Combigan Eye Drop

Combigan Eye Drops are a prescription eye medication that contains Brimonidine Tartrate and Timolol Maleate. It is used to lower high pressure inside the eye (intraocular pressure) in people with ocular hypertension or open-angle glaucoma. Combigan combines two medications in one drop to help control eye pressure when a single medication is not enough.

Below is a quick overview of critical Combigan facts for patients and caregivers:

Combigan Eye Drops are indicated for reducing elevated intraocular pressure (IOP) in patients with:

• Glaucoma
• Ocular hypertension

Combigan is indicated for patients whose intraocular pressure is not adequately controlled with a single ophthalmic medication or who require replacement therapy. By lowering high eye pressure, Combigan helps reduce the risk of:

• Optic nerve damage
• Progressive vision loss associated with glaucoma

Combigan Eye Drops combine two medications that work together to lower elevated intraocular pressure (IOP), a significant risk factor for optic nerve damage and vision loss in glaucoma.

Brimonidine tartrate (alpha-2 adrenergic receptor agonist):

• Primarily reduces aqueous humor production and may also enhance uveoscleral outflow.

Timolol maleate (non-selective beta-adrenergic receptor inhibitor):

• Decreases the amount of fluid created inside the eye

Combined effect:

• Effectively lowers elevated intraocular pressure
• Helps reduce the risk of vision loss and optic nerve damage caused by glaucoma

Onset of action:

• Brimonidine typically reaches peak pressure-lowering effect within about 2 hours.
• Timolol reaches peak effect within 1 to 2 hours.

With regular use, Combigan helps maintain consistent intraocular pressure.

Follow your healthcare provider’s instructions carefully. General steps include:

• Wash your hands before applying the drops
• Tilt your head back and gently pull down the lower eyelid
• Place one drop into the affected eye
• Close your eyes and gently press the inner corner near the nose for about 1 minute
• Wipe away any excess liquid
• Replace the cap tightly after use

Important tips:

• Avoid touching the dropper tip to any surface
• Remove contact lenses before use and wait at least 15 minutes before reinserting
• If using other eye medicines, wait at least 5 minutes between drops

The recommended dosage of Combigan Eye Drops is based on official prescribing information.

Additional instructions:

• Use Combigan at the same time each day for consistent eye pressure control
• If using more than one eye medication, wait at least 5 minutes between products
• Do not use more than directed by your healthcare provider

What Happens If You Take Too Much Combigan Eye Drops?

There have been rare reports of overdose with timolol-containing eye drops causing systemic effects similar to oral beta-blockers. Symptoms of overdose may include:

• Dizziness or headache
• Slow heartbeat (bradycardia)
• Low blood pressure (hypotension)
• Shortness of breath
• Bronchospasm (breathing difficulty)
• Severe cardiovascular effects, including heart block or heart failure (rare)

Brimonidine overdose (especially if swallowed) has been reported mainly in infants and children and may require supportive medical care. If excess medication is applied, wipe away the excess solution, stop use, and seek immediate medical support or contact a poison control center for guidance.

Combigan may cause different side effects depending on the condition being treated. Some effects are common and mild, while others may be serious and require medical attention. Commonly reported Combigan Eye Drops side effects are listed below:

Common Side Effects

The most commonly reported side effects include:

• Eye redness
• Eye itching or irritation
• Burning or stinging sensation after use
• Watery eyes or increased tearing
• Dry eyes
• Blurred vision (temporary)
• Feeling like something is in the eye
• Headache
• Dry mouth

Rare or Serious Side Effects

Although these are less common, some side effects can be severe. Seek immediate medical care if you experience:

• Slow heartbeat or irregular heartbeat
• Shortness of breath or breathing difficulty
• Swelling of the feet, ankles, or hands
• Worsening heart failure symptoms (fatigue, weight gain, swelling)
• Serious allergic reactions (swelling of the throat or face, rash, trouble breathing)
• New or worsening eye pain, redness, or discharge

Some of the medication in Combigan Eye Drops may be absorbed into the bloodstream. Because of this, side effects similar to oral beta-blockers may occur, including serious heart and breathing complications in certain patients.

What Are the Precautions for Combigan Eye Drops?

To ensure effectiveness and safety during treatment, patients should follow these precautions:

• Asthma, emphysema, chronic bronchitis, or other lung diseases
• Heart conditions, including heart failure or a slow heart rate
• Poor blood circulation (such as Raynaud’s phenomenon or vascular insufficiency)
• Diabetes (may mask symptoms of low blood sugar)
• Overactive thyroid (hyperthyroidism)
• Muscle weakness conditions, such as myasthenia gravis
• Depression or a history of severe allergic reactions

What Are the Warnings for Combigan Eye Drops?

This medication may lead to the following serious medical conditions:

• Severe respiratory reactions such as bronchospasm, especially in people with asthma or lung disease
• Heart-related complications, including worsening heart failure or dangerously slow heartbeat
• Increased sensitivity to allergens, with reduced response to emergency allergy treatments like epinephrine
• Worsening muscle weakness, particularly in people with myasthenic disorders
• Eye hypersensitivity reactions, which may include redness or irritation
• Masking of low blood sugar symptoms in patients with diabetes
• Low blood pressure and circulation problems
• Masking of signs of overactive thyroid (such as a fast heart rate)

Seek immediate medical help if any severe symptoms occur.

Pregnancy and Breastfeeding

Pregnancy:

Animal studies have shown risks at high doses; use only if the benefits outweigh the potential risks. There are no adequate, well-controlled studies of Combigan in pregnant women. Combigan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Breastfeeding:

Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue Combigan, taking into account the importance of the drug to the mother. Always consult a healthcare provider before using Combigan during pregnancy or while breastfeeding.

Various medications may increase side effects or affect how Combigan works. Always consult a healthcare provider before combining Combigan with other medicines. Medicines that may interact include:

Yes. Depending on eye pressure levels, treatment response, and medical history, doctors may prescribe alternative glaucoma medications instead of Combigan.

Treatment choice depends on eye pressure levels, medical history, and the individual patient's response. A doctor should determine the most appropriate alternative.

Buying prescription eye medications for glaucoma and high eye pressure from local U.S. pharmacies can be expensive. Ordering Combigan Eye Drops online from Polar Bear Meds helps reduce overall treatment costs while maintaining quality and safety standards.

• Get Combigan Eye Drops at significantly lower prices than many U.S. retail pharmacies.
• All medications are dispensed by licensed, reputable Canadian pharmacies.
• Guaranteed authentic and quality-controlled products.
• Fast and secure shipping across the United States, typically within 3-5 business days via Xpress Post.
• Discreet packaging with order tracking for added assurance.
• Simple online ordering with easy prescription upload.
• Transparent pricing with no hidden fees.
• Additional savings are available with the coupon code WELCOMEPB10, which provides 10% off your first order.
• Dedicated customer support team to assist with prescriptions, orders, and delivery questions.

A valid prescription from a licensed healthcare provider is required to purchase Combigan Eye Drops.

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021398s007lbl.pdf
• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=feaf1480-a4b8-4486-992a-96be3a596243
• https://pmc.ncbi.nlm.nih.gov/articles/PMC3699296/#:~:text=All%20studies%20of%20Combigan%20have,three%20times%20daily%20for%20brimonidine.