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Efavirenz is a prescription-only antiretroviral medication used in combination with other HIV medicines to treat HIV-1 infection in adults and pediatric patients. It is approved to help reduce viral load and improve immune function, but it is not a cure for HIV. Efavirenz must be taken under the supervision of a qualified healthcare provider, with regular monitoring to ensure safety and effectiveness. For patients managing long-term HIV treatment, licensed Canadian pharmacy options may help provide access to prescribed medication at more affordable pricing.
| Category | Details |
|---|---|
| Generic Name | Efavirenz |
| Brand Name | Sustiva |
| Drug Class | Non‑nucleoside reverse transcriptase inhibitor (NNRTI) |
| Status | FDA‑approved |
| Indications | In combination with other antiretroviral agents for the treatment of HIV‑1 infection in adults and pediatric patients ≥3 months old and weighing ≥3.5 kg |
| Formulations | Oral tablets (film‑coated) |
| Strengths | 50 mg, 200 mg, 600 mg |
| Limitations of Use | Must be used in combination with other antiretroviral agents; not recommended as monotherapy |
| Key Warnings | - Risk of serious psychiatric symptoms (severe depression, suicidal ideation, psychosis) - Nervous system symptoms (dizziness, insomnia, impaired concentration) - QTc prolongation - Hepatotoxicity - Risk of severe skin reactions (Stevens‑Johnson syndrome) |
| Precautions | - Use caution in patients with psychiatric illness, seizure disorders, or liver disease - Monitor liver function tests -Avoid use in pregnancy, particularly during the first trimester; use effective contraception. |
| Common Side Effects | Dizziness, insomnia, abnormal dreams, headache, rash, nausea |
| Serious Adverse Reactions | Severe psychiatric events, hepatotoxicity, Stevens‑Johnson syndrome, QTc prolongation |
| Prescription Status | Rx only |
| Storage | Store at 20–25°C (68–77°F); protect from moisture and light |
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Efavirenz Tablets are FDA‑approved for use in combination with other antiretroviral agents for the treatment of HIV‑1 (human immunodeficiency virus type 1) infection in:
Important Safety Information: Serious Psychiatric Adverse Reactions
Serious psychiatric symptoms, including depression, suicidal thoughts, and psychosis-like behavior, have been reported in patients taking Efavirenz. Close monitoring is recommended, especially in patients with a history of mental health conditions.
Efavirenz should not be used in:
Efavirenz (Sustiva) requires careful monitoring due to the following important safety considerations:
Regular follow-up with a provider is essential to ensure safe and effective treatment.
While taking Efavirenz:
Efavirenz must be taken exactly as prescribed as part of combination HIV therapy.
Efavirenz is prescribed as part of combination antiretroviral therapy for HIV‑1 infection. Efavirenz dosing must be individualized based on patient age, weight, and liver function, and taken exactly as directed by a provider.
| Patient Group | Administration Notes | |
|---|---|---|
| Adults and pediatric patients ≥40 kg | 600 mg once a day | Take Efavirenz tablets on an empty stomach, preferably at bedtime, to lower CNS side effects |
| Patients with hepatic impairment | Not recommended in moderate or severe impairment | Use caution in mild hepatic impairment; monitor liver function closely |
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| Weight Range | Efavirenz Recommended Dose |
|---|---|
| 3–<4 kg | 100 mg once daily |
| 4–<5 kg | 150 mg once daily |
| 5–<6 kg | 200 mg once daily |
| 6–<7 kg | 250 mg once daily |
| 7–9 kg | 300 mg once daily |
| 9–12 kg | 350 mg once daily |
| 12–15 kg | 400 mg once daily |
| 15–20 kg | 450 mg once daily |
| 20–25 kg | 500 mg once daily |
| 25–32 kg | 550 mg once daily |
| 32–40 kg | 600 mg once daily |
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Pediatric patients dose adjusted according to body weight. Use the FDA-approved pediatric dosing table; administer on an empty stomach, preferably at bedtime. Tablets may need to be divided or compounded if smaller doses are required.
Efavirenz Tablets are an NNRTI (non-nucleoside reverse transcriptase inhibitor). It works by directly binding to HIV-1 reverse transcriptase, an enzyme required for viral replication.
By binding to this enzyme, Efavirenz inhibits the RNA-dependent and DNA-dependent DNA polymerase activities of reverse transcriptase. This action prevents the conversion of viral RNA into DNA, thereby reducing the ability of HIV-1 to replicate in the body.
Efavirenz does not inhibit human DNA polymerases and must be used in combination with other antiretroviral agents for effective treatment.
Efavirenz Tablets are best taken once daily at bedtime. Taking it at bedtime may help reduce central nervous system effects such as dizziness, abnormal dreams, or drowsiness, which are more noticeable during the first weeks of treatment.
Efavirenz should be taken on an empty stomach, as food, especially high-fat meals, can raise the risk of side effects and increase drug levels in the blood.
This is not a complete list of possible Efavirenz side effects. Contact your provider if you experience any severe, persistent, or unusual symptoms while taking Efavirenz.
| Common Side Effects of Efavirenz | Serious or Clinically Significant Reactions |
|---|---|
| Dizziness, impaired concentration | Severe psychiatric reactions (depression, suicidal thoughts, psychosis, paranoia, mania) |
| Abnormal dreams, insomnia, somnolence | Serious skin reactions (Stevens‑Johnson syndrome, erythema multiforme) |
| Rash (usually mild to moderate) | Hepatotoxicity (elevated liver enzymes, hepatitis, liver failure) |
| Headache, fatigue | Seizures in susceptible individuals |
| Nausea | QT prolongation (risk of arrhythmia) |
| Diarrhea | Embryo‑fetal toxicity (avoid in first trimester) |
| — | Immune reconstitution syndrome (may unmask infections/autoimmune conditions) |
| — | Fat redistribution/accumulation (central obesity, facial wasting, dorsocervical fat pad, breast enlargement) |
| — | Lipid elevations (total cholesterol, triglycerides) |
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Taking more than the prescribed dose of Efavirenz may increase the risk of adverse reactions. There is no specific antidote for Efavirenz overdose. Treatment consists of general supportive measures, including monitoring of vital signs and clinical status.
Reported overdose experiences have included increased nervous system symptoms (such as dizziness or abnormal movements). If you suspect an Efavirenz overdose, contact your healthcare provider immediately or call your local Poison Control Center for guidance.
If Efavirenz (Sustiva) is not suitable or accessible, other HIV‑1 agents may be considered based on medical guidance. The choice depends on individual health needs, resistance patterns, and medical guidance. You may consider the following Efavirenz Tablets alternatives:
Efavirenz can interact with certain prescription drugs, over-the-counter medications, and herbal supplements. Inform your provider about all products you are taking before starting treatment to help prevent serious drug interactions.
| Drug Class / Category | Avoid or monitor closely. Increased risk of QT prolongation and cardiac arrhythmias. | Risk / Recommendation |
|---|---|---|
| Antiviral (HCV combination) | Elbasvir / Grazoprevir | Contraindicated. May significantly reduce antiviral concentrations, leading to treatment failure. |
| Antifungal (Azole) | Voriconazole | Contraindicated at standard doses. Efavirenz reduces voriconazole levels and increases Efavirenz exposure. Alternative therapy is recommended. |
| Herbal Products | St. John’s wort | Contraindicated. Induces metabolism of Efavirenz, reducing plasma levels and increasing risk of virologic failure. |
| Anticonvulsants | Phenytoin, Carbamazepine, Phenobarbital | Use with caution. May alter Efavirenz or anticonvulsant concentrations; therapeutic drug monitoring may be required. |
| Antiarrhythmics / QT‑prolonging agents | Certain class IA and III antiarrhythmics | Avoid or monitor closely. Increased risk of QT prolongation and cardiac arrhythmias. |
| Protease Inhibitors (HIV therapy) | Atazanavir, Lopinavir/ritonavir | Dose adjustment required. Complex pharmacokinetic interactions; consult specialist guidance. |
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If you're looking to order Efavirenz Tablets online from Canada for long-term HIV treatment, Polar Bear Meds provides a trusted and affordable option. We help patients safely buy Efavirenz Tablets online by partnering with a licensed Canadian pharmacy network to ensure reliable, quality-assured medication.
Our Efavirenz Tablets may cost significantly less than U.S. retail pharmacy prices (often up to 80%), helping you save on ongoing therapy. After your prescription is reviewed and your order is verified, it is typically delivered to your U.S. address within 3–5 business days via Xpress Post with tracking. Delivery times may vary depending on your location in the U.S.
Simply upload your prescription, choose your quantity, and complete checkout securely with transparent pricing. New customers receive 10% off when they order Efavirenz Tablets online using the coupon code WELCOMEPB10 at checkout.
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The information provided about Efavirenz Tablets is for educational purposes only. It is not a substitute for any professional medical advice, diagnosis, or treatment. Always use Efavirenz Tablets exactly as prescribed by your licensed healthcare provider. Do not change your dose or schedule without medical guidance. If you have questions about side effects, missed doses, overdose, pregnancy, or interactions, consult your doctor or pharmacist.
Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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