Candesartan Cilexetil

Candesartan

Candesartan, an FDA-approved angiotensin II receptor blocker, contains Candesartan Cilexetil, effectively managing hypertension and heart failure by relaxing blood vessels. Available in tablet form, dosages range from 4 to 32 milligrams, with administration typically once daily, orally, with or without food. Recommended for adults with hypertension or heart failure, it’s contraindicated in pregnant women, severe liver disease patients, or those allergic to its components. Common side effects are lightheadedness, dizziness, migraine, and fatigue, with precautions advised for kidney issues or potassium supplement use. In case of a missed dose, take it promptly or skip it if nearing the next scheduled dose. Overdose symptoms require immediate medical attention. Keep it at room temperature, away from moisture and heat, and follow healthcare provider instructions closely, particularly noting allergic reaction signs.

Product Overview

Candesartan is an FDA-approved medication for angiotensin II receptor blockers (ARBs). Its active ingredient, Candesartan Cilexetil, is formulated to address hypertension and heart failure. It operates by inhibiting angiotensin II, a compound that narrows blood vessels, resulting in vessel relaxation and decreased blood pressure. It is available in tablet form in strengths ranging from 4 to 32 milligrams. The dosage a healthcare practitioner recommends is based on the patient’s health conditions and response to treatment. It is usually taken orally, with or without food, once daily.

Candesartan is suitable for adults diagnosed with hypertension or heart failure. It is not recommended for pregnant women, those with severe liver disease, or individuals allergic to any components of the medication. Typical side effects may consist of dizziness, headaches, and fatigue. You are recommended to stand up slowly from lying or sitting positions to lower the risk of dizziness. Precautions should be taken in individuals with kidney problems or those using potassium supplements.

Patients should take a dose as soon as they recall if a dose is missed. However, they should skip the missed one if it’s near the next scheduled dose. Symptoms of overdose may include rapid or slow heartbeat, severe dizziness, or fainting, requiring urgent medical attention. Candesartan should be stored at room temperature, away from moisture and heat, and any unused medication should be properly disposed of. Patients should adhere to healthcare provider guidance and heed warning signs such as swelling of the face, lips, tongue, or throat, indicating a possible allergic reaction.

Uses of Candesartan

• It is used in the treatment of Hypertension (high blood pressure), Heart failure, and prevention of heart attack and stroke.

How to Use Candesartan?

Dosage

Strengths and Forms

Form: Oral tablet

Strengths: 4mg, 8mg, 16mg, 32mg

Recommended Dosage for Different Patients

For High Blood Pressure:

• Adult Dosage (Ages 18 to 64 Years):

1. 1. • Standard Dose: 16 mg once daily, with a total 8-32 mg range in 1 or 2 divided doses.
      • For Moderate Liver Problems: 8 mg per day.
      • For Severe Kidney Problems: Starting dose of 8 mg or less daily.

• Child Dosage (Ages 6 to 17 Years):

1. 1. • Based on Weight: 4-8 mg per day for children under 50 kg; 8-16 mg per day for children over 50 kg.
      • Doses can range from 2-16 mg/day for lighter children and 4-32 mg/day for heavier children.

• Child Dosage (Ages 1 to 5 Years):

1. 1. • Typical Range: 0.05–0.4 mg/kg of body weight per day, with a standard starting dosage of 0.20 mg/kg daily.

• Child Dosage (Under 1 Year of Age):

1. 1. • Not recommended for children younger than 1 year due to lack of studies.

• Senior Dosage (Ages 65 Years and Older):

1. • No specific recommendations, but consider lower doses or different schedules due to potentially slower drug processing in older adults.

For Heart Failure:

• Adult Dosage: 

1. 1. • Starting from 4 mg once daily, with a maximum dosage of 32 mg daily. 

• Children Dosage: 

1. • It is not recommended for children for heart failure treatment.

[Note: These Candesartan dosage recommendations may differ from individual to individual. Discuss it with your healthcare professional, and they’ll decide your dosage accordingly.]

How to Take It?

Here are the instructions to take Candesartan tablets:

• Adhere strictly to your doctor’s guidance.
• Usually ingested orally, with or without meals.
• Swallow the tablet whole, accompanied by water.
• Maintain a consistent daily schedule for taking Candesartan.
• If you miss a dose, do not take an extra one; take the next scheduled dose.
• Refrain from consuming alcohol while using Candesartan.
• Inform your doctor about any other medications you use to prevent potential interactions.

[Note: Your healthcare professional will decide the correct amount of Candesartan for you based on your condition. They may adjust your Candesartan dosage as needed over time.]

How Does Candesartan Work?

Candesartan inhibits the action of angiotensin II, a hormone that constricts our blood vessels and raises blood pressure. By blocking angiotensin II receptors, Candesartan causes blood vessels to widen, decreasing resistance to blood flow and reducing blood pressure. This vasodilation relieves the workload on the heart and improves blood flow to vital organs. Additionally, Candesartan may mitigate the adverse effects of angiotensin II on the cardiovascular system and blood vessels, such as inflammation and oxidative stress.

Important Safety Information

Side Effects

Common side effects of Candesartan may include:

• Dizziness
• Headache
• Fatigue
• Nausea
• Hypotension (low blood pressure)
• Back pain
• Upper respiratory tract infection

Mild side effects of Candesartan may include:

• Dry cough
• Stomach pain
• Diarrhea
• Muscle cramps
• Insomnia
• Skin rash

Adverse side effects of Candesartan may include:

• Hyperkalemia
• Kidney impairment
• Allergic reactions (rare)
• Liver problems (rare)
• Angioedema (severe swelling)
• Decreased white blood cell count (rare)
• Serious hypotension (low blood pressure)

[Note: This list may not cover all possible Candesartan side effects. Always discuss with your healthcare giver for medical advice about side effects.]

Warnings

Pregnancy: Avoid Candesartan during the second and third trimesters as it can harm or even be fatal to the baby. If you find out you’re pregnant while on Candesartan, inform your doctor immediately.

Kidney Issues: If you have existing kidney problems or severe heart failure, be cautious with Candesartan. It may worsen kidney function. While using the drug, you should monitor your kidney health regularly.

High Potassium: Candesartan can increase potassium levels in your blood, especially if you already have kidney issues or are taking potassium supplements. Make sure to have regular check-ups to monitor your potassium levels.

Low Blood Pressure: When starting the medication or increasing the dosage, Candesartan may lead to a drop in blood pressure. This can cause symptoms like dizziness, lightheadedness, or even fainting.

Swelling: Though rare, Candesartan can cause severe swelling of the face, lips, throat, or tongue, which can be life-threatening. If you encounter such symptoms, seek medical attention promptly.

Liver Problems: In rare cases, Candesartan may lead to liver issues, manifesting as yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea. If you notice any of these symptoms, consult your doctor promptly.

Interactions: Candesartan may interact with other medications, particularly those affecting blood pressure, potassium levels, or kidney function. Inform your doctor about all medications that you are taking.

Allergic Reactions: Patients can encounter allergic reactions to Candesartan, like redness, skin irritation, eczema, lightheadedness, or trouble breathing. 

Fluid and Electrolyte Imbalance: Candesartan may disturb the balance of fluids and electrolytes in your body, especially if you have heart failure or are taking diuretics. Monitoring of electrolyte levels is crucial, particularly for high-risk individuals.

Precautions

• If you’re pregnant, it’s crucial to avoid Candesartan as it may cause potential harm to your baby.
• Regular kidney function tests are important, especially if you have a history of kidney problems.
• Monitor your potassium levels regularly, particularly if you have kidney issues or are taking potassium supplements.
• When getting up from sitting or lying down, take your time to avoid feeling lightheaded or fainting.
• Watch for allergy symptoms such as rash or problem breathing, and seek medical attention promptly if they occur.
• If you observe symptoms like yellowing of the skin or eyes (jaundice) or persistent nausea, inform your doctor, as these could indicate potential liver issues.
• Before starting Candesartan, inform your doctor about all the medications you’re currently taking to prevent any potential interactions.
• If you have heart failure or are on diuretics, it’s important to monitor your fluid and electrolyte levels regularly.
• In the rare event of severe swelling of the face, lips, throat, or tongue, seek immediate medical attention.
• Take precautions with activities requiring alertness, as Candesartan may cause dizziness or fainting, particularly initially or with dosage adjustments.

Candesartan Contraindications

• Severe hepatic impairment and cholestasis
• Children under 1 year of age
• Pregnancy
• Using candesartan alongside aliskiren is contraindicated in those who have diabetes mellitus or medium to severe renal impairment (GFR <60 mL/min/1.73m²)

Missed Dose

• Take the missed dose of Candesartan when you recall it.
• If your next planned dose is approaching, skip the missed one.
• Avoid consuming double doses to compensate.

[Note: If you have missed a dose of Candesartan and are still deciding when to take the next dose, immediately consult your doctor or pharmacist.]

Overdose

Symptoms may include dizziness, fainting, rapid or slow heartbeat, or difficulty breathing. Do not try to manage an overdose on your own.

[Note: If you overdosed on Candesartan, get medical help instantly or call the Poison Help line at 1-800-222-1222.]

Storage

• Keep Candesartan at room temperature, shielded from moisture and heat.
• Store it in its original container, tightly sealed, and out of children’s reach.
• Refrain from storing it in the bathroom or close to the kitchen sink.

[Note: Consult with your healthcare practitioner about the proper disposal of unused Candesartan and any questions you may have regarding their storage.]

Candesartan Interactions

Here’s a list of drugs known to interact with Candesartan:

• Amiloride
• Bemiparin
• Dalteparin
• Heparin
• Acetylsalicylic Acid (aspirin)
• Aspir 81 (aspirin)
• Aspirin Low Strength (aspirin)
• Benadryl (diphenhydramine)
• Celebrex (celecoxib)
• CoQ10 (ubiquinone)
• Crestor (rosuvastatin)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Jardiance (empagliflozin)
• Lipitor (atorvastatin)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• Nexium (esomeprazole)
• Omega-3 (omega-3 polyunsaturated fatty acids)
• Ozempic (semaglutide)
• Paracetamol (acetaminophen)
• Plavix (clopidogrel)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Ventolin (albuterol)
• Vitamin B Complex 100 (multivitamin)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xarelto (rivaroxaban)
• Zyrtec (cetirizine)

[Note: This list is not complete, and Candesartan may interact with other drugs. If you take prescription, over-the-counter, or herbal medicines, tell your doctor about them.]

Candesartan Alternatives

Here are some alternatives to Candesartan:

• Atacand (candesartan cilexetil)
• Cozaar (losartan)
• Benicar (olmesartan)
• Avapro (irbesartan)
• Micardis (telmisartan)
• Diovan (valsartan)

[Note: Your healthcare professional will select the best Candesartan alternative. You should discuss your healthcare provider before using these alternative medications. You may experience serious side effects if you take them on your own. 

Frequently Asked Questions

How long does Candesartan take to work?

Candesartan typically starts to work within about 2 hours to reduce high blood pressure. However, it may take up to 4 weeks for the full effect. If you’re taking Candesartan for heart failure, it might take weeks or even months before you feel better. Remember to follow your healthcare provider’s guidance and be patient as the medication progresses.

Can I stop Candesartan on my own?

It’s recommended to finish the entire prescribed course of candesartan and avoid abruptly stopping it, as this could lead to the return of symptoms or worsening of the condition. Always discuss with your healthcare provider before altering your medication regimen.

Who should not take Candesartan?

Candesartan may not be suitable for you if you:

• Have allergic reactions to Candesartan or any other medicine.
• Are experiencing diarrhea or have recently had it.
• Have severe liver disease or a problem with bile drainage from your gallbladder.
• Have diabetes, heart, liver, or kidney problems.
• Are trying to get pregnant, are already pregnant, or are breastfeeding. 

Always consult your doctor for personalized advice.

Can I take Candesartan if I’m pregnant or breastfeeding? 

Candesartan is not recommended during pregnancy as it can reduce fluid around your baby, potentially harming their kidneys and lungs. If you’re already pregnant, stop taking Candesartan and consult your doctor. While breastfeeding, it might be okay to take Candesartan, but talk to your doctor or pharmacist first. They can give you the best advice based on your specific situation.

What foods should I avoid while on Candesartan?

While taking Candesartan, avoid potassium-rich foods such as spinach, bananas, green leafy vegetables, and peas. Additionally, be cautious with foods containing a high amount of fat. These interactions may affect the functioning of the medication. Always consult your doctor for personalized advice.

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