Comtan

Buy Comtan Online from Licensed Canadian Pharmacies

Comtan (entacapone) is a prescription medication used in the treatment of Parkinson’s disease. It is not taken on its own but is always combined with levodopa and carbidopa to help extend the effectiveness of the treatment. Many people with Parkinson’s notice that, over time, their symptoms, such as tremor, stiffness, or slowed movement, return before their next scheduled dose of levodopa. This is known as the “wearing-off” effect.

Comtan works by slowing the breakdown of levodopa in your body, which allows it to remain active for longer periods. The result is more consistent symptom control and reduced “off” times during the day. Available as 200 mg tablets in bottles of 100, Comtan is prescribed under medical supervision to support better daily management of Parkinson’s symptoms.

Comtan is used together with levodopa and carbidopa to manage:

• Parkinson’s disease [especially when the effects of levodopa begin to wear off (“end-of-dose wearing-off”)]

Benefits of Comtan

• Helps smooth out fluctuations in motor control by extending the effect of levodopa between doses.
• Reduces “off” time (periods when symptoms return) in Parkinson’s patients.
• May allow a reduction in the dose of levodopa if dyskinesia (involuntary movements) becomes problematic.
• Improves overall “on” time (periods of better mobility and less symptoms).
• Enhances steadier dopaminergic stimulation in the brain (fewer peaks and troughs of levodopa levels).
• It can help reduce symptoms such as tremor, stiffness, slowness of movement, and poor muscle control associated with wearing off.
• Because it inhibits the enzyme (COMT) that breaks down levodopa, it helps levodopa remain effective for longer.

Dosage of Comtan for Parkinson’s Disease

• Adults: One 200 mg tablet each time levodopa/carbidopa is taken, up to 8 times per day.
• Maximum daily dose: 1,600 mg (that is, 200 mg × 8 doses) per day.
• Children: There is no established dosage for children; use must be determined by a physician.

Below are guidelines to help you use Comtan safely and effectively:

• Always take Comtan together with each dose of levodopa/carbidopa; it has no benefit when used on its own.
• Take these tablets with or without food, but if you take with food, it may help reduce nausea.
• Maintain the dosing schedule as prescribed; consistency helps maintain steady medication levels.
• Do not change dose or stop suddenly without medical advice. Abrupt changes may worsen Parkinson’s symptoms.
• Monitor for signs of side effects, especially early in treatment, and inform your healthcare provider of any unusual symptoms.
• Use caution when engaging in tasks needing alertness (driving, operating machinery), because Comtan may cause drowsiness or sudden sleep episodes.
• Stay hydrated, especially if side effects like diarrhea or vomiting occur, to prevent dehydration.

Comtan (entacapone) is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken alongside levodopa and carbidopa, Comtan slows down the breakdown of levodopa in the body, thereby increasing its availability and prolonging its effect. This helps to smooth out the peaks & troughs in levodopa concentrations, reducing periods when Parkinson’s symptoms reappear (“off” time) and improving overall motor function.

Common Comtan side effects may include:

• Nausea, vomiting, or stomach discomfort
• Diarrhea
• Dizziness, drowsiness, or feeling sleepy
• Dry mouth
• Uncontrolled or involuntary movements (dyskinesia)
• Increased sweating

Serious side effects (rare):

• Hallucinations, confusion, or other mental/mood changes
• Very stiff muscles, fever, fast or irregular heartbeat
• Severe or ongoing diarrhea
• Restless muscle movements or worsening of Parkinson’s symptoms
• Muscle pain, weakness, and dark urine (possible sign of serious muscle breakdown)

Note: Contact your primary healthcare provider if you experience any serious symptoms or unusual changes.

Before you begin using Comtan, there are measures to be aware of:

• People with liver impairment should use Comtan with caution, as drug levels may be significantly higher.
• Avoid combining Comtan with non-selective MAO inhibitors (for example, phenelzine, tranylcypromine) due to the risk of catecholamine metabolism interference.
• Monitor for changes in mental status, especially in those with a history of psychiatric illness or psychosis.
• Be alert for impulse control disorders (increased gambling, sexual urges, spending) while taking Comtan together with levodopa/carbidopa.
• Caution must be exercised when driving or operating machinery due to potential drowsiness or sudden sleep episodes.
• Pregnancy and breastfeeding. Safety has not been fully established. Use only if clearly needed & under medical supervision.

To use Comtan safely, you should consider these precautions:

• Inform your doctor of all medical conditions, especially liver disease, low blood pressure, or psychiatric disorders.
• Tell your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements.
• Avoid alcohol or other substances that increase drowsiness.
• Be careful when standing up from sitting or lying down. Orthostatic dizziness can occur.
• Keep regular follow-ups to monitor response and side effects; your doctor may adjust your levodopa dose.
• Use it with caution in senior citizens, as they may be more sensitive to side effects like confusion or drowsiness.

If you miss a dose of Comtan tablet taken with levodopa/carbidopa, take it as soon as you remember. If it is very close to the time for your next dose, skip the missed one—do not double up. Always resume your regular dosing schedule.

If an overdose is suspected, seek medical attention immediately. Symptoms may include severe drowsiness, agitation, confusion, or other unusual behaviors. Provide full information about all medications taken so that appropriate treatment may be given.

Proper storage helps maintain drug effectiveness and safety:

• Store at room temperature, ideally around 25 °C (77 °F); small fluctuations (15-30 °C) are acceptable.
• Keep away from excess moisture, heat, and direct light.
• Do not store in the bathroom or other humid places.
• Keep the bottle of tablets tightly closed when not in use.
• Keep out of reach of children.

Below are some drugs that may interact with Comtan:

• Sinemet (carbidopa/levodopa)
• Azilect (rasagiline)
• Eldepryl (selegiline)
• Coumadin (warfarin)
• Ciprofloxacin (ciprofloxacin)
• Prozac (fluoxetine)

If Comtan is not suitable, other medications may be considered (with a doctor’s guidance):

• Tasmar (tolcapone)
• Ongentys (opicapone)
• Azilect (rasagiline)
• Eldepryl (selegiline)
• Mirapex (pramipexole)
• Requip (ropinirole)

Why Buy Comtan from Polar Bear Meds?

At Polar Bear Meds, we’re committed to making prescription medications like Comtan more accessible and affordable for patients in the U.S. Our prices are significantly lower than typical U.S. pharmacy retail rates without compromising on safety or quality. Every order is sourced exclusively from licensed and trusted pharmacies and undergoes complete prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all U.S. states, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.

Comtan Cost & Coupons

Get Comtan delivered straight from Canada to your doorstep in the U.S. You can also save more by using the coupon code “WELCOMEPB10” for 10% off on your first order. There are no hidden handling or processing fees, as we believe in complete transparency. Looking to save even more? Join our referral program and earn a $20 credit every time you refer a friend or a family member. Your referral will also receive a $20 credit, so everyone wins. Additionally, after every 10 verified customers' referrals, you'll receive a $100 credit in your account as a thank-you for spreading the word.

AtPolar Bear Meds, your safety is our priority. Every order is dispensed from a fully licensed Canadian pharmacy following strict standards for quality, security, and patient care. To conveniently buy Comtan from Canada at a substantial cost, call us at 1-888-779-2193 toll-free.

The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.