Secukinumab
Cosentyx Pre-Filled Syringe
Cosentyx is classified as a human interleukin-IL-17A antagonist. This FDA-approved prefilled syringe is used to treat moderate to severe plaque psoriasis. Suitable for adult patients, the medication provides relief to people requiring systemic therapy or phototherapy. While the recommended dosage of Cosentyx prefilled syringe is 300 mg subcutaneous injection at weeks 0, 1, 2, 3, and 4 every four weeks, 150 mg of these injections are also acceptable in some patients. However, even the best medications have their side effects. Patients using these prefilled syringes are prone to developing various infections. Therefore, it is essential to use this medication under the guidance of a medical professional.
Product Overview
Cosentyx is an immunosuppressant injection that helps the body reduce the effects of chemical substances causing inflammation. The injection contains the active ingredient secukinumab, a monoclonal antibody indicated for treating moderate to severe plaque psoriasis, including raised, silvery flaking of the skin in patients over 6 years old. The medication is also approved by the FDA for ankylosing spondylitis, psoriatic arthritis, active non-radiographic axial spondyloarthritis in adults, and active enthesitis-related arthritis in children aged 4 years or above.
Cosentyx is a prefilled injection available in various strengths, including 150 mg and 300 mg. The drug is injected under the skin of the abdomen, thigh, or upper arm and is suitable for adults or children suffering from psoriasis. The drug reduces the immune system’s inflammatory response by targeting and neutralizing interleukin-17A, a protein involved in inflammatory processes. As a result, it offers relief from the painful symptoms of autoimmune diseases.
While the medication provides various benefits to patients, it can have common side effects that include upper respiratory infections, headache, and injection site reactions. Therefore, it is important to inform your healthcare provider if you have any medical conditions or ongoing medications to avoid drug reactions. In case you have mistakenly missed your dose, take it as soon as possible unless it is close to the time for the next dose. Always follow the guidance of your healthcare provider regarding the use and storage of Cosentyx and promptly report any adverse effects or concerns for appropriate management.
Uses of Cosentyx Pre-Filled Syringe
Prescribed by medical professionals, Cosentyx is used to treat the following conditions:
- Moderate to Severe Plaque Psoriasis: It causes discolored and scaly skin patches. This medication is prescribed to patients who can have systemic therapy.
- Psoriatic Arthritis: A condition that causes both scaly skin patches and painful, swollen joints.
- Active Ankylosing Spondylitis: A form of arthritis that severely affects the spine.
- Non-Radiographic Axial Spondyloarthritis: This condition is similar to active ankylosing spondylitis but can not be seen on X-rays.
- Enthesitis-Related Arthritis: Entheses are areas on bone where ligaments and tendons are attached. This condition affects inflamed entheses.
- Hidradenitis Suppurativa: It causes painful bumps on the skin, which are different in size.
How to Use Cosentyx Pre-Filled Syringe?
Dosage
Strengths and Forms
- Liquid Solution in a Single-Dose Prefilled Syringe Pens: 150 mg/mL and 300 mg/2 mL
- Liquid Solution in a Single-Dose Prefilled Syringes: 75 mg/0.5 mL and 150 mg/mL
- Liquid Solution in a Single-Dose Vial For Intravenous Infusion:125 mg/5 mL
Recommended Dosage for Different Patients
For Psoriatic Arthritis
- For adults suffering from both plaque psoriasis and psoriatic arthritis, 300 mg once a week is recommended, continuing for 5 weeks. After this duration, doctors prescribe a 300 mg dose once every 4 weeks. Doses can vary from 300 mg injections to 150 mg two injections.
- For adults with only active psoriatic arthritis, the doses may differ based on the severity of the condition. The usual dose is 150 mg once a week for 5 weeks, then 150 mg every 4 weeks.
- In certain cases, patients might still notice the symptoms with 150 mg doses, so the doctor may increase it to 300 mg every 4 weeks.
- Children weighing 15 kg to less than 50 kg are advised to take 75 mg.
- Children weighing 50 kg and more are advised to take 150 mg.
For Plaque Psoriasis
- Adults are advised to take 300 mg once per week for 5 weeks. After some time, it will be 300 mg once every 4 weeks.
- The doses are given either as one 300 mg injection or two 150 mg injections.
- Children weighing less than 50 kg are prescribed 75 mg injection once a week for 5 weeks and then once every 4 weeks.
- Children weighing 50 kg and above, it is recommended to take 150 mg.
For Ankylosing Spondylitis
- 150 mg injection once a week for 5 weeks for adults. Then, 150-mg injection every 4 weeks.
- A 150-mg injection every 4 weeks.
- In some cases, you might experience symptoms with your usual dose, so the doctor may increase your dosage to 300 mg every 4 weeks.
For Non-Radiographic Axial Spondyloarthritis
- Adults are advised to take 150 mg once a week for 5 weeks, with a changing dose of 150 mg every 4 weeks.
- Patients can also take 150 mg every 4 weeks without any loading dose.
For Enthesitis-Related Arthritis
- Adults weighing 15 kg and below are recommended to take 75 mg injections.
- Adults with 50 kg and above, it is 150 mg.
- For children weighing 15 kg to less than 50 kg, the dose is 75 mg.
- For children weighing 50 kg and more, it is 150 mg.
[Note: Remember that these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
If it is a subcutaneous injection:
- Subcutaneous Cosentyx injection is self-administered at home and is injected between the skin and muscle.
- Take the injection pen out of your refrigerator and wait 15 to 30 minutes till it reaches room temperature.
- Administer it within 1 hour of taking it out from the refrigerator.
- Do not microwave or place the injection in hot water to warm the medication.
- The solution of your injection should be clear or light yellowish. Call your pharmacist if it looks cloudy or has particles in it.
- Do not shake the dosing pen.
- Inject the medication anywhere on the thighs, outer arm, or abdomen except the navel.
- Avoid using the injection in the same place two times in a row.
- Avoid injecting in the hard, swollen, or red bruised skin.
- Discard the syringe or pen after one use.
- Do not reuse the syringe.
- Follow the instructions provided by your doctor to avoid any complications.
If it is an intravenous injection
- A medical professional administers an intravenous Cosentyx injection.
- Do not try to administer this injection yourself at home.
- Ensure that the healthcare provider is professionally trained.
- Check if the nurse is mixing the solution with sterile saline before giving you the injection.
- Check for any symptoms after taking the injection, as the medication can cause changes in the body, and inform your doctor immediately.
- Get the doses at the scheduled time.
- Follow the instructions provided by your doctor while taking the injection.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Cosentyx Pre-Filled Syringe Work?
Cosentyx is approved to treat plaque psoriasis in adults and children. These conditions can affect any part of your body but commonly occur in the areas near the knees, elbows, and scalp. It has been observed that psoriasis and psoriatic arthritis are caused due to an overactive immune system. This, in turn, causes inflammation in the body and leads to various side effects like redness, fever, and white patches in the mouth. These conditions arise due to a protein in your body named IL-17A, which is responsible for the overactive immune system. To avoid such situations, Cosentyx is used as it restricts or blocks this protein in the body. As a result, the patient is provided with reduced inflammation and symptoms associated with it.
Important Safety Information
Side Effects
Common side effects of Cosentyx prefilled syringe may include:
- Diarrhea
- Common cold
- Bladder pain
- Bloody urine
- Burning sensation in the stomach or chest
- Fever
- Headache
- Indigestion
- Not feeling hungry
- Lower back or side pain
- Vomiting
- Muscle pain
- Tiredness
Mild side effects of Cosentyx prefilled syringe may include:
- Breathing difficulty
- Throat dryness
- Ear congestion
- Voice changes
- Blisters on the lips
- Scaling on the skin
- White patches on the mouth or tongue
Serious side effects of Cosentyx prefilled syringe may include:
- Infections
- Skin reactions
- Allergic reactions
- Inflammatory bowel disease
- Hives
[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]
Warnings
- Infections: As observed in the clinical trials, Cosentyx-treated patients experienced a higher infection rate than placebo-treated subjects. Therefore, people using this medication should be cautious about the infections it may develop.
- Hypersensitivity Reactions: Patients using Cosentyx injections have a high chance of developing anaphylaxis and urticaria. If you notice such a serious allergic reaction in your body, consult your doctor immediately.
- Pre-Treatment Evaluation for Tuberculosis: Check if you have active or latent TB infections before you start Cosentyx treatment. Consider taking anti-TB therapy prior to starting your psoriasis medication. To avoid risks, visit the doctor frequently and closely monitor for signs of active TB during and after treatment.
- Inflammatory Bowel Disease: Using Cosentyx may exacerbate the symptoms of inflammatory bowel disease (IBD). Based on the clinical trials among adults with hidradenitis suppurativa, IBD incidences were higher in those receiving 300 mg of Cosentyx every two weeks compared to those receiving it every four weeks.
- Eczematous Eruptions: Patients receiving these prefilled syringe medications reported severe eczematous eruptions, including atopic dermatitis-like eruptions, dyshidrotic eczema, and erythroderma, with some cases resulting in hospitalizations. Therefore, seek medical assistance before taking any medication.
- Hypersensitivity in Latex-Sensitive People: If you are sensitive to latex, you might need to be cautious while using the Cosentyx sensoready pen and prefilled syringe. These medications have removable caps that contain natural rubber latex, which may cause a hypersensitivity reaction in latex-sensitive people. Talk to your doctor for detailed information.
- Immunizations: Before starting these injections, ensure that all age-appropriate immunizations are up to date according to current guidelines. Cosentyx may affect the body’s response to live vaccines, so avoid using live vaccines in patients undergoing treatment with this medication.
Precautions
- Do not use Cosentyx if you have a severe allergic reaction to any of its ingredients. It may contain some inactive ingredients that can cause adverse effects in certain populations. Tell your doctor beforehand if you have any problems.
- Before initiating your treatment, communicate with your doctor if you are being treated for any infection or have any ongoing infection that does not go away.
- Avoid coming in contact with any patient having TB.
- Contact your healthcare provider right away if you notice symptoms such as excessive sweating, fever, chills, muscle aches, cough, shortness of breath, etc.
- If you are undergoing any surgery or medical procedure, inform your doctor or dentist about the products you use, including prescription and nonprescription drugs and herbal products, to avoid any drug interaction.
- For pregnant women, it is advised to talk with a medical professional to avoid any harm to the fetus.
- If you are using Cosentyx while breastfeeding, consider taking medical guidance as the drugs might pass into breast milk and affect the infant.
- Discuss every risk and benefit before starting your treatment with Cosentyx to avoid any complications in the future.
- Avoid drinking alcohol as it may interact with the ingredients of Cosentyx.
Missed Dose
- If you miss a dose of your Cosentyx injection, take it as soon as you remember.
- For the next dose, talk with your doctor or pharmacist about when to take it.
- To make sure that you don’t skip a dose, try using a medication reminder or download a reminder app.
- Do not take action without consulting your healthcare provider.
[Note: If you have missed a medication dose and are unsure when to take the next one, consult your doctor or pharmacist immediately.]
Overdose
Do not take over the dosage of your Cosentyx medication. Follow the dosage instructions as prescribed by your medical professional. However, in case you have taken too much of the medication, contact your doctor or call 911. In the case of intravenous injection, which is administered by professionals only, there is no risk of overdose, and if it happens, the medical professionals will take the required steps.
[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]
Storage
- Store your Cosentyx prefilled syringe in a refrigerator, within the temperature of 36°F to 46°F (2°C to 8°C).
- Keep the injections in the original container until you use them.
- Do not keep the medication in the direct sunlight.
- You can keep the injections at room temperature of up to 86°F (30°C) for a brief period of 4 days.
- Throw the injections if it has been kept outside of the refrigerator for more than 4 days.
- Keep it from freezing.
- Discard the medication when not in use or if it’s past its expiration date.
- Keep the prefilled injection out of children’s reach.
- Do not keep the injection in moist or damp areas like the bathroom or near the sink.
- Do not flush the injection down the toilet.
- Ask your doctor or read the information leaflet to know how to discard the medication properly.
[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]
Cosentyx Interactions
There are certain drugs that may interact with Cosentyx and cause adverse effects in the patient’s patient’s body. So, if you are taking any medication that may contain the mentioned drugs, consult with your doctor.
- Abatacept
- Adenovirus Vaccine, Live
- Anifrolumab-fnia
- Bacillus of Calmette and Guerin Vaccine, Live
- Baricitinib
- Cholera Vaccine, Live
- Dengue Tetravalent Vaccine, Live
- Ebola Zaire Vaccine, Live
- Influenza Virus Vaccine, Live
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Monkeypox Vaccine, Live Non-Replicating
- Smallpox Vaccine
- Typhoid Vaccine, Live
- Varicella Virus Vaccine, Live
- Yellow Fever Vaccine
- Zoster Vaccine, Live
[Note: This isn’t a complete list, and there could be other drugs that interact with Cosentyx prefilled injections. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Cosentyx Alternatives
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
Can I travel with Cosentyx?
Yes, you can travel with Cosentyx, but keeping it refrigerated or within the specified temperature range is important. To make it easier for people, the brand provides a complete kit full of tools, including an insulated travel kit. All you need to do is sign up to get your travel bag and other resources. Additionally, consult with your medical provider for precise information and to get the necessary documentation for seamless travel.
Can I continue my regular activities while taking Cosentyx?
Most patients can continue their regular activities while on Cosentyx. However, if you experience fatigue or discomfort, it is advisable to listen to your body and avoid tiring activities. Always consult your healthcare provider if you have any concerns about specific activities or exercise routines.
How quickly can I expect to see results with Cosentyx?
While there is no specified duration, one may expect to see the results of Cosentyx in at least 3 weeks. As observed in clinical trials, up to 60% of adults saw at least 20% improvement in 16 weeks. However, the full effect will take place in several months. Individual responses can also vary, so it’s important to follow your healthcare provider’s instructions and continue regular follow-ups to monitor progress.
Are there any lifestyle changes I should consider while on Cosentyx?
While on Cosentyx, maintaining a healthy lifestyle can help manage your condition. This includes a balanced diet, regular exercise, adequate rest, and stress management techniques. Discuss any specific lifestyle changes with your doctor to ensure they align with your treatment plan.
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