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Fenofibrate

Fenofibrate

Fenofibrate is an FDA-approved medication that is used to regulate abnormal blood lipid levels. It contains Fenofibrate as its active ingredient and effectively treats mixed dyslipidemia, primary hypercholesterolemia, and severe hypertriglyceridemia. The medication is available in oral tablets and capsules with a strength of 145 mg, usually taken once daily with or without food. The dosage of the medication depends on your condition and your body’s response to treatment. For safe and efficient medication use, consult your healthcare provider and use the medication exactly as directed. To ensure the medication you are using is safe for use, buy Fenofibrate online from trusted sources.

Product Overview

Fenofibrate is a medication containing the active ingredient Fenofibrate. It is primarily used to manage abnormal blood lipid levels. It effectively treats mixed dyslipidemia, primary hypercholesterolemia, and severe hypertriglyceridemia. Additionally, it helps reduce the risk of cardiovascular disease in individuals with elevated triglycerides and reduces HDL cholesterol by activating lipoprotein lipase, enhancing lipid breakdown and elimination from the blood.

Fenofibrate, available in oral tablets and capsules with strengths of 145 mg, is typically taken once daily. It is suitable for patients with various hyperlipoproteinemia types, including Type IIa, IIb, IV, and V, as well as elderly patients with hyperlipoproteinemia. Dosages may vary based on the specific condition and patient response, and following your healthcare provider’s instructions is crucial for optimal results. Fenofibrate works by activating specific receptors in the body, reducing triglycerides and LDL cholesterol levels while increasing HDL cholesterol.

Common side effects include abdominal pain, back pain, constipation, diarrhea, headache, and nausea. Severe side effects may include liver problems, gallstones, pancreatitis, and severe allergic reactions. Before starting Fenofibrate, patients should inform their doctor about allergies, medical history, or current medications. If a dose is missed, take it as soon as possible unless it’s close to the next dose; do not double up doses. In case of an overdose, seek immediate medical help. Store Fenofibrate in its original container at room temperature, away from direct sunlight, moisture, and heat. Dispose of unused medication properly, preferably through a medicine take-back program. Always consult your healthcare provider for personalized advice and follow their guidance carefully.

Uses of Fenofibrate

It is recommended for use in:

  • Mixed dyslipidemia
  • Primary hypercholesterolemia
  • Severe hypertriglyceridemia
  • Reducing the risk of cardiovascular disease and death, especially in specific populations with elevated triglyceride levels and reduced HDL cholesterol. 

How to Use Fenofibrate?

Dosage

Form: Oral tablet 

Strength: 145 mg

Form: Oral capsule 

Strength: 145 mg

Recommended Dosage for Different Patients

For Hyperlipoproteinemia Type IIa (Elevated Low-Density Lipoprotein)

  • Tricor: take 145 mg by mouth, once daily.
  • For Lofibra and similar medications, take 160–200 mg orally daily with food.
  • Antara: once daily, take 130 mg orally.
  • Triglide: 160 mg taken once daily by mouth.
  • 150 mg of lipofen taken once daily with meals.
  • Fenoglide: Take 120 mg once daily, preferably with food.

For Elevated LDL + VLDL Hyperlipoproteinemia Type IIb

  • Tricor: take 145 mg by mouth, once daily.
  • For Lofibra and similar medications, take 160–200 mg orally daily with food.
  • Antara: once daily, take 130 mg orally.
  • Triglide: 160 mg taken once daily by mouth.
  • 150 mg of lipofen taken once daily with meals.
  • Fenoglide: 120 mg taken once daily by mouth with meals.

For Type IV Hyperlipoproteinemia (Elevated VLDL)

  • Tricor: 48–145 mg taken once daily by mouth.
  • Lofibra and similar medications: 54 mg to 200 mg taken once daily with meals.
  • Antara: 43–130 mg taken orally once daily.
  • Triglide: 50–160 mg taken orally once daily.
  • Lipofen: Take 50–150 mg once a day, preferably with food.
  • Fenoglide: 40–120 mg taken orally once a day, preferably with food.

For Type V Hyperlipoproteinemia (Raised VLDL + Chylomicrons)

  • Tricor: 48–145 mg taken once daily by mouth.
  • Lofibra and similar medications: 54 mg to 200 mg taken once daily with meals.
  • Antara: 43–130 mg taken orally once daily.
  • Triglide: 50–160 mg taken orally once daily.
  • Lipofen: Take 50–150 mg once a day, preferably with food.
  • Fenoglide: 40–120 mg taken orally once a day, preferably with food.

For Hyperlipoproteinemia (Geriatric use)

  • Tricor: Take 48 mg once daily by mouth. Before increasing the dosage, observe the effects on lipid levels and renal function; a maximum of 145 mg/24 hours should be taken.
  • Lofibra and similar drugs: 54–67 mg taken orally once a day with meals. Customize dosage based on patient response and make any necessary adjustments after repeat lipid assessments every 4 to 8 weeks.
  • Antara: take 43 mg once daily by mouth. Customize dosage based on patient response and make any necessary adjustments after repeating lipid assessments every 4 to 8 weeks.
  • 50 mg of triglide taken orally once daily. Customize dosage based on patient response and make any necessary adjustments after repeat lipid assessments every 4 to 8 weeks.
  • Lipofen: Take 50 mg once daily, preferably with food. Customize dosage based on patient response and make any necessary adjustments after repeat lipid assessments every 4 to 8 weeks.
  • Fenoglide: 40–120 mg taken orally once a day, preferably with food

[Note: These recommendations may vary from person to person. Discuss them with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • For safe and efficient use, carefully read and follow the instructions for use given on your prescription label. 
  • Take this medication orally as prescribed by your doctor, usually once daily. Do not take it in more quantity or longer than needed, as this can lead to side effects. 
  • Do not switch between brands and forms of Fenofibrate without consulting your doctor. 
  • Some forms of this medication may be taken with or without food to aid in better absorption. Consult your healthcare provider to know more.
  • The medication dosage depends on your response to the medication and your medical condition. 
  • You may start taking the medication at an average dose, and your doctor may increase or decrease your dose depending on the laboratory test results.
  • Do not chew, break, dissolve, open, or crush the tablet or capsule. Swallow it whole. 
  • If you are taking certain other drugs with this medication, keep a gap of at least one hour before or at least four to six hours after taking this medication. 
  • To get the most benefit from this medication, it is crucial to maintain consistency in dosage and take it around the same time every day. 
  • While you are taking this medication, you may need to have medical tests for liver function frequently, even if you have no symptoms. Tests can help you and your doctor decide if this medication works best for you. Let your doctor know if you feel unusual fatigue, loss of appetite, or yellow eyes, skin, or urine. 
  • Notify your doctor if you experience weakness, muscle tenderness, cramps, or pain while taking this medication.  
  • Continue to take this medication even if you feel well. 
  • Following your doctor’s diet, weight management, and exercise guidance is crucial. 
  • It may take upto 60 days to get the full benefit of this medication. 
  • It is not recommended to consume alcohol while taking this medication as it can increase your risk of liver damage and increase triglyceride levels in your body.
  • Avoid eating foods high in cholesterol or fat otherwise, the medication will not be as effective.
  • Let your doctor or healthcare provider know if your condition does not improve or if it worsens. 
  • If your test results do not improve after 60 days, your doctor may suggest you discontinue Fenofibrate.
  • Store the medication at room temperature away from open flame, moisture, heat, and direct light.
  • Do not share this medication with others, even if they have the same symptoms as you. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Fenofibrate Work?

Fenofibrate is an oral fibrate medication that is mainly used to treat hyperlipidemia (abnormal blood lipid levels). It activates an enzyme called lipoprotein lipase, which increases the breakdown of lipids and enhances the elimination of triglyceride-rich particles from the blood³. By doing so, it helps reduce triglyceride levels. It also affects LDL and HDL cholesterol concentrations. It slightly changes these cholesterol levels by activating specific receptors called peroxisome proliferator-activated nuclear receptors in the body. These receptors play a role in regulating the synthesis and breakdown of lipoproteins. It reduces the levels of triglycerides and LDL cholesterol and increases the levels of HDL cholesterol.

Important Safety Information

Side Effects

Common side effects of Fenofibrate may include: 

  • Abdominal pain
  • Abnormal laboratory tests
  • Back pain
  • Constipation 
  • Diarrhea
  • Flatulence
  • Headache
  • Indigestion 
  • Inflammation of the nose
  • Nausea
  • Rash
  • Runny nose
  • Sneezing 
  • Vomiting

Mild side effects of Fenofibrate may include: 

  • Breathing difficulties
  • Increased creatine phosphokinase (CPK) level in blood
  • Increased liver enzymes

Adverse side effects of Fenofibrate may include: 

  • Gallstones
  • Pancreatitis 
  • Rhabdomyolysis
  • Toxic epidermal necrolysis
  • Liver problems. Symptoms can include:
    • yellowing of your skin or the whites of your eyes
    • dark-colored urine
    • pain in the abdomen (stomach area)
    • decreased appetite
    • unexplained or unusual weakness
  • Severe allergic reactions. Symptoms can include:
    • swelling of the face, eyes, lips, tongue, hands, arms, feet, ankles, or lower legs
    • trouble breathing or swallowing
    • rash
    • peeling or blistering skin

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]

Warnings

  • Fenofibrate can cause severe liver damage, which can occur in the initial few weeks of treatment or after some months of taking the medication. You may require a liver transplant, and this may be life-threatening. Symptoms of liver damage may include abdominal pain, indigestion, yellowing of eyes, urine, or skin. Call your doctor at once if you experience any of the mentioned symptoms. 
  • This medication can cause allergic reactions, including angioedema and anaphylaxis, which can be life-threatening. Some allergic reactions can occur days, a few days, or weeks after starting to take this medication. Call 911 or head to the nearest emergency if you experience symptoms such as rash, itching, rashes, tongue, throat, or face inflammation, or trouble breathing. 
  • Fenofibrate can cause myopathy and other muscle problems. Myopathy can cause muscle weakness, pain, and tenderness and may lead to rhabdomyolysis. Let your doctor know if you notice unusual or bothersome symptoms such as fatigue and fever. They may suggest you discontinue taking this medication. If you experience muscle problems after stopping treatment with this medication, call your doctor immediately. 

Precautions

  • Before taking this medication, let your doctor or healthcare provider know:
    • If you are allergic to the medication, to any other ingredient in the medication, to other fibrates, or any other allergies. 
  • About your complete personal medical and family history, especially if you have  the following conditions:
    • Gallbladder disease
    • Kidney disease
    • Liver disease
    • Alcohol use
  • If you are planning to undergo surgery, including a dental procedure, tell your doctor, surgeon, or healthcare provider about all your medications, including Fenofibrate. Also, tell them about any prescription medications, over-the-counter drugs, or herbal supplements you may be taking. 
  • If you are pregnant, suspect pregnancy, or planning to get pregnant soon, let your doctor know before taking this medication. Fenofibrate should only be used during pregnancy when it is clearly needed. Discuss the risks and benefits in detail with your doctor. 
  • It is not known if Fenofibrate passes into breast milk. Due to the possible risk to the baby, it is not recommended to take this medication while nursing a baby or for five days after the last dosage. Consult your doctor before taking this medication before breastfeeding.
  • Fenofibrate should be used cautiously in liver, kidney, and heart disease patients.      

Contraindications

Fenofibrate is contraindicated for use in patients who have:

  • Severe renal dysfunction
  • Active liver disease
  • Gallbladder disease
  • Known hypersensitivity to Fenofibrate or any of the ingredients present in the medication.
  • Pregnancy or nursing mothers.  

Missed Dose

  • To get the most benefit from this medication, it is recommended that you maintain consistency in dosage and take it around the same time every day to help you remember.
  • If you missed taking a dose of Fenofibrate, take it as soon as you remember. 
  • However, if it is almost time to take the next medication dose, you may omit the missed dose and continue according to your regular dosing schedule.
  • Do not take double or extra doses of the same medication to compensate for the missed dose. 
  • Do not take two doses of Fenofibrate simultaneously. 
  • You should try setting a reminder on your phone to avoid missing doses in the future. 

[Note: If you have missed a medication dose and are unsure when to take the next one, consult your doctor or pharmacist immediately.]

Overdose

Do not take the medication in more quantities or for longer than recommended, as it can cause unwanted side effects. If someone has overdosed on Fenofibrate and is experiencing severe symptoms such as difficulty breathing, seizures, and loss of consciousness, seek medical help right away. You can call 911 or head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Storage

  • Keep Fenofibrate away from direct sunlight, moisture, and excess heat in its original container. 
  • Do not keep the medication in the bathroom.
  • Keep the medication in a safe place, away from the sight and reach of children and pets. 
  • Different forms of Fenofibrate have different storage guidelines. Check the patient information leaflet or consult your healthcare provider and pharmacist about the proper storage, handling, and disposal of your medication. 
  • Do not use and keep medications that are outdated or no longer needed. 
  • Do not throw unwanted medications in the household garbage bin, pour them into wastewater, or flush them down the drain unless instructed otherwise. 
  • You must dispose of expired and unwanted medications in a way that prevents children, animals, and others from consuming them. 
  • The best way to eliminate unwanted medication is the medicine-take-back program. 
  • You can contact your healthcare provider and local waste disposal company to learn how to discard the medication safely. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Fenofibrate Interactions

  • Acenocoumarol
  • Anisindione
  • Atorvastatin
  • Ciprofibrate
  • Colchicine
  • Colestipol
  • Cyclosporine
  • Dicumarol
  • Ezetimibe
  • Fluvastatin
  • Lovastatin
  • Phenprocoumon
  • Pitavastatin
  • Pravastatin
  • Rosiglitazone
  • Rosuvastatin
  • Simvastatin
  • Warfarin

[Note: This isn’t a complete list, and there could be other drugs that interact with Fenofibrate. Tell your doctor about any prescription, over-the-counter, or herbal products you’re taking.]

Fenofibrate Alternatives

  • Leqvio (Inclisiran)
  • Atorvastatin
  • Lopid (gemfibrozil)
  • Nexletol (bempedoic acid)
  • Lovaza (omega-3 polyunsaturated fatty acids)
  • Vascepa (icosapent ethyl)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can Fenofibrate be used in combination with statins for better lipid control?

Yes, Fenofibrate can be combined with statins in certain cases to achieve better lipid control. This combination may be prescribed for patients who do not reach their lipid goals with statins alone. However, this combination therapy can increase the risk of muscle toxicity, including myopathy and rhabdomyolysis. It is crucial to consult with a healthcare provider before combining these medications to ensure they are safe and appropriate for individual health conditions.

What should I monitor while taking Fenofibrate for lipid disorders?

Patients taking Fenofibrate should regularly monitor their lipid levels, liver function tests (LFTs), renal function, and muscle enzyme levels, particularly creatine phosphokinase (CPK). Regular monitoring helps assess the medication’s effectiveness and detect potential side effects early. Any unusual symptoms, such as muscle pain, tenderness, or weakness, should be reported to a healthcare provider immediately.

Are there any specific dietary recommendations while taking Fenofibrate?

To enhance the medication’s effectiveness, patients should follow a diet low in saturated fat and cholesterol while taking Fenofibrate. They should also avoid high-fat meals, as these can interfere with the medication’s ability to lower lipid levels. Maintaining a healthy diet, regular physical activity, and weight management are essential to managing lipid disorders in conjunction with medication.

How does Fenofibrate impact the risk of cardiovascular disease in patients with elevated triglycerides and low HDL cholesterol?

Fenofibrate can significantly reduce the risk of cardiovascular disease in patients with elevated triglycerides and low HDL cholesterol by lowering triglyceride levels and increasing HDL cholesterol levels. It works by activating peroxisome proliferator-activated receptors (PPARs), which are crucial in lipid metabolism. By improving lipid profiles, Fenofibrate helps reduce the risk of developing cardiovascular events such as heart attack and stroke. However, the benefit may vary based on individual risk factors and adherence to overall treatment plans, including lifestyle modifications.

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