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Clotrimazole / Betamethasone Dipropionate 

Clotrimazole and Betamethasone

Clotrimazole/Betamethasone is a combination medication used to treat fungal skin infections such as athlete’s foot, jock itch, and ringworm. Clotrimazole is an antifungal that stops fungus growth by disrupting their cell membranes, while Betamethasone is a corticosteroid that reduces inflammation, redness, and itching. Available as a cream or lotion, this medication should be applied as directed by a healthcare provider. It is crucial to complete the entire course of treatment to prevent the recurrence of the infection. Patients should be aware of potential side effects, including skin irritation and more serious risks like adrenal gland problems.

Product Overview

Clotrimazole/Betamethasone Dipropionate is a potent topical medication combining Clotrimazole, an azole antifungal, with Betamethasone, a corticosteroid. This combination effectively treats various dermatological fungal infections, including athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). Clotrimazole works by inhibiting the growth of fungus on the skin by disrupting the production of ergosterol, a critical component of fungal cell membranes. Betamethasone decreases the skin’s inflammatory responses, thereby reducing swelling, redness, and itchiness associated with these infections.

The medication is typically available in two forms: a cream and a lotion, both containing 0.05% of Betamethasone and 1% of Clotrimazole. It is applied to the affected skin areas twice daily, and the duration of treatment varies depending on the type and severity of the infection—ranging from one to four weeks. It is crucial not to discontinue the treatment prematurely to avoid the recurrence of the infection. While generally safe when used as directed, Clotrimazole/betamethasone can cause side effects. Common side effects include minor skin irritation, dryness, and a burning sensation at the application site. More severe reactions can occur, such as an increase in infections, signs of hormonal imbalance (like fatigue or weight gain), or severe allergic reactions characterized by rash, swelling, or breathing difficulties. 

Due to its corticosteroid component, it is advised not to use this medication over large body areas or for extended periods without medical supervision. Patients are encouraged to discuss their medical history with their healthcare provider, especially if they have a history of liver disease, diabetes, or an immune system disorder, as these conditions can alter the medication’s effectiveness and safety. Regular follow-up and adherence to the prescribed treatment regimen are essential for successful management of fungal skin infections with Clotrimazole/betamethasone.

Uses of Clotrimazole / Betamethasone

It is used to treat the following conditions mentioned below:

  • Athlete’s foot
  • Ringworm
  • Jock itch

How to Use Clotrimazole / Betamethasone?


This medication is available in the following dosage forms & strengths:

  • Cream: 0.05% / 1% (15g, 45g)
  • Lotion: 0.05% / 1% (30mL)

Recommended Dosage for Different Patients

Topical Dosage Forms (Cream or Lotion) for Fungal Infections

  • For Tinea Cruris and Tinea Corporis
      • Adults and children 17 years of age and older: Apply to the affected skin area(s) twice daily, in the morning and evening, for one week.
      • Children younger than 17 years of age: Use is not recommended.
  • For Tinea Pedis
    • Adults and children 17 years of age and older: Apply to the affected skin area(s) twice daily, in the morning and evening, for two weeks.
    • Children younger than 17 years of age: Use is not recommended.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • It is crucial that you use this medicine exactly as directed by your doctor. Do not use it more than recommended, do not use it more frequently, and do not use it for a longer duration than your doctor has prescribed. Doing otherwise may lead to unwanted side effects or skin irritation.
  • This medication should be accompanied by a patient information leaflet. Ensure that you read and follow these instructions carefully. If you have any questions, consult your doctor.
  • This medicine is intended for use on the skin only. Avoid contact with your eyes, nose, mouth, or vagina, and do not apply it on your face or under your arms.
  • To fully clear up your skin infection, it is vital to continue using this medicine for the entire duration of the treatment, even if your symptoms start to improve within a few days. Fungal or yeast infections can be particularly slow to resolve, and you may need to continue using this medication daily for several weeks or more. If you discontinue the medication prematurely, your symptoms may return. Ensure you do not miss any doses.
  • The dosage of this medicine will vary among patients. You should follow your doctor’s instructions or adhere to the directions provided on the label. The information provided here represents only average dosages. If your prescribed dosage differs, do not alter it unless your doctor specifically instructs you to do so.
  • The amount of medicine you take depends on its strength. Additionally, the number of doses you take each day, the time intervals between doses, and the duration for which you take the medicine are all determined by the specific medical condition you are treating.

Here are some steps on how to take this medicine:

  • Wash Your Hands: Always wash your hands before and after applying this medicine. This helps prevent the spread of infection and ensures that the application area remains clean.
  • Apply the Medicine: Apply a thin layer of the medicine to the affected skin area. Gently rub it in until it is evenly distributed.
  • Avoid Bandaging: Do not bandage or wrap the treated skin unless your doctor specifically instructs you to do so. Keeping the area open helps the skin breathe and aids the effectiveness of the treatment.
  • Clothing Considerations: After applying the medicine, allow it to dry before dressing. Avoid covering the treated area with tight-fitting clothes unless your doctor advises you to. This helps prevent irritation and ensures the medicine remains on the skin.
  • Duration of Use: Do not use the cream to treat tinea cruris (jock itch) and tinea corporis (ringworm of the body) for more than two weeks and for tinea pedis (athlete’s foot) for more than four weeks unless directed by your doctor. Using the medicine for longer than recommended can increase the risk of side effects.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Clotrimazole / Betamethasone Work?

Clotrimazole/Betamethasone Dipropionate is a combination medication designed to combat fungal infections. Clotrimazole, an azole antifungal, operates by halting the fungus’s ability to form a protective covering, thereby impeding its growth and survival. Meanwhile, Betamethasone, a corticosteroid akin to cortisol, a natural hormone produced by the body, diminishes specific chemicals responsible for inflammation (manifested as swelling, redness, and itchiness) in the skin.

Symptoms of fungal infections, such as itching or soreness, typically improve within a few days of initiating treatment. However, red and scaly skin may require a longer duration to resolve. It’s advisable to continue using Clotrimazole for at least 2 weeks, even if symptoms alleviate, to prevent the recurrence of the infection. If symptoms persist beyond seven days, consulting a healthcare professional is recommended for potential adjustments to the treatment regimen, including prolonging the duration or opting for a more potent medication.

Important Safety Information

Side Effects

Common side effects of Clotrimazole / Betamethasone may include:

  • Burning at the application site
  • Itching at the application site
  • Irritation at the application site
  • Dryness at the application site

Mild side effects of Clotrimazole / Betamethasone may include:

  • Stretch marks
  • Skin thinning/discoloration
  • Acne
  • Extreme and unwanted hair growth
  • Small red bumps on the skin (folliculitis)

Serious side effects of Clotrimazole / Betamethasone may include:

  • Skin infections worsening (indicated by increased redness, swelling, or irritation)
  • Symptoms of corticosteroid absorption into the bloodstream (more likely in children, long-term users, or those applying over large areas of the skin), including:
    • Unusual or extreme tiredness
    • Weight loss
    • Headache
    • Increased urination or thrust
    • Swelling of ankles and feet
    • Vision problems
  • Signs of a serious allergic reaction:
    • Rash
    • Severe dizziness
    • Swelling and Itching (especially of the tongue/face/throat)
    • Trouble breathing

If you experience other effects not listed here, contact your doctor or pharmacist. Always discuss the benefits and risks of your medication with your healthcare provider to ensure it’s right for your specific health needs.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


When deciding to use a medicine, it’s important to weigh the risks of taking the medicine against the benefits it will provide. This is a decision you and your doctor will make together. Here are some considerations for this medicine:

  • Allergies: Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medications. Additionally, tell your healthcare professional about any other allergies you may have, such as to foods, dyes, preservatives, or animals. For over-the-counter products, carefully read the label or package ingredients.
  • Pediatric: The use of this topical combination cream is not recommended for children younger than 17 years of age due to the lack of established safety and effectiveness.
  • Geriatric: While studies to date have not identified any geriatric-specific problems that would limit the usefulness of Clotrimazole and betamethasone topical combination in the elderly, caution is advised. Elderly patients may have age-related conditions such as thinning skin or skin ulcers, which may require extra caution when using this medication.

The presence of other medical problems may affect the use of this medicine. It is crucial that you inform your doctor about any other medical issues you have, particularly:

  • Bacterial infections of the skin or Tuberculosis (TB) of the skin: Betamethasone may worsen these conditions.
  • Hyperglycemia (high blood sugar), Herpes, Diabetes, Skin diseases with impaired circulation (example, stasis dermatitis), Cataracts, Intracranial hypertension (increased pressure in the head): Use this medicine with caution as it may exacerbate these conditions.
  • Glaucoma, Varicella (chickenpox), Liver failure: The likelihood of experiencing side effects may increase with these conditions.
  • Cushing’s syndrome (adrenal gland disorder), Infection of the skin at or near the application site, large sores, broken skin, or severe skin injury at the application site, Vaccination (cowpox), and Other virus infections of the skin: Betamethasone may accelerate the spread of viral infections.
  • Diaper dermatitis (diaper rash): The use of this medicine is not recommended for patients with this condition.

Ensure your doctor is aware of all your current health issues to safely manage your treatment with this medication.


  • If there is no improvement in your skin infection within one week for jock itch or ringworm of the body, or within two weeks for athlete’s foot, or if the condition worsens, consult your doctor immediately.
  • Using this medicine excessively or for an extended period may heighten the risk of adrenal gland problems, particularly in children and those who use large amounts over long durations. If you experience any of the following symptoms while using this medicine, contact your doctor immediately: 
    • Blurred vision
    • Dizziness or fainting
    • A fast, pounding, irregular or heartbeat
    • Increased urination or thirst
    • Irritability
    • Unusual tiredness
    • Weakness 
  • Consult your doctor promptly if you develop a skin rash, burning, stinging, swelling, redness, or irritation on the skin.
  • If you notice blurred vision, difficulty reading, or any other changes in vision during or after treatment, see your doctor immediately. You may need to have your eyes examined by an ophthalmologist (eye doctor).
  • Avoid applying cosmetics or other skincare products to the areas treated with this medicine.

To fully clear your skin infection and prevent its recurrence, adhering to these health habits is crucial:

  • For patients using this medicine for athlete’s foot:
      • Dry Feet Thoroughly: After bathing, make sure to carefully dry your feet, especially between the toes.
      • Choose Appropriate Socks: Avoid socks made of wool or synthetic materials like rayon or nylon. Opt for clean, cotton socks instead, changing them daily or more often if your feet tend to sweat a lot.
      • Wear Ventilated Footwear: Choose shoes that are well-ventilated, such as those with holes, or wear sandals to allow your feet to breathe.
      • Use Powders: After applying Clotrimazole and betamethasone combination cream and once it has absorbed into the skin, apply a bland, absorbent powder like talcum powder or an antifungal powder. Apply the powder freely between your toes, on your feet, and in your socks and shoes once or twice a day. Note that while helpful, the powder should not be used as the sole treatment for your fungal infection.
  • For patients using this medicine for jock itch, it’s important to follow these health habits:
      • Dry the Groin Area Thoroughly: After bathing, make sure to carefully dry the groin area to prevent moisture buildup, which can promote fungal growth.
      • Choose Appropriate Underwear: Avoid tight-fitting underwear or those made from synthetic materials like rayon or nylon. Instead, opt for loose-fitting cotton underwear that allows better air circulation and reduces moisture retention.
      • Use Powders: Apply a bland, absorbent powder such as talcum powder or an antifungal powder freely once or twice a day. Make sure to use the powder after the Clotrimazole and betamethasone combination cream has been applied and fully absorbed into the skin. Remember, the powder should not be used as the sole treatment for your fungal infection.
  • For patients using this medicine for ringworm of the body, consider these important health habits:
    • Dry Thoroughly After Bathing: Ensure you dry your body carefully after showering or bathing to prevent excess moisture, which can encourage fungal growth.
    • Minimize Heat and Humidity: If possible, avoid environments that are overly hot and humid. Try to keep moisture from accumulating in the affected areas of your body.
    • Wear Ventilated Clothing: Choose clothing that is well-ventilated to allow air circulation and reduce moisture buildup on your skin.
    • Use Powders: Apply a bland, absorbent powder such as talcum powder or an antifungal powder freely once or twice a day. It is important to apply the powder after the Clotrimazole and betamethasone combination cream has fully absorbed into the skin. Do not rely on the powder as the only treatment for your fungal infection.

If you have any questions or concerns about these guidelines or your treatment, do not hesitate to check with your doctor.


  • It is contraindicated in people who have hypersensitivity to Clotrimazole or Betamethasone.

Missed Dose

  • If you forget to apply a dose of this medicine, do so as soon as you remember. 
  • If it’s nearly time for your next scheduled dose, skip the missed one and resume your regular dosing routine.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


If someone accidentally ingests a large amount of the medication, seek immediate medical assistance or, contact the Poison Help line at 1-800-222-1222 or call 911. Excessive doses or prolonged usage of Betamethasone and Clotrimazole topical may result in:

  • Thinning skin
  • Easy bruising
  • Alterations in body fat distribution (particularly in areas like the neck, back, face, and waist)
  • Heightened acne or facial hair growth
  • Menstrual irregularities
  • Erectile dysfunction
  • Decreased libido.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Keep it from freezing.
  • Ensure it’s out of the reach of children.
  • Discard outdated or no longer needed medicine.
  • Consult your healthcare professional for proper disposal methods of any unused medicine.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Clotrimazole / Betamethasone Interactions

While some medications should never be used together, there are instances where two different drugs may be combined despite a potential interaction. In such cases, your doctor might adjust the dosage or take other necessary precautions. It’s crucial that your healthcare professional is aware of all the medications you are taking when you are prescribed this medicine. The following interactions have been noted due to their potential significance, though this list may not cover all possible interactions.

Using this medicine with any of the following medications is generally not recommended. Your doctor may choose not to prescribe this medication or may alter the medications you are currently taking.

  • Desmopressin

Using this medicine with any of the following medications is generally not recommended but may be necessary in certain situations. If both medicines are prescribed together, your doctor might adjust the dosage or the frequency of use for one or both of the medications to better suit your treatment needs.

  • Aldesleukin
  • Mestranol
  • Macimorelin
  • Darunavir
  • Flumequine
  • Drospirenone
  • Balofloxacin
  • Nadroparin
  • Lomefloxacin
  • Methylergonovine
  • Norgestrel
  • Tacrolimus
  • Dihydroergotamine
  • Ergonovine
  • Bupropion
  • Levofloxacin
  • Enoxacin
  • Gatifloxacin
  • Atazanavir
  • Besifloxacin
  • Lutetium Lu 177 Dotatate
  • Desogestrel
  • Cosyntropin
  • Ethynodiol
  • Moxifloxacin
  • Ciprofloxacin
  • Nirmatrelvir
  • Ergoloid Mesylates
  • Gestodene
  • Norfloxacin
  • Methysergide
  • Estradiol
  • Rufloxacin
  • Ergotamine
  • Norethindrone
  • Cobicistat
  • Nadifloxacin
  • Methylergonovine
  • Sparfloxacin
  • Drospirenone
  • Bemiparin
  • Prulifloxacin
  • Dienogest
  • Nicergoline
  • Pazufloxacin
  • Carbamazepine
  • Gemifloxacin
  • Sargramostim
  • Nomegestrol
  • Fleroxacin
  • Tosufloxacin
  • Lisuride
  • Norgestimate
  • Ritonavir
  • Somatrogon-ghla
  • Ethinyl Estradiol
  • Aspirin
  • Ofloxacin
  • Gatifloxacin

Using this medicine alongside certain other medications may increase the risk of specific side effects. However, in some cases, the combined use of both drugs might be the best approach for your treatment. If both medicines are prescribed together, your doctor may adjust the dosage or modify how frequently you use one or both of the medications.

  • Gallamine
  • Metocurine
  • Phenobarbital
  • Primidone
  • Trimetrexate
  • Licorice
  • Fosphenytoin
  • Rifapentine
  • Alcuronium
  • Hexafluorenium
  • Atracurium
  • Saiboku-To
  • Auranofin
  • Phenytoin
  • Rifampin

Other Interactions: Certain medications should not be taken at or around the time of consuming food or specific types of food, as interactions can occur. Additionally, consuming alcohol or tobacco while on certain medications may also lead to interactions. It’s important to discuss with your healthcare professional how your medication interacts with alcohol, food, or tobacco.

[Note: This isn’t a complete list, and there could be other drugs that interact with Clotrimazole / Betamethasone Dipropionate. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Clotrimazole / Betamethasone Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

Do you rub in Clotrimazole and Betamethasone dipropionate cream?

Yes, when applying Clotrimazole and betamethasone dipropionate cream, you should apply a thin layer to the affected skin area and gently rub it in. Avoid covering the treated area with a bandage or wrapping, and do not wear tight-fitting clothing over it unless your doctor specifically instructs you to do so.

When should I stop using Clotrimazole-betamethasone cream?

The duration of treatment can vary between 1 to 4 weeks, depending on the condition being treated. It’s important to continue using the cream for at least 2 weeks, even if your symptoms disappear, to prevent the infection from returning. If your symptoms do not improve within 7 days of starting treatment, or if they worsen, you should consult your doctor for further advice. This helps ensure that the treatment is effective and that you are addressing the infection adequately.

Can I use betamethasone cream on my private parts?

Betamethasone cream should be used with caution, particularly in sensitive areas. It is important not to apply betamethasone cream directly to the private parts, face, or underarms unless specifically directed by a healthcare provider. Avoid getting the cream in your eyes, nose, mouth, or vagina, as it is intended for external use on the skin only.

Can Clotrimazole and betamethasone cream be used for yeast infection?

This combination can be appropriate in certain cases. The Clotrimazole component is an antifungal that helps in treating yeast infections by killing the yeast, while Betamethasone reduces inflammation and itching. However, it’s crucial not to use a cream that contains only Betamethasone for treating yeast infections, as this will not address the fungal infection and may actually exacerbate it. Always consult a healthcare professional before using this combination to ensure it is suitable for your specific condition and to receive guidance on proper application.

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