Orilissa

Orilissa is a prescription-only medication used to manage the three most common types of endometriosis pain. This includes painful periods, pelvic pain between periods, and pain during sex. It belongs to a class of drugs called gonadotropin‑releasing hormone (GnRH) receptor antagonists. Unlike birth control pills or opioids, Orilissa is specifically designed to target the hormonal activity that fuels endometriosis symptoms.

Here’s a quick snapshot of Orilissa at a glance:

Orilissa is FDA-approved to help manage:

• Moderate to severe pain caused by endometriosis, including daily pelvic pain and painful periods.

Orilissa reduces pain from endometriosis by lowering estrogen levels in the body. It does this by blocking GnRH receptors in the pituitary, thereby reducing signals from the brain that normally trigger estrogen and progesterone production. With less estrogen available, endometriosis tissue becomes less active, helping to relieve pain and related symptoms.

The Orilissa dosing schedule is outlined in the table below for easy reference.

If you’re prescribed Orilissa for endometriosis pain management, your doctor will usually recommend the following administration guidelines:

• Take Orilissa tablets by mouth with a full glass of water.
• Swallow the Orilissa tablet whole and do not crush, chew, or break it.
• Take the medication at the same time each day to keep hormone levels steady.
• You may take Orilissa with or without food. If the medicine upsets your stomach, take this tablet with food.
• Do not take more tablets than prescribed in a single day.
• Continue taking Orilissa unless your healthcare provider tells you to stop.
• Do not use estrogen-containing birth control pills with Orilissa, as they may reduce its effectiveness.

Not everyone experiences side effects, and many are mild or temporary. Orilissa side effects may include:

• Do not share your Orilissa tablets with others, even if they have similar endometriosis symptoms.
• Orilissa can cause bone loss that may worsen with longer use and may not fully recover after stopping.
• You can use effective non-hormonal birth control, such as condoms or spermicide, while taking Orilissa and for 28 days after stopping.
• The medicine can raise liver enzymes and may not be safe for people with severe liver problems.
• Orilissa should not be taken during pregnancy because it can increase the risk of miscarriage.
• Some people may experience mood changes, depression, or suicidal thoughts. This is why mental health should be monitored closely.
• Avoid grapefruit and grapefruit juice while taking Orilissa tablets. They may increase side effects.
• Periods may become irregular or stop while taking Orilissa. Consult with your doctor in that situation.

If you are following the Orilissa dosing schedule and realize you have missed a dose, take it as soon as possible on the same day. If it is already the next day, skip the missed Orilissa tablet and continue with your daily dosing schedule. Do not take extra tablets to make up for a missed Orilissa dose, as this may increase the risk of serious side effects.

An Orilissa (elagolix) overdose can be serious. If you suspect an Orilissa overdose, contact the poison control center or your healthcare provider immediately. Possible Orilissa overdose symptoms may include:

• Severe hot flashes
• Nausea
• Headaches
• Mood changes
• Bone pain

Orilissa (elagolix) is unique because it is the first oral GnRH antagonist approved for endometriosis pain. Other common options include hormonal therapies like Myfembree and norethindrone. Injectable GnRH agonists such as Lupron Depot are also used for treatment.

Orilissa does not require refrigeration. Instead, you need to follow these Orilissa storage guidelines:

• Store Orilissa tablets at 20°C-25°C (68°F-77°F).
• Protect these tablets from moisture and humidity.
• Do not store Orilissa in the bathroom or near the kitchen sink.
• Keep these tablets away from direct sunlight and heat sources.
• Always store this medication out of reach of children and pets.
• Dispose of unused or expired tablets safely, in accordance with pharmacy or local disposal guidelines.

A total of 410 different medications have documented interactions with Orilissa (elagolix). Out of these drug interactions, 59 are classified as major, 334 fall into the moderate category, and 17 are considered minor. It is also linked to 3 specific disease-related interactions. Some Orilissa interactions are:

• Major Orilissa Interactions
  • Capivasertib
  • Troleandomycin
  • Indinavir
  • Hydrocodone
  • Lonafarnib
  • Lumateperone
  • Relugolix
  • Ketoconazole
  • Sunvozertinib
• Minor Orilissa Interactions
  • Fenfluramine
  • Ruxolitinib topical
  • Lidocaine
  • Atazanavir
  • Ziprasidone
  • Cevimeline
  • Prucalopride
  • Indacaterol
  • Fostemsavir
• Moderate Orilissa Interactions
  • Rivaroxaban
  • Lamotrigine
  • Brentuximab
  • Osilodrostat
  • Talazoparib
  • Black cohosh
  • Ixazomib
• Orilissa Disease Interactions
  • Hepatic impairment
  • Osteoporosis
  • Depression/anxiety

Orilissa (elagolix) is one option for managing moderate to severe endometriosis pain, but several alternatives exist. Orilissa alternatives are:

• Myfembree (relugolix, estradiol, and norethindrone acetate)
• Depo‑Provera (medroxyprogesterone acetate)
• Lupron Depot (leuprolide)
• Norethindrone acetate (Aygestin)
• Danazol
• Ibuprofen
• Naproxen

When you buy Orilissa online, it can be financially overwhelming as the cost of this medication is high in the U.S. High Orilissa costs can be difficult for many patients to manage. That’s why so many patients choose to buy Orilissa online from Polar Bear Meds. We help make endometriosis pain management more affordable by offering this medication at up to 80% lower cost than U.S. pharmacies.

We source elagolix (Orilissa) for endometriosis pain from licensed Canadian pharmacies. New customers can save even more by just using our Orilissa coupon code 'WELCOMEPB10' for an additional 10% off. You can expect orders within 3-5 business days via Xpress Post. This makes it easy for you to access Orilissa for endometriosis pain management.

• https://www.orilissa.com/
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210450s000lbl.pdf
• https://my.clevelandclinic.org/health/drugs/21257-elagolix-tablets
• https://www.webmd.com/drugs/orilissa-elagolix
• https://www.drugs.com/drug-interactions/elagolix,orilissa.html