Candesartan

Candesartan, an FDA-approved angiotensin II receptor blocker, contains Candesartan Cilexetil, effectively managing hypertension and heart failure by relaxing blood vessels. Available in tablet form, dosages range from 4 to 32 milligrams, with administration typically once daily, orally, with or without food. Recommended for adults with hypertension or heart failure, it’s contraindicated in pregnant women, severe liver disease patients, or those allergic to its components. Common side effects are lightheadedness, dizziness, migraine, and fatigue, with precautions advised for kidney issues or potassium supplement use. In case of a missed dose, take it promptly or skip it if nearing the next scheduled dose. Overdose symptoms require immediate medical attention. Keep it at room temperature, away from moisture and heat, and follow healthcare provider instructions closely, particularly noting allergic reaction signs.

Product Overview

Candesartan is an FDA-approved medication for angiotensin II receptor blockers (ARBs). Its active ingredient, Candesartan Cilexetil, is formulated to address hypertension and heart failure. It operates by inhibiting angiotensin II, a compound that narrows blood vessels, resulting in vessel relaxation and decreased blood pressure. It is available in tablet form in strengths ranging from 4 to 32 milligrams. The dosage a healthcare practitioner recommends is based on the patient’s health conditions and response to treatment. It is usually taken orally, with or without food, once daily.

Candesartan is suitable for adults diagnosed with hypertension or heart failure. It is not recommended for pregnant women, those with severe liver disease, or individuals allergic to any components of the medication. Typical side effects may consist of dizziness, headaches, and fatigue. You are recommended to stand up slowly from lying or sitting positions to lower the risk of dizziness. Precautions should be taken in individuals with kidney problems or those using potassium supplements.

Patients should take a dose as soon as they recall if a dose is missed. However, they should skip the missed one if it’s near the next scheduled dose. Symptoms of overdose may include rapid or slow heartbeat, severe dizziness, or fainting, requiring urgent medical attention. Candesartan should be stored at room temperature, away from moisture and heat, and any unused medication should be properly disposed of. Patients should adhere to healthcare provider guidance and heed warning signs such as swelling of the face, lips, tongue, or throat, indicating a possible allergic reaction.

It is used in:

• The treatment of Hypertension (high blood pressure), Heart failure, and prevention of heart attack and stroke.

Forms & Strengths of Candesartan

Candesartan is available in oral tablet form and comes in the following strengths:

• 4 mg
• 8 mg
• 16 mg
• 32 mg

Recommended Dosage for Candesartan in Different Patients

The dosage of Candesartan varies based on the patient’s age, medical condition, and overall health. Below is a general guideline for different patient groups:

For High Blood Pressure (Hypertension)

Candesartan Dosage in Adults (Ages 18 to 64 Years)

• Standard Dose: 16 mg once daily (Range: 8-32 mg/day, taken as a single dose or divided into two doses).
• For Moderate Liver Problems: 8 mg per day.
• For Severe Kidney Problems: Starting dose of 8 mg or less per day.

Candesartan Dosage for Children (Ages 6 to 17 Years)

• Children under 50 kg: 4-8 mg per day.
• Children over 50 kg: 8-16 mg per day.
• Dosage Range: 2-16 mg/day for lighter children, 4-32 mg/day for heavier children.

Candesartan Dosage for Children (Ages 1 to 5 Years)

• Typical Range: 0.05–0.4 mg/kg of body weight per day.
• Standard Starting Dose: 0.20 mg/kg daily.

Candesartan Dosage for Infants (Under 1 Year of Age)

• Not recommended due to a lack of studies.

Candesartan Dosage for Seniors (Ages 65 Years and Older)

• No specific recommendations, but lower doses or adjusted schedules may be considered due to potentially slower drug processing in older adults.

For Heart Failure

Candesartan Dosage in Adults

• Starting Dose: 4 mg once daily.
• Maximum Dosage: 32 mg daily.

Candesartan Dosage in Children

• Not recommended for heart failure treatment in children.

[Note:These dosage recommendations may vary from person to person. Always consult your healthcare professional, who will determine the appropriate dosage for your specific condition.]

Here are the instructions to take Candesartan tablets:

• Adhere strictly to your doctor’s guidance.
• Usually ingested orally, with or without meals.
• Swallow the tablet whole, accompanied by water.
• Maintain a consistent daily schedule for taking Candesartan.
• Continue taking the medication even if you feel well, as stopping suddenly can be dangerous.

[Note: Your healthcare professional will decide the correct amount of Candesartan for you based on your condition. They may adjust your Candesartan dosage as needed over time.]

Candesartan inhibits the action of angiotensin II, a hormone that constricts our blood vessels and raises blood pressure. By blocking angiotensin II receptors, Candesartan causes blood vessels to widen, decreasing resistance to blood flow and reducing blood pressure. This vasodilation relieves the workload on the heart and improves blood flow to vital organs. Additionally, Candesartan may mitigate the adverse effects of angiotensin II on the cardiovascular system and blood vessels, such as inflammation and oxidative stress.

Common Side Effects of Candesartan: When you consider Candesartan dose for high blood pressure, you may experience the following side effects: 

• Dizziness: This is a common side effect because Candesartan lowers blood pressure, which can temporarily decrease blood flow to the brain when you suddenly stand up or move quickly. This sensation might make you feel unsteady or like you’ll faint, especially when rising from a sitting or lying position.
• Headache: The mechanism isn’t fully understood, but headaches may occur as the body adjusts to lower blood pressure or changes in blood flow.
• Fatigue: Feeling unusually tired or weak may also be a side effect of Candesartan, possibly due to its blood pressure-lowering effects. The body might take some time to adjust to a new blood pressure level, which can initially lead to feelings of lethargy or weakness.
• Nausea: Some people may experience nausea as a side effect of taking Candesartan. This could be due to the medication affecting the stomach lining or gastrointestinal tract. 
• Hypotension (low blood pressure): Since Candesartan is used to reduce high blood pressure, it may occasionally lower blood pressure too much, which is termed hypotension. Like other angiotensin receptor blockers, Candesartan works by relaxing and expanding your blood vessels. Symptoms can include dizziness, fainting, blurred vision, or weakness.
• Back Pain: While not directly linked to Candesartan’s blood pressure-lowering action, back pain can sometimes occur when people are taking the medication. This could be due to various factors, including muscle relaxation or changes in body mechanics as a response to lower blood pressure, or it could be coincidental and unrelated to the medication. 
• Upper Respiratory Tract Infection: This side effect can lead to signs similar to a common cold, including sore throat, nasal congestion, sneezing, or coughing. While it’s not fully understood why some blood pressure medications might increase susceptibility to respiratory infections, it’s thought that alterations in immune response or a coincidence might be at play. 

Mild Side Effects of Candesartan: When you use Candesartan for blood pressure control, you may suffer from the following mild side effects:

• Dry Cough: Candesartan can cause a dry, persistent cough as a side effect. This occurs because the drug affects the way the body handles certain chemicals like bradykinin, which can irritate the respiratory tract & lead to coughing. This type of cough is non-productive, meaning it does not produce phlegm.
• Stomach Pain: Some users of Candesartan may experience stomach pain. This side effect can arise from the drug’s effect on digestive processes, potentially causing discomfort or mild pain in the abdominal area. It’s usually not severe but can be bothersome.
• Diarrhea: Candesartan can affect gastrointestinal motility and the absorption of electrolytes and water, which might lead to diarrhea. This side effect is typically mild and temporary as the body adjusts to the medication.
• Muscle Cramps: The use of Candesartan can sometimes lead to electrolyte imbalances, particularly if the body loses too much potassium or sodium. This imbalance can cause muscle cramps or spasms, which are involuntary muscle contractions that are often painful.
• Insomnia: Candesartan can sometimes affect sleep patterns, leading to insomnia. This side effect may occur because the medication alters blood pressure, which in turn can influence how the brain regulates sleep-wake cycles. People experiencing insomnia might find it hard to fall asleep or stay asleep, which might result in feeling tired or unrefreshed during the day.
• Skin Rash: Some individuals might develop a skin rash while taking Candesartan. This rash could appear as small, red, raised bumps on the skin, which might be itchy or mildly irritating. The rash is generally a sign of a mild allergic reaction as the body adjusts to the new medication. 

Adverse Side Effects of Candesartan: Like all medications, it can have side effects, although not everyone will experience them. Here are some of the adverse side effects associated with Candesartan:

• Hyperkalemia: This condition refers to having too much potassium in the blood. Since potassium plays a critical role in heart function and muscle contraction, hyperkalemia can be dangerous. High levels of potassium can lead to irregular heart rhythms, which may be life-threatening. Symptoms might include weakness, fatigue, and palpitations.
• Kidney Impairment: Candesartan can affect kidney function, leading to decreased kidney efficiency or kidney failure in severe cases. This can result in fluid buildup, swelling in extremities, difficulty urinating, and a sudden rise in potassium levels, which can further impact heart health.
• Allergic Reactions: Although rare, allergic reactions to Candesartan can occur. These allergic reactions can be serious and include signs like swelling of the lips, face, tongue, or throat, which might lead to difficulty breathing and require immediate medical attention.
• Liver Problems: Candesartan can rarely cause liver issues, which might present as jaundice (yellowing of the skin or eyes), severe fatigue, nausea, vomiting, and pain in the upper right abdomen. If not addressed quickly, liver complications can lead to severe metabolic disturbances.
• Angioedema (Severe Swelling): Angioedema is a potentially serious side effect of Candesartan characterized by sudden and severe swelling of the deeper layers of your skin, often affecting the eyes, lips, and sometimes the throat. This swelling can be life-threatening if it occurs in the throat, as it could obstruct breathing and require immediate medical intervention.
• Decreased White Blood Cell Count (Rare): Candesartan can infrequently lead to a decrease in white blood cells, compromising the immune system’s ability to fight infections. This reduction can leave individuals more susceptible to frequent infections, potentially leading to severe health complications. 
• Serious Hypotension (Low Blood Pressure): Serious hypotension is another significant side effect of Candesartan. It leads to shallow blood pressure that can cause fainting, dizziness, and an increased risk of falls. In extreme cases, low blood pressure can restrict blood flow to important organs, potentially resulting in shock and organ damage. 

[Note: This list may not cover all possible Candesartan side effects. Always discuss with your healthcare giver for medical advice about side effects.]

When you buy Candesartan online, you should know the following warnings associated with this:

• Pregnancy: Avoid Candesartan during the second and third trimesters as it can harm or even be fatal to the baby. If you find out you’re pregnant while on Candesartan, inform your doctor immediately.
• Kidney Issues: If you have existing kidney problems or severe heart failure, be cautious with Candesartan. It may worsen kidney function. While using the drug, you should monitor your kidney health regularly.
• High Potassium: Candesartan can increase potassium levels in your blood, especially if you already have kidney issues or are taking potassium supplements. Make sure to have regular check-ups to monitor your potassium levels.
• Low Blood Pressure: When starting the medication or increasing the dosage, Candesartan may lead to a drop in blood pressure. This can cause symptoms like dizziness, lightheadedness, or even fainting.
• Swelling: Though rare, Candesartan can cause severe swelling of the face, lips, throat, or tongue, which can be life-threatening. If you encounter such symptoms, seek medical attention promptly.
• Liver Problems: In rare cases, Candesartan may lead to liver issues, manifesting as yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea. If you notice any of these symptoms, consult your doctor promptly.
• Interactions: Candesartan may interact with other medications, particularly those affecting blood pressure, potassium levels, or kidney function. Inform your doctor about all medications that you are taking.
• Allergic Reactions: Patients can encounter allergic reactions to Candesartan, like redness, skin irritation, eczema, lightheadedness, or trouble breathing. 
• Fluid and Electrolyte Imbalance: Candesartan may disturb the balance of fluids and electrolytes in your body, especially if you have heart failure or are taking diuretics. Monitoring of electrolyte levels is crucial, particularly for high-risk individuals.

If you want to order Candesartan medication online, follow these precautions:

• If you’re pregnant, it’s crucial to avoid Candesartan as it may cause potential harm to your baby.
• Regular kidney function tests are important, especially if you have a history of kidney problems.
• Monitor your potassium levels regularly, particularly if you have kidney issues or are taking potassium supplements.
• When getting up from sitting or lying down, take your time to avoid feeling lightheaded or fainting.
• Watch for allergy symptoms such as rash or problem breathing, and seek medical attention promptly if they occur.
• If you observe symptoms like yellowing of the skin or eyes (jaundice) or persistent nausea, inform your doctor, as these could indicate potential liver issues.
• Before starting Candesartan, inform your doctor about all the medications you’re currently taking to prevent any potential interactions.
• If you have heart failure or are on diuretics, it’s important to monitor your fluid and electrolyte levels regularly.
• In the rare event of severe swelling of the face, lips, throat, or tongue, seek immediate medical attention.
• Take precautions with activities requiring alertness, as Candesartan may cause dizziness or fainting, particularly initially or with dosage adjustments.

The major contraindications to Candesartan are:

• Severe hepatic impairment and cholestasis
• Children under 1 year of age
• Pregnancy
• Using Candesartan alongside aliskiren is contraindicated in those who have diabetes mellitus or medium to severe renal impairment (GFR <60 mL/min/1.73m²)

Take the missed dose of Candesartan when you recall it. If your next planned dose is approaching, skip the missed one. Avoid consuming double doses to compensate.

[Note: If you have missed a dose of Candesartan and are still deciding when to take the next dose, immediately consult your doctor or pharmacist.]

If you suspect an overdose after increasing the Candesartan dose, be aware of potential symptoms, which can include dizziness, fainting, either a rapid or slow heartbeat, and difficulty breathing. It is crucial that you do not attempt to handle an overdose situation by yourself.

[Note: If you overdosed on Candesartan, get medical help instantly or call the Poison Help line at 1-800-222-1222.]

When you order Candesartan medication online, you should know the following storage guidelines:

• Store Candesartan at room temperature, specifically between 68°F- 77°F (20°C-25°C).
• It can tolerate temporary exposure to temperatures ranging from 59°F-86°F (15°C-30°C), helpful during transportation.
• It should be shielded from moisture and heat.
• Store it in its original container, tightly sealed, and out of children’s reach.
• Refrain from storing it in the bathroom or close to the kitchen sink.

[Note: Consult with your healthcare practitioner about the proper disposal of unused Candesartan and any questions you may have regarding their storage.]

Here’s a list of drugs known to interact with Candesartan:

• Amiloride
• Bemiparin
• Dalteparin
• Heparin
• Acetylsalicylic Acid (aspirin)
• Aspir 81 (aspirin)
• Aspirin Low Strength (aspirin)
• Benadryl (diphenhydramine)
• Celebrex (celecoxib)
• CoQ10 (ubiquinone)
• Crestor (rosuvastatin)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Jardiance (empagliflozin)
• Lipitor (atorvastatin)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• Nexium (esomeprazole)
• Omega-3 (omega-3 polyunsaturated fatty acids)
• Ozempic (semaglutide)
• Paracetamol (acetaminophen)
• Plavix (clopidogrel)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Ventolin (albuterol)
• Vitamin B Complex 100 (multivitamin)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xarelto (rivaroxaban)
• Zyrtec (cetirizine)

What Are the Other Candesartan Interactions?

In addition to interactions with other medications, Candesartan can also interact with alcohol and food.

• Alcohol & Candesartan: Drinking alcohol when taking Candesartan may intensify its effects on lowering blood pressure, which could lead to dizziness or lightheadedness. It is recommended to avoid alcohol when you begin taking Candesartan or after any increase in your dose until you know how the medication impacts you.
• Food & Candesartan: When you’re prescribed Candesartan, it’s important to consider dietary interactions that could impact the effectiveness of the medication. Specifically, you should limit your potassium-rich foods like spinach, bananas, green leafy vegetables, and peas. These foods can alter the potassium levels in your blood, potentially interfering with the medication’s intended effects. Additionally, foods high in fat should be consumed cautiously as they might affect how the drug is absorbed and processed in your body. 

[Note: This list is not complete, and Candesartan may interact with other drugs. If you take prescription, over-the-counter, or herbal medicines, tell your doctor about them.]

Here are some alternatives to Candesartan:

• Atacand (Candesartan cilexetil)
• Cozaar (losartan)
• Benicar (olmesartan)
• Avapro (irbesartan)
• Micardis (telmisartan)
• Diovan (valsartan)

[Note: Your healthcare professional will select the best Candesartan alternative. You should discuss your healthcare provider before using these alternative medications. You may experience serious side effects if you take them on your own.

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