneeded medicine in such a way that does not allow children, animals, and other people to consume it.
• Consult your healthcare professional for proper disposal of unused medicine. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Are the Bystolic Interactions?

Bystolic is combined with other medications, the interactions can affect the efficacy and the risk profile of the treatment. To prevent such drug interactions, tell your doctor or healthcare provider about any prescription, non-prescription, over-the-counter drugs, herbs, or vitamin supplements you are using currently or plan to use alongside Bystolic. Here are the main interactions with Bystolic:

• Amlodipine: This is a calcium channel blocker often used to treat high blood pressure and angina. When used with Bystolic, amlodipine can enhance the blood pressure-lowering effects, but it can also increase the risk of hypotension (abnormally low blood pressure).
• Aspirin: Regular use of aspirin, even at low strengths, can reduce the blood pressure-lowering effects of Bystolic. However, it’s often prescribed together for heart disease prevention, under careful medical supervision.
• Aspirin Low Strength (aspirin): Similar to regular aspirin, low-dose aspirin might reduce the efficacy of Bystolic in lowering blood pressure. The combination is generally safe but requires monitoring.
• Atorvastatin: A statin used to lower cholesterol. There are no significant interactions with Bystolic, but combining them can be part of a broader approach to cardiovascular risk management.
• Clonidine: This medication is used to treat high blood pressure. When combined with Bystolic, there may be an additive effect in lowering blood pressure, but abrupt discontinuation of clonidine while taking Bystolic can cause a rebound hypertension, which is a sudden spike in blood pressure.
• Crestor (rosuvastatin): Another statin for cholesterol management. There are no direct interactions with Bystolic, but as part of a treatment regime, it helps in managing overall cardiovascular health.
• Furosemide: A diuretic used to reduce fluid retention and treat hypertension. Using it with Bystolic can enhance the blood pressure-lowering effects but may also increase the risk of renal impairment and electrolyte imbalances.
• Gabapentin: This is used for nerve pain and seizures. There are no direct interactions with Bystolic, but care should be taken as both medications can potentially cause dizziness or drowsiness.
• Hydrochlorothiazide: A diuretic that’s often combined with beta-blockers like Bystolic to enhance the blood pressure-lowering effect. Monitoring is necessary for potential electrolyte imbalances and kidney function.
• Levothyroxine: This is used for thyroid hormone replacement. Bystolic may slow down the heart rate significantly in some patients, which can be problematic in those also needing levothyroxine.
• Meloxicam: A non-steroidal anti-inflammatory drug (NSAID) that can reduce the efficacy of Bystolic in lowering blood pressure and potentially increase the risk for kidney issues.
• Prednisone: A steroid that can raise blood pressure, potentially counteracting the effects of Bystolic. Close monitoring is advised when these drugs are used concurrently.
• Trazodone: An antidepressant that can lower blood pressure as a side effect. When combined with Bystolic, there’s an increased risk of an additive hypotensive effect.
• Xanax (alprazolam): An anti-anxiety medication. When taken with Bystolic, both drugs can increase the sedative effects, potentially leading to excessive drowsiness or dizziness.

What Are Other Important Bystolic Interactions?

Beyond interactions with specific medications, Bystolic (nebivolol) can also interact with certain substances such as alcohol, herbal supplements, and other over-the-counter products. Here’s a closer look at these types of interactions:

• Alcohol: Consumption of alcohol can enhance the blood pressure-lowering effects of Bystolic, leading to increased risks of dizziness, fainting, and even heart rate disturbances. It’s generally advisable to limit or avoid alcohol while taking Bystolic.
• St. John’s Wort: This herbal supplement, often used for depression, can affect the metabolism of many medications. St. John’s Wort may reduce the effectiveness of Bystolic by increasing the metabolism of the drug, leading to lower levels in the blood and reduced efficacy.
• Herbal Supplements: Other herbs and supplements can also interact with Bystolic:

• Hawthorn: Commonly used for heart health, hawthorn can potentiate the effects of beta-blockers like Bystolic, potentially leading to lower blood pressure and heart rate.
• Ginkgo Biloba: Known for its blood-thinning properties, Ginkgo Biloba may increase the risk of bleeding when taken with Bystolic, especially if combined with other blood thinners.
• Garlic: Although garlic is often used to lower blood pressure, combining it with Bystolic might result in an excessive drop in blood pressure.

• Caffeine: While not an herbal supplement, caffeine’s effect on the cardiovascular system can interfere with Bystolic. Caffeine can increase blood pressure and heart rate, which may counteract some of Bystolic’s effects.
• Licorice: Licorice can increase blood pressure and interfere with the effectiveness of hypertension treatments. It should be used cautiously, if at all, in patients taking Bystolic.
• Omega-3 Fatty Acids: Commonly found in fish oil supplements, omega-3s can help lower blood pressure. While generally beneficial, they should be used under medical supervision when combined with Bystolic to ensure that blood pressure does not drop too low.

[Note: This isn’t a complete list, and there could be other drugs that interact with Bystolic. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Bystolic Alternatives?

If you’re looking for alternatives to Bystolic, there are several other medications available that can also help manage high blood pressure. However, you should not use a new medication or change your existing prescription without consulting your doctor, as it can cause unwanted side effects. Here are some common alternatives:

• Metoprolol (metoprolol)
• Atenolol (atenolol)
• Carvedilol (carvedilol)
• Propranolol (propranolol)
• Bisoprolol (bisoprolol)
• Labetalol (labetalol)
• Sotalol (sotalol)
• Nadolol (nadolol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Bystolic Cost & Coupons

Patients in the U.S. looking to lower their expenses on Bystolic might consider buying from Canadian online pharmacies such as Polar Bear Meds, which provide more cost-effective alternatives. Polar Bear Meds offers the best price for bystolic 5 mg, shipped straight from Canada to the U.S. New clients can receive a 10% discount on their initial purchase using the Bystolic 10 mg coupon code ‘WELCOMEPB10.’ Furthermore, by participating in our referral program, U.S. customers can obtain additional Bystolic 5 mg coupon, further reducing the cost and enhancing the accessibility to buy Bystolic online.

Frequently Asked Questions

Why is Bystolic different from other beta blockers?

Bystolic (nebivolol) stands out because it’s cardioselective, especially targeting beta-1 receptors in the heart. Plus, it has the added benefit of widening blood vessels through nitric oxide, which many other beta-blockers don’t do. This combination helps reduce blood pressure effectively by slowing the heart rate and enhancing blood flow.

How effective is Bystolic in reducing blood pressure?

In a study, individuals who took Bystolic alone experienced a reduction of approximately 15 mmHg in both systolic and diastolic blood pressures. In another study involving patients already on other blood pressure medications, adding Bystolic lowered their systolic blood pressure by about 4 mmHg to 6 mmHg and diastolic blood pressure by about 3 mmHg to 5 mmHg. The extent of blood pressure reduction can vary depending on factors such as the dosage of the medication.

How fast does Bystolic start to lower blood pressure?

Bystolic can begin to reduce blood pressure within the first two weeks of treatment. However, the onset of its effects can vary among individuals. This variation is partly because your healthcare provider may gradually increase your dosage every few weeks when you initially start the medication to determine the most effective dose for you.

Can Bystolic be used to prevent migraine headaches?

Some beta-blockers, like propranolol, are approved for migraine prevention. Although the FDA hasn’t approved Bystolic for this, some studies have found that nebivolol could be helpful for preventing migraines. However, treatment guidelines haven’t quite recommended using it for migraines. If you struggle with migraine headaches, consult with your medical professional about the best options for you.

Is Bystolic an effective beta-blocker?

Yes, Bystolic is an effective beta-blocker that specifically targets the heart, resulting in fewer side effects compared to other beta-blockers. However, it is important to note that Bystolic, as a brand-name medication, can be costly. Additionally, skipping doses may elevate your blood pressure and increase the risk of chest pain, heart attack, and irregular heart rhythm.

Is Bystolic safe for kidneys?

When you buy Bystolic online, it requires careful consideration when prescribed to individuals with kidney disease or compromised kidney function. The primary concern is that impaired kidneys may not efficiently eliminate the drug from the body. This inefficiency may lead to an accumulation of Bystolic in the system, increasing the risk of side effects. Therefore, for patients with kidney issues, healthcare providers might adjust the dosage of Bystolic or monitor kidney function more closely during treatment to reduce potential risks. It’s essential for patients with kidney concerns to discuss their condition thoroughly with their healthcare provider to ensure that any prescribed medicines are safe given their specific health circumstances.

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