Certolizumab Pegol

Cimzia Autoinjector 200mg

Cimzia (certolizumab pegol) is a biologic medication approved by the FDA for treating various inflammatory conditions such as psoriatic arthritis, rheumatoid arthritis, Crohn’s disease, and others. It works by blocking tumor necrosis factor (TNF), a substance in the body that causes inflammation and leads to immune system diseases. Cimzia is administered through subcutaneous injections and is intended for long-term treatment to manage symptoms and prevent disease progression. Patients need to be aware of potentially serious side effects, including increased risk of infections and cancer, and should discuss these thoroughly with their healthcare provider before starting treatment.

Product Overview

Cimzia (certolizumab pegol) is a targeted biological therapy primarily used to treat a range of chronic inflammatory conditions. Approved for adults, it is effective against diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, non-radiographic axial spondyloarthritis, Crohn’s disease, ulcerative colitis, and uveitis. These conditions are characterized by an overactive immune system that leads to inflammation and tissue damage.

Cimzia functions by inhibiting the action of tumor necrosis factor (TNF), a protein that plays a vital role in the inflammatory process. By blocking TNF, Cimzia reduces inflammation and helps control symptoms of the diseases it treats. The medication is administered through subcutaneous injections, which can be done in a medical setting or at home after proper training. For most conditions, the starting dose of Cimzia involves a higher frequency of administration, which may decrease depending on the patient’s response to the treatment. Long-term management typically requires ongoing, regular injections to maintain disease control.

Potential side effects of Cimzia include common issues such as upper respiratory infections and headaches, as well as serious risks like heart failure, blood disorders, liver problems, and nerve issues. There is also a heightened risk of serious infections due to the immunosuppressive action of the drug and the possible increased risk of certain types of cancers. Patients considering Cimzia should have a detailed discussion with their healthcare providers about the benefits and risks, especially in the context of their specific health conditions and history. Regular monitoring and adherence to prescribed treatments are crucial for achieving the best outcomes while minimizing risks.

Uses of Cimzia

Cimzia is approved for use in adults to treat the following conditions:

• Uveitis
• Non-radiographic axial spondyloarthritis
• Ulcerative colitis
• Psoriatic arthritis
• Plaque psoriasis
• Crohn’s disease
• Ankylosing spondylitis
• Rheumatoid arthritis

How to Use Cimzia?

Dosage

Cimzia is administered as a subcutaneous injection, which means it is injected under the skin, either in the thigh or abdomen. The medication is available in two forms:

• Solution in a Single-Dose Prefilled Syringe: This form is ready to use and contains the medication in liquid form within a syringe.
• Powder in a Single-Dose Vial: This form consists of a powder that a healthcare professional must mix with a liquid to create an injectable solution.

Both forms of Cimzia are available in a dosage strength of 200 mg.

Recommended Dosage for Different Patients

Dosage for Plaque Psoriasis in Adults

• • Standard Dosage: The typical dosage for adults with plaque psoriasis is 400 mg, administered as two separate 200 mg injections every two weeks.

• Dosage for Individuals Weighing 198 Pounds (90 Kilograms) or Less:

• Initial Treatment:

• • • First dose: 400 mg (two injections of 200 mg each).
    • Second dose: Administer another 400 mg (two injections of 200 mg each) two weeks after the first dose.
    • Third dose: Administer another 400 mg (two injections of 200 mg each) four weeks after the first dose.
  • Subsequent Treatment: After the initial treatment phase, reduce the dosage to 200 mg (one injection) every two weeks.

Dosage for Crohn’s Disease in Adults

• Initial Treatment:
• • First dose: 400 mg, administered as two injections of 200 mg each.
  • Second dose: Another 400 mg (two injections of 200 mg each) given two weeks after the first dose.
  • Third dose: Another 400 mg (two injections of 200 mg each) given four weeks after the first dose.
• Maintenance Treatment: If your symptoms of Crohn’s disease have reduced after the initial treatment, the dosage will then change to 400 mg (two injections of 200 mg each) every four weeks.

Dosage for Rheumatoid Arthritis and Psoriatic Arthritis in Adults

• Initial Treatment:

• • First dose: 400 mg, administered as two injections of 200 mg each.
  • Second dose: Administer another 400 mg (two injections of 200 mg each) two weeks after the first dose.
  • Third dose: Administer another 400 mg (two injections of 200 mg each) four weeks after the first dose.
• Ongoing Maintenance Treatment: After the initial treatment phase, the dosage can be adjusted based on your needs and doctor’s recommendation:
  • Option 1: 200 mg (one injection) every two weeks.
  • Option 2: 400 mg (two injections of 200 mg) every four weeks.

Dosage for Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in Adults

• Initial Treatment:

• • First dose: 400 mg, administered as two injections of 200 mg each.
  • Second dose: Another 400 mg (two injections of 200 mg each) given two weeks after the first dose.
  • Third dose: Another 400 mg (two injections of 200 mg each) given four weeks after the first dose.
• Maintenance Treatment: Following the initial doses, the recommended dosage options are:
  • 200 mg (one injection) every two weeks, or
  • 400 mg (two injections of 200 mg each) every four weeks.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

• Initially, your doctor or a healthcare professional will administer the Cimzia injection in their office. They may also instruct you on how to perform self-injections at home using a prefilled syringe. If you’re interested in learning to administer your injections, discuss this with your doctor.
• Cimzia is intended for long-term treatment. If it is determined to be safe and effective for you, you will likely continue using it over the long term.
• Cimzia is given as a subcutaneous injection, which means it is injected just under the skin. The primary areas for Cimzia injections are:
  • The stomach area (your belly), avoiding a 2-inch circle around your navel (belly button)
  • The top and outer parts of your thighs, avoiding the inner thighs and areas close to your knee
• The easiest method for subcutaneous injection is to pinch up a fold of skin on your stomach or thigh using your thumb and forefinger. Detailed instructions will be provided, and your healthcare professional can demonstrate how to inject Cimzia.
• To prevent your skin from thickening or becoming lumpy, avoid injecting in the same spot repeatedly. Instead, rotate between different injection sites.
• Do not share your Cimzia injections with anyone else. Each injection is intended for single use only.

How Do You Inject Cimzia?

Before injecting Cimzia, remove the carton with the prefilled syringes from the refrigerator. Check the expiration date on both the syringe carton and the label. If the expiration date has passed, do not use the syringe and contact your pharmacist for further guidance.

1. Remove the prefilled syringe from the carton and place it on a clean surface, allowing it to warm to room temperature for 15 to 20 minutes. Avoid using any external methods to speed up the warming process. If you are not using the second syringe immediately, return the carton containing the remaining prefilled syringe to the refrigerator. Before proceeding with the injection, ensure that the liquid in the syringe is clear, colorless to yellow, and free from particles. Do not inject the medication if it appears cloudy, discolored, or contains particles.
2. Wash your hands thoroughly with soap and warm water, then dry them with a clean towel. 
3. Select your injection site either on your stomach, avoiding a 2-inch circle around the navel, or on the upper part of your thighs, avoiding the inner thighs and areas close to your knee. 
4. Clean the chosen injection site with an alcohol swab and allow the area to dry completely before proceeding.
5. Pick up the prefilled syringe using your dominant hand, holding it so that the needle points upward. It’s normal to see air bubbles in the syringe, and there’s no need to remove them before injecting. The presence of air bubbles will not harm you when injecting the solution. Using your other hand, carefully remove the plastic ring needle cover by pulling it straight up on the plastic ring.
6. With your other hand, gently hold and pinch a fold of skin at the cleaned injection site. Using a quick, “dart-like” motion, insert the needle into the pinched skin at approximately a 45-degree angle. Once the needle is in, release the pinched skin but keep the syringe steady in position. Slowly press the plunger down until the syringe is completely empty. After the injection, carefully pull the needle out of the skin and immediately place it in an approved sharps disposal container.
7. Place a dry cotton ball or gauze pad over the injection site for a few seconds after removing the needle. 
8. Avoid rubbing the injection site to minimize irritation. If your prescribed dose of Cimzia is 400 mg, you will need to administer two separate injections of 200 mg each. 
9. Make sure to use different injection sites on your thigh or abdomen for each injection.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Cimzia Work?

Cimzia is utilized to manage various conditions such as Crohn’s disease, psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic spondyloarthritis, all of which stem from an overactive immune system. Under normal circumstances, your immune system safeguards against infections and cancers. However, an overactive immune system produces excessive proteins leading to inflammation—a common denominator across the conditions treated by Cimzia. This inflammation manifests as symptoms like diarrhea and abdominal pain in Crohn’s disease, joint pain and stiffness in arthritis, and thick, scaly skin patches in psoriasis.

Cimzia, classified as a biologic therapy, operates by mitigating inflammation. Biologics, crafted from living cells, are engineered to target specific proteins in the body. Cimzia belongs to the category of biologics known as tumor necrosis factor (TNF) blockers. TNF, an inflammation-inducing protein, is excessively produced in the conditions addressed by Cimzia. By binding to TNF and inhibiting its effects, Cimzia diminishes skin plaques in psoriasis, joint inflammation in arthritis, and bowel inflammation in Crohn’s disease. Following the initial injection, Cimzia begins to take effect. However, it may take several weeks before noticeable symptom reduction occurs.

Important Safety Information

Side Effects

Common side effects of Cimzia can include:

• Injection Site Reaction may include symptoms such as: 
  • Redness
  • Bruising
  • Pain
  • Swelling 
• Herpes Infections include:
  • Oral herpes
  • Genital herpes
  • chickenpox
• High Blood Pressure
• Rashes
• Urinary Tract Infection
• Headache (in patients who have arthritis or psoriasis)
• Joint Pain (in patients with Crohn’s disease
• Mild Allergic Reaction
• Upper Respiratory Infection: Includes:
  • Common cold
  • Flu 

Serious side effects and their symptoms can include:

• Possible risk of cancers
• Risk of serious infections
• Serious allergic reaction
• Immune system reactions, such as lupus-like syndrome. Signs may include:
  • Rash on the arms or cheeks (gets worse when exposed to the sun)
  • Joint pain
  • Shortness of breath
• Blood disorders, like low numbers of white or red blood cells and platelets. Signs may include:
  • Bruising or bleeding easily
  • Skin or gums looking pale
  • Fever
• Heart failure. Signs may include:
  • Sudden weight gain
  • Swollen ankles or feet
  • Shortness of breath
• Liver problems, including reactivation of the hepatitis B virus. Signs may include:
  • Fatigue
  • Vomiting
  • Jaundice (whites of your eyes & yellowing of your skin)
  • Abdominal pain
  • Loss of appetite
  • Nausea
• Nerve problems that include:
  • Peripheral neuropathy
  • Optic neuritis (inflamed optic nerves)
  • Guillain-Barré syndrome
  • Seizures
  • Multiple sclerosis

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

FDA warnings: Risk of serious infections and possible risk of cancer

This medication comes with boxed warnings. These warnings are the most vital alerts from the Food and Drug Administration (FDA). They inform doctors and patients about the potential for dangerous side effects.

• Risk of Serious Infections: Cimzia weakens your immune system, making it harder to fight off germs and increasing your risk of serious infections. These infections can include tuberculosis (TB) and bacterial, fungal, or viral infections that may spread throughout your body. Serious infections might require hospital treatment and can sometimes be fatal. If you develop a serious infection, your doctor might stop Cimzia. Before starting Cimzia, your doctor will test you for TB and other infections. Inform your doctor if you think you have an infection, if you frequently get infections, or if your infections keep returning. Infections may need to be treated before you begin Cimzia. Contact your doctor immediately if you experience any symptoms of infection while taking Cimzia.
• Possible Risk of Cancer: Cimzia may increase the risk of developing certain types of cancer, including lymphoma, leukemia, and skin cancer. Your doctor will closely monitor you throughout your Cimzia treatment with blood tests and skin examinations. Contact your doctor immediately if you notice any changes in your skin while taking Cimzia. Other rare cancers, including Lymphoma, have been reported in teenagers and children treated with medications known as tumor necrosis factor (TNF) blockers. Cimzia, a TNF blocker, is not prescribed for use in children under 18 years of age.

Precautions

Before taking Cimzia, discuss your health history with your doctor. Cimzia may not be suitable for you if you have certain medical conditions or other health factors. These include:

• History of Hepatitis B Infection: If you’ve ever had hepatitis B, Cimzia could reactivate the virus in your body, potentially leading to liver failure and death. Your doctor will perform blood tests to check for the hepatitis B virus before you start Cimzia. If you have the hepatitis B virus, your doctor will determine whether Cimzia is appropriate for you.
• Heart Failure: Cimzia can cause or worsen heart failure. If you have heart failure, your doctor will monitor you closely while you are taking Cimzia.
• Nerve Problems: Cimzia can cause or worsen symptoms of nerve problems. Examples include multiple sclerosis, Guillain-Barré syndrome, seizures, optic neuritis, or peripheral neuropathy. If you have any nerve-related issues, discuss with your doctor whether Cimzia is suitable for you.
• Problems with Your Blood Cell Counts: In rare cases, Cimzia may lower your blood cell counts. If you have a history of blood cell problems, your doctor will closely monitor your blood cell counts while you are taking Cimzia.
• Allergy to Cimzia or Other TNF Blockers: If you’ve had an allergic reaction to Cimzia or any of its ingredients before, your doctor will not prescribe it for you. Cimzia is a type of drug called a tumor necrosis factor (TNF) blocker. If you’ve ever had an allergic reaction to another TNF blocker, such as Humira or Remicade, your doctor will determine if Cimzia is suitable for you.
• Sensitivity to Latex: If you are sensitive to latex, your doctor will not prescribe the Cimzia prefilled syringe. The cap of the prefilled syringe contains natural rubber latex, which could cause an allergic reaction.
• Lymphoma or Other Cancers: Cimzia may increase your risk of lymphoma or other types of cancer. If you have a history of lymphoma or any other cancer, inform your doctor before starting Cimzia treatment. Cimzia could potentially worsen your condition or increase the risk of cancer recurrence. Your doctor will assess whether Cimzia is a safe treatment option for you.

Other Important Precautions 

Alcohol: Cimzia isn’t known to interact with alcohol. However, alcohol can worsen some of Cimzia’s side effects. For example, both Cimzia and alcohol can cause headaches, so drinking alcohol while on Cimzia may increase the risk and severity of headaches. Additionally, alcohol might make your condition worse. For instance, alcohol can worsen the symptoms of plaque psoriasis, which Cimzia treats. If you drink alcohol, talk with your doctor to determine whether it’s safe to do so while using Cimzia.

Pregnancy and Breastfeeding: It’s not known whether it’s safe to use Cimzia during pregnancy or while breastfeeding. Currently, there haven’t been enough clinical trials in pregnant people to determine the drug’s safety during pregnancy. However, two studies show that when Cimzia was taken during the third trimester, developing fetuses were exposed to a meager amount of the medication. Additionally, animal studies of Cimzia did not show an increased risk of congenital anomalies (birth defects). However, animal studies don’t always predict what may happen in humans.

It’s important to note that untreated Crohn’s disease and rheumatoid arthritis during pregnancy may increase certain risks, including pregnancy loss. Therefore, your doctor will likely recommend treating these conditions during pregnancy. They will also likely suggest signing up for the pregnancy registry for Cimzia. A pregnancy registry collects information about the effects of a drug when taken during pregnancy, helping to determine whether it may be safe to use during this time. A small amount of Cimzia can pass into breast milk. In clinical trials, this amount did not cause side effects in children exposed to the drug through breast milk. If you’re pregnant, breastfeeding, or planning to become pregnant or breastfeeding, talk with your doctor before using Cimzia.

Contraindications 

• Cimzia should not be administered to patients with a prior history of hypersensitivity reaction to certolizumab pegol or any of its components.
• Hypersensitivity reactions may manifest as angioedema, anaphylaxis, serum sickness, or urticaria.

Missed Dose

• Keep your appointments with your doctor for Cimzia injections. If you miss one, contact your doctor’s office immediately to reschedule.
• If you’re self-administering Cimzia at home and forget a dose, take it as soon as you remember. Then, consult your doctor to adjust your treatment schedule accordingly.
• To avoid missing doses, consider marking your Cimzia schedule on your calendar or setting up reminders on your phone.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdose 

• Adhere strictly to your doctor’s prescribed dosage of Cimzia.
• If you suspect an overdose, contact your doctor immediately.
• Alternatively, reach out to America’s Poison Centers or use its online tool for guidance.
• In cases of severe symptoms, call 911 or proceed to the nearest emergency room without delay.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

Storage

• Store Cimzia vials and prefilled syringes in a refrigerator between 36°F and 46°F (2°C and eight °C). Keep them in their cartons to shield them from light. Avoid freezing.
• If required, Cimzia prefilled syringes can be kept at room temperature (up to 77°F/25°C) for up to 7 days, stored in their carton to protect them from light.
• Unopened Cimzia vials can be stored at room temperature (up to 77°F/25°C) for up to 6 months if necessary.
• Once stored at room temperature, don’t return Cimzia prefilled syringes or vials to the refrigerator.
• When you no longer need Cimzia, dispose of any leftover medication safely to prevent accidental ingestion by others and minimize environmental impact.
• Refer to the FDA website for guidance on medication disposal, or consult your pharmacist for proper disposal instructions.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Cimzia Interactions

Cimzia can interact with several other medications, leading to different effects. Some interactions may reduce the effectiveness of a drug, while others can increase side effects or make them more severe. It’s important to inform your doctor about all medications, supplements, and vitamins you are taking to avoid potential interactions. Additionally, Cimzia can affect certain lab test results, which might require adjustments to your treatment plan. Always discuss possible interactions with your doctor to ensure the safe and effective use of Cimzia.

Interactions with Other Medications

Here is a list of medications that can interact with Cimzia. This list does not include all drugs that may interact with Cimzia. Before starting Cimzia, talk with your doctor and pharmacist. Inform them about all prescriptions, over-the-counter, and other medicines you take. Also, mention any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions and ensure your treatment is safe and effective. If you have any questions about drug interactions that may affect you, ask your doctor or pharmacist for more information.

Interactions with Immunosuppressant Drugs: Immunosuppressants are medications that lower the activity of your immune system. Cimzia also lowers immune system activity. When you take Cimzia with an immunosuppressant, your risk of serious infections can increase. Common immunosuppressant drugs that may heighten this risk when used with Cimzia include:

• Rasuvo (methotrexate)
• Otrexup (methotrexate)
• Trexall (methotrexate)
• Corticosteroids such as prednisone (Rayos)

Interactions with Certain Other Biologics: Cimzia is a biologic medication, which means it is produced from living cells. It is generally advised not to use Cimzia alongside other biologics that treat conditions like arthritis, Crohn’s disease, or psoriasis. This is because combining these medications can significantly increase your risk of serious infections. Examples of other biologics that should not be used with Cimzia include:

• Kineret (anakinra)
• Rituxan (rituximab)
• Orencia (abatacept)
• Tysabri (natalizumab)

Interactions with Live Vaccines: Receiving a live vaccine while on Cimzia can lead to serious infections. Live vaccines use weakened forms of viruses or bacteria, which normally do not cause infections in people with healthy immune systems. However, if your immune system is weakened due to Cimzia, these vaccines might lead to infections. Therefore, it’s recommended to avoid live vaccines while taking Cimzia, such as:

• Tuberculosis
• The nasal spray form of the flu vaccine
• Yellow fever
• Chickenpox
• Measles, mumps, and rubella (MMR)

It is safe to receive inactive (non-live) vaccines, such as the flu shot, while you are taking Cimzia.

Interactions with Herbs & Supplements

Currently, there are no specific herbs or supplements known to interact with Cimzia. Nonetheless, it’s important to consult with your doctor or pharmacist before using any herbal or supplemental products while taking Cimzia.

Interactions with Lab Tests

Cimzia does not influence blood clotting in your body. However, it may alter the results of certain lab tests that assess how long it takes your blood to clot. An example of such a test is the activated partial thromboplastin time (aPTT) test. Abnormal results from this test may incorrectly suggest a blood clotting issue when there is none. If you are scheduled for a test that checks your blood clotting, ensure your doctor is aware that you are taking Cimzia. Typically, you will only need this type of test if there is a concern about a potential blood clotting problem.

[Note: This isn’t a complete list, and there could be other drugs that interact with Cimzia. Make sure to tell your doctor about any prescription, over-the-counter, or herbal products you’re taking.]

Cimzia Alternatives

1. Otrexup (methotrexate)
2. Rasuvo (methotrexate)
3. Trexall (methotrexate)
4. Soriatane (acitretin)
5. Otezla (apremilast)
6. Humira (adalimumab)
7. Enbrel (etanercept)
8. Remicade (infliximab)
9. Siliq (brodalumab)
10. Taltz (ixekizumab)
11. Tremfya (guselkumab)
12. Skyrizi (risankizumab)
13. Cosentyx (secukinumab)
14. Ilumya (tildrakizumab)
15. Stelara (ustekinumab)
16. Rayos (prednisone)
17. Entocort EC (budesonide)
18. Azulfidine (sulfasalazine)
19. Azulfidine EN-tabs (sulfasalazine)
20. Azasan (azathioprine)
21. Imuran (azathioprine)
22. Purinethol (6-mercaptopurine)
23. Purixan (6-mercaptopurine)
24. Tysabri (natalizumab)
25. Entyvio (vedolizumab)
26. Advil (ibuprofen)
27. Motrin IB (ibuprofen)
28. Naprosyn (naproxen)
29. Plaquenil (hydroxychloroquine)
30. Arava (leflunomide)
31. Simponi (golimumab)
32. Simponi Aria (golimumab)
33. Kineret (anakinra)
34. Orencia (abatacept)
35. Rituxan (rituximab)
36. Xeljanz (tofacitinib)
37. Xeljanz XR (tofacitinib)
38. Actemra (tocilizumab)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is it safe to take antibiotics while you’re on Cimzia?

Yes, it is generally safe to take antibiotics while using Cimzia if your doctor prescribes them. Cimzia is a medication that can reduce the activity of your immune system, making you more susceptible to infections. Therefore, if you develop a bacterial infection while on Cimzia, antibiotics may be necessary to treat it effectively. However, in cases of serious infections, your doctor might advise you to temporarily stop taking Cimzia until the infection is resolved with antibiotics. It’s important to closely follow your doctor’s guidance regarding the use of antibiotics and the management of Cimzia during infections.

Can I take Cimzia if I have diabetes?

Yes, you can take antibiotics while using Cimzia if your doctor prescribes them. However, it’s important to be aware that both diabetes and Cimzia can increase your susceptibility to infections. To help reduce this risk, consider the following precautions:

• Ensure all your immunizations are up to date before starting Cimzia.
• Get the flu shot annually to protect against influenza.
• If possible, avoid close contact with people who are currently infected.
• Frequently wash your hands to help prevent the spread of germs.
• Practice good foot care, particularly if you have diabetes, to prevent foot ulcers and infections.

If you experience any symptoms of an infection while taking Cimzia, it’s crucial to see your doctor immediately for proper assessment and treatment.

Should I expect weight gain with Cimzia?

No, weight gain is not typically expected as a side effect of Cimzia. Clinical trials involving this medication did not report weight gain among the participants. However, it’s important to note that Cimzia can potentially lead to new or worsening heart failure, which may cause swelling in the legs or ankles. This swelling could be mistaken for sudden weight gain.

If you notice any weight gain while using Cimzia, especially if it’s accompanied by other symptoms like swelling in your legs or ankles, it’s essential to consult your doctor. They can help determine the cause of the weight gain and advise on the appropriate course of action to manage it.

When should I stop taking Cimzia?

You should consider stopping Cimzia and contact your doctor immediately if you suspect you have an infection or if you experience symptoms of a disease. Symptoms can include fever, fatigue, cough, flu-like symptoms, or any new or worsening symptoms. It is crucial because Cimzia, as an anti-TNF therapy, can potentially lower your immune system’s ability to fight infections, making you more susceptible to serious, sometimes fatal, infections.

Additionally, there have been cases of certain cancers, including lymphoma, in individuals receiving anti-TNF therapy like Cimzia. If you notice any unusual symptoms, such as unexplained weight loss, persistent fever, bruising, bleeding, or lymphadenopathy (swollen lymph nodes), it’s important to inform your doctor right away.

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