Emtricitabine / Tenofovir Alafenamide

Descovy

Descovy is an FDA-approved prescription medication used both for HIV treatment and as pre-exposure prophylaxis (PrEP) to lower the risk of contracting HIV. This drug, consisting of emtricitabine and tenofovir alafenamide, is available in two tablet strengths and can be taken daily with or without food. It functions by blocking the enzyme essential for HIV replication, thus helping to prevent the virus from proliferating. Common side effects may include headaches, liver damage, and kidney issues. Consistent dosage is crucial to avoid diminished efficacy and the development of drug resistance. So, if you want to buy Descovy online to treat & reduce the risk of HIV, you need to get a prescription from your doctor.

Product Overview

Descovy is a combination of antiretroviral medication made up of emtricitabine and tenofovir alafenamide, used to treat and prevent HIV infections as part of pre-exposure prophylaxis (PrEP). This drug comes in tablet form and is taken orally once a day, with or without food, simplifying adherence to the treatment regimen. It’s crucial for users to consistently follow their dosing schedule to prevent HIV resistance and maintain the drug’s effectiveness.

The medication works by inhibiting reverse transcriptase, an enzyme vital for HIV to replicate and propagate within the body. By blocking this enzyme, Descovy effectively curbs HIV replication, leading to reduced viral loads and increased CD4 cell counts, enhancing immune function. However, potential side effects range from common issues like headaches and gastrointestinal discomfort to more severe conditions such as immune reconstitution syndrome, kidney and liver damage, and lactic acidosis, all requiring close medical supervision.

For individuals using Descovy for PrEP, it is essential to maintain a confirmed HIV-negative status through regular testing. This is critical as using Descovy while HIV-positive, without complementary antiretrovirals, can cause drug resistance. Currently, Descovy is not recommended for PrEP in cisgender women due to insufficient data on its effectiveness in preventing HIV via vaginal intercourse. Additionally, interactions with other medications, such as certain seizure drugs and antibiotics, may affect Descovy’s effectiveness, necessitating adjustments to treatment plans. Patients should discuss their complete medical history, including kidney and liver health, with their healthcare provider to confirm Descovy’s suitability.

What Is Descovy Medication Used For?

Descovy has received approval from the Food and Drug Administration (FDA) for the following uses:

• Treating HIV
• Reducing the risk of HIV as part of pre-exposure prophylaxis (PrEP)

What Strength Does Descovy Come In?

Descovy comes as a tablet that is taken by mouth. It’s available in two strengths:

• 200 milligrams (mg) of emtricitabine per 25 mg of tenofovir alafenamide
• 120 milligrams (mg) of emtricitabine per 15 mg of tenofovir alafenamide

What Is the Typical Dosage of Descovy?

The dosage of Descovy for HIV management and PrEP, depends on several factors, including your medical condition and how severe it is. Your doctor will typically start you on a specific dose and may adjust it as needed based on how you respond to the medication. It’s important to remember that the dosage mentioned here is just a general guideline. If your doctor has prescribed a different dose for you, it’s crucial not to change it without first consulting them. Always follow your healthcare provider’s instructions to ensure the best possible outcome for your treatment.

Dosage for HIV Treatment

The standard dosage for treating HIV is one tablet of 200 mg emtricitabine/25 mg tenofovir alafenamide taken daily. This dosage is suitable for adults and children who weigh at least 35 kilograms (kg), approximately 77 pounds (lb). Descovy should be used in conjunction with other HIV medications for effective treatment.

Dosage for PrEP

Descovy for pre-exposure prophylaxis (PrEP), the recommended dosage is also a 200 mg emtricitabine/25 mg tenofovir alafenamide tablet taken once daily. This applies to adults and adolescents who weigh at least 35 kg (about 77 lb). Descovy is utilized alone for PrEP.

Pediatric Dosage for HIV Treatment

The recommended pediatric dosage for HIV treatment varies based on the child’s body weight:

• For children weighing more than 14 kg to less than 25 kg (approximately 31 lb to less than 55 lb), the dosage is one 120-mg emtricitabine/15-mg tenofovir alafenamide tablet per day.
• For children weighing more than 25 kg to less than 35 kg (approximately 55 lb to 77 lb), the dosage is one 200-mg emtricitabine per 25-mg tenofovir alafenamide tablet per day.

For these pediatric doses, it’s important to note that other medications taken in combination with Descovy should not include protease inhibitors that require co-administration with other drugs.

[Note: These recommendations mentioned above can vary from person to person. Discuss it with your doctor or pharmacist, and they will customize your Descovy dosage accordingly.]

How Do You Take Descovy?

Always take Descovy exactly as your doctor or healthcare provider has instructed. Don’t change the dose or how you take it without talking to your doctor first. Here’s how to take Descovy properly:

• Consume Descovy once daily, ideally at the same time every day, to maintain constant drug levels in your body.
• If you are using Descovy for HIV pre-exposure prophylaxis (PrEP), it is crucial to take it daily. Do not skip doses or only take them when perceived exposure to HIV occurs.
• To ensure you do not forget to take your medication, consider setting a daily reminder on your phone. Additionally, using a medication timer can help keep you on schedule.
• Descovy can be taken with or without food so that you can use it easily in your daily routine regardless of meal times.
• Do not crush, split, or chew Descovy tablets unless advised by a healthcare provider. If you experience difficulty swallowing the tablets, consult your pharmacist or doctor for alternatives or solutions.
• Descovy is generally prescribed as a long-term treatment option. If it is deemed safe and effective for you, you will likely be advised to continue taking it over an extended period. Always discuss any concerns, queries, or side effects with your doctor to ensure it remains the best treatment option for you.

[Note: Your doctor or healthcare giver will decide the right amount of Descovy for you based on your condition, following guidelines & studies on the drug. They’ll adjust it as needed over time.]

How Does Descovy Work in the Body?

Descovy contains two active ingredients that are classified as nucleoside reverse transcriptase inhibitors (NRTIs). These components inhibit HIV replication by blocking a specific enzyme necessary for the virus to replicate its genetic material. This blockade prevents the virus from multiplying, reducing HIV levels and allowing CD4 cell counts to rise. This enhances your immune system’s ability to ward off infections. When used for HIV pre-exposure prophylaxis (PrEP), Descovy acts quickly to thwart the virus’s initial attack on your immune system, beginning to work within hours of ingestion. For PrEP, it is recommended to continue taking Descovy for at least 7 days to achieve optimal preventive effects. If Descovy is being used to treat HIV, it may take several weeks or months before there is a significant decrease in HIV levels and a return to normal CD4 cell counts.

What Are the Important Safety Information for Using Descovy?

What Are the Side Effects of Descovy?

Common Descovy Side Effects: While taking Descovy for HIV management, you may experience some common side effects. These are usually mild and temporary, lasting anywhere from a few days to a couple of weeks. However, if they persist, become bothersome, or feel more intense, it’s important to reach out to your doctor or pharmacist to ensure your safety and well-being. Common side effects of Descovy may include:

• Abdominal Pain: You might feel discomfort or pain in your stomach area. This is generally not serious, but if it gets worse or lasts too long, speak with your healthcare provider.
• Nausea: Feeling sick to your stomach is a common side effect. If it leads to vomiting or doesn’t go away, let your doctor know.
• Diarrhea: Some people experience loose or frequent stools. If this continues or becomes severe, it’s a good idea to consult with your healthcare professional.
• Headache: A headache may occur as your body adjusts to the medication. If your headache is persistent or severe, consider speaking with your doctor for advice on how to manage it.
• Fatigue: You may feel more tired than usual while on this medication. If you feel unusually exhausted for an extended period, it’s important to mention it to your healthcare provider.

Adverse/Serious Descovy Side Effects: While Descovy can be very effective, it may also cause some serious side effects. If you experience any of these, it’s important to talk to your doctor right away. In some cases, these side effects could be life-threatening, so if you feel like you’re having a medical emergency, call your local emergency number or 911 immediately. Serious side effects of Descovy may include:

• Immune Reconstitution Syndrome: This is a condition where your immune system starts reacting to infections more strongly. Symptoms include:
  • Fatigue (feeling very tired)
  • Fever (feeling hot and having a high temperature)
  • Weakness (feeling very weak)
• Kidney Damage: If you notice any signs of kidney problems, contact your doctor immediately. Symptoms can include:
  • Fatigue (feeling unusually tired)
  • Nausea (feeling sick to your stomach)
  • Vomiting (throwing up)
  • Weakness (lack of strength)
  • Urinating Less Than Usual (peeing less than normal)
• Liver Damage: Serious liver problems can happen. Symptoms include:
  • Abdominal Pain (pain in your stomach area)
  • Vomiting (throwing up)
  • Dark-Colored Urine (your pee may be a dark brown color)
  • Nausea (feeling sick to your stomach)
  • Loss of Appetite (not feeling hungry)
  • Jaundice (your skin or eyes may turn yellow)
• Lactic Acidosis: This is when there’s too much lactic acid in your body, and it can be serious. Symptoms can include:
  • Dizziness (feeling lightheaded or faint)
  • Trouble Breathing (difficulty getting enough air)
  • Fruity-Smelling Breath (your breath may smell sweet or fruity)
  • Fatigue (feeling very tired)
  • Nausea (feeling sick)
  • Vomiting (throwing up)
  • Muscle Pain (aches and soreness in your muscles)
  • Rapid or Unusual Heartbeat (your heart may race or feel irregular)
  • Hands or Feet That Feel Cold and Look Blue (your extremities may feel numb or change color)
• Decreased Bone Density: Over time, this medication may cause bones to become weaker, increasing the risk of fractures. This condition is called osteoporosis, where bones are more likely to break or fracture easily.
• Risk of Resistance to Descovy Treatment: This means that your body may stop responding to the medication, which could make it less effective.
• Risk of Worsening of Hepatitis B: If you have hepatitis B, Descovy could make your symptoms worse, so it’s very important to inform your doctor if you have this condition.
• Allergic Reactions: You might have an allergic reaction to Descovy. This can include symptoms like skin rashes, swelling, or trouble breathing. If you notice any signs of an allergic reaction, seek medical help immediately.

[Note: This list might not cover all possible side effects of Descovy. Always talk to your doctor or pharmacist for medical advice about this medication’s side effects.]

What Is the Black Box Warning for Descovy?

Descovy comes with significant FDA Boxed Warnings, the highest level of alert issued by the Food and Drug Administration. These warnings highlight the potential severe side effects associated with the medication and are intended to inform both healthcare providers & patients about the risks that may require careful consideration.

• Risk of worsening of hepatitis B: One of the primary concerns outlined in these warnings is the risk of severe exacerbation of hepatitis B. This risk has been observed in individuals who are infected with the HBV (hepatitis B virus) and have discontinued treatment with emtricitabine, tenofovir disoproxil fumarate, or medications containing both. The same complications may arise with the use of Descovy. Therefore, if you are diagnosed with hepatitis B, it is crucial that your healthcare provider closely monitors your liver function for an extended period after you cease taking Descovy, or any other related drugs. This monitoring helps to detect any worsening conditions early, and if necessary, initiate appropriate treatment for hepatitis B.
• Risk of resistance to Descovy treatment: Another significant risk associated with Descovy involves the development of drug resistance, particularly when used for pre-exposure prophylaxis (PrEP) to prevent HIV. Descovy for pre-exposure prophylaxis (PrEP) should only be administered in individuals who are confirmed to be HIV-negative. Using Descovy for PrEP in HIV-positive individuals can lead to the development of resistance, where HIV becomes less responsive or entirely unresponsive to the effects of Descovy. This resistance diminishes the drug’s effectiveness and compromises its utility in treating or preventing HIV. To manage this risk, healthcare providers are advised to perform HIV testing before starting Descovy and to continue testing every three months throughout the treatment period. If HIV is detected, an alternative treatment strategy will be recommended to manage your health effectively.

What Precautions Should Be Taken While Using Descovy?

Before you buy Descovy online or start taking it, have a detailed discussion with your doctor regarding your medical history. Certain health conditions and factors may make Descovy an inappropriate choice for your treatment. Here’s what you need to consider:

• Kidney Health: Descovy for HIV management has been linked to the development of new kidney issues or the exacerbation of existing kidney problems in some individuals. If you have any history of kidney disease, it’s essential to share this with your healthcare provider. Your doctor will assess your kidney function to determine whether Descovy for long-term HIV management is a safe option for you, considering its potential impact on renal health.
• Liver Health: The active components in Descovy have been associated with serious liver complications in some cases, which have been fatal for some individuals. If you have any liver conditions, including hepatitis B (as highlighted in the FDA warning), you should inform your doctor. It’s important for your healthcare provider to evaluate your liver function and consider any potential risks before prescribing Descovy. This step ensures that the treatment does not further jeopardize your liver health.
• Alcohol Consumption: While there are no known interactions between Descovy and alcohol, guidelines for individuals with HIV or those at risk for HIV suggest moderation in alcohol consumption. For women, this is defined as no more than one drink per day, and for men, no more than two drinks per day. Moderate drinking is recommended because it is believed to reduce the chances of engaging in risky behaviors, like unprotected sex, which enhances the risk of transmitting or contracting HIV. Moreover, limiting alcohol intake is beneficial for maintaining an effective immune response. Keeping HIV at low levels in your blood is easier when your immune system is not compromised by excessive alcohol consumption.
• Pregnancy: The safety of Descovy during pregnancy remains unclear. While animal studies haven’t shown any adverse effects on the fetus when the active ingredients of Descovy are administered, these results cannot be directly extrapolated to humans due to physiological differences. To gather more comprehensive data on the effects of Descovy and other antiretroviral drugs during pregnancy, the Antiretroviral Pregnancy Registry was established. This registry collects and analyzes information from pregnant women who have used antiretrovirals, aiming to assist healthcare professionals in assessing the safety of these medications during pregnancy. Participation in this registry can help build a clearer understanding of Descovy’s safety profile for pregnant users.  
• Breastfeeding: If you are HIV-positive, it is recommended not to breastfeed while taking Descovy for HIV management. One of the active drugs in Descovy, emtricitabine, is known to pass into human breast milk. There is uncertainty about whether the other active ingredient, tenofovir alafenamide, also transfers into breast milk. The primary concern with breastfeeding while on Descovy is the potential for side effects in the infant and the possibility of developing resistance to HIV treatments—where the virus becomes insensitive to the drugs. This could compromise the child’s ability to receive effective treatment for HIV in the future. Centers for Disease Control & Prevention advises individuals with HIV in the United States to refrain from breastfeeding to prevent the transmission of the virus to the infant. This guidance aims to decrease the risk of HIV infection among newborns and is based on current public health recommendations.

What If I Miss a Dose of Descovy?

• If you miss a dose of Descovy, take it as soon as you remember.
• If you’re taking Descovy for HIV treatment, missing doses could lead to the virus becoming resistant to the medication. This means the virus might become harder to treat, making Descovy less effective.
• For those using Descovy for HIV prevention (PrEP), missing doses increases the risk of getting HIV, as the protection it offers weakens if you don’t take it regularly.
• To help remember, you can set reminders on your phone or use a medication timer. These simple steps can help you stay on track and keep Descovy working effectively.

[Note: If you have missed a dose of Descovy and are unsure about when to take the next dose, immediately consult your doctor or pharmacist.]

What to Do If You Take Too Much Descovy?

It is important not to exceed the dosage of Descovy for HIV management recommended by your doctor. If you suspect that you may have taken more than the prescribed amount of Descovy, immediately contact your doctor for guidance. However, if you experience severe symptoms as a result of the overdose, do not hesitate to call 911 or go to the nearest emergency room to ensure you receive prompt medical attention.

[Note: If you consumed more than the dose of Descovy as your doctor recommended, get medical help quickly or call the Poison Help line at 1-800-222-1222.]

How Do You Store Descovy?

Properly storing Descovy is essential to keep the medication safe and effective. If you decide to buy Descovy online, it’s important to follow these simple storage guidelines to ensure the medication works as intended:

• Store Descovy tablets at room temperature, ideally between 68°F-77°F (20°C-25°C). Ensure they are kept in a tightly sealed container to maintain their integrity and effectiveness.
• Do not store Descovy in locations prone to moisture, such as bathrooms. Exposure to damp conditions can compromise the quality of the medication.
• Safely dispose of any unused Descovy tablets if you no longer require the medication. Proper disposal is crucial to prevent accidental ingestion by children, pets, or anyone for whom the medication was not prescribed. 
• Responsible disposal of this medication helps protect the environment from potential harm caused by pharmaceuticals.

[Note: Discuss with your doctor about the proper disposal of any unused medicine & any questions you may have regarding its storage.]

What Drugs Should Not Be Taken with Descovy?

Descovy for pre-exposure prophylaxis (PrEP) or HIV management can interact with various other medications, which can impact how well the drug works or cause unwanted side effects. Some medications may reduce the effectiveness of Descovy, while others might increase the risk of side effects, including potential kidney damage. It’s very important to discuss all the medications, vitamins, or supplements you’re taking with your healthcare provider to make sure your treatment is safe and effective.

• Descovy and Seizure Medications: Some medications used to treat seizures, known as anticonvulsants, can lower the amount of Descovy’s active ingredient, tenofovir alafenamide, in your bloodstream. This reduces how well Descovy works to treat HIV. Common seizure medications that can cause this interaction include:
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • Oxcarbazepine (Trileptal)
  • Phenobarbital
  • Phenytoin (Dilantin, Phenytek)
• Descovy and Certain Antibiotics: Certain antibiotics can lower the effectiveness of Descovy for HIV management by decreasing the amount of tenofovir alafenamide in your blood. This can make Descovy less effective in treating HIV. Some antibiotics known to cause this interaction are:
  • Rifabutin (Mycobutin)
  • Rifampin (Rimactane)
  • Rifapentine (Priftin)
• Descovy and Certain Antivirals: Some antiviral medications, used to treat other infections, can raise the levels of Descovy in your body, which can lead to kidney problems. This happens because these antivirals can slow down your kidneys’ ability to get rid of Descovy. Medications that may cause this include:
  • Gentamicin (Gentak)
  • Valacyclovir (Valtrex)
  • Valganciclovir (Valcyte)
  • Acyclovir (Zovirax)
  • Ganciclovir (Zirgan)
• Descovy and Tipranavir + Ritonavir: Taking Descovy for long-term HIV management along with tipranavir (Aptivus) and ritonavir (Norvir) can reduce the amount of tenofovir alafenamide in your body. This reduces the effectiveness of Descovy. Because of this interaction, it’s not recommended to take Descovy with both of these medications at the same time.

Are There Any Other Alternatives to Descovy?

While Descovy for long-term HIV management is an effective medication, other factors beyond just the drug itself can affect how well it works in your body. These include certain foods, drinks, herbal remedies, and your overall lifestyle choices. It’s important to be aware of these factors because they can either increase or decrease the effectiveness of the medication, or even cause unwanted side effects.

Here’s how some common factors may impact your treatment with Descovy:

• Foods and Beverages: Certain foods and drinks can interact with medications, potentially affecting how they work. For example:
  • Alcohol: Drinking alcohol in excess may interfere with how well Descovy works and could increase the risk of side effects, especially liver problems.
  • High-fat meals: Eating meals that are very high in fat may affect how your body absorbs the medication, potentially reducing its effectiveness.
  • Grapefruit: Grapefruit or grapefruit juice can interfere with certain medications by changing how they are processed in your body, though this isn’t a specific concern for Descovy, it’s something to keep in mind with other drugs.
• Herbal Remedies: Some herbal supplements may interfere with the effectiveness of Descovy:
  • St. John’s Wort: This herbal supplement, often used for mood support, can reduce the effectiveness of some HIV medications, including those in the Descovy class, by speeding up how quickly your body breaks down the drug.
• Lifestyle Choices: Your lifestyle and overall health play a role in how well your body responds to medication:
  • Extreme exercise that causes dehydration can affect kidney function, which is important to monitor while on Descovy.
  • Smoking tobacco or using recreational drugs can affect how medications are metabolized in your body, potentially reducing their effectiveness.
• Other Medications: You may be taking other drugs, whether prescription or over-the-counter, can interact with Descovy:
  • Certain antibiotics and antifungals
  • Medications for heart conditions
  • Over-the-counter medications

[Note: This isn’t a complete list, & there could be other drugs that interact with Descovy. Make sure to tell your doctor or pharmacist about any prescription, over-the-counter medicines, & herbal products you’re taking.]

What Are the Alternatives to Descovy?

If you’re using Descovy, it may not be the right choice for everyone, or it might not give you the results you’re hoping for. As a result, many people are looking for alternatives to Descovy. There are several well-known substitutes available that might work better for your needs.

If you’re thinking about switching from Descovy, it’s important to consult with your doctor. Based on your age, health, and specific medical needs, they can recommend the best treatment option for you. Some common alternatives to Descovy include:

• Genvoya (tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat)
• Juluca (dolutegravir/rilpivirine)
• Evotaz (atazanavir/cobicistat)
• Stribild (tenofovir disoproxil fumarate/elvitegravir/emtricitabine/cobicistat)
• Epzicom (abacavir/lamivudine)
• Symfi (efavirenz/lamivudine/tenofovir disoproxil fumarate)
• Truvada (tenofovir disoproxil fumarate/emtricitabine)
• Isentress (raltegravir)
• Biktarvy (bictegravir/tenofovir alafenamide/emtricitabine)
• Cabenuva (cabotegravir/rilpivirine)
• Tivicay (dolutegravir)
• Triumeq (dolutegravir/abacavir/lamivudine)
• Symtuza (tenofovir alafenamide/darunavir/emtricitabine/cobicistat)

[Note: Your doctor will choose what is best for you. Don’t use any of these alternative medications of Descovy without consulting your healthcare provider or doctor. Self-medicating may lead to serious side effects.]

Descovy Coupons & Cost

Descovy, a vital medication for HIV prevention, can be expensive in the U.S., with monthly costs often reaching hundreds or even thousands of dollars without insurance. However, you can significantly lower your out-of-pocket expenses by choosing to buy Descovy online from Canada through Polar Bear Meds. Our platform offers affordable Descovy for daily HIV care at a fraction of the cost you’d find locally, making it easier for you to access this crucial medication affordably. Plus, with our Descovy coupon code WELCOMEPB10, you can enjoy an extra 10% off your first purchase. By joining our referral program, you can save even more, potentially cutting your costs by up to $200.

Frequently Asked Questions

Can you drink alcohol with Descovy?

There is no known interaction between Descovy and alcohol. However, it’s always a good idea to check with your doctor. They can provide advice on how much alcohol, if any, is safe for you to consume while taking Descovy.

How quickly does Descovy work?

When you take Descovy as prescribed, it can be up to 99% effective in preventing HIV. To get the full protection, you need to take it every day for at least 7 days. Before that, it’s not clear how well the medication works in preventing HIV.

Is Descovy better for your kidneys?

Descovy works just as effectively as another medication called Truvada for HIV prevention, but with a lower risk of affecting your kidneys. However, Descovy can still cause kidney problems, including kidney failure. Your doctor will check your kidney health with blood and urine tests before you start taking Descovy and during treatment.

Should I eat before taking Descovy?

You can take Descovy with or without food, so there’s no need to worry about eating beforehand. Just make sure to take one pill every day, and do so consistently for the best results.

When is the best time of day to take Descovy?

You can take Descovy at any time of day that works for you. To help remember, it’s best to take it at the same time each day. If you forget to take your dose, take it as soon as you remember — but only on the same day. Never take two doses to make up for a missed one.

If I am using Descovy tablets for PrEP, what else can I do to get protected against HIV?

When you use Descovy for PrEP (HIV prevention), it’s important to take the tablet every day, as skipping doses can increase your risk of contracting HIV. To further protect yourself, always use condoms during sexual activities. Condoms provide an extra layer of defense against HIV and other sexually transmitted infections. To ensure that the condom stays intact and works well, use water-based or silicone-based lubricants. These lubricants are safe to use with condoms and can help prevent them from breaking or slipping during use.

Does Descovy cure HIV?

No, Descovy does not cure HIV. Currently, there is no cure for HIV. However, Descovy can help reduce the amount of HIV in your blood to undetectable levels, meaning the virus is not detectable with standard tests. It’s important to understand that even when HIV is undetectable, it hasn’t been completely eradicated from the body. 

Can Descovy tablets be used for PrEP by cisgender women?

Descovy is not currently approved by the FDA for use as PrEP in cisgender women, who are women assigned female at birth. This is because Descovy has not been tested specifically in clinical trials for its effectiveness in preventing HIV in cisgender women, especially for those at risk of exposure through vaginal intercourse. As a result, it is unclear whether Descovy can provide effective HIV prevention for cisgender women.

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