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Famotidine is an FDA-approved medication that is available as an over-the-counter and prescription medication. It is used to treat various gastrointestinal conditions such as peptic ulcer disease, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and pathological hypersecretory conditions. It contains Famotidine as its active ingredient, a histamine H2 receptor antagonist that reduces gastric acid production and alleviates acid reflux symptoms. It is available in the form of a tablet and liquid suspension with strengths of 20, 40, and 40 mg/5ml, respectively, taken orally by mouth. The medication dosage depends upon the individual’s condition, response to treatment, and weight. Consult your healthcare provider and physician and follow their advice for a safe and efficient use of the medication. To ensure your medication is authentic, you should Buy Famotidine (Famotidine) online from trusted and reliable sources.  

Product Overview

Famotidine contains the active ingredient Famotidine, a histamine H2 receptor antagonist used to treat various gastrointestinal conditions such as peptic ulcer disease, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and pathological hypersecretory conditions. Famotidine works by blocking the histamine H2 receptor in the stomach, reducing gastric acid production, which helps heal ulcers and alleviate acid reflux symptoms.

Famotidine is available in tablet form (20 mg and 40 mg) and as a liquid suspension (40 mg/5 ml). Depending on your healthcare provider’s instructions, it is typically taken by mouth, with or without food. The dosage varies based on the condition being treated and the patient’s weight. Adults and children weighing 40 kg or more can use it for conditions such as erosive esophagitis, GERD, and stomach ulcers. A healthcare provider should determine the dosage and usage for children weighing less than 40 kg.

Common side effects include constipation, diarrhea, dizziness, and headache. Severe side effects may involve heart rhythm issues, muscle problems, and liver issues. Precautions should be taken if you have kidney disease, are pregnant or breastfeeding, or are elderly. If you miss a dose, take it as soon as you remember unless it is close to the next dose. Do not double doses. In case of an overdose, seek immediate medical attention. Store Famotidine in a tightly closed container at room temperature, away from moisture and heat. Discard any unused medication after 30 days. Consult your healthcare provider or pharmacist for more detailed information and personalized advice.

Uses of Famotidine

It is used to treat:

  • Peptic ulcer disease
  • Gastroesophageal reflux disease 
  • Zollinger-Ellison syndrome
  • Pathologic gastrointestinal hypersecretory conditions
  • Esophagitis
  • Prevention of NSAID-induced peptic ulcers
  • Aspiration pneumonitis

How to Use Famotidine?


Famotidine comes in the form of a liquid suspension and tablet taken by mouth. It is available in the strength of:

  • Tablet- 20 mg, 40 mg 
  • Liquid suspension- 40 mg/5 ml

Recommended Dosage for Different Patients/Famotidine

Prevention of an ulcer

  • Adults- 20 mg once daily by mouth. 
  • Pediatric patients- The doctor should determine the usage and dosage. 

Treatment of erosive esophagitis

  • Adults and children weighing 40 kg or more- 20 mg once or twice daily or 40 mg once daily at night. 
  • For children weighing less than 40 kg, the doctor should determine the usage and dosage. 

Treatment of gastroesophageal reflux disease

  • Adults and children weighing 40 kg or more- 20 mg twice daily up to six weeks. 
  • For children weighing less than 40 kg, the doctor should determine the usage and dosage. 

Treatment of stomach ulcers

  • Adults and children weighing more than 40 kg or more- 20 mg twice daily up to eight weeks.
  • For children weighing less than 40 kg, the doctor should determine the usage and dosage. 

Treatment of too much stomach acid

  • Adults- 20 mg once every six hours. Your doctor may make dosage adjustments as required. 
  • For children weighing less than 40 kg, the doctor should determine the usage and dosage.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • For a safe and efficient use of the medication, use it exactly as directed by your doctor. 
  • Carefully read and follow the instructions for use on your prescription label. If you have any questions about the safe use of your medication, consult your healthcare provider or physician. 
  • The dosage and treatment length depends on your response to treatment and your medical condition. In children, the dosage is also determined by weight. 
  • Famotidine 20 mg tablet is to be taken orally by mouth with or without food. 
  • Famotidine is injected by an infusion pump directly into the vein. If you are unable to do this yourself, your healthcare provider will give you this injection. 
  • If you are taking Pepcid suspension, shake the bottle well for at least 5 to 10 seconds before using this medication. 
  • Measure the liquid suspension carefully. You may use a dosing syringe or use a medicine dose-measuring device. 
  • Do not chew, break, or crush the Famotidine tablet. But if you are unable to swallow it whole, you can do so. 
  • Do not take the medication less or more than prescribed, in more quantities, or more frequently, as it can cause unwanted side effects. 
  • Usually, the ulcers heal within four weeks of receiving treatment with Famotidine. But it may take up to eight weeks of taking this medication for your ulcer to heal completely. 
  • You should continue taking this medication unless your doctor tells you otherwise. 
  • This medication is only a part of a complete treatment program that may also include changes in lifestyle and diet. Follow all instructions given by your physician or dietician. 
  • You should not share your medication with others, even if they have the same symptoms as you. 
  • Store the medication at room temperature, away from light, moisture, and heat. 
  • Discard unused Famotidine that is older than thirty days, even if it has medication left in it. 
  • Let your doctor know if your condition does not improve or worsen. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Famotidine Work?

Famotidine is a histamine H2 receptor antagonist that works by blocking the histamine two receptors in your stomach that help release acid in your stomach. By blocking this receptor, this drug lowers the amount of acid released in your stomach. When histamine binds to H2 receptors on the surface of certain cells in the stomach lining, it triggers the release of hydrochloric acid. Famotidine decreases the volume and acidity of gastric juice, which can help heal peptic ulcers and prevent their recurrence. It also relieves heartburn and acid reflux by reducing acid reflux into the esophagus. Its effects typically last for several hours after a single dose.

Important Safety Information

Side Effects

Common side effects of Famotidine may include:

  • Adult side effects may include:
    • Constipation 
    • Diarrhea 
    • Dizziness 
    • Headache 
  • Side effects in children less than one year of age may include:
    • Agitation 
    • Crying for no apparent reason 
    • Unusual restlessness

Adverse side effects of Famotidine may include:

  • Issues regarding heart rate and rhythm. Symptoms may include: 
    • Drowsiness 
    • Fainting 
    • Irregular heartbeat and rhythm
    • Shortness of breath
  • Severe muscle problem. Symptoms may include:
    • Fever
    • Unusual, unexplainable muscle pain
    • Weakness
  • Neurological issues. Symptoms may include:
    • Agitation
    • Anxiety 
    • Depression
    • Seizures
    • Sexual disorientation
    • Trouble sleeping 
  • Liver problems. Symptoms may include: 
    • Abdominal pain 
    • Change in color of urine
    • Decreased appetite
    • Unexplained or unusual pain 
    • Yellowing of skin or eyes
  • Skin problems. Symptoms may include: 
    • Blisters 
    • Mouth ulcers or sores
    • Rash 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Heartburn and the initial signs of a heart attack are frequently misdiagnosed. You should seek immediate medical assistance if you experience angina or heavy feeling in the chest, anxiety, lightheadedness, nausea, or pain spreading to your arm, jaw, or shoulders. 
  • This medication may cause a severe allergic reaction. Its symptoms may include: 
    • Hives 
    • Rashes 
    • Swelling in your eyes, face, tongue, or throat 
    • Trouble breathing 
  • Don’t take this medication if you have ever had an allergic reaction to it or other medications belonging to the drug class histamine receptor blockers. Taking the medication in such cases can be life-threatening.
  • This medication should be used cautiously by people with kidney disease as their body may not be able to get this medication out from the body, leading to an increase in Famotidine levels in your body. This can cause a state of confusion or QT prolongation. 
  • There is not enough data to support the safety and efficacy of using this medication during pregnancy. Famotidine should only be taken during pregnancy when it is clearly needed, as it is not known if it causes harm to the unborn baby. 
  • This medication may pass into breast milk and cause unwelcome side effects in the baby. 
  • The kidneys of geriatric patients do not work as well as they used to. This may cause their bodies to process the medication more slowly, causing the medication to stay in their bodies for a longer time. This increases the risk of unwanted side effects. 
  • This medication is not recommended for use in children weighing less than 40 kg. The strengths of Famotidine are greater than those of the recommended dose for these children. For pediatric patients, the doctor may determine the dosage and length of treatment. 


  • Before taking this medication, tell your doctor or healthcare provider if you are allergic to it or any other histamine H2 receptor antagonist. 
  • Tell your doctor about all the medications you are taking, including all prescription, over-the-counter drugs, and herbal supplements you may be taking. Tell them about any other medication you may be taking for heartburn. 
  • Do not take the over-the-counter medication with any prescription medication unless your doctor tells you otherwise.  
  • Inform your doctor if you have an inherited condition known as phenylketonuria, have ever had kidney disease, or have difficulty swallowing. 
  • Consult your doctor if you are pregnant, breastfeeding, suspecting a pregnancy, or planning to become pregnant while taking this medication.  
  • To ensure that this medication is safe for you to use, share your complete medical history with your doctor or healthcare provider and tell them if you have or ever had any of the following conditions: 
    • Asthma 
    • Breathing problems 
    • COPD 
    • History of Long QT syndrome 
    • Kidney or liver disease
    • Stomach cancer or other problems 
  • It is not recommended to consume large amounts of alcohol while you are taking this medication. You should also avoid taking medications and beverages that contain alcohol. 
  • Some side effects caused by this medication can actually be signs and symptoms of a much more severe condition. Seek immediate medical assistance if you experience any of the following symptoms:
    • Heartburn with drowsiness, lightheadedness, or sweating. 
    • Pain in joints 
    • Shortness of breath 
    • Unusual sweating 
    • Unexplained weight loss
  • Get help immediately if you experience trouble/pain swallowing, bloody vomit, bloody/black stools, frequent chest pain, frequent wheezing, stomach pain, or nausea/vomiting. These may be signs of a serious condition. 
  • You should not use this medication in children less than 12 years of age unless prescribed by a licensed healthcare professional. 
  • Geriatric patients may be more sensitive to certain side effects of this medication, including mental/mood changes, unusual fatigue, and seizures. 


Famotidine is contraindicated for use in patients who:

  • Have hypersensitivity to Famotidine and other histamine H2 receptor antagonists. 
  • Are less than 12 years of age

Missed Dose

  • For the best results from the medication, it is crucial to maintain consistency in dosage and take it around the same time every day. 
  • If you forget to take the dose, you should take it as soon as you remember. 
  • On the other hand, you can skip the missed dose and carry on with your usual dosing schedule if your next dose is almost due. 
  • Do not take extra or double doses to compensate for the missed dose. 
  • Do not take two doses of the same medication simultaneously.
  • Set a reminder on your phone to prevent missing a dose. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]


You should not take the medication less or more than prescribed, for longer than recommended, or in large quantities. If someone has overdosed on the medication and is experiencing severe symptoms such as difficulty breathing, seizures, and loss of consciousness, immediately seek medical assistance. You can call 911 or head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • You should store this medication in a tightly closed container at room temperature, away from direct sunlight, moisture, and excess heat. 
  • Do not keep it in the bathroom. 
  • Do not allow the medication to freeze. 
  • Keep Famotidine in a safe place, away from the sight and reach of children. 
  • Discard unused Famotidine that is older than thirty days, even if it has medication left in it. 
  • Do not keep medications that are outdated or no longer needed. 
  • Discard unwanted medications in such a way that children, pets, and others cannot consume them. 
  • Do not throw the medication carelessly in your household garbage bin or pour it into the drain. 
  • Do not flush it in the toilet or wastewater. 
  • The best way to eliminate unwanted medication is to give it away through a medicine take-back program. 
  • Call your healthcare provider, pharmacist, or local waste disposal company to learn how to dispose of unwanted medications. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Famotidine Interactions

Famotidine can interact with the following medications and affect how it may work. 

  • Alendronate
  • Aripiprazole
  • Axitinib
  • Atazanavir
  • Bosutinib
  • Blessed thistle
  • Ceftibuten
  • Cyanocobalamin
  • Dapsone
  • Dasatinib
  • Delavirdine
  • Devil’s claw
  • Digoxin
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Mefloquine
  • Metformin
  • Pazopanib
  • Phytoestrogens
  • Pimozide
  • Ponatinib
  • Risedronate
  • Vandetanib

[Note: This isn’t a complete list, and there could be other drugs that interact with Famotidine. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Famotidine Alternatives

  • Aciphex (rabeprazole)
  • Axid (nizatidine)
  • Dexilant (dexlansoprazole)
  • Gaviscon (aluminum hydroxide/magnesium carbonate)
  • Nexium (esomeprazole)
  • Pepcid (Famotidine)
  • Prevacid (lansoprazole)
  • Prilosec (omeprazole)
  • Protonix (pantoprazole)
  • Rolaids (calcium carbonate/magnesium hydroxide)
  • Tagamet (cimetidine)
  • Tums (calcium carbonate)
  • Zegerid (omeprazole/sodium bicarbonate)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

What is the role of Famotidine in managing pathological hypersecretory conditions like Zollinger-Ellison syndrome?

Famotidine is a histamine H2 receptor antagonist that reduces gastric acid production. In pathological hypersecretory conditions like Zollinger-Ellison syndrome, Famotidine helps manage symptoms by inhibiting excessive acid secretion, thereby reducing the risk of ulcers and associated gastrointestinal discomfort.

How does Famotidine interact with other medications, such as metformin and digoxin?

Famotidine can potentially interact with various medications, including metformin and digoxin, by altering their absorption or effectiveness. For example, due to reduced stomach acidity, it may decrease the absorption of certain drugs, such as ketoconazole and itraconazole. Patients should consult their healthcare provider to manage and monitor these interactions effectively.

Are there any long-term side effects associated with the chronic use of Famotidine?

Long-term use of Famotidine is generally well-tolerated, but it can lead to potential side effects such as vitamin B12 deficiency, especially in patients taking the drug for an extended period. Other possible long-term effects include an increased risk of gastrointestinal infections and potential alterations in kidney function, particularly in elderly patients.

How does the efficacy of Famotidine compare to proton pump inhibitors (PPIs) for GERD treatment?

Famotidine and proton pump inhibitors (PPIs) are both effective for treating GERD, but they work differently. Famotidine acts as an H2 receptor antagonist, providing quick relief by reducing stomach acid. PPIs, like omeprazole and esomeprazole, offer longer-lasting acid suppression by inhibiting the proton pump mechanism. The choice between them depends on the severity and frequency of symptoms, with PPIs often being preferred for more chronic or severe cases.

Can Famotidine be used in patients with renal impairment, and what precautions should be taken?

In patients with renal impairment, the dosage of Famotidine needs to be adjusted to prevent drug accumulation and potential toxicity. It is crucial to consult a healthcare provider for appropriate dose modifications and monitoring of renal function to avoid adverse effects like confusion or QT prolongation. Regular assessment of kidney function is recommended during prolonged treatment.

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