Edarbi

Patients widely use Edarbi to treat hypertension. Approved by the FDA, this medication is safe and effective for adults. This drug is an angiotensin receptor blocker (ARB) that prevents blood vessels from contracting. This process reduces blood pressure and enhances the body’s blood flow. However, for dosage guidance, patients need to contact their healthcare provider as the dosage is based on the severity of the condition and the patient’s body needs. Your practitioner may prescribe other medicines with Edarbi to effectively manage your blood pressure levels. Therefore, patients are advised not to start or discontinue this treatment in the absence of medical guidance.

Edarbi is a prescription medication indicated for the treatment of high blood pressure (hypertension). It contains azilsartan medoxomil, an angiotensin II receptor blocker (ARB) that relaxes blood vessels, allowing blood to flow more smoothly. Edarbi is FDA-approved and effective in reducing the risk of events like heart attack, stroke, and kidney problems by maintaining healthy blood pressure levels.

This medication is available in tablet form, with strengths of 40 mg and 80 mg. It is typically taken once daily, with or without food. It is suitable for adults who require blood pressure management. Its active ingredient, Azilsartan medoxomil, works by blocking the action of angiotensin II, a natural substance in the body that tightens blood vessels. By preventing this action, the medication helps lower blood pressure and improve overall cardiovascular health.

Common side effects of Edarbi include dizziness, fatigue, and diarrhea. It’s important to take the drug as prescribed and not to miss doses. If a dose is missed, take it as soon as remembered unless it’s almost time for the next dose. In case of an Edarbi overdose, get immediate medical attention. Patients should notify their medical provider of any existing medical conditions, especially kidney or liver issues, and all other medications they are taking to avoid potential interactions. For storage purposes, it is generally advised to keep your medicines at a specified temperature, away from moisture and heat, and keep them out of children’s reach. Always follow the healthcare provider’s instructions and attend regular check-ups to monitor blood pressure and overall health while on Edarbi.

Below are some of the uses of Edarbi:

• Treatment of Hypertension: This medication is primarily used to reduce high blood pressure in patients. 
• Prevention of Cardiovascular Events: Lowered blood pressure minimizes the risk of heart problems like stroke and heart attacks. 
• Combination Therapy: Edarbi can be used with other anti-hypertensive agents to manage high blood pressure effectively.

Dosage

Strengths and Forms

Edarbi is available in an oral tablet form that comes in the strength of:

• 40 mg, and
• 80 mg

Recommended Dosage for Different Patients

• For Adults: The recommended daily dose of Edarbi is 40 mg, which can be taken orally once a day. Doctors may increase the dosage to a maximum of 80 mg once a day when the blood pressure is not controlled and requires additional reduction.
• For Older Adults: No dose adjustment is needed for elderly patients. Patients aged ≥75 years have reported abnormally high creatinine values. No other differences in safety and efficacy were observed between older adults and younger patients. However, caution should be practiced in patients aged ≥75 due to the risk of hypotension.
• For Hepatic Impaired Patients: The medication is not well-studied in patients with severe hepatic impairments, so it is not recommended for this group. However, a lower dose with caution is advised in mild to moderate hepatic-impaired patients. Moreover, a maximum of 80 mg dose is recommended for patients with liver diseases. Do not exceed the maximum dose for these patients.
• For Renal Impaired Patients: Caution is necessary for severe renal impairment and ESRD patients (end-stage renal disease). Furthermore, no dose adjustment is required for mild or moderate renal impairment.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• Before jumping to the general steps, make sure that you are following the instructions on your prescription label.
• Read the patient’s information leaflet provided by your doctor or pharmacist.
• Do not alter the dosages without consulting your medical provider.
• Take the medicine by mouth with or without food as instructed by your healthcare professional.
• Try to swallow the tablets as a whole with a full glass of water.
• In case you are unable to swallow them, seek expert advice.
• Do not crush, break, or chew your tablets.
• Take your medicines at the same time each day.
• Closely monitor your blood pressure and kidney function.
• If you are noticing symptoms like nausea, vomiting, or excessive sweating after taking the medicine, call your doctor, as it can cause dehydration.
• Keep using the medicine as long as it is prescribed, even if you do not feel unwell.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Edarbi is an anti-hypertensive drug containing azilsartan medoxomil. This active ingredient belongs to the angiotensin-receptor blocking (ARB) drug class. Angiotensin II is a naturally occurring substance that is a strong vasoconstrictor, constricting blood vessels and thus increasing blood pressure. When a patient takes a dose of Edarbi 40 mg, the drug starts working by blocking the effects of these natural substances and allowing blood vessels to relax. All these processes lead to reduced blood pressure. This improved blood flow helps lower the chances of cardiovascular issues like stroke, heart attack, and kidney problems, contributing to overall cardiovascular health.

Common side effects of Edarbi may include:

• Diarrhea
• Dizziness
• Headache
• Cough
• Sweating
• Increased blood creatine phosphokinase
• Muscle spasms

Serious side effects of Edarbi may include:

• Low blood pressure (Hypotension). Its symptoms include:
  • Dizziness
  • Fainting
  • Confusion
  • Weakness or tiredness
• Kidney Damage. Its symptoms may include:
  • Lack of urination
  • Swelling in ankles, legs, or feet
  • Weakness
  • Chest pain
  • Difficulty while breathing
  • Seizures
• Allergies. Its symptoms may include:
  • Wheezing
  • Fast heartbeats
  • Fever
  • Swollen lymph nodes
  • Swelling on the face, lips, tongue, throat, or mouth
  • Throat tightness
  • Itching
  • Skin rash
  • Red bumps on skin (hives)
  • Stomach pain
  • Joint pain

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

• Hypotension in Volume- or Salt-Depleted Patients: Those with an active renin-angiotensin-aldosterone–system (RAAS) may experience low blood pressure levels at the beginning of the treatment with Edarbi. Patients should either correct the condition before taking this medication or start the treatment under careful medical supervision. Moreover, if you have heart or cerebrovascular disease, closely monitor your health as your blood pressure can drastically drop, leading to heart attack or stroke.
• Valvular Stenosis: Patients with aortic stenosis may be at an increased risk of lowered coronary perfusion (blood flow to the heart) because they do not develop as much resistance.
• Dual Blockage of the Renin-Angiotensin System (RAS): Studies have reported adverse effects on patients co-administering ARBs like Edarbi with aliskiren. This combination increases the risks of hypotension, stroke, hyperkalemia, syncope, impaired renal function, and renal failure, especially in patients with diabetes mellitus and moderate to severe renal impairment. Furthermore, mixing ARBs with other RAS-blocking agents is also not recommended. Consult with your doctor before making any decision.
• Hepatic/Biliary/Pancreatic: Edarbi has not been studied in patients with severe hepatic impairment, so its use is not recommended in these patients. Patients having mild or moderate hepatic impairment should use a lower starting dose, not exceeding a maximum dose of 80 mg. Moreover, patients having liver diseases, especially biliary obstructive disorders, should exercise caution as most azilsartan is eliminated in the bile.
• Angioedema: A case of angioedema caused by the use of Edarbi was also reported. If you are experiencing angioedema of the face, lips, and tongue, discontinue using your medications and seek medical assistance. 

Boxed Warning

FDA issues black box warnings to medications that can cause adverse reactions to specific populations. The authority warns patients and healthcare providers against the use of these medications, and Edarbi has also received boxed warnings. According to the FDA, using this medication during pregnancy can harm the developing child as it contains angiotensin receptor blockers. It can even cause injury, leading to the death of the fetus. Therefore, doctors usually do not recommend Edarbi when pregnancy is detected.

• Before starting your treatment with Edarbi, tell your healthcare provider about any allergies, as overlooking this part can cause adverse reactions.
• Notify your doctor beforehand about your medical history, especially heart issues, kidney problems, persistent vomiting or diarrhea, and electrolyte imbalance.
• If you are going through any medical procedure or surgery, remember to inform your healthcare professional/dentist about the products you use, including prescription drugs, nonprescription drugs, and herbal products.
• Do not use this medication until your doctor has prescribed it to you.
• Do not alter or stop your treatment unless your practitioner has said so.
• Avoid sharing your medication with others even if they have the same condition, as each individual’s body needs are different.
• Avoid driving or using machinery that demands alertness or coordination, as the medication may have certain side effects that can prove life-threatening.
• Closely monitor your health progress to ensure that the medicines are working properly.
• If your condition is not improving and you are experiencing severe nausea, vomiting, or diarrhea, talk to your doctor, as these conditions may cause dehydration.
• Drink plenty of fluids during the summer.
• Avoid combining medications unless your doctor has prescribed them.

Edarbi is contraindicated in:

• Patients who have hypersensitivity to azilsartan medoxomil or any ingredient of the medication.
• Using this medication with aliskiren-containing drugs in patients with diabetes mellitus or moderate/severe renal impairment.
• Pregnant women
• Breastfeeding women

If you have not taken a dose of Edarbi, you can:

• Take the missed dose whenever you remember.
• If it is time for your next dose, you can skip the missed one and take a new dose according to your regular dosing schedule.
• Remember not to take double doses of Edarbi.
• Use medication apps or set reminders on your phone to avoid missing any doses.
• If you are still unsure or have questions about the missing dose, you can ask your medical provider.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

An overdose of Edarbi may cause adverse reactions to the patients. If you have mistakenly taken an exceeding amount of your maximum daily dose and are experiencing the following symptoms, do not overlook the situation and get immediate medical help or call 911. The symptoms of overdose may include:

• Hypotension (low blood pressure)
• Tachycardia (rapid heartbeats)
• Bradycardia (slow heartbeats)

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

• Keep your medications in a tightly closed container within the temperature range of 15-30°C.
• Avoid keeping the medicines in moisture and light.
• Do not keep them under direct sunlight.
• Do not flush the medications down the toilet.
• Keep the container in a safe place, out of reach, and sight of children and pets.
• Avoid storing the tablets in damp areas like the bathroom or near the sink.
• Read the product’s label for detailed storage instructions.
• Ask your doctor or pharmacist how to dump the product when not in use.
• Discard the medicines when they are past their expiration date.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

• Aspirin
• Hydralazine
• Amlodipine
• Antacid
• Aliskiren
• Amiloride
• Apomorphine
• Benazepril
• Captopril
• Enalapril
• Enalaprilat
• Finerenone
• Fosinopril
• Lisinopril
• Lithium
• Moexipril
• Perindopril
• Potassium bicarbonate
• Potassium chloride
• Potassium citrate
• Potassium gluconate
• Potassium iodide
• Potassium phosphate
• Quinapril
• Ramipril
• Sparsentan
• Spironolactone
• Trandolapril

[Note: This isn’t a complete list, and there could be other drugs that interact with Edarbi. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re you’re taking.]

• Lisinopril
• Amlodipine
• Hydrochlorothiazide
• Metoprolol
• Atenolol
• Carvedilol
• Losartan
• Valsartan
• Olmesartan
• Metoprolol succinate
• Nebivolol
• Lisinopril
• Benazepril
• Enalapril
• Quinapril
• Ramipril
• Nifedipine
• Verapamil

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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