Estradiol Hemihydrate, Norethisterone Acetate

Evorel Conti

Evorel Conti is a combination hormone replacement therapy patch containing estradiol hemihydrate and norethisterone acetate. It is used to alleviate menopausal symptoms such as mood changes, hot flashes, night sweats, vaginal dryness, and osteoporosis in post-menopausal women. It is available in the form of patches that come in the strength of 3.2 mg of estradiol and 11.2 mg of norethisterone acetate to be worn continuously, replacing each patch twice a week. It works by supplementing the body’s declining hormone levels, thus reducing the severity of menopausal symptoms. For personalized advice and guidance, you can consult a licensed healthcare provider and ask them if you have any queries or concerns regarding medication usage. 

Product Overview

Evorel Conti is a combination hormone replacement therapy (HRT) patch containing estradiol and norethisterone acetate. Estradiol, a form of estrogen, is used to alleviate menopausal symptoms such as mood changes, night sweats, hot flashes, and vaginal dryness. Norethisterone acetate, a progestogen, helps prevent the thickening of the womb lining, which can occur with estrogen-only HRT. This combination helps maintain hormonal balance and provides effective relief from menopausal symptoms.

Evorel Conti is available in patches containing 3.2 mg of estradiol and 11.2 mg of norethisterone acetate per patch. It is designed to be worn continuously, with each patch replaced twice a week. This method ensures a steady release of hormones into the bloodstream. Evorel Conti is suitable for postmenopausal women who have not had a period for at least 12 months. It works by supplementing the body’s declining hormone levels, thus reducing the severity of menopausal symptoms.

Common side effects of Evorel Conti include skin irritation at the application site, headaches, breast tenderness, and mood changes. Following the prescribed dosage and consulting a healthcare provider if severe side effects occur is essential. Precautions should be taken if there is a history of hormone-sensitive conditions or cardiovascular disease. If you miss a dose, apply a new patch as soon as possible, but never use two patches to make up for the missed dose. In case of an Evorel Conti overdose, seek immediate medical attention. Store Evorel Conti patches in a cool, dry place away from direct sunlight. Always consult a licensed healthcare professional for guidance on using HRT and report any unusual symptoms promptly.

What Are the Uses of Evorel Conti?

It is used to treat:

• Menopausal symptoms including mood changes, hot flashes, night sweats & vaginal dryness
• Osteoporosis in post-menopausal women

What Are the Forms & Strengths of Evorel Conti?

Evorel Conti is available in the form of patches, which come in the following strengths:

• 3.2 mg of estradiol 
• 11.2 mg of norethisterone acetate

What Are the Recommended Dosage of Evorel Conti?

For Treating Menopausal Symptoms 

• If you are changing from an HRT drug that gives you withdrawal bleeding, you should use the Evorel Conti patch at the end of the treatment cycle or 14 days after you finish using another HRT product. 
• If you are using another type of HRT, the day you start taking this medication depends on which type of HRT you have been using. 
• If you have not been using another type of HRT, you may put on the Evorel Conti patch at any time. 
• You should change the patch twice a week and start a new pack of Evorel Conti as soon as you finish one.  

[Note: These recommendations may vary from person to person. Discuss them with your doctor, and they’ll customize your dosage accordingly.]

How to Use Evorel Conti? 

• Before using Evorel Conti, you should carefully read and follow the instructions for use in the patient information leaflet and medication guide. If you have any questions or concerns, ask your doctor. 
• Use the patches exactly as your doctor directs. Do not use it more or less than prescribed, in large quantities, or more frequently. 
• Your physician will direct you to use this medication with the lowest dose for the shortest time possible. 
• If you have not been using another type of HRT, you may put on the Evorel Conti patch at any time. 
• Using the notches as a guide, open and peel and tear along the edges of the pouch. 
• With the protective backing facing towards you, bend and feel off half of it. Then, remove the Evorel Conti patch. 
• You should not touch the sticky side of the patch as it may not stick properly. 
• Apply the open half of the Evorel Conti patch and press it onto your skin.
• Remove the remaining backing & press down the rest of the path. 
• Press the patch with your palm and ensure it is firmly stuck down.   
• As soon as you open the protective pouch, apply the Evorel Conti patch to a clear, dry area of the skin. 
• You should change the patch twice a week and not leave a break between each patch to make sure a regular hormone supply is delivered. 
• Change your patches on the same two days each week.
• Usually, most women wear the patch on the thigh or buttock. 
• You should not apply the patch on or near the breasts. 
• Apply the patch under loose clothing. Do not apply it to the same skin area twice in a row, under elasticated areas, or a tight waistband. 
• Do not apply the patch to damaged areas of the skin, such as cuts, spots, or irritated areas. 
• Do not apply the patch in the skin area where you have applied cream, talc, or moisturizer.
• You should wait at least one hour after applying the patch before you try any activity or exercise that will make you sweat, as this may affect how the patch sticks to your skin. 
• If your patch falls off or you need to replace it during the week, put it in a different place. 
• To remove the patch, gently peel one edge of the patch away from your skin. Then, fold the patch in half with the sticky sides together.
• If any glue remains on your skin, it will eventually go away on its own, or you can use baby oil to remove it.
• Dispose of the used patch in the household trash, keeping it out of reach of children & pets. Do not flush used Evorel Conti patches down the toilet.
• If a patch accidentally falls off, you should apply a new one but continue to follow your original patch change schedule.
• If you just bathed or showered, wait until your skin cools down before applying a new patch.
• Contact your doctor if you need more patches.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Evorel Conti Work?

Evorel Conti is a Hormone Replacement Therapy used to manage symptoms of menopause. It contains two types of female hormones: estradiol and norethisterone. These hormones are released through a patch placed on the skin, ensuring a constant release. Evorel Conti alleviates symptoms related to menopause, such as hot flushes. It’s suitable for postmenopausal women who have been without natural periods for at least 18 months. The patch contains both hormones continuously, replacing the estrogen normally produced by the ovaries. A progestogen is also included to prevent the thickening of the womb lining. Most women do not have regular monthly periods with Evorel Conti, but some bleeding or spotting may occur initially.

Important Safety Information for Using Evorel Conti

What Are the Side Effects of Evorel Conti?

Common Side Effects of Evorel Conti: Similar to all medications, Evorel Conti may also cause certain side effects for some people who use it. It is essential to mention that not everyone using it experiences these side effects. These symptoms don’t usually require medical attention and disappear within a few days as your body adjusts to the medication. 

• Breast tenderness or pain
• Headache
• Irregular vaginal bleeding or spotting
• Nausea
• Abdominal pain or discomfort
• Skin irritation at the patch application site
• Mood changes
• Weight changes

Mild Side Effects of Evorel Conti: This medication may cause mild side effects in some people, which don’t usually require medical attention and disappear within a few days or weeks. If you experience persistent or bothersome effects, you should immediately consult your healthcare provider and report any new or worsening symptoms to your doctor. 

• Bloating
• Fluid retention
• Leg cramps
• Back pain
• Skin rash
• Hair changes (increased growth or loss)
• Changes in libido
• Vaginal discharge

Serious Side Effects of Evorel Conti: In rare cases, Evorel Conti may cause serious side effects in certain people using it. The chances of experiencing adverse side effects while using Evorel Conti may be based on various factors such as age, overall health & duration of use. Adverse side effects require immediate medical attention and may become life-threatening if not treated properly. You should discontinue using this medication and call your doctor or 911 immediately if you experience any of the side effects given below.

• Blood clots, including pulmonary embolism (PE) or deep vein thrombosis (DVT). Its symptoms may include swelling, pain, leg redness, or sudden shortness of breath. 
• Breast cancer
• Endometrial cancer. 
• Ovarian cancer
• Heart attack. Its symptoms may include chest pain, shortness of breath, nausea, and arm or jaw pain.
• Stroke. It can cause sudden numbness, confusion, vision problems, or severe headaches.
• Gallbladder disease
• Severe allergic reactions. Its symptoms may include swelling of the face/throat, difficulty breathing, and hives. 
• High blood pressure

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]

Are There Any Warnings for Evorel Conti? 

• You should not use this medication if you have an allergy to Evorel Conti, estradiol hemihydrate, or norethisterone acetate. 
• Do not use this medication if you have or ever had the following conditions:
  • Breast cancer
  • Thickening of the lining of the womb
  • Unexplained vaginal bleeding 
  • Blood clots 
  • Liver disease
  • Blocked arteries
• Prolonged use of Evorel Conti, which contains estrogen, may increase the chances of breast cancer. Studies have shown a substantial increase in breast cancer risk with the use of menopausal hormone therapy. Women using combined estrogen-progestogen therapy are at a higher risk compared to those using estrogen-only preparations. Regular breast examinations and mammography evaluations are recommended for all women using Evorel Conti.
• Hormone replacement therapy (HRT), including Evorel Conti, is associated with a higher risk of developing venous thromboembolism, such as pulmonary embolism (PE) or deep vein thrombosis. Women with a personal or family history of thromboembolism or recurrent spontaneous abortions should be thoroughly evaluated for thrombophilic predisposition before starting therapy. Evorel Conti should be discontinued if VTE develops after initiating therapy. Individuals should seek prompt medical assistance if they have potential thromboembolic symptoms like painful leg swelling, sudden chest pain, or difficulty breathing.

What Are the Evorel Conti Precautions?

• Close supervision is required for patients with conditions that may be aggravated by Evorel Conti, including uterine fibroids, endometriosis, hypertension, liver disorders, diabetes mellitus, migraine, epilepsy, and a history of endometrial hyperplasia. Regular monitoring and evaluation are essential to manage these conditions effectively during therapy.
• Continuous monitoring is necessary for conditions such as cardiac or renal dysfunction, liver function disturbances, and hypertriglyceridemia. 
• Patients with a history of cholestatic jaundice or hypertriglyceridemia should be closely monitored due to potential complications like pancreatitis. Therapy should be discontinued if jaundice or liver function deterioration occurs or if there is a significant increase in blood pressure or onset of migraine-type headaches.
• This medication is not recommended for use in children. 
• Evorel Conti is indicated for use in only postmenopausal women. You should not use this medication if you are pregnant, suspect a pregnancy, or might become pregnant, as this drug may cause harm to the unborn baby. If you are pregnant or think you may be pregnant, discontinue using these patches and call your doctor at once. 
• You should not breastfeed an infant while you are using these patches. 
• Before using Evorel Conti, you should tell your doctor about all the medications you are currently using or plan to use, including prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. 
• If you are required to have a blood test, inform your doctor or the laboratory staff that you are using Evorel Conti, as this medicine can affect the results of certain tests. 

What Are the Contraindications of Evorel Conti? 

Evorel Conti is contraindicated for use in patients who have:

• Known hypersensitivity to estradiol, norethisterone acetate, or any other ingredient of this medication
• Family history of breast cancer
• Known or suspected estrogen-dependent malignant tumors or pre-malignant tumors
• Undiagnosed genital bleeding
• Known current, or past, or suspected breast cancer
• Pregnancy and lactation
• Current liver disease or a history of liver condition as long as liver function tests have failed to return to normal
• Previous or current venous thromboembolism 
• Known thrombophilic conditions
• Inherited thrombophilia
• Active or past arterial thromboembolic disease
• Porphyria
• Patients with inherited genetic mutations
• Early menstrual periods
• History of non-cancerous breast diseases
• Previous treatment using radiotherapy to the chest or breast
• Previous treatment with diethylstilboestrol
• Depression is not well controlled with treatment.
• A history of depression with the use of estrogen and/or progesterone/progestogen-containing medicines irrespective of the indication, dosage formulation, and route of administration.

What If You Missed a Dose of Evorel Conti?

• Missing a dose of Evorel Conti may increase the risk of breakthrough bleeding and spotting. 
• You should change the patch on the same two days every week. 
• If you have missed changing the patch, you should apply it as soon as you remember. However, consistency should be maintained. 
• If it is almost time to apply a new patch, you may omit the missed dose and change it on the scheduled day. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose. 
• You can set a reminder on your phone to prevent missing doses further. Medication reminders work best for this purpose.
• You can consult your healthcare provider or physician if you are still uncertain when to change the patch.  

[Note: If you have missed a medication dose and are unsure when to take the next one, consult your doctor or pharmacist immediately.]

What Happens If You Take Too Much of Evorel Conti?

It is unlikely for an Evorel Conti overdose to occur due to the way it is administered. The most common symptoms of having too much estrogen or progestogen in your body are nausea, unexplained vaginal bleeding, fatigue, acne, depression, or stomach pain. If someone has accidentally swallowed the patch, immediate medical assistance should be taken. You can call 911, poison control helpline, or head to the nearest emergency room.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store an Evorel Conti?

• Store Evorel Conti in its original container at room temperature at or below 25°C, away from direct sunlight, moisture, and excess heat. Do not keep it in the bathroom, near the sink, or in places with high humidity. 
• Keep all medications, including Evorel Conti, in a safe place that is out of the reach and sight of children and pets. 
• Do not use medications that have passed their expiration date, which is the last day of the month mentioned on the back of the prescription or carton. 
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• With that said, do not pour them into the drain, flush them down the toilet, or throw them into the household garbage bin. 
• You should dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• The best way to eliminate expired and unwanted medications is to give them in the medicine take-back program. 
• You can consult your pharmacist, healthcare provider, and local waste disposal company to learn how to properly dispose of unwanted medications.  

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Evorel Conti?

Certain medications may interact with Evorel Conti and affect how it may work. Before taking this medication, you should consult your doctor or pharmacist and tell them about all the medications you are taking or plan to take, including all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. The list given below does not include all possible interactions of Evorel Conti, and there may be other drugs that interact with Evorel Conti. Your doctor may change your dosage of one or both medications or suggest you take some alternative medications. Drug interactions with Evorel Conti are as follows:

• Rifampicin
• Rifabutin
• Nevirapine
• Efavirenz
• Ritonavir
• Nelfinavir
• Carbamazepine
• Phenytoin
• Phenobarbital
• Primidone
• Bosentan
• Modafinil
• Aprepitant
• Cimetidine
• Erythromycin
• Clarithromycin
• Ketoconazole
• Itraconazole
• Voriconazole
• Fluconazole
• Cyclosporine
• Theophylline
• Corticosteroids
• Lamotrigine
• Levothyroxine
• Warfarin
• Aspirin
• NSAIDs such as ibuprofen, naproxen
• Metoprolol
• Propranolol
• Atorvastatin
• Simvastatin
• Tacrolimus
• Verapamil
• Diltiazem
• Amiodarone
• Digoxin
• Metformin
• Insulin
• Fexofenadine
• Omeprazole
• Gabapentin
• Pregabalin
• Valproic acid
• Tramadol
• Codeine
• Morphine
• Fentanyl

What Are the Other Evorel Conti Interactions?

You should not use certain medications at or around the time of eating or consuming certain food items since interactions may occur. Consuming alcohol or tobacco with certain medications may also cause interactions. The interactions given below have been selected based on their significance and are not exhaustive. Using this medication with any of the following herbs, supplements, food items, and beverages may cause an increased risk of certain side effects. Still, in some cases, it may be unavoidable. When both medications are combined, your doctor may change the dose or frequency of one or more medications or give you special instructions regarding dietary changes. 

• Alcohol 
• Grapefruit juice
• St. John’s Wort

[Note: This isn’t a complete list, and there could be other drugs that interact with Evorel Conti. Make sure to tell your doctor about any prescription, over-the-counter, or herbal products you’re taking.]

What Are the Evorel Conti Alternatives?

People look for alternative medicines to Evorel Conti when they do not suit them or do not get the desired results. There are many effective medicines for Evorel Conti available in the market. However, you should consult your healthcare provider or physician before changing your medication or starting a new one. Some popular alternatives to Evorel Conti are as follows:

• Estraderm
• Estradot
• Femseven
• Mirena 
• Progynova
• Provera (medroxyprogesterone acetate)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Evorel Conti Cost & Coupons

The cost of Evorel Conti varies depending on health insurance coverage. Many Americans find their insurance doesn’t cover medications like Evorel Conti, leading to high out-of-pocket expenses. To reduce these costs, some turn to services like Polar Bear Meds, where they can purchase Evorel Conti from Canada at a lower price. Polar Bear Meds offers a convenient and affordable option for obtaining this medication. Additionally, first-time customers can use the coupon code WELCOMEPB10 to receive a 10% discount on their initial order. This approach can help make managing health more affordable and accessible.

Frequently Asked Questions

What is the difference between Evorel 50 and Evorel Conti?

Evorel 50 is an estrogen-only hormone replacement therapy (HRT) patch containing estradiol, used primarily for managing menopausal symptoms. Evorel Conti, on the other hand, is a combination HRT patch that includes both estradiol and norethisterone acetate. The combination in Evorel Conti helps prevent endometrial hyperplasia, making it suitable for women with an intact uterus, while Evorel 50 is typically used for those without a uterus.

How long can you stay on Evorel Conti patches?

The duration of using Evorel Conti patches varies based on individual health needs & responses to treatment. Generally, hormone replacement therapy should be used at the lowest dose for the briefest duration possible required to manage menopausal symptoms. Regular reviews with a healthcare provider are essential to evaluate the benefits and risks and to determine the appropriate length of treatment for each patient.

Which Evorel patch goes on first?

When starting Evorel patches, you should apply the Evorel Conti patch first if you’re transitioning from another continuous combined HRT. If you’re beginning HRT for the first time or switching from an estrogen-only or sequential HRT, consult your healthcare provider for specific instructions. Consistency in patch application days and location is crucial for maintaining steady hormone levels and effective symptom management.

How quickly do Evorel Conti patches work?

Evorel Conti patches typically start to alleviate menopausal symptoms within a few days to weeks of consistent use. The time frame for noticeable improvement can vary among individuals, depending on factors such as the severity of symptoms and overall health. It is important to follow the prescribed regimen and have regular consultations with your healthcare provider to monitor progress and make any necessary adjustments.

Can Evorel Conti patches cause weight gain?

Weight gain may be a side effect of Evorel Conti patches, though it varies from person to person. The hormonal changes induced by HRT can lead to fluid retention and changes in body fat distribution, which might contribute to weight gain. Maintaining a balanced diet & regular exercise can help manage weight while using Evorel Conti. Consult your healthcare provider if you experience substantial weight changes or other concerning symptoms.

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