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Cantharidin

Cantharone

Cantharone is an FDA-approved topical medication containing 0.7% cantharidin, used for treating warts and molluscum contagiosum. Applied by healthcare professionals, it induces blistering under the lesion for easier removal. It’s crucial to avoid overapplication and contact with sensitive areas. Side effects can include skin irritation and allergic reactions. Cantharone should be stored at room temperature and used with caution, adhering strictly to medical advice for safe and effective treatment.

Product Overview

Cantharone is a topical solution primarily used for the treatment of warts and molluscum contagiosum. The active ingredient in Cantharone is cantharidin, which works by causing a blister to form under the wart or lesion, effectively separating it from the skin and aiding in its removal. This treatment stimulates the immune system to recognize and attack the wart, contributing to its eradication.

Cantharone is available in a topical solution form with a concentration of 0.7% (7mg/mL). It is typically administered by a healthcare professional in a medical setting and applied directly to the affected skin every three weeks as needed. The solution is applied carefully to avoid contact with healthy skin, eyes, nose, or mouth and allowed to dry for up to five minutes. This medication is suitable for use by individuals with warts or molluscum contagiosum, except for those with certain contraindications such as allergies to cantharidin or specific types of warts.

Patients using Cantharone may experience side effects such as skin color changes, skin flushing, ulcers, or swelling. More severe side effects include intense skin irritation, blistering, allergic reactions, and breathing difficulties. Precautions should be taken to avoid overapplication and use on sensitive areas. In case of a missed dose, patients should consult their healthcare provider for further instructions. For overdoses or accidental ingestion, immediate medical attention is required. Cantharone should be stored at room temperature, away from excessive heat, moisture, or direct sunlight.

Uses of Cantharone

  • Get rid of warts

How to Use Cantharone?

Dosage

  • It comes in the form of Topical solution and has a Strength of 0.7% (7mg/mL).

Recommended Dosage for Different Patients

Molluscum Contagiosum Treatment

For Adults:

  • Indication: Used for the topical treatment of molluscum contagiosum.
  • Application: A healthcare professional should apply the medication to cover each lesion every three weeks as needed. Do not use more than two cantharidin applicators in a single session.

For Pediatric Patients:

  • Indication: Approved for the topical treatment of molluscum contagiosum in patients aged 2 years and older.
  • Under 2 years: The safety and efficacy of the treatment have not been established for this age group.
  • 2 years and older: A clinician should apply the medication to cover each lesion every three weeks as needed. Do not use more than two cantharidin applicators in a single session.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

Due to its toxicity, Cantharone should only be used topically in a professional medical setting, where it is applied to the lesions by a doctor.

  • A nurse or trained healthcare professional should apply the medicine in a medical facility.
  • The medicine is applied to the skin every 3 weeks as needed.
  • Avoid contact with the eyes, nose, or mouth.
  • Do not apply topical steroids, creams, lotions, or sunscreen to the treated area.
  • Allow the medicine to dry for up to 5 minutes.
  • Avoid touching or allowing the treated area to come in contact with the mouth, nose, genital areas, or eyes for at least 24 hours after application or until it is washed off.
  • Prevent children from licking or biting the treated areas.
  • Do not inhale vapors from the topical solution during treatment.
  • Do not cover the treated area with a bandage unless directed by your doctor.
  • The medicine is flammable, so avoid fire, flame, or smoking near the treated areas during and after treatment until it is washed off your skin.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Cantharone Work?

Cantharone, which contains cantharidin as its active ingredient, works by causing a blister to form under the wart. This blister separates the wart from the skin, allowing it to be easily removed. Cantharone also stimulates the immune system to recognize and attack the wart, aiding in its removal.

Important Safety Information

Side Effects

Common side effects may include: 

  • Changes in skin color
  • Flushing or redness of the skin
  • Skin ulcers
  • Swelling of the skin
  • Unusually warm skin

Serious side effects may include: 

  • Severe skin irritation or burning
  • Blistering or ulceration of the skin
  • Allergic reactions such as rash, itching, or swelling
  • Difficulty breathing or swallowing
  • Dizziness or lightheadedness

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

  • For External Use Only: Cantharone should only be applied to the skin. It should not be ingested, inhaled, or come into contact with the eyes or mucous membranes.
  • Avoid Overapplication: Applying too much Cantharone can increase the risk of skin irritation and blistering. Follow your healthcare provider’s instructions regarding the amount to apply.
  • Risk of Blistering: Cantharone works by causing a blister to form under the wart or lesion, which can be painful. It is important to monitor the treated area for excessive blistering or discomfort.
  • Keep Away from Children: Cantharone should be kept out of reach of children, as accidental ingestion can be harmful and potentially fatal.
  • Allergic Reactions: If you experience signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, discontinue use and seek medical attention immediately.
  • Avoid Use on Certain Areas: Cantharone should not be used on facial warts, genital warts, or other sensitive areas due to the risk of irritation and scarring.

Precautions

  • If you are allergic to cantharidin or any of its components, other drugs, foods, or substances, inform your doctor about your allergy and the symptoms you experienced.
  • Do not use cantharidin if you have a type of wart called mosaic wart, if the skin around the treated area is swollen or irritated, if you have any blood flow problems, or if you have high blood sugar (diabetes).
  • Avoid using cantharidin on areas of the skin with birthmarks, moles, bleeding warts, or warts with hair growth.
  • If you consume alcohol, refrain from drinking alcohol for several hours after treatment with cantharidin.
  • Do not use cantharidin if you are pregnant or breastfeeding.

Missed Dose

Cantharone is a topical solution containing 0.7% cantharidin, usually applied by a healthcare professional in a clinic or doctor’s office. Since it is not stored at home, there is no concept of a “missed dose” for Cantharone. If you have any concerns or need further treatment, please contact your healthcare provider to reschedule the next application.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdose 

Cantharone can be dangerous, even deadly if ingested. In case of an overdose or accidental swallowing, symptoms such as loss of consciousness or difficulty breathing may occur. Other signs of overdose may include intense stomach pain, seizures, weakness, abnormal bleeding or bruising, and changes in urine output.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Storage

  • Keep it at room temperature.
  • Store it in a secure location away from excessive heat, moisture, or direct sunlight.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Cantharone Interactions

No specific drug interactions have been reported in relation to Cantharone.


[Note: This isn’t a complete list, and there could be other drugs that interact with Cantharone. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Cantharone Alternatives

  • Salicylic Acid (salicylic acid)
  • Podophyllin (podophyllin)
  • Imiquimod (lmiquimod)
  • Cryotherapy (liquid nitrogen)
  • Trichloroacetic Acid (trichloroacetic acid)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Does Cantharone leave scars?

Using Cantharone can cause blistering, and sometimes, this might leave a small scar once the treated area heals. However, scars are not very common. It’s crucial to follow your doctor’s instructions on how to use Cantharone properly to minimize the risk of scarring. If you have concerns about scarring, discuss them with your doctor before starting the treatment.

How often should I apply this topical solution?

Your doctor will guide you on how often to apply Cantharone based on your specific condition. Usually, it’s applied once a week, but the frequency can vary. Follow their instructions carefully. Applying too much or too often can lead to complications. If you’re unsure about the application frequency, don’t hesitate to check with your doctor for personalized guidance.

When should Cantharone be applied?

Cantharone should not be applied concurrently with topical steroids, creams, lotions, or sunscreen. It is recommended to wait for 24 hours after the treatment or until Cantharone has been washed off before applying any other topical products.

What are the serious side effects that require immediate medical attention?

Although rare, some individuals may experience severe and potentially life-threatening side effects from medication. If you experience any of the following signs of an allergic reaction, such as a rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; difficulty breathing, swallowing, or speaking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat, get immediate medical attention. 

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