Cabergoline

Cabergoline is an FDA-approved medication containing the active ingredient Cabergoline. It treats high prolactin levels by stimulating dopamine receptors and reducing prolactin production. It is available in tablet form in strengths of 0.25 mg, 0.5 mg, and 1 mg. The recommended dosage is based on response and condition. It is generally safe for adults, but adjustments may be needed for liver or kidney issues. Side effects like nausea and headache can occur; medical advice is crucial. Precautions for specific conditions or medications are necessary. Missed doses should be taken promptly, avoiding doubling up, with overdose requiring immediate medical attention. Store tablets at room temperature, away from moisture and heat, and keep out of children’s reach. Adhering to prescribed dosage and medical guidance is vital with Cabergoline.

Cabergoline is a medication approved by the FDA to treat disorders linked with high prolactin levels (a hormone produced by the pituitary gland). The main ingredient in Cabergoline is Cabergoline, a dopamine receptor agonist. It functions by stimulating dopamine receptors in the brain, thereby reducing the production of prolactin and alleviating symptoms associated with hyperprolactinemia.

Cabergoline is available in tablet form in strengths: 0.25 mg, 0.5 mg, and 1 mg. The dosage and administration frequency may vary depending on your condition. It is usually taken orally, with or without food. Cabergoline is generally safe for adults, but dosage adjustments may be necessary for those with liver or kidney problems. Like any medication, Cabergoline may cause side effects such as nausea, dizziness, headache, fatigue, and gastrointestinal disturbances. Following medical advice and reporting any persistent or severe side effects is important. Precautions should be taken in individuals with particular medical conditions, or those taking specific medications, so talking to a healthcare practitioner is crucial before starting Cabergoline.

If a dose of Cabergoline is missed, it should be consumed as soon as remembered unless it is almost time for the next dose. Doubling up on doses should be avoided. In case of an overdose, medical attention should be sought immediately. Cabergoline tablets should be kept at room temperature distant from dampness and heat, and out of reach of children. Sticking to the prescribed regimen and following all instructions a healthcare professional provides when taking Cabergoline is crucial.

• It treats hyperprolactinemia (excessive prolactin hormone in the blood).

Dosage

It comes in the form of Oral tablets and has three strengths:

• 0.25mg
• 0.5mg
• 1mg

Recommended Dosage for Different Patients

For Adults with Hyperprolactinemia

• A dose of 0.25 mg two times a week is recommended as an initial dose.
• The dose should be increased by 0.25 mg twice a week, no more than every four weeks, depending on the patient’s prolactin level.
• Two times a week, 1 mg is the maximum dose.

Renal Dose Adjustments

• No adjustment is recommended.

Liver Dose Adjustments

• Use with caution.

Dose Adjustments

• It is recommended to start at the lower end of the dosing range in older people.
• It is possible to discontinue this drug and check serum prolactin levels for 6 months before reinitiating treatment.

[Note: These Cabergoline dosage recommendations may differ from individual to individual. Discuss it with your healthcare professional, and they’ll decide your dosage accordingly.]

• Follow your doctor’s instructions precisely.
• Usually taken orally, with or without food.
• Typically, it’s taken twice a week, but dosage varies.
• Begin with a lower dose, then increasing gradually is advised.
• Swallow the tablet whole; don’t crush or chew it.
• If you miss a dose, take it as soon as you remember.
• Avoid doubling doses to make up for missed ones.
• Don’t stop taking it without consulting your doctor.

[Note: Your healthcare professional will decide the correct amount of Cabergoline for you based on your condition. They may adjust your Cabergoline dosage as needed over time.]

Cabergoline, a dopamine agonist, regulates prolactin levels by activating dopamine receptors in the brain. By mimicking dopamine, it suppresses prolactin secretion from the pituitary gland. This action is beneficial in treating conditions like hyperprolactinemia and prolactinomas, where elevated prolactin levels lead to various health issues. Cabergoline helps restore hormonal balance, alleviating symptoms such as irregular menstrual cycles, infertility, and lactation in non-pregnant individuals. Additionally, it aids in shrinking prolactinomas by reducing prolactin production, making it an effective therapeutic option for related disorders.

Common side effects of Cabergoline may include:

• Nausea
• Headache
• Dizziness
• Fatigue
• Constipation
• Drowsiness
• Abdominal pain
• Nasal congestion

Mild side effects of Cabergoline may include:

• Mild nausea
• Occasional headache
• Transient dizziness
• Minor fatigue

Adverse side effects of Cabergoline may include:

• Severe gastrointestinal disturbances
• Hallucinations
• Orthostatic hypotension
• Cardiac valve disorders (rare, with long-term use)
• Mental health changes (such as depression or psychosis, in rare cases)

[Note: This list may not cover all possible Cabergoline side effects. Always discuss with your healthcare giver for medical advice about side effects.]

• Cardiac Valve Disorders: Long-term use of Cabergoline may increase the risk of cardiac valve disorders. Regular cardiac monitoring is advised, especially for patients on prolonged treatment.
• Fibrosis: Cabergoline has been associated with developing fibrotic disorders, including pleural effusion, pulmonary fibrosis, and cardiac fibrosis. The signs and symptoms of fibrosis should be monitored during treatment.
• Hypotension: Cabergoline can cause orthostatic hypotension, leading to dizziness or fainting upon standing. Caution is advised, especially when initiating therapy or increasing the dosage.
• Mental Health Effects: Psychiatric adverse reactions, including hallucinations, confusion, and psychosis, have been reported with cabergoline use. Changes in behaviour or mood should be monitored, particularly during the initial treatment period.
• Impulse Control Disorders: Cabergoline may increase the chances of impulse control disorders like compulsive shopping, gambling, eating, or hypersexuality. Patients and caregivers should be vigilant and promptly report any unusual behaviors to healthcare providers.
• Pregnancy: Cabergoline should not be used during pregnancy unless the potential benefits outweigh the risks. It may cause harm to the fetus. Effective contraceptive methods are recommended for women of childbearing age during treatment.
• Liver Function: Patients with hepatic impairment should be monitored closely while taking Cabergoline, as it is primarily metabolized in the liver. Dosage adjustments may be necessary for these individuals.
• Breastfeeding: Cabergoline is excreted in breast milk and may pose risks to nursing infants. Breastfeeding should be discontinued during cabergoline therapy.
• Surgery: Patients undergoing surgery should inform their healthcare providers about cabergoline use, as it may interact with certain anesthetic agents and affect blood pressure control.

• Regularly check your heart health, as Cabergoline might pose risks for cardiac valve disorders with long-term use.
• Be vigilant for fibrosis symptoms like breathing difficulties or chest pain, especially during prolonged treatment.
• Be cautious of sudden drops in blood pressure, which can cause dizziness, especially when standing up. Take care when starting or adjusting the dose.
• Stay alert for any changes in mood or behavior, like hallucinations or confusion, particularly when starting Cabergoline.
• Watch for any new urges or compulsions like excessive gambling or eating, and report them to your doctor promptly.
• If you’re of childbearing age, discuss effective contraception methods with your doctor, as Cabergoline may harm the fetus.
• If you have liver problems, your healthcare professional may need to modify your dosage or monitor you more closely during Cabergoline treatment.
• If you’re nursing, stop breastfeeding while taking Cabergoline, as it can get into breast milk and harm your baby.
• Before any surgery, inform your healthcare providers about your Cabergoline use, as it can interact with anesthesia and affect blood pressure control.

It is contraindicated in patients with:

• Hypertension under control or known hypersensitivity to ergot derivatives.
• History of cardiac valvular disorders.

• If you forget a dose, take it as soon as you recall unless your next dose is imminent.
• If the next dose is near, skip the missed one and resume your regular regimen.
• Taking two doses to compensate for not taking one is not a good idea.

[Note: If you have missed a dose of Cabergoline and are still deciding when to take the next dose, immediately consult your doctor or pharmacist.]

• Symptoms of overdose may include nausea, vomiting, hallucinations, and fainting.
• Do not attempt to self-treat or induce vomiting unless directed by a healthcare professional.

[Note: If you overdosed on Cabergoline, get medical help instantly or call the Poison Help line at 1-800-222-1222.]

• Store Cabergoline tablets in their original packaging.
• Keep them at room temperature, away from moisture and heat.
• Shield from direct sunlight.
• Ensure they’re inaccessible to children and pets.
• Don’t transfer Cabergoline to other containers unless advised.

[Note: Consult with your healthcare practitioner about properly disposing of unused Cabergoline and any questions you may have regarding their storage.]

Here are the drugs that may interact with Cabergoline:

• Adderall (amphetamine/dextroamphetamine)
• Adderall XR (amphetamine/dextroamphetamine)
• Aspirin Low Strength (aspirin)
• Benadryl (diphenhydramine)
• Cialis (tadalafil)
• CoQ10 (ubiquinone)
• Crestor (rosuvastatin)
• Cymbalta (duloxetine)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lexapro (escitalopram)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Prozac (fluoxetine)
• Singulair (montelukast)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Topamax (topiramate)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Vyvanse (lisdexamfetamine)
• Wellbutrin XL (bupropion)
• Xanax (alprazolam)
• Zoloft (sertraline)
• Zyrtec (cetirizine)

[Note: This list is not complete, and Cabergoline may interact with other drugs. If you take prescription, over-the-counter, or herbal medicines, tell your doctor about them.]

• Parlodel (bromocriptine)
• Permax (pergolide)
• Norprolac (quinagolide)
• Dopergin (lisuride)
• Apokyn (apomorphine)
• Dostinex (cabergoline)
• Mirapex (pramipexole)
• Requip (ropinirole)
• Mirapex ER (extended-release pramipexole)
• Neupro (rotigotine)

[Note: Your healthcare professional will select the best Cabergoline alternative. You should talk to your healthcare professional before using these alternative medications. You may experience serious side effects if you take them on your own.

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