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Estring Vaginal Ring

Estring vaginal rings have estradiol, a type of estrogen, which is a hormone essential for various body functions. Estring releases estrogen through the skin of the vaginal wall and is used after menopause to help with problems like dryness, burning, itching in the vaginal area, discomfort during urination, and pain during sex. It is an FDA-approved medication and needs a prescription from a doctor to buy Estring vaginal rings online from Canadian Pharmacy.

Product Overview

Estring Vaginal Ring is an FDA-approved medication containing estradiol, a type of estrogen that helps with various bodily functions. It’s commonly used post-menopause to alleviate symptoms such as vaginal dryness, itching, and discomfort during sex. The ring, with 2 mg of estradiol, releases a steady dose over 24 hours, placed in the upper vagina for three months. To use, wash your hands, insert the ring comfortably, and remove it after three months. If it falls out, rinse and reinsert. Exceeding 90 days won’t cause overdose but may reduce effectiveness, increasing infection risk.

Estring works by delivering estradiol directly to vaginal tissues, minimizing systemic absorption. Common side effects include nausea, headache, and changes in menstrual periods. A boxed warning highlights the need for tests if experiencing abnormal vaginal bleeding. It’s not for pregnant individuals or those planning pregnancy. Missed doses should be addressed promptly. Store Estring at room temperature, away from children, and don’t use it after expiration.

Interactions of Estring (Estradiol) with drugs like warfarin and corticosteroids are possible, and alternatives include Vivelle dot Patches and Estrace Cream. FAQs cover age suitability, sexual activity impact, estradiol’s role, and differences from NuvaRing. Hair loss is a rare side effect; consult a doctor for persistent issues. Always follow healthcare provider guidance and consult them for advice.

Uses of Estring Vaginal Ring

  • The Estring vaginal ring helps with severe changes during menopause in and around the vagina.

How to Use an Estring Vaginal Ring?


Estring usually comes in one strength: Estring vaginal ring 2 mg of estradiol. This means it has 2 mg of estradiol, releasing about 7.5 micrograms of estradiol every 24 hours.

Guidelines for Inserting and Removing Estring Vaginal Ring

For Insertion:

  • Start by washing your hands thoroughly.
  • Find a comfortable position, like lying down or squatting.
  • Hold the Estring between your thumb and forefinger, creating an oval shape, and gently insert it into the vagina as far as it comfortably goes.
  • Release the ring, ensuring it sits comfortably in the upper part of the vagina.
  • After insertion, rewash your hands. 

For Removal:

  • Wash your hands and select a comfortable position.
  • Insert your finger into the vagina, locate the Estring, and gently pull it downward and out. If you encounter difficulty, try bearing down, like having a bowel movement to help lower the estrogen.
  • Inspect the Estring after removal, ensuring it is intact.
  • Dispose of it properly in a waste container and wash your hands thoroughly. 

How to Take It?

  • Put the Estring (estradiol vaginal ring) deep in the upper part of the vagina.
  • Keep the ring in place for three months, then take it out. If needed, replace it with a new one.
  • Check if you still need the treatment every 3 or 6 months.
  • If the ring comes out during the 90-day period, rinse it in lukewarm water and put it back yourself. If needed, a doctor or nurse can help.
  • Keeping the ring in for more than 90 days won’t cause an overdose, but it might make the treatment less effective and increase the risk of infections or erosions in the vagina.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines on the medication. They’ll adjust it as needed over time.]

How Does an Estring Vaginal Ring Work?

Estring works by releasing estradiol directly into the vaginal tissues. Estradiol is an estrogen hormone that helps restore and maintain the health of vaginal tissues, addressing symptoms such as dryness and discomfort. The localized delivery minimizes systemic absorption, making it a suitable option for women experiencing menopausal symptoms.

Important Safety Information

Side Effects

Common side effects of Estring Vaginal Ring

  • Nausea 
  • Vomiting 
  • Bloating 
  • Headache
  • Stomach Cramps
  • Swelling in Your Hands or Feet 
  • Weight Gain
  • Breast pain
  • Vaginal Itching or Discharge 
  • Changes in Your Menstrual Periods 
  • Breakthrough Bleeding

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about other severe side effects.]


Boxed Warning

Endometrial Cancer: If you have ongoing or repeating abnormal vaginal bleeding without a known cause, it’s important to get proper tests done, including endometrial sampling, to check for cancer.

Cardiovascular and Other Risks: Estrogen, with or without progestin, should not be used to prevent heart disease or dementia. Because of these risks, doctors should prescribe estrogen, with or without progestin, at the lowest effective doses and for the shortest time necessary based on the treatment goals and individual risks.


Smoking: Stay away from smoking as it can significantly raise the chances of blood clots, stroke, or heart attack when using Estring.

Grapefruit Juice: Be cautious with grapefruit and grapefruit juice as they may cause unwanted side effects when interacting with estradiol. Avoid using grapefruit products.

Pregnant: Don’t use an Estring vaginal ring if you are planning for pregnancy. Don’t use any other vaginal products unless your doctor advises you to do so.

Missed Dose

Take out the vaginal ring and replace it as soon as you remember. Avoid using an additional vaginal ring to compensate for the missed wearing time. If the vaginal ring comes out, rinse it with warm water and reinsert it. If it slips down into the lower part of the vagina, use your finger to push it in further.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


  • Keep the Estring vaginal ring in its original package until you’re ready to use it. 
  • Store it at room temperature between 15°C to 25°C (59°F to 77°F), away from direct sunlight and moisture. 
  • Don’t expose the ring to very hot or very cold temperatures. 
  • Keep the Estring estradiol vaginal ring away from children and pets. 
  • Make sure not to use Estring after its expiration date, as it might not work properly.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Estring Vaginal Ring Interactions

Estradiol in Estring may interact with other drugs, potentially affecting their efficacy. 

  • CYP3A4 Inhibitors 
  • CYP3A4 Inducers 
  • Barbiturates
  • Warfarin 
  • Corticosteroids
  • Insulin and Oral Hypoglycemics
  • Thyroid hormones
  • Tamoxifen
  • Selective Serotonin Reuptake Inhibitors 

[Note: This isn’t a complete list, and there could be other drugs that interact with Estring Vaginal Ring. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Estring Vaginal Ring Alternatives

  • Vivelle dot Patches
  • Estrace 0.01% Cream
  • Paxil CR
  • Neurontin
  • Catapres

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

Is there an age limit for using Estring?

There isn’t a specific age limit for using Estring, but it’s more about whether it’s suitable for your needs. If you’re experiencing symptoms like vaginal dryness or discomfort during menopause, Estring might be helpful. Talk to your healthcare provider to see if it’s right for you. They can provide guidance based on your health and individual circumstances.

How does Estring impact sexual activity?

Estring may help improve comfort during sexual activity by relieving symptoms like vaginal dryness. By releasing a low dose of estrogen directly where it’s needed, Estring can enhance moisture and reduce discomfort. If you’re experiencing challenges during intimacy due to menopausal symptoms, discuss it with your healthcare provider to see if Estring could be a helpful option for you.

What is the main function of estradiol in the female body?

Estradiol plays various roles in the female body, with its primary function being the development and upkeep of the reproductive system. In the menstrual cycle, higher levels of estradiol contribute to the maturation and release of the egg. Additionally, it thickens the lining of the uterus, creating an environment suitable for the implantation of a fertilized egg.

What is the difference between the NuvaRing and the Estring?

The Estring ring is prescribed by doctors to help with problems after menopause, like intense itching, burning, and dryness in the vagina. It stays in the vagina for three months. The NuvaRing is prescribed for birth control and stays in place for three weeks. After that, it is taken out and replaced with a new ring.

Does Estring cause hair loss?

It’s common for people not to experience any side effects or have minor ones like hair loss. If you notice hair loss or any other side effects that bother you, contact your doctor or seek medical attention.

Our Guarantee

At, we assure you the most affordable price to buy Estring vaginal ring from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access the Estring vaginal ring at a substantial cost, call us at 1-888-779-2193 toll-free.


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