Calcipotriene/Betamethasone Topical

Enstilar

Enstilar is a once-daily topical medication used for the treatment of plaque psoriasis. It contains two active ingredients, calcipotriene & betamethasone dipropionate, that help reduce inflammation, redness, and itching and restrict the growth of skin cells. Since Enstilar is available as a foam medication, it is a convenient treatment option for patients with plaque psoriasis. Moreover, it is an FDA-approved topical medication, ensuring its effectiveness and safety. It is suitable for adult use, and children and patients above 65 years old should talk to a medical practitioner about using this medication. Additionally, Enstilar is a prescription drug, so patients are advised not to share their medicine with other individuals, even if they share the same condition. Doing so can increase the risk of side effects, causing life-threatening situations. Lastly, if you consider buying this medication, consult a medical professional. Besides dosage and indications, they will provide guidance on the cost of enstilar foam.

Product Overview

Enstilar is a prescription medication specifically formulated to treat plaque psoriasis, a recurring skin condition characterized by red, scaly patches. It contains two active ingredients: calcipotriene, an artificial form of vitamin D that helps slow the rapid growth of skin cells, and betamethasone dipropionate, a potent corticosteroid that minimizes inflammation, redness, and itching. Enstilar is FDA-approved and offers an effective treatment option for those with moderate to severe plaque psoriasis.

Enstilar is available in a topical foam form, combining calcipotriene 0.005% and betamethasone dipropionate 0.064%. It is applied directly to the affected areas of the skin once daily. Suitable for adult patients, Enstilar should be applied by gently rubbing the foam into the treated area until fully absorbed. The medication should not be used on the face, groin, or underarms, and it is crucial to avoid exceeding 60 grams every four days.

Common side effects of Enstilar may include skin irritation, itching, or dryness. Patients should avoid covering the treated area unless directed by a healthcare provider. In case of a missed dose, apply it as soon as possible, but if it’s near the time for the next dose, skip the missed one. Do not double up. Overdose can lead to adverse effects, including increased corticosteroid side effects; seek immediate medical attention if an overdose is suspected. Store Enstilar at room temperature, away from heat and direct sunlight, and keep it out of reach of children.

What Are the Uses of Enstilar?

This medication is used for the following purposes:

• Treatment of Plaque Psoriasis: Doctors usually prescribe this medicine to treat plaque psoriasis in adults and children aged 12 and above.
• Reduces Swelling and Redness: Betamethasone dipropionate in Enstilar helps in reducing skin redness, swelling, itching, and irritation associated with plaque psoriasis.
• Controls Overactive Skin Cells: Another component of Enstilar (calcipotriene) helps in treating the overactive skin cells that cause scaling and thickness due to psoriasis.

What Are the Forms & Strengths of Enstilar?

Enstilar is available in the form of topical foam containing 0.005% of calcipotriene and 0.064% of betamethasone dipropionate.

What Are the Recommended Dosage of Enstilar?

The dosage recommendations for Enstilar depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.  

Dosage for Plaque Psoriasis

• Apply the foam to affected areas once a day for up to four weeks. 
• Do not use more than 60g of Enstilar every four days. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Enstilar?

• Read the medication guide or PIL (patient information leaflet) carefully to avoid any complications. This guide will provide detailed insight on how to use Enstilar foam. If you have any concerns or questions, ask a medical expert.
• Follow the application instructions as your doctor prescribes.
• Do not exceed or subceed the doses without consulting your healthcare professional.
• Enstilar is a topical medication that can be used directly on the skin.
• If you use other calcipotriol-containing products, such as gel or ointment, do not take more than 15 g each day. 
• Now, there are different administration steps for different parts of the affected area. 

For Body Psoriasis

• Shake the can for a few seconds before applying the medicine.
• Then remove the cap and apply directly on the affected area. Make sure that you are holding the can at least 3 cm away from the skin.
• You can spray the medication by holding the can in any orientation except holding it horizontally. 
• After applying the foam to the infected area, rub it gently.
• When done spraying, put the cap back on to avoid accidentally pressing the can.
• Wash your hands thoroughly after using the spray unless you are applying the foam to the hand.
• Make sure that the medicine is not getting in contact with eyes, face, or mouth. If it happens, rinse or clean the area.
• Avoid bandage or covering the medicated area. 
• To get the best benefit, apply the medicine during the day or at night. 

For Scalp Psoriasis

• Firstly, comb the hair to remove any loose scale.
• Shake the can before application, then, holding the can at least 3 cm away, spray the medicine directly into the palm.
• Apply the foam on the affected area of the scalp and rub it gently. 
• Apply a thin layer of foam so that it can be easily washed out. 
• Avoid washing the hair immediately after applying the medication. 
• Do not cover the treated area with any bandage or clothes.
• When washing your hair after applying the medicine, use mild or non-medicated shampoo on dry hair. You can easily remove the medicine on dry hair, as water can dilute the cleansing effect of the shampoo.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Enstilar Work?

Enstilar works by combining two active ingredients, calcipotriene and betamethasone dipropionate, to effectively manage plaque psoriasis. Calcipotriene is a form of an artificial vitamin D that helps slow down the rapid growth of skin cells, which is a key issue in psoriasis. Betamethasone dipropionate is a potent corticosteroid that minimizes inflammation, redness & itching associated with psoriasis. Together, these ingredients help clear up plaques and improve the appearance of the skin. Enstilar’s foam formulation allows for easy application, ensuring that the medication is evenly distributed on the affected areas for effective treatment.

Important Safety Information for Using Enstilar

What Are the Side Effects of Enstilar?

Common Side Effects of Enstilar: This medication can cause various side effects. However, these reactions are mainly temporary, lasting from a few days to a few weeks. If these side effects get intense or persist for a long time, contact your medical provider immediately. Common side effects of Enstilar may include:

• Itching: Enstilar contains certain active and inactive components that can cause irritation to the skin. This is a common side effect that usually lessens within a few days. If it persists for a long time and you may notice additional skin damage or infection, talk to your doctor.
• Skin irritation: You may experience irritation on your skin after using this medication. If it is a mild irritation, you do not have to panic; it is just a reaction to the drug, which will disappear once your body adjusts to the drug’s components. Some of its signs may include:
  • Redness
  • Dryness
  • Swelling
  • Peeling
  • Skin rash
• Inflammation: Enstilar can cause inflammation, especially in areas where it is applied. This inflammation may lead to swelling, warmth, and skin tenderness, indicating an immune response to the medication’s active ingredients.
• Change in Skin Color: Calcipotriene and betamethasone may lighten or darken your skin, especially in the treated area. This pigmentation is temporary, but you may need medical assistance if it does not improve with time.
• Exacerbation of Psoriasis: Due to allergic reactions, Enstilar can sometimes worsen your existing psoriasis symptoms. This exacerbation can be indicated by increased redness, scaling, and thickening of the plaques. To avoid psoriasis exacerbating, you can consult a medical professional. They will adjust the doses or treatment plan according to your body’s needs.
• Skin Pain: After applying Enstilar foam spray, you may notice a burning sensation or skin pain in the treated area. This pain usually lasts for a few days, but if the pain persists & interferes with daily activities, use soothing creams or consult a professional.
• Extreme Sensitivity to Light: This foam spray can make your skin extremely sensitive to sunlight, resulting in discomfort. Even brief sun exposure can result in sunburn or rashes. To avoid such a situation, use sunscreen.  
• Unstable Sugar Levels: Diabetic patients may experience unstable blood sugar levels while using this foam spray. Therefore, check your glucose levels frequently and consult a doctor if you notice significant changes.  
• Skin Thinning: Long-term use of Enstilar can lead to skin thinning, making your skin prone to bruising, tearing, and infections. 
• Swelling or Blockage of Hair Follicles: Also known as folliculitis, this medication can cause hair follicles to become inflamed or blocked. This can result in red, swollen bumps on the skin, which may require extra treatments to manage.

Serious Side Effects of Enstilar: Besides the above common side effects, Enstilar can cause several adverse reactions that can be life-threatening. If you notice any unusual sign that may seem concerning, talk to a healthcare practitioner immediately. Serious side effects of Enstilar may include:

• High levels of calcium: Calcipotriol, one of the active ingredients in Enstilar, is a vitamin D analog that increases calcium absorption and reabsorption. This action can lead to high serum calcium levels in the body if absorbed systemically in excessive amounts. Overdosing and application to large skin areas can increase this side effect, causing serious complications in the future. If you notice any of the following symptoms, contact your medical professional:
  • Weakness
  • Bone pain
  • Feeling thirsty
  • Peeling frequently
  • Headache
  • Nausea
  • Vomiting
  • Constipation
  • Not feeling hungry
  • Muscle aches or cramps
  • Depressed or cranky
• Cushing Syndrome: This condition is a rare hormonal disorder that happens when your body is exposed to excessive cortisol (a hormone produced by the adrenal glands). Too much application of this topical corticosteroid foam can lead to systemic absorption, causing this side effect. Some of its signs may include:
  • Weight gain, especially in the upper part of the body
  • Acne or skin thinning that bruises easily
  • Tiredness
  • Anxiety
  • Adrenal gland problems
• Increased Blood Sugar: Enstilar foam spray contains corticosteroids like calcipotriol and betamethasone, which can increase blood sugar by interfering with glucose metabolism. This happens as corticosteroids reduce insulin sensitivity and promote gluconeogenesis, leading to hyperglycemia. Its symptoms are:
  • Feeling thirsty
  • Headaches
  • Difficulty concentrating
  • Frequent urination
  • Weakness or tiredness
  • Weight loss
• Eye problems: Enstilar is a topical medication for psoriasis. If accidentally applied near or into the eyes, it can lead to several eye problems. Long-term exposure to the eyes can worsen the situation and cause dryness or inflammation, requiring immediate medical attention. Some of the eye problems that you may experience as a side effect of this medication may include:
  • Blurred or double vision
  • Eye pain or redness
  • Seeing halos around lights
  • Headache
  • Change in color vision
  • Facing problems driving at night
  • Partial or complete vision loss
• Skin Reactions: Enstilar contains calcipotriol and betamethasone as its active ingredients that can cause severe allergic reactions in certain people. While mild reactions can be treated with over-the-counter soothing creams, serious skin reactions require medical assistance. Some adverse hypersensitivity reactions may include:
  • Skin itchiness
  • Dryness
  • Scaly skin
  • Cracked skin
  • Swelling or burning skin
  • Bumps or blisters on the skin

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Enstilar? 

Enstilar can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you decide to buy Enstilar foam spray online, you should remain cautious as it has several warnings, which are as follows:

• Flammable: Enstilar foam is a flammable medication. So, patients are advised to avoid fire and smoking during and immediately after the foam application.
• Hypercalcemia and Hypercalciuria: This medication can cause hypercalcemia, or an increased level of calcium in the blood, and hypercalciuria, or excess calcium in the urine. If you are experiencing such conditions, stop using the medicine until your calcium levels return to normal.  
• Effects on Endocrine System: The application of topical corticosteroids, including Enstilar foam, can be absorbed into your bloodstream. This absorption can result in reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis. There are certain factors that can increase the risk of HPA axis suppression, including using high-potency steroids, excessive application, long-term use, occlusive dressings, liver failure, altered skin barrier, and young age. If you have HPA axis suppression, do not take your medication, reduce the frequency of application, and use less-potent corticosteroids. 
• Allergic Contact Dermatitis: This condition can occur with topical calcipotriene and corticosteroids. Doctors usually diagnose this condition by observing a failure to heal or improvement after using a topical corticosteroid. So, patch testing is advised before using this medication.
• Risks of Ultraviolet Light Exposures: Patients using this foam on the exposed skin should avoid excessive exposure to natural or synthetic sunlight like tanning booths and sun lamps. Therefore, doctors usually avoid or limit the use of phototherapy in patients using Enstilar foam. 

What Are the FDA Boxed Warning for Enstilar?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Enstilar does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or notice any unwanted symptoms, it’s best to consult with an expert.

What Are the Enstilar Precautions?

When considering treatment with Enstilar, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Enstilar foam for scalp psoriasis and plaque psoriases:

• Before starting this medication, tell your doctor about your allergies or if you are allergic to ingredients like taclonex, wynzore, or any of the ingredients present in the medication. The product may contain certain inactive components that can cause severe allergic reactions.
• When considering treatment with Enstilar, tell your doctor about your or your family’s medical history, especially of:
  • Hypercalcemia
  • Skin infections
  • Skin thinning at the treatment site
• If you are undergoing surgery or any medical procedure, inform your healthcare provider about the products you use. This includes all prescription drugs, nonprescription medications, or herbal products.
• Do not cover the treated area with clothing or even a bandage unless your practitioner advises otherwise. Doing so may increase the amount of medicine absorbed through your skin, increasing the risk of side effects.
• Enstilar is only for skin use, so avoid using it around your eyes, underarms, or on the face. 
• You can stop using this medicine when your condition is under control because using excessive amounts of Enstilar for prolonged periods can increase the risk of side effects.
• Avoid applying topical calcipotriene/betamethasone suspension to your scalp within 12 hours before or after any chemical hair treatments, such as coloring or perming.  
• Do not wash your hair immediately after using the medicine.
• Patients above 65 years of age and children are at great risk of developing serious side effects of Enstilar. Talk to a healthcare practitioner before using this medication.
• It is not known whether Enstilar affects the unborn baby. So, if you are pregnant or planning to have a baby, talk to a medical professional. Discuss every risk and benefit with them. They will help you decide whether this medication is safe and how it may affect the child.
• Similar to pregnancy, it is unclear if the medication enters into the breast milk or not. So, consult a medical expert when breastfeeding your child. If you use this medication, make sure to use it on the smallest area and for a short period of time. Do not apply the foam to areas where it may come in contact with the baby’s mouth or eyes.

What Are the Contraindications of Enstilar

There are no specific contraindications of Enstilar, but if you have the following conditions, do not use enstilar foam for scalp psoriasis and plaque psoriases:

• Allergic reactions to calcipotriol, betamethasone, or any of the other ingredients present in the medication’s composition. 
• Problems with calcium levels in the blood.
• Certain types of psoriasis, such as erythrodermic psoriasis or pustular psoriasis
• Ulcers and wounds
• Acne

What If You Missed a Dose of Enstilar?

Generally, it is advisable not to miss the application of Enstilar, but if someone forgets, they should:

• Apply the medication as soon as possible or whenever they remember.
• If it is almost time for the next application, omit the missed one and follow the regular dosing schedule as your medical professional instructed.
• Remember not to apply the medication twice simultaneously just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your mobile phone to avoid skipping any doses.
• Apply the medication at the same time every day to get the most benefit out of it.
• If patients are still unsure about the missed doses, talk to an expert physician. They will guide each patient and suggest alternate options suiting their body needs.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Enstilar?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly apply an excessive amount of Enstilar foam. High doses or prolonged use of Enstilar can cause:

• Skin thinning
• Easy bruising
• Changes in body fat, especially on the face, neck, waist, or back
• Increase acne or facial hair
• Menstrual problems
• Loss of interest in sex

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911. Moreover, if you have accidentally swallowed the medicine, do not panic and seek immediate medical assistance. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store Enstilar?

Proper storage instructions are essential to maintain the safety and effectiveness of the medication. If you plan to buy Enstilar foam spray online, you should follow the below storage guidelines:

• Store the medication at a temperature of 20- 25°C (68 -77°F) with excursions permitted to  15-30°C or 59-86°F.
• Keep the spray can somewhere safe, away from the reach and sight of children and pets.
• Do not puncture or incinerate the spray can. 
• Do not flush the medication down the toilet.
• Avoid exposing the medication to heat, as this product is flammable.
• Do not store the medication at temperatures above 49°C or 120°F.
• Avoid refrigerating the product.
• Protect the product from direct sunlight.
• Use the spray can within six months after opening it.
• Avoid keeping it in damp or moist areas like the bathroom or near the sink.
• Avoid spraying the medication on an open flame.
• Avoid smoking while applying this medication.
• You can keep the product in a box to protect it from light.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• Ask a medical professional how to discard the product properly without damaging the environment.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Enstilar?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients using Enstilar foam for scalp psoriases must know the drugs that may interact with their medication. Below are some of the drugs that can interact with Enstilar:

• Acetohexamide
• Albiglutide
• Benzthiazide
• Bexagliflozin
• Canagliflozin
• Chlorothiazide
• Dapagliflozin
• Dehydroepiandrosterone
• Estrone
• Estropipate
• Fluoxymesterone
• Futibatinib
• Glipizide
• Glyburide
• Hydrochlorothiazide
• Hydroflumethiazide
• Indapamide
• Insulin lispro
• Linagliptin
• Liraglutide
• Metformin
• Methyclothiazide
• Nandrolone
• Nateglinide
• Oxandrolone
• Oxymetholone
• Paricalcitol
• Pemigatinib
• Quinestrol
• Repaglinide
• Rosiglitazone
• Saxagliptin
• Semaglutide
• Teriparatide
• Tolazamide
• Erdafitinib
• Nadofaragene firadenovec

What Are the Other Enstilar Interactions?

Other than the above drugs, Enstilar also has the following disease interactions:

• Hypercalcemia
• Diabetes
• Diaper rash
• Hyperadrenocorticism
• Infections
• Ocular toxicities

[Note: This isn’t a complete list, and there could be other drugs that interact with Enstilar. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Enstilar Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to Enstilar are as follows:

• Tremfya
• Otezla
• Skyrizi
• Stelara
• Humira
• Cimzia
• Zoryve

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Enstilar Cost & Coupons

It is important to note that the cost of Enstilar is not the same everywhere. The actual price of this medication depends on several factors, including your insurance plan, location, and the pharmacies you use. Enstilar, with its therapeutic qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here, you can buy Enstilar online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Enstilar foam coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

When should I stop using Enstilar?

You should stop using Enstilar as directed by your healthcare provider, typically when your psoriasis symptoms improve or resolve. Prolonged use without medical supervision may lead to unwanted side effects or reduced effectiveness. It’s important to consult your doctor before stopping the medication to ensure that your treatment plan is both safe and effective.

Does Enstilar cause skin thinning?

Enstilar contains a corticosteroid that can potentially cause skin thinning if used excessively or over a prolonged period, especially in sensitive areas. This risk increases if applied under occlusion, such as with bandages. To minimize this, follow your doctor’s instructions carefully, avoid overuse, and monitor your skin regularly for any changes or signs of thinning.

Can Enstilar cause weight gain?

Weight gain is not a common side effect of Enstilar, as it is primarily a topical treatment. However, systemic absorption of corticosteroids, even from topical use, can potentially cause weight gain if used extensively or improperly. If you observe any unexpected weight changes or other concerning symptoms, consult your medical provider for further guidance and evaluation.

How fast does Enstilar work?

Enstilar usually begins to show improvement in psoriasis symptoms within a few days to a week of consistent application. Full benefits may take several weeks, depending on the severity of your condition. It’s important to use the medication exactly as prescribed and to give it enough time to achieve optimal results. Patience and adherence to treatment are key.

Can I use Enstilar twice a day?

Enstilar is typically recommended for once-daily application to manage psoriasis effectively. Using it more frequently than prescribed dosage can increase the risk of side effects such as skin irritation or thinning. Always follow your doctor’s instructions regarding how often to apply Enstilar. If you feel your symptoms require more frequent use, consult your healthcare provider for advice.

Can you buy enstilar foam over the counter?

No, Enstilar foam is not available over the counter, as it is a prescription medication. You may need a medical expert’s prescription to buy Enstilar. This step ensures that you are using the medication for its indicated use. Consulting a medical professional will not only guide the uses and dosage of this medication but also provide information on the cost of Enstilar foam. This will ensure that your budget remains unaffected.

Is Enstilar a strong steroid?

Enstilar foam spray contains betamethasone dipropionate (one of the active ingredients). This component is a potent topical steroid used to reduce inflammation & relieve symptoms of psoriasis, including redness, itching, and swelling.

How long should you leave Enstilar on?

While there are many answers to this, it is best to leave the Enstilar foam on the affected area for about 30 minutes. This will allow the medication to be completely absorbed by the skin. Do not forget to rub the foam gently for effective results, but avoid covering the area with tight clothing or bandages. For accurate information, consult a medical professional. 

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