Ipratropium Bromide / Albuterol (Salbutamol Sulfate)

Ipratropium / Albuterol (Salbutamol) is an FDA-approved combination medication for managing respiratory problems such as asthma, chronic bronchitis, emphysema, and COPD. It contains two active ingredients: ipratropium bromide & albuterol sulfate. It is available in the form of a metered-dose inhaler containing 18 mcg ipratropium bromide and 90 mcg albuterol sulfate per actuation and a nebulizer solution with 0.5 mg ipratropium bromide and 2.5 mg albuterol sulfate per 3 ml. You should consult your physician, pharmacist, or respiratory therapist for safe and efficient medication use. You can buy Ipratropium / Albuterol online at the best prices from the best Canadian online pharmacy to ensure your medication is secure and authentic.

Ipratropium Bromide / Albuterol (Salbutamol Sulfate) combines two active ingredients: ipratropium bromide and albuterol sulfate, used to manage respiratory conditions such as asthma, chronic bronchitis, emphysema, and chronic obstructive pulmonary disease (COPD). Ipratropium bromide, a short-acting anticholinergic, helps to relax and open the air passages to the lungs, making breathing easier. Albuterol sulfate, a short-acting beta-2 adrenergic agonist, provides quick relief by relaxing the airway muscles and increasing airflow to the lungs.

This medication is available in two forms: a metered-dose inhaler containing 18 mcg ipratropium bromide and 90 mcg albuterol sulfate per actuation and a nebulizer solution with 0.5 mg ipratropium bromide and 2.5 mg albuterol sulfate per 3 ml. Adults should use two puffs four times daily for inhalation aerosol, at most 12 puffs in 24 hours. For the nebulizer solution, adults should use one 3 ml vial four times daily, with up to 2 additional treatments per day if necessary. A doctor should determine usage and dosage for children.

Common side effects include cough, headache, dry mouth, nausea, and dizziness. Serious side effects may include paradoxical bronchospasm, severe allergic reactions, and cardiovascular effects. Precautions include informing your doctor of any allergies, current medications, and medical history, particularly related to glaucoma, urinary retention, cardiovascular disorders, and pregnancy. If a dose is missed, take it as soon as remembered, but do not double it. In case of an overdose of the medication, seek immediate medical assistance. Store the medication in its original container at room temperature, away from light and moisture, and keep it out of reach of children and pets. Always follow your healthcare provider’s instructions and consult them with any concerns.

It is used to treat:

• Asthma
• Chronic bronchitis
• Emphysema
• Chronic obstructive pulmonary disease

Form: Metered-dose inhaler

Strength: 18 mcg ipratropium bromide and 90 mcg albuterol sulfate per actuation

Form: Solution 

Strength: 0.5 mg ipratropium bromide and 2.5 mg albuterol sulfate per 3 ml 

Recommended Dosage for Ipratropium / Albuterol (Salbutamol)

For symptoms of COPD

When used with an inhaler

• The recommended dosage of Ipratropium / Albuterol for adults is two puffs four times daily and as required. You should not use more than twelve puffs in a day.
• The safety and efficacy of Ipratropium / Albuterol have not been established in children, so the doctor will determine the usage and dosage.

When used with a nebulizer

• The recommended dosage for adults is one 3 ml vial in the nebulizer daily. Two additional treatments daily may be used if necessary.
• The safety and efficacy of Ipratropium / Albuterol have not been established in children, so the doctor will determine the usage and dosage.

When used with an inhaler

• The recommended dosage for adults is one puff four times daily. Additional treatments may be used daily, but up to six puffs should be used daily.
• The safety and efficacy of Ipratropium / Albuterol have not been established in children, so the doctor will determine the usage and dosage.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• Ipratropium / Albuterol combination medication is available as a solution to be infused by mouth using a nebulizer or as a spray.
• Before taking Ipratropium / Albuterol, you should carefully read and follow the instructions for use given on the prescription label provided by your physician, pharmacist, or healthcare provider.
• It is typically used four times a day. Do not use it more or less than prescribed or more frequently without consulting your doctor.
• You should not take more than two extra doses of Ipratropium / Albuterol nebulizer daily.
• Your doctor may suggest that you take additional doses of Ipratropium and Albuterol if you experience wheezing, shortness of breath, or chest tightness.
• Call your doctor or healthcare provider at once if your symptoms worsen, if you feel like this inhalation is no longer able to control your symptoms, or if you have to take extra doses more frequently.
• If you are using it in inhaler form, the medication will come in cartridges. Each cartridge is designed to provide 120 inhalations of Ipratropium and Albuterol, which will last for a month if you use one inhalation four times daily.
• After you use all the inhalation doses, the inhaler will lock and not release any more medication.
• You should periodically check the dose indicator on the side of the inhaler to see how much Ipratropium or Albuterol is left.
• When the indicator enters the red area, the cartridge contains enough medication for a week, and you should get your prescription refilled so you do not run out of medication.
• Be careful not to get Ipratropium / Albuterol inhalation into your eyes as you can develop narrow-angle glaucoma, which may further cause loss of vision. If you already have narrow-angle glaucoma, getting this medication into your eyes may worsen your condition. If you experience symptoms such as widened pupils, blurred vision, eye pain or redness, and vision changes such as seeing unusual colors or halos around lights, immediately call your doctor.
• Before using this inhaler for the first time, carefully read and follow the directions for use given in the patient information leaflet and consult your doctor if you need help understanding any part of it.
• You can seek advice from your doctor, healthcare provider, or respiratory therapist and ask them to show you how to use the inhaler and practice using it while s/he watches.

Follow these instructions to prepare your inhaler for use:

• You should put it together before using it for the first time. Take the inhaler out of the box with the orange cap on it closed.
• Gently press the safety catch and pull off the clear base on the inhaler. Do not touch the piercing element inside the base.
• Remove the cartridge from the box and insert the narrow end into the inhaler. Press it against a hard surface to ensure it is inserted correctly. Replace the clear plastic base.
• Hold the Ipratropium / Albuterol inhaler upright with the orange cap closed and turn the clear base towards the direction of the white indicator until it clicks.
• Now flip the orange cap to open it fully. Point the Ipratropium / Albuterol inhaler towards the ground.
• Carefully press the dose release button and close the orange cap.
• Repeat these steps until you see a spray coming out of the inhaler, typically four to six times, then repeat these steps three more times.
• Your inhaler is now primed, and you may use it. You only need to prime it again if you haven’t used it for more than three days.
• Discard the inhaler after three months of putting it together.

Follow these instructions to prepare your inhaler for use:

• Hold the Ipratropium / Albuterol inhaler upright with the orange cap closed and turn the clear base towards the direction of the white indicator until it clicks.
• Open the cap of the inhaler and breathe out slowly & completely.
• Now place the Ipratropium / Albuterol mouthpiece in your mouth and close your lips around it. Do not cover the air vents of the inhaler with your lips.
• Point the Ipratropium / Albuterol inhaler toward the back of your throat and breathe in deeply and slowly.
• While you are breathing in, gently press the dose release button of the inhaler and continue to breathe in completely while the medication is released into your mouth.
• Hold your breath for as long as comfortably you can.
• Take the inhaler out of your mouth and replace the cap. Close the cap until you are ready to use it again.
• Follow these instructions to inhale your medication using a nebulizer:
• Remove one vial of Ipratropium / Albuterol solution from the foil pouch, twist off the top of the vial, and squeeze all the liquid into the nebulizer’s reservoir.
• Connect the reservoir to the face mask or mouthpiece.
• Connect the reservoir to the compressor and put the mouthpiece or face mask in your mouth.
• Turn on the compressor while seated comfortably in an upright position.
• Breathe in calmly and evenly through your mouth for about 5-15 minutes until a mist stops forming in the nebulizer’s chamber.
• Clean your nebulizer or inhaler regularly. Carefully read and follow the directions for use in the patient information leaflet, and ask your pharmacist or physician if you have any queries or concerns regarding the medication use.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Ipratropium and Albuterol (salbutamol) work together to improve breathing in patients with respiratory conditions like COPD or asthma. Albuterol is a short-acting beta-2 adrenergic agonist, while Ipratropium is a short-acting anticholinergic. Albuterol provides quick relief, while Ipratropium offers longer-lasting effects. The combination is often more effective than either medication alone.

Common side effects of Ipratropium / Albuterol (Salbutamol) may include:

• Cough
• Headache
• Dry mouth
• Nausea
• Dizziness
• Throat irritation
• Nervousness or anxiety

Mild side effects of Ipratropium / Albuterol (Salbutamol) may include:

• Tremors
• Increased heart rate
• Palpitations
• Muscle cramps
• Flushing
• Difficulty urinating
• Constipation
• Upset stomach
• Altered taste sensation

Adverse/Serious side effects of Ipratropium / Albuterol (Salbutamol) may include:

• Paradoxical bronchospasm (sudden worsening of breathing)
• Severe allergic reactions (anaphylaxis)
• Cardiovascular effects (significant changes in heart rhythm or blood pressure)
• Worsening of narrow-angle glaucoma
• Acute urinary retention
• Hypokalemia (low potassium levels)
• Severe muscle spasms or weakness
• Chest pain
• Irregular heartbeat
• Signs of pneumonia or other respiratory infections

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• In rare cases, inhaled medications can cause sudden worsening of breathing. Discontinue Ipratropium / Albuterol use and seek immediate medical attention if this occurs.
• If your breathing problems worsen suddenly or if you feel that your medications are not working as well as they should be, you should immediately call your doctor. Overuse of Ipratropium / Albuterol may increase your risk of death, so it is crucial to use it in the dose and frequency prescribed.
• Ipratropium / Albuterol may cause rapid heartbeat, increased blood pressure, or ECG changes, especially in patients with heart conditions.

• Before using this medication, let your physician or pharmacist know if you are allergic to Ipratropium, Albuterol, levalbuterol, or any other ingredients present in the product or if you are allergic to any other medications. Ask your doctor for the complete list of the ingredients.
• Before using Ipratropium / Albuterol, tell your doctor about all your medications, including prescription, non-prescription, over-the-counter drugs, and herbal supplements. You may need to adjust your medications’ dosage or monitor your symptoms carefully for unwanted side effects.
• Before taking Ipratropium / Albuterol, let your doctor or healthcare provider know if you are currently taking the following medications or have discontinued taking them within two weeks: antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine or monoamine oxidase (MAO) inhibitors such as isocarboxazid, phenelzine, tranylcypromine, selegiline. Non-prescription medications for colds may interact with albuterol and ipratropium inhalation. Make sure to tell your doctor or pharmacist that you are taking or planning to take any of these medications while using Ipratropium / Albuterol.
• Before using Ipratropium / Albuterol, tell your doctor or healthcare provider if you have or ever had the following conditions:
  • A prostate condition
  • Bladder blockage
  • Diabetes
  • Difficulty urinating
  • Glaucoma
  • Heart, liver or kidney disease
  • High blood pressure
  • Hyperthyroidism
  • Irregular heartbeat
  • Seizures
• While using Ipratropium / Albuterol combination medication, tell your doctor if you are pregnant, suspect a pregnancy, or are planning to become pregnant while you are receiving treatment with this medication.
• If you are planning to have surgery, including a dental procedure, tell your doctor about all the medications you are using, including Ipratropium / Albuterol. Also, tell them about all prescription, non-prescription, over-the-counter, and herbal supplements you are taking.
• Ipratropium / Albuterol may sometimes cause difficulty breathing and wheezing immediately after inhalation. Call your doctor right away if you experience this. You should not use this medication again unless your doctor tells you to.

Ipratropium / Albuterol (Salbutamol) is contraindicated for use in patients who have:

• Hypersensitivity
• Atropine derivatives
• Narrow-angle glaucoma
• Urinary retention
• Cardiovascular disorders
• Pregnancy and breastfeeding

• To get the best results from your medication, you should maintain consistency in dosage and try to take it around the same time.
• If you have missed a dose of Ipratropium / Albuterol, you should take it as soon as you remember.
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication as per your regular dosing schedule.
• Do not take double or extra doses to compensate for the missed dose.
• You should try setting a reminder on your phone to prevent missing doses.

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

If someone has taken Ipratropium / Albuterol more than recommended and is experiencing severe side effects such as passing out, seizures, difficulty breathing, or if they can’t be woken up, immediately seek medical assistance. Call your doctor, 911, or head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

• Keep Ipratropium / Albuterol in its original container, tightly closed at a controlled room temperature, away from direct sunlight, moisture, and excess heat.
• Keep unused nebulizer solution vials in the foil pouch until you can use them.
• Do not keep Ipratropium / Albuterol in the bathroom.
• Do not allow the Ipratropium / Albuterol inhalation spray to freeze.
• Keep all medications, including Ipratropium / Albuterol, in a safe place, away from the sight and reach of children and pets.
• Do not keep medications that are outdated or no longer needed. Discard them safely.
• Do not pour it into wastewater, flush it down the toilet, or throw it into the household garbage bin.
• Dispose of unwanted medications in such a way that children, animals, and others cannot consume them.
• The best way to eliminate unwanted medication is to give it through a medicine take-back program.
• For more information on how to properly discard unwanted medication, consult your pharmacist, healthcare provider, or local waste recycling company.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

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[Note: This isn’t a complete list, and there could be other drugs that interact with Ipratropium / Albuterol (Salbutamol). Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re you’re taking.]

• Serevent (salmeterol)
• Foradil (formoterol) 
• Onbrez (indacaterol) 
• Arcapta (indacaterol)
• Spiriva (tiotropium)
• Incruse (umeclidinium)
• Seebri (glycopyrronium)
• Tudorza (aclidinium)
• Eklira (aclidinium)
• Flovent (fluticasone)
• Pulmicort (budesonide)
• QVAR (beclomethasone)
• Asmanex (mometasone)
• Advair (fluticasone)
• Seretide (salmeterol)
• Symbicort (budesonide/formoterol)
• Dulera (mometasone/formoterol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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