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Effexor is an FDA-approved serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of major depressive disorder (GAD), generalized anxiety disorder, panic disorders & (SAD) social anxiety disorder. This medication adjusts the levels of serotonin and norepinephrine in the brain to help improve mood and emotional stability. Available in tablet and extended-release forms, Effexor comes in doses ranging from 25 mg to 225 mg. Patients should start with a typical dose of 75 mg daily, adjusted by a healthcare provider based on response and tolerance. Side effects can include nausea, increased sweating, insomnia, and more severe conditions like increased blood pressure or serotonin syndrome. Effexor requires careful dosage management and adherence to prescribed guidelines to ensure safety and effectiveness. Always store Effexor properly and follow medical advice for any concerns.

Effexor Overview

Effexor is referred to as a serotonin-norepinephrine reuptake inhibitor (SNRI). It primarily treats major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorders. Venlafaxine, the main active ingredient, modulates serotonin & norepinephrine levels in the brain, which are neurotransmitters critical for regulating mood and emotional stability. By enhancing these neurotransmitters, Effexor effectively alleviates symptoms associated with these disorders, offering significant relief to those affected by such mental health challenges.

Effexor is available in various forms and strengths: tablets in 25 mg to 100 mg dosages and extended-release tablets and capsules from 37.5 mg up to 225 mg. The starting dose for adults dealing with depression is 75 mg daily, potentially adjusted based on therapeutic response up to a maximum of 225 mg per day. Patients must take this medication as their healthcare provider prescribes, with doses carefully adjusted to minimize side effects while maximizing benefits.

Potential side effects of Effexor include nausea, headaches, dizziness, insomnia, increased sweating, and sexual dysfunction. More severe risks involve increased blood pressure, abnormal bleeding, and, in rare cases, a risk of severe conditions such as serotonin syndrome or mania. Patients should avoid abrupt discontinuation to prevent withdrawal symptoms and manage their dosage under strict medical supervision. Effexor should be stored at an average temperature, away from moisture and heat, and out of reach of children. Patients are advised to follow their healthcare expert’s instructions closely and report any adverse effects or unusual symptoms immediately. Regular monitoring and adherence to prescribed guidelines are essential for safely benefiting from this medication.

Uses of Effexor 

  • Major depressive disorder
  • Anxiety disorders
  • Social phobia
  • Panic disorder

Effexor Dosage

Effexor comes in the following forms and strengths:

Tablets (HCL Salt) – Generic:

  • 25 mg
  • 37.5 mg
  • 50 mg
  • 75 mg
  • 100 mg

Tablets, Extended-Release (HCL Salt) – Generic:

  • 37.5 mg
  • 75 mg
  • 150 mg
  • 225 mg

Capsules, Extended-Release (HCL Salt):

  • 37.5 mg (Effexor XR, Generic)
  • 75 mg (Effexor XR, Generic)
  • 150 mg (Effexor XR, Generic)

Tablets, Extended-Release (Besylate Salt):

  • 112.5 mg (Venbysi XR)

Recommended Effexor Dosage for Different Patients

Usual Adult Dosage for Depression

Immediate Release:

  • Initial Dose: 37.5 mg taken orally twice a day, or 25 mg taken orally thrice a day
  • Maintenance Dose: 75 to 150 mg per day, administered in divided doses
  • Maximum Dose:
    • For moderately depressed outpatients: Up to 225 mg per day
    • For severely depressed inpatients: Up to 375 mg per day

Extended Release:

  • Starting Dose: 75 mg taken orally once a day
  • Maintenance Dose: 75 to 225 mg taken orally once a day
  • Maximum Dose:
    • For moderately depressed outpatients: Up to 225 mg per day
    • For severely depressed inpatients: Up to 375 mg per day

Usual Adult Effexor Dosage for Generalized Anxiety Disorder

Extended Release:

  • Starting Dose: 75 mg taken orally once daily
  • Maintenance Dose: 75 to 225 mg taken orally once a day
  • Maximum Dose: 225 mg per day

Usual Adult Dosage for Social Anxiety Disorder

Extended Release:

  • Standard Dose: 75 mg taken orally once a day

Usual Adult Dosage for Panic Disorder

Extended Release:

  • Starting Dose: 37.5 mg taken orally once a day for the first 7 days, followed by an increase to 75 mg once a day
  • Maintenance Dose: 75 to 225 mg taken orally once a day
  • Maximum Dose: 225 mg per day

[Note: Dosage recommendations can differ based on individual needs. Consult with your doctor to customize the dosage specifically for you.]

How to Take Effexor?

  • The typical starting dose for Effexor is 75 mg once daily.
  • If needed, your doctor may gradually increase the dose up to a maximum of 225 mg per day.
  • It is advised not to cross a daily dosage of 225 mg.
  • Effexor should be taken with food to reduce stomach upset.
  • Swallow Effexor capsules or tablets whole; do not crush, chew, or open them.
  • Take Effexor at the same time each day, either in the morning or evening.
  • Increase the dose gradually, in increments of 75 mg every four days at a minimum.
  • Do not stop taking Effexor abruptly, as this can cause withdrawal symptoms.
  • When discontinuing, your doctor will gradually taper off your dose over several weeks or months.
  • Take Effexor exactly as prescribed, and do not adjust the dose without your doctor’s approval.
  • Avoid taking Effexor with an MAOI or within 14 days after discontinuing an MAOI to prevent a potentially severe drug interaction.

[Note: Your doctor will determine the appropriate dosage for you based on your condition and ongoing research on the medication, making adjustments as necessary over time.]

How Does Effexor Work?

Effexor, or venlafaxine, is a medication classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by blocking the reabsorption (reuptake) of the brain’s two neurotransmitters, serotonin and norepinephrine. This action helps to increase the availability of these chemicals, which are critical for mood regulation and emotional stability. Effexor is primarily prescribed for major depressive disorder (GAD), generalized anxiety disorder, panic disorders & social anxiety disorder. By boosting neurotransmitter levels, Effexor effectively reduces symptoms of depression and anxiety, enhancing overall emotional health.

Effexor Side Effects

Common side effects of this medication include: 

  • Nausea and vomiting
  • Constipation
  • Dry mouth
  • Dizziness
  • Increased sweating
  • Headache
  • Insomnia or drowsiness
  • Loss of appetite
  • Anxiety or nervousness
  • Sexual dysfunction (decreased libido, difficulty achieving orgasm)
  • Blurred vision
  • Tremors
  • Increased blood pressure
  • Weight changes (gain or loss)
  • Abnormal dreams or nightmares

Mild side effects of this medication include:

  • Nausea
  • Dry mouth
  • Constipation
  • Dizziness
  • Increased sweating
  • Insomnia or drowsiness
  • Headache
  • Nervousness or anxiety
  • Blurred vision
  • Loss of appetite
  • Mild tremors
  • Abnormal dreams or nightmares
  • Fatigue or tiredness
  • Mild irritability
  • Mild sexual side effects (decreased libido, difficulty achieving orgasm)

Serious side effects of this medication include:

  • Serotonin syndrome: This medication is a potentially life-threatening condition that can occur when taking Effexor, especially in combination with other serotonergic drugs. Symptoms include agitation, confusion, high fever, increased heart rate, tremors, and muscle rigidity.
  • Increased blood pressure: Effexor can cause a sustained increase in blood pressure levels, which can be problematic for individuals with pre-existing hypertension or other cardiovascular conditions.
  • Abnormal bleeding: Effexor may impair platelet aggregation, increasing the risk of abnormal bleeding, especially in patients taking other medications that affect coagulation.
  • Angle-closure glaucoma: Effexor may cause mydriasis (pupil dilation), which can precipitate an acute angle-closure glaucoma attack in susceptible individuals.
  • Mania or hypomania: In individuals having bipolar disorder, Effexor may induce manic or hypomanic episodes.
  • Discontinuation syndrome: Abruptly stopping Effexor can cause withdrawal symptoms such as nausea, dizziness, headache, irritability, insomnia, and sensory disturbances.
  • Liver toxicity: In rare cases, Effexor has been associated with liver injury, which may manifest as elevated liver enzymes or jaundice.
  • Seizures: Although rare, Effexor may lower the seizure threshold, potentially increasing the risk of seizures, especially in patients with a history of seizure disorders or those taking other medications that can lower the seizure threshold.
  • Suicidal thoughts or behavior: For younger adults, Effexor may elevate the risk of suicidal thoughts or behavior, especially during the initial phases of treatment.

[Note: This list does not include all potential side effects. Always consult your healthcare expert for medical advice regarding side effects.]

Effexor Warnings

  • Do not take Effexor if you are allergic to venlafaxine or desvenlafaxine (Pristiq).
  • Avoid using Effexor if you have taken an MAO inhibitor within the past 14 days, as this could lead to a dangerous drug interaction. Such inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
  • Inform your medical expert if you are currently using any stimulant medications, opioids, herbal products, or medications for depression, mental health disorders, Parkinson’s disease, migraines, serious infections, or for the prevention of nausea and vomiting, as these could interact with venlafaxine and potentially cause a severe condition known as serotonin syndrome.
    • Before starting Effexor, ensure it is safe for you by discussing with your doctor if you have a history of any of the following:
    • Bipolar disorder (manic depression);
    • Heart disease, high blood pressure, high cholesterol, or high triglycerides;
    • Diabetes;
    • Lung disease;
    • Glaucoma;
    • Thyroid disorders;
    • Seizures;
    • Sexual dysfunction;
    • Bleeding disorders;
    • Low levels of sodium in the blood;
    • Liver or kidney disease.
  • Young individuals starting an antidepressant may experience an increase in suicidal thoughts. It is essential to monitor for any shifts in mood or symptoms, and caregivers should also observe for sudden behavioral changes.
  • Taking Effexor during pregnancy could be harmful to the baby, yet discontinuing the medication may also be unsafe. Do not start or stop taking Effexor without consulting your doctor. If you are pregnant, you might be added to a pregnancy registry to monitor the effects of venlafaxine on the baby.
  • Consult with your certified medical expert to determine if it is safe to breastfeed while taking Effexor.

Effexor Boxed Warning 

  • Effexor XR carries a boxed warning from the Food and Drug Administration (FDA), the agency’s most stringent warning. This warning highlights the serious risks associated with the drug.
  • Effexor XR is associated with an increased risk of suicidal thoughts and behaviors in young individuals, particularly those 24 years old and younger. This heightened risk is consistent across all antidepressants, not just Effexor XR.
  • Caregivers of young people taking Effexor XR should vigilantly monitor for any signs of deteriorating depression or emerging suicidal thoughts and behaviors. It is important to note that Effexor XR is not FDA-approved for use in children.

Effexor Precautions

Before starting Effexor XR, discuss your medical history with your medical professional to determine if this medication suits you. Effexor XR may not be appropriate if you have certain health conditions or factors:

  • Bipolar Disorder or Mania: Effexor XR is not recommended for treating bipolar disorder as it can exacerbate manic episodes. Your doctor will evaluate your risk for bipolar disorder, including any family history, before prescribing Effexor XR.
  • Medications Affecting Bleeding: Effexor XR can increase the risk of abnormal bleeding. If you are taking medications that also heighten this risk, such as certain pain relievers (aspirin, ibuprofen, naproxen) or anticoagulants (like warfarin), discuss these with your doctor. For more information, refer to the “Effexor XR interactions” section.
  • Unmanaged High Blood Pressure: If your high blood pressure is uncontrolled, Effexor XR may not be safe for you. It’s essential to manage your blood pressure before beginning treatment with Effexor XR.
  • Seizures: If you have a history of seizures, consult your doctor to assess if Effexor XR is safe for you, as it may increase seizure risk.
  • Allergic Reactions: Do not take Effexor XR if you have had an allergic reaction to it or any of its ingredients in the past. If you’re unsure about past allergic reactions, verify with your doctor.
  • Unmanaged Angle-Closure Glaucoma: Effexor XR can increase eye pressure, making it unsafe for those with unmanaged angle-closure glaucoma. Confirm your condition with your doctor before using Effexor XR.
  • Use in Children: Effexor XR is not approved for use in children due to an increased risk of suicidal thoughts and behaviors.
  • Pregnancy: The safety of Effexor XR during pregnancy has not been established. If you are expecting or considering pregnancy, consult your doctor about possible risks.

Effexor Contraindications 

  • Effexor XR should not be used by patients who have experienced a hypersensitivity reaction to venlafaxine or any of the product’s inactive ingredients.
  • Additionally, Effexor XR is contraindicated for patients who are currently using or have used any monoamine oxidase inhibitor (MAOI), including medications such as linezolid and intravenous methylene blue, within the last 14 days.

Effexor XR Missed Dose

If you miss a dose of Effexor, take it when you remember. However, if it’s nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Never double the dose to make up for a missed one, as it can elevate the risk of side effects. Inform your healthcare provider about any missed doses or irregularities in taking Effexor.

[Note: If you miss a medication dose and are uncertain when to take the next one, promptly consult your doctor or pharmacist.]

Effexor XR Overdose 

An overdose of Effexor can be potentially dangerous and life-threatening. Here are some important points regarding an Effexor overdose:

Symptoms of overdose:

  • Nausea and vomiting
  • Tachycardia (rapid heart rate)
  • Drowsiness
  • Dizziness
  • Confusion
  • Seizures
  • Coma
  • Cardiac arrhythmias
  • Electrocardiogram (ECG) changes
  • Hypertension or hypotension
  • Serotonin syndrome (agitation, confusion, hyperthermia, muscle rigidity)

It’s important to note that the severity of an Effexor overdose can vary depending on the amount ingested, the individual’s age, weight, and underlying medical conditions. Any suspected overdose should be treated as a medical emergency to minimize the risk of potentially life-threatening complications.

[Note: If you have taken more than the recommended dose, seek immediate medical assistance or call the Poison Help line at 1-800-222-1222.]

Effexor XR Storage

  • Effexor should be stored at an average temperature between 20°C to 25°C).
  • Do not store Effexor in areas with high heat or humidity, such as bathrooms or near sinks.
  • Effexor capsules or tablets should be kept in their original container with a tightly closed lid to protect them from moisture and light.
  • Effexor should be stored in a dry place and protected from direct sunlight or bright light.
  • Store Effexor in a secure location out of the reach of children & pets to prevent accidental ingestion.
  • Verify the expiration date on the bottle or packaging, and do not use Effexor after the expiration date has passed.
  • Once you have finished your course of treatment or if the medication has expired, properly discard any remaining Effexor capsules or tablets. Contact your local pharmacy or medical center to learn the correct way to dispose of unused or expired medications.

[Note: Talk to your healthcare professional about the correct way to dispose of unused medication and any storage questions you might have.]

Effexor XR Interactions

  • Monoamine Oxidase Inhibitors (MAOIs): It’s important to refrain from using Effexor alongside MAOIs or within two weeks of stopping an MAOI due to the danger of developing serotonin syndrome, a potentially deadly complication.
  • Serotonergic Drugs: Combining Effexor with other serotonergic drugs (e.g., selective serotonin reuptake inhibitors (SSRIs), triptans, tramadol, and St. John’s wort) increases the risk of serotonin syndrome.
  • Drugs that Prolong QT Interval: The use of Effexor alongside medications that can prolong the QT interval, like antiarrhythmics, antipsychotics, and some antibiotics, may increase the likelihood of QT prolongation and torsade de pointes.
  • Drugs Metabolized by CYP2D6: As a strong inhibitor of the CYP2D6 enzyme, Effexor can increase the blood levels of drugs processed by CYP2D6 (e.g., certain antidepressants, antipsychotics, beta-blockers, and antiarrhythmics).
  • Anticoagulants and Antiplatelet Drugs: Effexor may increase the risk of bleeding when combined with anticoagulants (e.g., warfarin) or antiplatelet drugs (e.g., aspirin, clopidogrel).
  • Antihypertensive Agents: Effexor may increase blood pressure, potentially reducing the effectiveness of antihypertensive medications.
  • Lithium: Combining Effexor with lithium may increase lithium levels and the risk of lithium toxicity.
  • Drugs that Lower Seizure Threshold: Effexor may increase the risk of seizures when combined with medications that lower the seizure threshold (e.g., certain antidepressants, antipsychotics, tramadol).
  • Alcohol: Consuming alcohol while taking Effexor may increase the risk of sedation, dizziness, and other adverse effects.

[Note: This isn’t a complete list, and there could be other drugs that interact with Effexor. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Effexor XR Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions For Effexor 

What distinguishes the immediate-release from the extended-release form of Effexor?

The primary difference between the immediate-release and extended-release versions of Effexor lies in the duration of action and how quickly they reach peak concentration levels in the body. The extended-release version is formulated to last longer and peaks later, allowing for once-daily dosing. In contrast, the immediate-release version is absorbed and eliminated more quickly, typically requiring 2 to 3 daily doses to maintain stable blood levels. Furthermore, the immediate-release version is specifically approved only for treating major depressive disorder. In contrast, the extended-release version is also approved by the FDA to treat (GAD) generalized anxiety disorder, panic disorder & (SAD) social anxiety disorder.

Does Effexor XR have an immediate effect?

Effexor typically does not show immediate effects. While some individuals may notice improvements in their mood and anxiety levels within the first 1 to 2 weeks, it usually takes about 6 to 8 weeks of consistent administration of this medication to experience the full benefits of the medication. The effects build gradually over time as the body adjusts to the medication.

Can Effexor XR cause weight gain?

Weight gain is not typically associated with Effexor; it leads to weight loss in some individuals more frequently. If you experience any changes in your weight while on this medication, consult with your healthcare expert.

Why can withdrawing from Effexor XR be particularly challenging?

Effexor significantly impacts neurotransmitters in the brain, and with prolonged use, the brain adapts to its presence. Abrupt cessation can lead to serious withdrawal symptoms such as nausea, vomiting, mood swings, and sensations often described as “brain zaps.” To minimize these effects, it’s important to discontinue the medication gradually under the guidance of a healthcare provider, ensuring a safer and more comfortable discontinuation process.

Can Effexor XR capsules be crushed, split, or chewed?

Effexor XR capsules should not be crushed, split, or chewed. However, an alternative method is available for those with difficulty swallowing the capsules. You can open the capsule & sprinkle its contents onto a small amount of applesauce. Make sure to use all the contents from the capsule. Swallow the mixture promptly without chewing, and follow it with a full glass of water to ensure you receive the complete dose of Effexor XR.

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