Desvenlafaxine Succinate

Desvenlafaxine Succinate

Desvenlafaxine Succinate is an oral medication used primarily to treat major depression. It belongs to the class of antidepressants known as serotonin-norepinephrine reuptake inhibitors (SNRIs). Available in extended-release tablets of 25 mg, 50 mg, and 100 mg, it helps maintain mental balance by increasing levels of serotonin and norepinephrine in the brain. Special dosage considerations are necessary for various age groups and those with kidney, liver, or heart conditions. Always consult a healthcare provider for personalized advice, safe usage, and how to safely buy Desvenlafaxine Succinate online for depression treatment.

Product Overview

Desvenlafaxine Succinate is a prescription medication in the form of an oral extended-release tablet, specifically designed to combat major depressive disorder. As a serotonin-norepinephrine reuptake inhibitor (SNRI), it works by preventing the breakdown of brain chemicals serotonin and norepinephrine, which are crucial for maintaining mental equilibrium. 

This drug is available in various strengths—25 mg, 50 mg, and 100 mg. The typical adult dosage starts at 50 mg daily, potentially increasing up to 400 mg based on medical advice and patient response. It is not recommended for children under 18 and requires careful consideration in older adults due to reduced kidney function which can affect drug processing and increase side effects.

Users must adhere to their prescription guidelines, avoiding any alterations like crushing or chewing the tablet. It’s crucial to discuss all potential drug interactions and side effects with a healthcare provider, especially the risks of serotonin syndrome, increased blood pressure, and withdrawal symptoms.

What Is Desvenlafaxine Used For?

• It is used to treat major depression.

What Strengths Do Desvenlafaxine Tablets Come In?

This medication comes in an oral extended-release tablet and is available in these three strengths:

• Desvenlafaxine 25 mg tablet
• Desvenlafaxine 50 mg tablet
• Desvenlafaxine 100 mg tablet

What Is the Typical Dosage of Desvenlafaxine Succinate?

Desvenlafaxine succinate dosage varies based on your specific health condition, its severity, and the particular form of the medication prescribed by your doctor. Below is the typical dosage of desvenlafaxine:

Dosage of Desvenlafaxine Succinate for Depression

• Adult Dosage (ages 18 to 64 years)

• • • Starting Dosage: Typically, 50 mg once per day.
    • Maintenance Dosage: Generally, the dose remains 50 mg once per day.
    • Maximum Dosage: Depending on your response and tolerance, your doctor might increase the dose to up to 400 mg per day.

• Child Dosage (ages 0 to 17 years): Desvenlafaxine is not approved for children under 18 years as its safety and effectiveness have not been established in this age group.

• Senior Dosage (ages 65 years and older)

• • Older adults may process drugs more slowly due to reduced kidney function, leading to prolonged drug presence in the body and increased risk of side effects.
  • Your doctor might start you on a reduced dose or alter your dosing schedule to prevent excessive drug build-up in your system.

Dosage Adjustments for Special Conditions

• Kidney Disease: The dosage may vary depending on your kidney function. Possible prescribed dosages are 50 mg daily, 25 mg daily, or 50 mg every other day.
• Liver Disease: If you have liver disease, your doctor might limit your dosage to 100 mg per day at most, starting with a standard dose of 50 mg per day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Do You Use Desvenlafaxine Succinate?

Using Desvenlafaxine Succinate, commonly known as Pristiq, involves a few simple guidelines to ensure its effectiveness. Here’s how you can properly use this medication:

• You should swallow the Desvenlafaxine tablet whole. Avoid crushing, splitting, or chewing it, as the tablet needs to stay intact to work properly.
• If swallowing tablets is challenging for you, there are ways to make it easier. Look for articles that offer tips on swallowing pills, or talk to your doctor or pharmacist about other available options that might work better for you.
• You can take Desvenlafaxine with or without food, so you can easily incorporate it into your daily routine.
• Try to take your medication at the same time each day. This consistency helps maintain a stable amount of the medication in your body, which is crucial for its effectiveness.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Desvenlafaxine Succinate Work?

Desvenlafaxine is a type of medication known as an antidepressant, specifically classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). Medications in this class work in a similar manner and are commonly used to treat similar mental health conditions.

Serotonin and norepinephrine are important chemicals in the brain that help regulate mood and emotional well-being. Desvenlafaxine helps by blocking the process that normally removes these chemicals from the brain, known as reuptake. By preventing this reuptake, desvenlafaxine increases the levels of serotonin and norepinephrine in the brain, which can help improve the symptoms of depression.

What Are the Important Safety Information for Desvenlafaxine?

What Are the Side Effects of Desvenlafaxine Succinate?

Desvenlafaxine Succinate, like any medication, can have side effects. Some are common and might go away as your body adjusts to the medicine, while others are more serious and need immediate medical attention. Here are the side effects of desvenlafaxine succinate:

Common Side Effects of Desvenlafaxine Succinate

These side effects usually last only a few days to a few weeks. If they continue, become bothersome, or intensify, it’s important to talk to your doctor or pharmacist. Common side effects may include:

• Nausea: Feeling sick to your stomach.
• Dry Mouth: A parched or sticky feeling in your mouth.
• Constipation: Difficulty in having a bowel movement.
• Vomiting: Throwing up.
• Tiredness: Feeling unusually fatigued or sleepy.
• Feeling Jittery: A sensation of nervousness or restlessness.
• Decreased Appetite: Not feeling hungry.
• Dizziness: Feeling unsteady or lightheaded.
• Trouble Sleeping: Difficulty falling or staying asleep.
• Blurry Vision: Not seeing clearly.
• Decreased Sex Drive: Reduced interest in sexual activity.
• Problems with Sexual Function: Difficulties with sexual performance or satisfaction.

Serious Side Effects of Desvenlafaxine Succinate

These side effects are rare but serious. If you notice any of these, contact your doctor immediately. Call 911 or your local emergency number if the side effects seem life-threatening or if you think you’re having a medical emergency:

• Serotonin Syndrome: This is a potentially life-threatening condition that can occur with drugs like Desvenlafaxine Succinate. Symptoms may include:
  • Agitation: Feeling excessively restless or troubled.
  • Hallucinations: Seeing or hearing things that aren’t there.
  • Seizures: Sudden disturbances in electrical activity in the brain, causing convulsions.
  • Nausea: Severe stomach discomfort that can accompany vomiting.
• Low Salt Levels (Hyponatremia): This occurs when there is not enough sodium in your blood. Symptoms can include:
  • Headache: Persistent or severe head pain.
  • Confusion: Difficulty in thinking clearly or concentrating.
  • Weakness: A decrease in muscle strength or energy.
  • Seizures: As described above.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Using Desvenlafaxine?

Understanding the warnings associated with Desvenlafaxine is crucial for using it safely and effectively. Here’s what you should be aware of before taking Desvenlafaxine:

• Increased Blood Pressure Warning: This medication may raise your blood pressure. Monitor your blood pressure after starting Desvenlafaxine, and call your doctor if you notice any significant changes.
• Serotonin Syndrome Warning: Desvenlafaxine can cause a serious condition known as serotonin syndrome, particularly when taken with other medications that affect serotonin levels. This condition happens when serotonin, a natural chemical in your brain, reaches dangerously high levels. Symptoms include agitation, hallucinations (seeing or hearing things that aren’t there), seizures, and nausea. If you experience any of these symptoms, contact your doctor immediately.
• Allergy Warning: Desvenlafaxine can cause severe allergic reactions. Symptoms of an allergic reaction include difficulty breathing and swelling of the throat or tongue. If you experience these symptoms, seek emergency medical help immediately by calling 911 or going to the nearest emergency room. If you’ve had an allergic reaction to Desvenlafaxine before, do not take it again as this could be life-threatening.
• Bleeding Risk Warning: Desvenlafaxine can affect how your body processes serotonin, which may increase your risk of bleeding. This is something to be mindful of, especially if you are prone to bleeding or are taking other medications that can increase bleeding risk.
• Withdrawal Symptoms Warning: If you suddenly stop taking Desvenlafaxine, you might experience withdrawal symptoms. These can include dizziness, headaches, sweating, stomach upset, or feeling irritable. To avoid these symptoms, do not stop taking Desvenlafaxine without first consulting your doctor. If you experience these symptoms after stopping the medication, contact your doctor.

What Is the Black Box Warning on Desvenlafaxine?

Desvenlafaxine has a “black box warning,” which is the strongest warning issued by the Food and Drug Administration (FDA). This warning is to alert doctors and patients about potential dangerous effects of the medication.

• Increased Risk of Suicidal Thoughts and Behaviors: Desvenlafaxine may increase the risk of suicidal thoughts and behaviors, particularly during the first four weeks of treatment or when the dose is changed. This risk is more significant in young people under the age of 24. If you start to have thoughts of harming yourself, it’s crucial to contact your doctor immediately.
• Use in Children: Desvenlafaxine has not been proven safe or effective for children under 18 years old. If it’s considered for use in children, the potential benefits must be carefully weighed against the risks.

What Precautions Should You Take While Taking Desvenlafaxine?

Desvenlafaxine comes with several important precautions:

• For People with High Blood Pressure: This medication can raise your blood pressure. If you already have high blood pressure, you should discuss this with your doctor. You might need treatment for high blood pressure or need to monitor your blood pressure regularly while taking this drug.
• For People with Glaucoma: Desvenlafaxine may dilate your pupils, which could trigger a glaucoma attack. If you have glaucoma, make sure to talk to your doctor about whether this medication is safe for you.
• For People with Seizure Disorders: This medication may cause seizures. If you have a history of seizures, inform your doctor before starting Desvenlafaxine.
• For People with Low Salt Levels: Desvenlafaxine can lower your salt levels. This risk is greater if your salt levels are already low, which can be the case for seniors, people taking diuretics, or those who are dehydrated. Discuss with your doctor whether this medication is safe for you.
• For People with Kidney Problems: This drug is eliminated from your body by the kidneys. If your kidneys aren’t functioning well, Desvenlafaxine may not clear from your body as quickly, potentially leading to increased side effects. Your doctor may prescribe a lower dose to help manage this.
• For People with Liver Problems: Desvenlafaxine is processed by your liver. If your liver isn’t working well, it may not process the drug effectively, leading to increased side effects. A lower dose may be necessary to prevent this.
• For Pregnant Women: There isn’t enough data about the safety of Desvenlafaxine during pregnancy. The risks of untreated depression during pregnancy must also be considered. If you’re pregnant or planning to become pregnant, discuss with your doctor whether the potential benefits of taking this drug outweigh the risks. If you become pregnant while taking Desvenlafaxine, inform your doctor immediately.
• For Women Who Are Breastfeeding: Desvenlafaxine may pass into breast milk and could cause side effects in a breastfeeding infant. Talk to your doctor if you are breastfeeding. You might have to choose between discontinuing breastfeeding or stopping the medication.
• For Seniors: Older adults may process drugs more slowly. A higher amount of Desvenlafaxine might stay in your body for a longer time, increasing the risk of side effects. If you are over 65, your doctor might start you on a lower dose to reduce the risk of side effects.
• For Children: Desvenlafaxine is not recommended for children under 18 years as it has not been studied in this age group.

What If You Miss a Dose of Desvenlafaxine Succinate?

It’s important to take your medication as prescribed to keep the right amount in your body for it to be effective. If you miss a dose of Desvenlafaxine, take it as soon as you remember. However, if it’s almost time for your next dose, just take the one dose and skip the one you missed. Do not take two doses at once to catch up; this can cause dangerous side effects.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Desvenlafaxine?

Taking too much Desvenlafaxine can lead to overdose, which is serious and dangerous. Symptoms of an overdose might include:

• Agitation: Feeling unusually restless or anxious.
• Hallucinations: Seeing or hearing things that aren’t real.
• Seizures: Episodes of abnormal electrical activity in the brain, which can cause convulsions.
• Nausea: Feeling sick to your stomach, potentially with vomiting.

If you think you’ve taken too much Desvenlafaxine, contact your doctor or the local poison control center immediately. If your symptoms feel severe, call 911 or go to the nearest emergency room right away.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How to Store Desvenlafaxine Succinate?

To ensure that Desvenlafaxine Succinate remains effective and safe to use, it’s important to store it correctly. Here’s how to do it:

• Temperature Conditions: Keep the medication at room temperature, ideally between 68°F and 77°F (20°C and 25°C). This range helps maintain the drug’s integrity.
• Protect from Light: Store Desvenlafaxine away from light. Light can degrade some medications, reducing their effectiveness.
• Avoid Moisture: Do not store this medication in moist or damp areas, such as bathrooms. Moisture can also affect the medication’s effectiveness.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Desvenlafaxine Succinate?

Desvenlafaxine oral tablets can interact with other medications, vitamins, or herbs you might be taking. An interaction occurs when another substance affects how a medication works, which can be harmful or prevent the drug from working properly.

To avoid interactions, your doctor should manage all your medications carefully. Always tell your doctor about all the medications, vitamins, or herbs you’re taking. If you want to know how Desvenlafaxine might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications That Should Not Be Used with Desvenlafaxine

Monoamine Oxidase Inhibitors (MAOIs): Do not use Desvenlafaxine with MAOIs, a type of antidepressant like phenelzine, tranylcypromine, selegiline, or isocarboxazid. These can raise your risk of serotonin syndrome, a serious condition caused by high levels of serotonin. Stop taking any MAOIs at least 14 days before starting Desvenlafaxine, or wait at least 7 days after stopping Desvenlafaxine to start MAOIs.

Interactions That Increase Risk of Side Effects

• Increased side effects from other medications: Taking Desvenlafaxine with certain medications may increase side effects from those drugs. Increased side effects can involve higher serotonin levels, potentially leading to serotonin syndrome, with symptoms like agitation, hallucinations, seizures, or nausea. Medication includes:
  • Other antidepressants such as SSRIs (like citalopram, fluoxetine, paroxetine), other SNRIs (like duloxetine, venlafaxine), and tricyclic antidepressants (like amitriptyline, imipramine).
  • Serotonergic drugs like triptans, fentanyl, tramadol, buspirone, lithium, tryptophan, amphetamines, and St. John’s wort.
• Drugs like desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, or tolterodine: These may require a dosage adjustment if your Desvenlafaxine dose is 400 mg daily due to increased side effects.
• Diuretics (water pills) like hydrochlorothiazide or furosemide: These can cause low salt levels, and if levels get too low, your doctor may switch you off Desvenlafaxine to another antidepressant.
• NSAIDs, aspirin, and anticoagulants like warfarin and others: These can increase your risk of bleeding when taken with Desvenlafaxine.

What Are the Other Desvenlafaxine Succinate Interactions?

Always discuss potential interactions with your doctor to ensure you use Desvenlafaxine safely and effectively. Below are some of the interactions of desvenlafaxine with foods, beverages, herbs, supplements, vitamins, vaccines and lab tests:

• Alcohol: Avoid drinking alcohol as it can increase side effects of Desvenlafaxine. Talk with your doctor about alcohol use.
• Herbs and supplements: Inform your doctor about any supplements, herbs, or vitamins you take to avoid interactions. Herbs that increase serotonin levels, like tryptophan, 5-HTP, St. John’s wort, and garcinia cambogia, can increase your risk of serotonin syndrome when taken with Desvenlafaxine.
• Vitamins: While there are no specific reports of vitamins interacting with Desvenlafaxine, new interactions might be recognized in the future.
• Food: There are no known food interactions with Desvenlafaxine, but talk to your doctor about any dietary concerns.
• Vaccines: No known interactions exist between Desvenlafaxine and vaccines, but your doctor or pharmacist can review your medications to confirm this.
• Lab tests: Desvenlafaxine might cause false positives in urine drug tests for drugs like phencyclidine (PCP) or amphetamines. If you need a drug test, inform your doctor so they can use specific tests that won’t show false positives.

[Note: This isn’t a complete list, and there could be other drugs that interact with Desvenlafaxine Succinate. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Desvenlafaxine Succinate Alternatives?

Medications, sometimes, may not work for you and for that reason doctor may suggest some alternatives to desvenlafaxine for treating major depressive disorder, including:

• SSRIs:

• • • Prozac (fluoxetine)
    • Celexa (citalopram)
    • Zoloft (sertraline)

• Other SNRIs:

• • • Pristiq (desvenlafaxine succinate)
    • Cymbalta (duloxetine)
    • Fetzima (levomilnacipran)
    • Effexor XR (venlafaxine)
    • Tricyclic Antidepressants
    • Doxepin 
    • Amitriptyline
    • Trimipramine Maleate

• MAOIs:

• • • Phenelzine
    • Selegiline

• Atypical Antidepressants:

• • Wellbutrin SR (bupropion)
  • Forfivo XL (bupropion)
  • Remeron (mirtazapine)
  • Viibryd (vilazodone)
  • Trintellix (vortioxetine)

Some Natural Alternatives to Desvenlafaxine

• Testing for allergies, nutritional deficiencies, & heavy metals
• Cleansing neurotoxic accumulations
• Sauna
• Chelating nutrients
• Nebulized glutathione
• Colon hydrotherapy

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternatives without consulting your doctor. Taking them by yourself may cause serious side effects.]

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Desvenlafaxine, prescribed for major depressive disorder, can be quite expensive in the U.S., sometimes costing a substantial amount each month without insurance. To help reduce this expense, you can get desvenlafaxine succinate from Canada through Polar Bear Meds, where it’s offered at significantly lower prices. To buy desvenlafaxine succinate online with coupon code “WELCOMEPB10” to enjoy an additional 10% off your first purchase. Also, consider joining our referral program to potentially save up to $200 on your medication expenses.

Frequently Asked Questions

Do you gain weight on desvenlafaxine?

Generally, desvenlafaxine does not lead to significant weight changes. Whether you’re taking it for a short time or over the long term, most people do not experience noticeable weight gain or loss.

Is desvenlafaxine a strong antidepressant?

Yes, desvenlafaxine is an effective antidepressant, especially at doses between 50 mg and 100 mg daily. It’s well-tolerated by most people and considered safe within these dosage limits. Interestingly, although it wasn’t initially intended for treating chronic pain, some people find it beneficial for this use as well.

Is it better to take desvenlafaxine in the morning or at night?

Desvenlafaxine can be taken either in the morning or at night. The key is to take it consistently at the same time every day to maintain its effectiveness throughout your treatment.

Is 50 mg of desvenlafaxine a lot?

The 50 mg dose of desvenlafaxine is actually both the starting and the therapeutic dose. It’s the recommended amount to begin treatment and to continue it effectively. This dosage works well for most people and should be taken daily, consistently, with or without food.

What happens if you just stop taking desvenlafaxine?

Stopping desvenlafaxine abruptly can lead to problems. If you discontinue it too quickly, you might face withdrawal symptoms, including dizziness, shaking, confusion, a tingling sensation, and headaches. It’s important to follow your doctor’s guidance carefully when it comes to tapering off this medication.

Is desvenlafaxine safe long term?

Desvenlafaxine can be safe for long-term use if you follow your healthcare provider’s directions. However, all medications can pose risks if not used correctly. Abruptly stopping desvenlafaxine can result in withdrawal symptoms, so sticking to your prescribed treatment plan and consulting your doctor if you consider discontinuing is crucial.

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