Finerenone
Kerendia
Kerendia is available as a brand-name drug and is used for the management of chronic kidney disease (CKD) that occurs due to type 2 diabetes. The medication is also FDA-approved, and it helps in slowing down kidney damage in adults, thus reducing the risk of kidney failure. Doctors usually prescribe this medication to adults, but the dosage may vary from person to person. Therefore, patients are advised to follow the doses mentioned in your prescription label. Additionally, there are certain side effects of this medication, so if you are feeling unusual, immediately contact your medical practitioner to avoid any future complications.
Product Overview
Kerendia is a prescription medication widely used to manage chronic kidney disease (CKD) associated with type 2 diabetes. Kidney problems develop when your kidneys fail to function properly, and patients with type 2 diabetes are more prone to such conditions. When this drug is absorbed into the system, it releases finerenone, a mineralocorticoid receptor antagonist that reduces the risk of kidney damage and cardiovascular events in affected patients. As approved by the FDA, the drug is safe and effective for treating the said condition.
Kerendia is available in tablet form, with strengths of 10 and 20 mg. Patients should take it once daily, with or without food, as directed by their medical provider. It is suitable for adults diagnosed with CKD and type 2 diabetes. Kerendia works by blocking the effects of the hormone aldosterone, which can cause harmful inflammation and fibrosis in the kidneys. Thus, it protects kidney function and reduces cardiovascular risks.
While the medication works effectively, it has some common side effects, which may include hyperkalemia (high potassium levels), hypotension (low blood pressure), and hyponatremia (low sodium levels). Patients should inform their medical practitioner about any existing medical conditions, especially kidney problems, electrolyte imbalances, or if they are pregnant or breastfeeding. If a dose is missed, take it as soon as remembered unless it is close to the time for the next dose. Do not double up to make up for the skipped dose, as it can cause adverse reactions of overdose. You can store Kerendia at room temperature, away from moisture and heat. Patients are advised to follow their healthcare practitioner’s guidance closely, ensuring proper use and monitoring for any serious side effects or interactions with other drugs.
Uses of Kerendia
It is primarily used to treat chronic kidney disease or CKD and reduce the risk of complications, which may include:
- Heart attack
- Impaired kidney functioning
- Hospitalizations for heart damage
- End stage renal disease, or ESRD
- Death caused by strokes
How to Use Kerendia?
Dosage
Strengths and Forms
Kerendia is available in an oral tablet form with the following strengths:
- 10 mg, and
- 20 mg
Recommended Dosage for Different Patients
For Kidney Disease Linked to Type 2 Diabetes
The recommended daily dose for these patients is 10 or 20 mg as prescribed by the doctor based on your kidney function tests. The patient’s kidney function test is determined by their eGFR or estimated glomerular filtration test. Here are the starting doses according to the patient’s eGFR:
- If eGFR ≥ 60, the starting dose will be 20 mg each day.
- If eGFR ≥ 25 to < 60, the starting dose will be 10 mg each day.
- If eGFR < 25, a different treatment option is suggested.
After your Kerendia treatment is initiated, your medical practitioner will order a blood test to check your blood potassium levels. This test will be done after four weeks of treatment initiation. In certain situations, these experts may adjust your dosage to a maximum of 20 mg each day.
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- Before you start taking your medication, read the patient information leaflet and follow your doctor’s instructions to avoid any complications.
- Wash your hands thoroughly before touching the tablets.
- Take the medicine by mouth, with or without food, once daily, as instructed by your healthcare provider.
- Swallow the tablet as a whole for effective results.
- If swallowing the tablet is difficult for you, you can seek expert guidance, crush the tablet, and mix it in water or with soft food like applesauce.
- Do not break the tablet.
- Avoid drinking the whole mixture at once.
- Do not prepare the mixture in advance for future use.
- Your medications are based on your medical condition and treatment response, so take it accordingly.
- Take the medicines at the same time each day to get the most benefit of it.
- Do not take less or higher doses of Kerendia as it causes adverse effects.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Kerendia Work?
Kerendia is used to reduce the risk of severe problems in patients with chronic kidney disease associated with type 2 diabetes. This condition develops when your kidneys lack the ability to filter your blood, leading to symptoms like swelling in hands or feet, troubled breathing, and changes in urination. Type 2 diabetes can raise the chances of developing CKD. This condition causes high levels of glucose in the blood, which can, over time, harm the blood vessels in your kidneys. Kerendia helps prevent heart and kidney problems associated with CKD.
These issues can occur from swelling or scarring in the kidneys, heart, or blood vessels, often due to excessive activity in mineralocorticoid receptors (MRs). These receptors are proteins that play a role in regulating blood pressure and maintaining the body’s electrolyte and fluid balance.
When a patient takes Kerendia, the drug works by reducing the MR activity, thus lowering the chances of developing conditions like end-stage renal disease, heart attacks, and hospitalizations from heart failure.
Important Safety Information
Side Effects
Common side effects of Kerendia may include:
- Low blood pressure (Hypotension)
- Low sodium level
- Dizziness
- Cold skin
- Confusion
- Troubled breathing
- Slow pulse
- Fainting
- Nausea
- Vomiting
- Headache
- Muscle weakness
- Cramps
- Stomach pain
- Fatigue
Serious side effects of Kerendia may include:
- High potassium level in the blood.
- Allergies
- Seizures
- Itchiness
- Skin flushing
- Skin rashes
- Swelling under the skin like lips, eyelids, hands or feet
- Swelling on tongue, mouth, or throat
- Anxiety
- Numbness in the limbs
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
- Kidney Problems: Kerendia is used for the treatment of CKD, which is related to type 2 diabetes. If you have other severe kidney problems, there is a high chance that you may experience serious side effects like high potassium levels in the blood. Talk to your doctor before you start your treatment with this medication.
- High Potassium Levels: The medication can result in high potassium levels, so if you already have increased levels of potassium in the blood, Kerendia may exacerbate your condition. Therefore, it is advised to frequently monitor your potassium levels throughout the treatment.
- Adrenal Insufficiency: If you are suffering from a condition like adrenal insufficiency, your doctor may not recommend Kerendia. Symptoms of adrenal insufficiency and side effects of Kerendia are similar, which may include:
- Low blood pressure
- Low blood sodium levels
- High potassium levels
Therefore, you are at increased risk of side effects if you are suffering from this condition. Consult with your doctor beforehand to know the best treatment option for you.
- Liver Problems: If you have severe liver problems like cirrhosis, inform your doctor once, as it is still unknown if Kerendia may be a safer option for patients with such conditions. Talk to your healthcare provider before making any decision.
Precautions
- Avoid eating grapefruit or even drinking grapefruit juice when taking this medication unless your doctor says otherwise. This is because the grapefruit can increase the risk of medicine’s side effects. Talk to your doctor or pharmacist for detailed information.
- Before you start your treatment with Kerendia, make sure that you are informing your doctor about any allergies you might have or if you are allergic to any of the product’s ingredients. This medication may contain certain inactive components that may cause adverse allergic reactions to patients.
- Before you start taking this medication, talk to your healthcare provider about your medical history. This step is crucial for patients who have a history of high potassium levels or low adrenal gland function and liver problems.
- It is highly likely that patients might experience high potassium levels. Therefore, if you are thinking of or using any potassium supplement or salt substitutes containing potassium, talk to your healthcare professional for expert advice.
- Do not drink alcohol or take substances like marijuana while taking this medication, as the drug used in it can make you feel dizzy. So, avoid driving or using machinery that needs your full concentration.
- Inform your doctor or dentist about every product you use when undergoing surgery or a medical procedure. These may include prescription drugs, nonprescription drugs, and herbal products.
Other Important Precautions
- Pregnancy: If you are pregnant or planning to have children while taking this medication, have a consultation with your medical practitioner, as its usage is advised when it is necessary. Make sure to discuss every risk and benefit with your doctor.
- Breastfeeding: There is not enough information on whether the drug passes into breast milk. Due to possible risks to the child, breastfeeding is not recommended during the treatment of the medication and for one day after the last dose. So, you are advised to consult with your doctor before making any decisions.
Contraindications
It is contraindicated in patients:
- Who have adrenal insufficiency
- Who is undergoing simultaneous treatment with strong g CYP3A4 inhibitors.
Missed Dose
The patients are advised to follow their prescriptions regularly, but if someone forgets to take a dose or two, they can:
- Try to take the missed dose as soon as possible.
- When it is nearly time for the new dose, you may omit the missed one and continue your regular dosing schedule.
- Do not take double doses to catch up for the missed one, as it can cause severe side effects.
- Try to take each tablet at the same time regularly.
- Use medication apps or set reminders on your phone to avoid skipping any doses.
- If you are unsure or have any queries about the situation, talk to your doctor.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
Doctors advise against overdosage of Kerendia. However, if you have mistakenly taken an exceeding amount of maximum doses and are experiencing overdose symptoms, immediately contact your doctor or call 911. The symptoms of overdose may include:
- Chest pain
- Troubled breathing
- Irregular heartbeats
- Nausea
- Vomiting
- Weakness
- Fatigue
[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]
Storage
- Keep your medications at a temperature between 20°C to 25°C.
- You can also store your tablets at a temperature of 15°C-30°C for a brief period of time.
- Keep the medicines away from light and moisture.
- Avoid keeping them in damp areas like the bathroom or near the sink.
- Make sure you keep the medicines somewhere safe in a closed container, away from children and pets.
- Discard the product when not in use or past its expiration date.
- Do not flush the medicines down the toilet.
- Consult your doctor or pharmacist to know how you can dispose of the product safely.
- Read your product’s label for detailed storage instructions.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Kerendia Interactions
- Lisinopril
- Losartan
- Aliskiren
- Alprostadil
- Ambrisentan
- Amiloride
- Amprenavir
- Benazepril
- Boceprevir
- Bosentan
- Ciprofloxacin
- Clarithromycin
- Cyclosporine
- Esmolol
- Ethacrynic acid
- Ethaverine
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Ketoconazole
- Methyldopa
- Metolazone
- Potassium bicarbonate
- Potassium chloride
- Potassium citrate
- Potassium gluconate
- Rifampin
- Rifapentine
- Trimethoprim
- Trofinetide
- Vemurafenib
- Verapamil
[Note: This isn’t a complete list, and there could be other drugs that interact with Kerendia. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Kerendia Alternatives
- Dapagliflozin
- Jardiance
- Empagliflozin
- Auvi-Q
- Epinephrine
- Np Thyroid
- Descovy
- Multivitamin/Fluoride
- Eszopiclone
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
What dietary changes should be considered when taking Kerendia?
When taking Kerendia, it is important to monitor and potentially reduce potassium-rich foods, as the medication can increase potassium levels. Additionally, maintaining a nutritious diet low in sodium and rich in fiber can help manage blood pressure and support overall kidney health. It is also advised to avoid taking grapefruit or grapefruit juices. For personalized diet charts, you can always contact your doctor.
What are the long-term effects of using Kerendia?
Long-term use of Kerendia can significantly delay the advancement of chronic kidney disease and reduce the risk of cardiovascular events. It helps maintain kidney function and improves heart health, contributing to better overall outcomes for patients with CKD and type 2 diabetes. The medication is typically used as a long-term option.
How does Kerendia differ from other CKD treatments?
Kerendia uniquely targets mineralocorticoid receptors (MRs) to reduce inflammation and fibrosis in the kidneys. Unlike other CKD treatments, it addresses kidney as well as cardiovascular risks in patients with type 2 diabetes, offering a complete approach to managing the disease.
What are the benefits of taking Kerendia?
Kerendia offers multiple benefits, including slowing the progression of chronic kidney disease, reducing kidney inflammation, and lowering the risk of cardiovascular events. By protecting both the kidneys and heart, it provides comprehensive care for patients with CKD and type 2 diabetes.
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