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Azilsartan and chlorthalidone 


Edarbyclor is an FDA-approved medication available on prescriptions provided by medical experts. It contains chlorthalidone, a diuretic and azilsartan medoxomil, an angiotensin receptor blocker. Doctors usually prescribe this medication for treating high blood pressure and preventing the risk of strokes, kidney problems, and heart attacks. While it is suitable for adult usage, the safety and effectiveness of Edarbyclor are unknown in children below 18 years of age. Patients are advised to go according to their prescription label as the dosages of the medication vary from person to person. It is important to note that sharing the medicine with people facing similar conditions without medical guidance is not allowed. This action can lead to harm to the other person.      

Product Overview

Edarbyclor is a prescription medication containing two active ingredients: azilsartan medoxomil and chlorthalidone, which is widely used to manage high blood pressure. Azilsartan medoxomil, an angiotensin II receptor blocker, helps relax blood vessels and reduce blood pressure. Chlorthalidone, a thiazide-like diuretic, reduces excess fluid in the body, further aiding in blood pressure control. Being FDA-approved, the medication offers a complete approach to hypertension management.

Available in tablet form, Edarbyclor comes in strengths of 40/12.5 mg and 40/25 mg. The recommended dosage is one tablet each day, taken with or without food. Suitable for adults, Edarbyclor works by blocking the action of angiotensin II, a substance that tightens blood vessels, and increasing urine output to eliminate excess sodium and fluid, effectively reducing blood pressure.

However, Edarbyclor has certain side effects, including dizziness, fatigue, and gastrointestinal disturbances. It is essential to avoid activities requiring alertness until you know how Edarbyclor affects you. Patients should inform their medical practitioner of any allergies, medical conditions, or other medications they are taking to avoid potential interactions. If a dose is missed, take it as soon as you remember, but skip it if it’s almost time for the next dose. In case of an Edarbyclor’s overdose, seek immediate medical assistance. Store Edarbyclor at room temperature, away from moisture and heat, in its original packaging to maintain efficacy. Regular monitoring by your healthcare professional is advised to ensure optimal treatment outcomes.

Uses of Edarbyclor

It is used for:

  • Treating hypertension (high blood pressure).
  • It may be used in patients whose condition is not managed by monotherapy.
  • Preventing the risk of cardiovascular problems like strokes and heart attacks, along with kidney issues.

How to Use Edarbyclor?


Strengths and Forms

Edarbyclor is available in an oral tablet form with the following strengths:

  • 40 mg/12.5 mg
  • 40 mg/25 mg

Recommended Dosage for Different Patients

For Adults

  • The initial dose of Edarbyclor is 40 mg of azilsartan and 12.5 mg of chlorthalidone once a day. Doctors may gradually increase the dosage to 40mg of azilsartan and 25mg of chlorthalidone after 2 to 4 weeks to maintain blood pressure. 
  • If a patient isn’t well-controlled on azilsartan medoxomil 80 mg, switching to Edarbyclor 40/12.5 mg may reduce 13/6 mm Hg (systolic/diastolic).
  • Similarly, if a patient isn’t well-controlled on chlorthalidone 25 mg, switching to Edarbyclor 40/12.5 mg may lead to an additional reduction of 10/7 mm Hg.

For Children 

  • Edarbyclor is not recommended for children under 18 years of age.

For Renal-Impaired Patients

  • No adjustment is needed for patients with mild/moderate renal impairment (GFR 30 to 90 mL/min/1.73 m2).

For Liver-Impaired Patients 

  • No adjustment is indicated for patients with mild/moderate liver impairment.
  • For patients having severe liver problems, the safety of the medication is still unknown.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Read the patient information leaflet available in your product’s box.
  • Follow the dosage instructions as your doctor has instructed.
  • Take the medication by mouth, with or without food, once a day. 
  • Avoid taking the medicines too close to your bedtime, as you may need to wake up frequently to urinate. Therefore, it is advised to take your medicines at least 4 hours before bedtime.
  • The dosage is based on your condition and body needs, so do not exceed or subceed the doses.
  • Swallow the tablets as a whole with water.
  • Do not break, chew, or crush your tablets.
  • If you are unable to swallow your medicines, ask your medical provider for alternate options.
  • Take these tablets at the same time each day to get the most benefit out of it.
  • Try to complete your course of treatment even if you feel well.
  • If you are taking other drugs like cholestyramine or colestipol to reduce your cholesterol levels, take Edarbyclor at least 2 hours prior or 4 hours post the cholesterol medicines.   
  • If you are not feeling well or do not see any improvements, contact your healthcare provider immediately.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Edarbyclor Work?

Edarbyclor works by combining azilsartan medoxomil and chlorthalidone. Azilsartan medoxomil blocks the action of angiotensin II, a hormone that tightens blood vessels, causing them to relax and widen, which lowers blood pressure. On the other hand, chlorthalidone increases urine output by helping the kidneys eliminate excess sodium and water from the body. This reduction in fluid volume further lowers blood pressure. Together, these actions improve blood flow and reduce the strain on the heart and arteries.

Important Safety Information

Side Effects

Common side effects of Edarbyclor may include:

  • Dizziness
  • Dehydration
  • Weakness
  • Confusion
  • Fatigue
  • Skin rash
  • Diarrhea
  • Nausea
  • Upset stomach
  • Cough
  • Drowsiness
  • Constipation

Serious side effects of Edarbyclor may include:

  • Low blood pressure
  • Electrolyte imbalance
  • Fainting
  • Little or no urination
  • Mood changes
  • Feeling thirsty
  • Not feeling hungry
  • Swelling
  • Weight gain
  • Difficulty in breathing
  • Muscle pain
  • Fast heartbeats
  • Seizures
  • Vision loss or blurred vision
  • Eye pain
  • Tunnel vision
  • Irregular heartbeats
  • Slurred speech
  • Loss of balance
  • High fever
  • Stiffy nose
  • Tremors

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Hypotension in Volume- or Salt-Depleted Patients: Patients with an activated renin-angiotensin system, such as those who are volume- or salt-depleted, may experience symptomatic hypotension at the beginning of treatment with Edarbyclor. These patients are not ideal candidates for initiating therapy with multiple medications. Therefore, it is recommended that the volume be corrected before administering Edarbyclor. If hypotension develops, put the patient in a supine position and, if needed, provide an intravenous infusion of normal saline. 
  • Impaired Renal Function: Patients with severe kidney problems are advised to consult with a professional before starting their medication, as chlorthalidone, one of the active ingredients of Edarbyclor, may lead to azotemia. If you are experiencing symptoms like increased blood urea nitrogen, discontinue the diuretic therapy.   
  • Hypokalemia: It is a dose-dependent side effect that may occur with chlorthalidone, and a combination of this drug with digitalis may worsen the effects of hypokalemia. Talk to an expert before combining any medication.
  • Hyperuricemia: Chlorthalidone can cause hyperuricemia or trigger gout in some patients. Consult with a medical practitioner before making any decisions.

Boxed Warning

The FDA has released a boxed warning against using Edarbyclor during pregnancy. A black box warning is among the most serious warnings of the FDA, and it warns patients and doctors regarding the harmful effects of the medication. Edarbyclor has also received such a warning. It has been advised that pregnant women or those who are planning to become pregnant should avoid using this medication. Using drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy can have serious complications. This may include reduced fetal kidney function and high chances of risks to the fetus and newborn. 

This complication arises due to oligohydramnios (low amniotic fluid), leading to underdeveloped lung and skeletal abnormalities in the fetus. More adverse effects may include low blood pressure, lack of urine production, skull underdevelopment, kidney failure, and even death. Therefore, as soon as patients notice pregnancy, its usage should be stopped. 


  • Make sure to inform the physician about your medical history. This may include liver or kidney disease, dehydration, gout, lupus, and untreated mineral imbalance. 
  • Avoid drinking alcohol or marijuana when taking Edarbyclor, as the drug can make you dizzy. Therefore, it is advised not to drive or use machinery requiring alertness. 
  • If you are experiencing excessive sweating, vomiting or diarrhea, visit your healthcare provider, as these conditions can cause dehydration and make you feel lightheaded. To prevent such situations, drink plenty of fluids.
  • The drug may affect blood sugar levels. So, if you are a diabetic patient taking Edarbyclor, ensure that you check your sugar levels. Discuss your progress report with your medical practitioner.
  • Tell your doctor beforehand if you have allergies or are particularly allergic to the medication’s ingredients. This product may contain certain inactive components that can cause severe allergic reactions in patients.
  • The medication can affect a patient’s potassium levels. So, if you are using any potassium supplements or salt substitutes containing potassium, talk with a medical professional.
  • Edarbyclor may make you more sensitive to the sun. Therefore, it is advised to avoid high exposure to the sun or avoid using tanning booths or sunlamps. When going out during the daytime, wear protective clothing. If you get sunburned or have redness, talk to an expert immediately. 
  • If you are undergoing any surgery or medical procedure, remember to tell your healthcare practitioner about the products you use. This includes all prescription drugs, nonprescription drugs, and herbal products.
  • Older patients are at high risk of side effects of this medication, especially dizziness and kidney problems. For such patients, seeking medical assistance before starting the treatment is recommended. 
  • Lactating women are recommended not to breastfeed their child while taking Edarbyclor as chlorthalidone, one of the drugs of the medication, passes into the breast milk and can harm the baby.


  • Edarbyclor is not recommended for patients with anuria.
  • Edarbyclor is not recommended for use in combination with drugs that contain aliskiren in patients with diabetes.

Missed Dose

If you have missed a dose of Edarbyclor, do not panic and try to take the skipped dose whenever you can. However, if it is time for your new dose, omit the last medicine and continue your regular dosing schedule. Do not take double doses at the same time to catch up for the missed dose, as it can cause harm, which can be life-threatening. If you have a habit of forgetting things, you can use medication apps or set reminders on your phone to avoid missing any dose. Lastly, you can always consult your healthcare provider for any additional queries or concerns.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


An overdose of Edarbyclor can cause serious symptoms. If you are experiencing any unusual things like fainting or difficulty breathing, get medical assistance immediately, or you can take emergency medical services by calling 911.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Keep the medication at a temperature of 25°C with excursions permitted to 15°-30°C.
  • Store the medicines in a tightly sealed container.
  • Protect the tablets from moisture and light. 
  • Do not keep them in damp areas like the bathroom or near the sink.
  • Keep them out of reach and out of sight of children and pets.
  • Do not flush the medicines down the toilet.
  • Discard the product when not in use or past its expiration date.
  • Ask your medical professional or pharmacist how to dispose of the medication properly.
  • Read your product’s label for detailed storage instructions.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Edarbyclor Interactions

Drug interactions may change the effectiveness and functioning of your medications, thus increasing the risk of severe side effects. While this document does not contain all drug interactions with Edarbyclor, it will provide some of the major drug interactions.

  • Alfuzosin
  • Aliskiren
  • Allopurinol
  • Alogliptin
  • Apomorphine
  • Arformoterol
  • Arsenic trioxide
  • Benazepril
  • Cisapride
  • Captopril
  • Dofetilide
  • Dolasetron
  • Dronedarone
  • Droperidol
  • Enalapril
  • Enalaprilat
  • Finerenone
  • Fosinopril
  • Lisinopril
  • Lithium
  • Levomethadyl acetate
  • Moexipril
  • Potassium chloride
  • Potassium citrate
  • Potassium iodide
  • Potassium phosphate
  • Quinapril
  • Ramipril
  • Sparsentan
  • Spironolactone
  • Trandolapril
  • Ziprasidone

[Note: This isn’t a complete list, and there could be other drugs that interact with Edarbyclor. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Edarbyclor Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is Edarbi and Edarbyclor the same?

Edarbi and Edarbyclor are both used to treat high blood pressure, but they differ in terms of composition. Edarbi contains azilsartan medoxomil, an angiotensin II receptor blocker (ARB), while Edarbyclor combines azilsartan medoxomil with chlorthalidone, a diuretic. The combination in Edarbyclor improves blood pressure reduction by combining the effects of both an ARB and a diuretic.

How much time does Edarbyclor take to show its results?

Edarbyclor can start to show its blood pressure-lowering effects within 2 weeks of starting the treatment. However, it may take up to 4 weeks or longer to get the most benefit out of it. Each patient’s response time is different, so it’s important to follow up with your healthcare provider to monitor the progress and make any necessary adjustments.

Can I drink coconut water while taking Edarbyclor?

There is no specific study or interaction that advises against drinking coconut water with Edarbyclor. However, it’s important to be mindful of your potassium levels. Edarbyclor contains chlorthalidone, a diuretic that can affect potassium levels in your body. Coconut water is high in potassium, so consuming it in moderation is advised. Always talk to your doctor to ensure it fits within your dietary and medication plan.

When is the best time to take Edarbyclor?

The best time to take this medication is usually in the morning. This timing helps to avoid frequent nighttime urination due to the diuretic component (chlorthalidone). There is no hard and fast rule to take the medication in the morning; patients can also take their medicine 4 hours before bedtime. Besides, you can always consult with your doctor about the appropriate times. These experts may tailor the timing based on your individual needs and lifestyle. Follow the same timing every day to avoid any complications.

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