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Diclofenac SR is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve inflammation, pain, and stiffness in adults. It is commonly prescribed for conditions such as rheumatoid arthritis, osteoarthritis, and other musculoskeletal or joint-related disorders.
Diclofenac SR (sustained-release) tablets, also known as extended-release (XR), are formulated to release the medication gradually over time. This controlled release allows the drug to stay active in the body longer, providing sustained pain relief and enabling convenient once-daily dosing.
Like other NSAIDs, Diclofenac SR should be used under medical supervision to ensure appropriate treatment. Diclofenac SR is commonly available in 75 mg and 100 mg strengths; however, our pharmacy currently provides only the 75 mg extended-release tablets.
| Category | Details |
|---|---|
| Generic Name | Diclofenac sodium (sustained‑release) |
| Brand Names (U.S.) | Voltaren SR |
| FDA Approval | First approved in the U.S. in 1988, sustained-release tablets were approved later |
| Drug Class | Nonsteroidal anti‑inflammatory drug (NSAID) |
| Indications | Relief of symptoms and signs of ankylosing spondylitis, rheumatoid arthritis, and osteoarthritis; management of pain |
| Age Limitations | Approved for adults; safety and efficacy not established in children under 18 years |
| Dosage Form | Extended‑release tablets |
| Strength | 75 mg, 100 mg |
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Diclofenac SR 75 mg is FDA‑approved for use in adults for relief of symptoms and signs of:
Diclofenac SR (sustained release) blocks cyclooxygenase (COX) enzymes, including COX-1 and COX-2. This action reduces the production of prostaglandins, the chemicals responsible for pain, inflammation, and swelling. The SR formulation releases the drug gradually over time, providing longer-lasting relief. This helps reduce symptoms such as arthritis-related pain, swelling, and stiffness, supporting improved daily function.
Diclofenac SR Warning: Risk of Heart and Stomach Problems
Diclofenac SR carries an FDA boxed warning due to an increased risk of serious cardiovascular events, including heart attack/stroke, which can be fatal. It also increases the risk of serious gastrointestinal bleeding, ulcers, and perforation, which may occur without warning. Diclofenac SR should not be used before or after heart bypass surgery (CABG), and the risk is higher in older adults and patients with a history of stomach problems.
Before you buy Diclofenac SR safely from Canada, ensure you follow these administration guidelines properly:
| Condition | Typical Starting Dose | Maintenance Dose |
|---|---|---|
| Osteoarthritis | 100 mg orally once daily | 100 mg once daily |
| Rheumatoid Arthritis | 100 mg orally once daily | 100 mg once daily (adjust if needed) |
| Ankylosing Spondylitis | 100 mg orally once daily | 100 mg once daily |
| General Pain Management (Off‑label) | 75-100 mg orally once daily | 75-100 mg once daily |
| Elderly Patients | 75 mg orally once daily | 75 mg once daily (under medical supervision) |
| Renal/Liver Impairment (Off‑label) | Lower dose as advised | Adjusted dose with monitoring |
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The Diclofenac SR side effects may vary from mild to serious. Some are common and expected, while others are rare but require medical attention.
| Common Side Effects | Mild Side Effects | Rare or Serious Side Effects |
|---|---|---|
| Nausea | Gas (flatulence) | Gastrointestinal bleeding |
| Diarrhea | Bloating | Stomach or intestinal ulcer |
| Constipation | Rash | Perforation of the GI tract |
| Headache | Itching | Severe allergic reactions (anaphylaxis) |
| Dizziness | Mild fatigue | Liver damage (hepatitis, jaundice) |
| Abdominal pain | Heartburn (acid reflux) | Kidney problems |
| Elevated liver enzymes | Fluid retention/edema | |
| High blood pressure | ||
| Heart attack or stroke |
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Diclofenac SR may interact with the following medications:
If Diclofenac SR is not suitable, other options may be considered under medical supervision:
Diclofenac and Diclofenac SR are both forms of the same medicine, but they differ in how quickly they work, how long their effects last, and how they are dosed. The table below highlights the main differences between Diclofenac and Diclofenac SR to help choose the right option for your needs:
| Feature | Diclofenac (Immediate‑Release) | Diclofenac SR (Sustained‑Release) |
|---|---|---|
| Formulation | Standard immediate‑release tablets | Sustained‑release (extended‑release) tablets |
| Onset of Action | Works quickly after intake | Slower onset, but longer duration |
| Duration of Effect | Short duration; requires multiple doses per day | Long duration; usually once daily dosing |
| Dosing Frequency | 2-3 times daily | 1 time daily (sometimes 2 if needed) |
| Use Cases | Short‑term pain relief, acute conditions | Chronic conditions like arthritis need continuous control |
| Advantages | Fast relief of pain | Convenient dosing, steady pain control |
| Disadvantages | More frequent dosing, higher risk of stomach irritation | Slower onset, but risk of long‑term side effects if not monitored |
| Examples | Diclofenac 25 mg, 50 mg tablets | Diclofenac SR 75 mg, 100 mg tablets |
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Many patients choose to order Diclofenac SR online safely through Polar Bear Meds at Canadian pharmacy pricing, which may be up to 80-90% lower than prices at many U.S. retail pharmacies. Actual savings may vary depending on the prescribed strength, ordered quantity, and product availability. Polar Bear Meds offers several programs that may help patients manage prescription medication costs while providing a reliable ordering experience:
The information provided about Diclofenac SR is intended for general informational purposes only and should not be considered medical advice, diagnosis, or treatment. Diclofenac SR is a prescription medication and must be used only under the supervision of a qualified healthcare professional. Individual responses, dosing requirements, and side effects may vary based on medical history, existing conditions, and other medications. Do not start, stop, or change the dose of Diclofenac SR without consulting your doctor.
Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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