Clobetasol Propionate

Clobetasol Ointment

Clobetasol Ointment is a strong corticosteroid (anti-inflammatory medication) used to treat various skin conditions like eczema, psoriasis, and dermatitis by reducing inflammation, itching, and redness. Applied on the outside of the body, it works by lowering the immune response in the affected area. Generally, the infected skin is covered with a thin layer once or twice daily, as directed by a healthcare professional. It’s important to adhere to the dosage instructions and avoid long-term usage, as it can lead to skin thinning or other side effects. This ointment is for external use only and should not be applied to broken or infected skin without medical supervision. 

Product Overview

Clobetasol ointment is widely used to treat various skin conditions like rash, dermatitis, allergies, etc. The ointment contains the active compound clobetasol propionate, which is a manufactured corticosteroid. This topical dermatologic ointment reduces skin inflammation, itching, and redness. When applied to eczema (red, itchy rashes), psoriasis (thick, scaly patches), and dermatitis (inflamed skin), it provides relief from all the irritation.

Available in a strength of 0.05%, the ointment should be applied thinly to the infected skin areas twice daily, as a healthcare provider prescribes. It is suitable for adults and children over 12 who suffer from resistant dermatoses where weaker corticosteroids have not been effective. It is crucial not to use this medication for any disorder other than that for which it was prescribed. It works by restricting blood vessels to reduce swelling and irritation. 

Potential side effects of Clobetasol Ointment include skin thinning, itching, and irritation at the application site. Patients are advised to follow expert instructions closely. If you missed a dose, apply the ointment immediately, but skip it if it’s nearly time for the next application. Store the ointment at room temperature and away from moisture and heat. It is essential to keep this and all medications out of children’s reach and use the ointment only for the duration prescribed to prevent adverse effects and resistance.

Uses of Clobetasol Ointment 

It is used to treat:

• Skin conditions like eczema, psoriasis, dermatitis, allergies, and rash.
• Reduces swelling, redness, and itching.
• Provides relief from the discomfort & irritation caused by various allergic reactions.
• Manages scalp conditions like seborrheic dermatitis and scalp psoriasis.

How to Use Clobetasol Ointment?

Dosage

Clobetasol has different strengths:

• Form: Topical cream (regular)
• Strengths: 0.05%
• Form: Topical cream (emollient)
• Strengths: 0.05%

Recommended Dosage for Different Patients

• Adult (18-64 Years): Apply directly on the infected areas of the skin two times a day. Try to rub it carefully.
• Children (12-17 Years): Apply the emollient cream to the children under the mentioned age group twice a day and rub the cream carefully.  
• Children (0-11 Years): Not recommended
• Senior (65 Years and Above): Older adults are less medically fit than younger adults. Therefore, their kidneys, liver, and heart may not work as well as they used to. Due to this, drugs process more slowly in their body, causing them to stay for a longer duration. Thus, leading to adverse side effects. That’s why doctors advise senior patients to lower dosage or a completely different treatment schedule. 

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

• Read the patient information leaflet thoroughly and follow the instructions carefully. 
• Use the ointment on the skin only.
• Do not get the medication into the eyes, nose, or mouth.
• Do not apply on the areas with cuts or burns. If it comes into contact with such areas, rinse it immediately.
• For effective results, do not skip any doses.
• Use only for the skin conditions as prescribed by your medical professional.
• Do not use the ointment on the face,underarms, or groin unless directed by an expert. 
• Before applying the medication, wash your hands properly with soap and water. Follow the procedure after the application, too.
• Apply a thin layer and rub it gently on the affected areas.
• Do not wrap the skin with any cloth or bandage unless the doctor consults it.
• Use the ointment on all the infected skin, not just the worst areas.
• If you use the medication twice a day, leave a gap of 8 to 12 hours.
• Do not use Clobetasol at the same time as other creams or moisturizers. 
• Wait for half an hour before applying the ointment to the area where you have used the other product. 
• For dermatitis, use the ointment for up to 1 week.
• For long-term problems like eczema and psoriasis, use the medication under expert supervision.
• Do not use it for more than 4 weeks without consulting with your doctor.
• Seek medical assistance for discontinuing or changing the current medication.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Clobetasol Ointment Work?

Clobetasol is mainly a topical corticosteroid which is applied on the skin. It works by performing three key actions. Firstly, it reduces the production of chemicals responsible for causing inflammation. This leads to decreased redness, itching, and swelling, thereby treating skin inflammation. Secondly, it slows down the formation of new cells, which is beneficial in reducing patches or scales seen in conditions like psoriasis. Lastly, it suppresses the body’s immune response, which is effective for treating skin issues forming from an overactive immune system, such as eczema.

Important Safety Information

Side Effects

Common side effects of Clobetasol Ointment 0.05% may include:

• Burning
• Stinging
• Skin irritation
• Itching
• Dryness
• Redness

Serious side effects of Clobetasol Ointment 0.05% may include:

• Thinning skin
• Acne
• Stretch marks
• Heat rash
• Discoloration
• Unwanted hair growth
• Tiredness
• Weight loss
• Headache
• Swelling
• Vision problems
• Trouble breathing

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

• Effects on  Adrenal Glands: Clobetasol may lead to adrenal insufficiency and cause your adrenal glands to stop functioning. From dizziness and fainting to fatigue, symptoms can vary. These effects occur during or after you discontinue the treatment with this drug. Contact a medical professional if you notice such side effects. These experts will suggest tests to check whether your glands are working properly. 
• Cushing’s Syndrome: There are cases when the drug used in the ointment gets absorbed through the skin, causing such syndrome. This condition is related to low hormone levels and its symptoms include high blood sugar and pressure.
• Skin Reactions: Clobetasol has a high risk of skin reactions if you cover the infected area with a bandage.  These reactions can be in the form of acne, inflammation of your hair follicles, rashes, etc. Do not cover your skin after applying this drug to avoid such effects.
• Liver Problems: If you have severe liver problems, it is advised to consult a doctor before applying this drug as an ointment on your skin. The liver processes the drug, so it is highly likely that your body may not support you to break down the drug. Thus resulting in drug buildup, thereby increasing the risk of side effects.
• Pregnant Women: If you are pregnant, consult with your healthcare expert about the usage of Clobetasol ointment 0.05%. Assess every risk and benefit before taking any action.
• Lactating Women: The drug may pass into the breastmilk nursing women, causing adverse effects in the infant. Therefore, always take the guidance of your doctor before making any decision.

Precautions

• Avoid the ointment if undergoing the treatment of rosacea or perioral dermatitis.
• Clobetasol propionate ointment produces HPA axis suppression. If it is detected, discontinue the drug, reduce the application frequency, or switch to a less strong steroid.
• Discontinue the ointment usage if irritation or allergic contact dermatitis develops.
• Before using this medication, tell your healthcare expert about any allergies to other corticosteroids, including hydrocortisone and prednisone. The ointment contains certain inactive ingredients that may cause allergic reactions. 
• Remember to tell your doctor your medical history if you have poor blood circulation or immune system problems.
• Avoid using the ointment if there is an infection in the area where it is supposed to be applied. Take medical guidance before applying it. 
• In rare cases, if you use corticosteroid medications for a long time, your body might find difficulty in responding to physical stress. Therefore, communicate with your healthcare provider before undergoing surgery or any medical procedure.
• While not proven, the medication may temporarily affect your child’s growth if used for a prolonged period. Consult with a medical professional frequently for preventive measures. 

Contraindications

Clobetasol propionate ointment 0.05% is contraindicated in patients with a history of hypersensitivity to any active ingredients or components of the drug preparations.

Missed Dose

• If you somehow forget the ointment’s application, apply whenever possible.
• At the time of your next application, you can skip the missed medication and follow your regular schedule.
• Do not try to make up for the skipped medication by applying double ointment.
• Ask your doctor for better guidance.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

Overdose

The ointment can be absorbed through the skin and cause adverse effects. Therefore, in case you have applied too much of the ointment, it can lead to symptoms like passing out or troubled breathing. In such cases, contact the poison control authority immediately. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Storage

• Store the ointment at room temperature of 68°F and 77°F (20°C and 25°C).
• Do not keep it in the freezer.
• Avoid storing the medication in moist or damp areas like bathrooms or near sinks. 
• Keep it away from children’s reach.
• Read the storage instructions of your product carefully.
• Do not poke holes in the ointment tube or throw in the fire.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Clobetasol Interactions

Clobetasol ointment contains Clobetasol propionate as its active ingredient which may have severe reactions when combined with other drugs due to its absorption through the skin. Here are some examples of these drugs:

• Abametapir: When Abametapir is used alongside Clobetasol propionate, there is a potential increase in the concentration of Clobetasol propionate in the bloodstream. This elevation in serum concentration may alter Clobetasol propionate’s effectiveness or side effects.
• Abatacept: Combining this drug with Clobetasol propionate results in a high risk of side effects. Therefore, it is important to be aware of this interaction. Patients are advised to closely monitor any potential complications. 
• Abemaciclib: Using this drug with your ointment medication can lead to increased metabolism of  Abemaciclib, affecting its efficacy and duration of action. Thus, it is required to make necessary adjustments in dosage or frequency of Clobetasol.  
• Acalabrutinib: Concurrent use of Acalabrutinib and Clobetasol propionate can lead to an increased metabolism of Acalabrutinib. This may influence the concentration of the drug in the body, potentially impacting its therapeutic effects or safety profile.
• Acarbose: When combined with Clobetasol propionate, there is a high risk of hyperglycemia (increased blood sugar levels). Therefore, these drug interactions demand careful monitoring of blood glucose levels.  

[Note: This isn’t a complete list, and there could be other drugs that interact with Clobetasol propionate. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Clobetasol Alternatives

• Tremfya (guselkumab)
• Stelara (ustekinumab)
• Methotrexate
• Triamcinolone topical
• Ustekinumab
• Skyrizi
• Remicade
• Infliximab

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

What is the difference between Clobetasol ointment and cream?

The major difference between the two products lies in their texture and consistency. Clobetasol ointment is a semi-solid, greasy substance that forms a stronger barrier on the skin. It is particularly suitable for thick skin or dry, scaly patches like those seen in psoriasis or eczema. At the same time, Clobetasol cream has a softer and smoother texture that gets easily absorbed into the skin. Creams are often chosen for treating conditions like dermatitis or rashes on visible body parts. 

Is Clobetasol an antifungal agent?

While Clobetasol is not properly an antibiotic, it contains combined medications of antibiotic properties. Additionally, it can be coadministered with an antibiotic like neomycin sulfate. This combination can be used to address both bacterial and fungal infections. Besides, it possesses anti-inflammatory properties, which makes the medication more effective in managing various skin conditions beyond infection.

Can Clobetasol be used on the face?

No, it is strictly advised not to use this medication on the face along with the groin or underarms. Clobetasol should not be used for treating skin infections or conditions like severe burns, cuts or if you have skin thinning, unless advised by a healthcare professional.

Can Clobetasol be used daily without risk?

Continuous use of Clobetasol over an extended period may result in systemic absorption of the medication. In rare instances, it can lead to potential adverse effects, including skin thinning and the development of stretch marks, particularly in areas of frequent application. Therefore, it’s crucial to adhere to prescribed guidelines regarding the frequency and duration of this medication to minimize any risk.

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