Ivabradine

Lancora

Lancora (ivabradine) is an FDA-approved medication for adults with chronic heart failure, designed to lower the risk of hospitalization due to worsening heart failure. Additionally, it is prescribed for children aged 6 months and older with stable heart failure resulting from an enlarged heart (dilated cardiomyopathy). Lancora is available in two dosage forms: film-coated tablets of 5 mg and 7.5 mg, packaged in quantities of 112 tablets, and an oral liquid form with a concentration of 5 mg per 5 mL. Lancora is available only with your doctor’s prescription. So, if you want to buy Lancore to treat chronic heart failure, then you need to get a valid prescription from your doctor.

Product Overview

Lancora (ivabradine) is a highly effective, FDA-approved medication designed to manage chronic heart failure in adults and children. For adults, it significantly reduces the risk of hospitalization due to worsening heart failure. For children aged 6 months and older, Lancora is used to treat stable heart failure caused by dilated cardiomyopathy, a condition characterized by an enlarged heart. Lancora is available in two forms: film-coated tablets (5 mg and 7.5 mg) packaged in quantities of 112 tablets and an oral liquid form with a concentration of 5 mg per 5 mL. This medication requires a doctor’s prescription to ensure it is used safely and effectively under medical supervision.

Lancora is specifically prescribed for heart failure management. In adults, it is used to prevent the progression of heart failure and the need for hospital treatment. For children, it addresses heart failure resulting from an enlarged heart. Ivabradine, the active ingredient in Lancora, works by slowing the heart rate, thereby reducing the heart’s workload and improving blood pumping efficiency. The recommended starting dose for adults is 5 mg taken twice daily with meals, which can be adjusted to a maximum of 7.5 mg twice daily based on heart rate and tolerance. 

When taking Lancora, it is essential to follow your doctor’s instructions precisely. The medication should be taken with food to enhance absorption. For those who cannot swallow tablets, the oral liquid can be used and measured accurately with a marked syringe. Avoid grapefruit products while on this medication, as they can interfere with its effectiveness. Common side effects of this medication may include blurred vision, dizziness, and slow heartbeats. Serious side effects like severe dizziness, chest pain, or allergic reactions should need immediate medical attention. Patients should inform their healthcare provider about all current medications to avoid potential drug interactions.

What Are the Uses of Lancora?

Lancora is prescribed for the treatment of heart failure. Here are the uses of Lancora:

• It helps prevent the progression of heart failure, reducing the need for hospitalization in adults.
• It is used to manage heart failure caused by an enlarged heart (dilated cardiomyopathy) in children.

What Are the Forms & Strengths of Lancora?

Ivabradine comes as a tablet and as an oral solution (liquid) to take by mouth. 

• Oral Tablets: 5 mg, 7.5 mg
• Oral Liquid: 5 mg per 5 mL 

What Are the Recommended Dosage of Lancora?

For Adults

Heart Failure:

• • Indication: Used to reduce the chance of hospitalization for worsening heart failure in patients with a left ventricular ejection fraction (LVEF) ≤35%, who are in sinus rhythm with a resting heart rate of ≥70 bpm, and are either on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use.

• Initial Dosage:

• • • 5 mg orally twice daily (BID) with meals.
    • After 2 weeks, assess the patient and adjust the dose to achieve a resting heart rate of 50-60 bpm.
    • Adjust the dose as needed based on resting heart rate and tolerability; the maximum dose should not exceed 7.5 mg BID.

• Dose Adjustments:

• • • HR >60 bpm: Increase the dose by 2.5 mg (given BID) up to a maximum dose of 7.5 mg BID.
    • HR 50-60 bpm: Maintain the current dose.
    • HR <50 bpm or signs of bradycardia: Decrease the dose by 2.5 mg (given BID); if the current dose is 2.5 mg BID, discontinue therapy.

• Dosage Modifications:

• • • Conduction defects or risk of hemodynamic compromise: Start with an initial dose of 2.5 mg PO BID; increase based on heart rate.

• Hepatic Impairment:

• • • Mild or moderate (Child-Pugh A or B): No dose adjustment required.
    • Severe (Child-Pugh C): Contraindicated.

• Renal Impairment:

• • CrCl 15-60 mL/min: No dose adjustment required.
  • CrCl <15 mL/min: No data available.

For Pediatric Use

Heart Failure:

• • Indication: Treatment of stable symptomatic heart failure due to DCM (dilated cardiomyopathy) in children aged ≥6 months who are in sinus rhythm with an elevated heart rate.

• Safety and Efficacy:

• • • <6 months: Not established.

• Dosage for Children ≥6 months:

• • • <40 kg (Oral Solution):
      • Initial: 0.05 mg/kg PO BID with meals.
      • Adjustment: Assess at 2-week intervals and adjust by 0.05 mg/kg to target a heart rate reduction of at least 20%, based on tolerability.
      • Maximum Dose (6 months to <1 year): Not to exceed 0.2 mg/kg BID.
      • Maximum Dose (≥1 year): 0.3 mg/kg BID; not to exceed 7.5 mg BID.
    • ≥40 kg (Oral Tablets):
      • Initial: 2.5 mg PO BID with meals.
      • Adjustment: Assess at 2-week intervals and adjust by 2.5 mg to target a heart rate reduction of at least 20%, based on tolerability, not to exceed 7.5 mg BID.
      • Dose Reduction for Bradycardia: If bradycardia develops, reduce to the previous titration step. For bradycardia at the initial dosage, consider reducing to 0.02 mg/kg BID.

• Dosage Modifications:

• • Hepatic Impairment:
    • Mild or moderate (Child-Pugh A or B): No dose adjustment is required.
    • Severe (Child-Pugh C): Contraindicated.
  • Renal Impairment:
    • CrCl 15-60 mL/min: No dose adjustment is required.
    • CrCl <15 mL/min: No data is available.

[Note: Remember that the recommendations mentioned above may vary from person to person. Discuss it with your doctor or pharmacist, and they’ll customize your Lancora dosage accordingly.]

How to Use Lancora?

Taking Lancora properly is crucial for their effectiveness and your safety. Here are some general guidelines on how to take medicines:

• Use Lancora exactly as prescribed by your doctor. 
• Do not use it more or less than directed, and do not use it more frequently or for a longer period than your doctor has ordered. 
• Take Lancora twice a day. Once in the morning with your meal and again 12 hours later in the evening, also with a meal.
• Lancora comes with a Medication Guide and patient instructions. Carefully read and follow these instructions. If you have any questions, ask your doctor.

Tablet Instructions

If you are prescribed to take Lancora tablets, here are the guidelines you need to follow: 

• Some Lancora tablets have a line down the middle. If your doctor instructs you to take half a tablet, carefully break it along the line. 
• Take half of the tablet as directed, and save the other half for your next dose.
• Always take this medication with food.

Oral Liquid Instructions

If you cannot swallow the tablet, use the oral liquid form of the medication. Here’s how to properly use the oral liquid:

• Empty the contents of the ampule into a medication cup. Do not open the foil pouch containing the ampule until you are ready to use it.
• Use a marked oral syringe to measure the exact dose.
• Place the tip of the oral syringe into your or your child’s mouth, aiming towards the cheek. Slowly push down on the plunger until the syringe is empty.
• Do not save or reuse any leftover oral liquid in the cup or syringe.
• Do not eat grapefruit or drink grapefruit juice while taking Lancora. Grapefruit can affect the absorption of the medicine in your body.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Lancora Work?

Ivabradine, the active ingredient in Lancora, works by slowing your heartbeat by a few beats each minute. This reduction in heart rate decreases the workload on your heart and improves your ejection fraction. Your healthcare provider will determine the appropriate dose for you, which may be adjusted based on your heart rate. When used in combination with other heart failure medications, ivabradine can:

• Slow the progression of heart failure
• Improve heart failure symptoms
• Enhance ejection fraction
• Reduce the likelihood of hospital stays for heart failure treatment

Important Safety Information for Lancora Usage

What Are the Side Effects of Lancora?

The potential side effects mentioned here do not necessarily affect every individual who uses this medication. If you have concerns about the side effects of Lancora, it’s important to have a conversation with your doctor about the possible risks and benefits this medication offers. It has been observed that at least 1% of individuals who have taken this medication have reported experiencing certain side effects. Fortunately, many of these side effects are manageable, and a number of them may diminish or resolve completely as your body adjusts to the medication over time. Common side effects of Lancora may include:

• Nervousness
• Blurred vision
• Lightheadedness, dizziness, or fainting
• Pounding in the ears
• Fast or irregular heartbeat
• Chest pain or discomfort
• Headache
• Slow or irregular heartbeat
• Unusual tiredness

While the side effects listed below are relatively uncommon, failing to seek medical attention if they occur could result in mild complications. Mild side effects of Lancora may include:

• A feeling of constant movement of self or surroundings
• Unusually warm skin
• Trouble seeing
• Sensation of spinning
• Flushing or redness of the skin
• Double vision

Discontinue the use of the medication and promptly seek medical assistance if you experience any of the following symptoms:

• Excessive tiredness
• Lack of energy
• Hoarseness
• Chest pain or pressure
• Fast, irregular, or pounding heartbeat
• Swelling of the face, throat, tongue, lips, and eyes
• Difficulty swallowing or breathing
• Slow or stopped heartbeat
• Worsening shortness of breath
• Dizziness

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Lancora?

Lancora (ivabradine) is used for certain heart conditions, but it comes with several important warnings.

• Serious Heart Conditions: Ivabradine is contraindicated for individuals with certain serious cardiac conditions. If you have “sick sinus syndrome” or “3rd-degree atrioventricular (AV) block,” using ivabradine may exacerbate your condition by further slowing your heart rate. These conditions are typically characterized by an abnormally slow heartbeat that can lead to severe symptoms such as dizziness, fatigue, or fainting. It is safe to use ivabradine only if you have a properly functioning pacemaker installed. A pacemaker can help maintain an adequate heart rate, counteracting the heart rate-lowering effect of ivabradine.
• Pacemaker Dependence: If you depend on a pacemaker to regulate your heart rate, using ivabradine is generally not recommended. Ivabradine can potentially disrupt the electrical activity of the heart, which the pacemaker is designed to correct. This interaction could lead to an irregular heart rate or impair the effectiveness of the pacemaker, resulting in adverse cardiac symptoms or complications. Ensure to consult your healthcare provider for alternative medications that do not interfere with pacemaker operations.

What Are the Lancora Precautions?

Before you start using medication, it is crucial to inform your doctor about any medical conditions you have, any known allergies, all medications you are currently taking, and whether you are pregnant or breastfeeding. Additionally, share any other significant health-related information. These details are essential as they may influence how you should use this medication.

• Driving and Operating Machinery: Ivabradine can cause side effects such as blurred vision, dizziness, or weakness. These side effects may impair your ability to drive or operate machinery safely. Therefore, you should avoid driving, operating machinery, or performing other hazardous tasks until you understand how this medication affects you. Ensure you can perform such activities safely before engaging in them.
• Heart Rate Reduction and Related Symptoms: Ivabradine is designed to slow down the heart rate. However, in some cases, it can alter the normal rhythm of the heart. If the heart rate slows excessively, you may experience unusual fatigue or lightheadedness. It is crucial to monitor these symptoms and inform your doctor if they occur.
• Risk of Atrial Fibrillation: Ivabradine can increase the risk of atrial fibrillation, a condition where the heart’s two smaller chambers (atria) beat rapidly and irregularly. Symptoms of atrial fibrillation include:
  • Shortness of breath
  • A pounding or irregular heartbeat
  • Dizziness

If you experience any of these symptoms, contact your healthcare provider immediately.

• QT Prolongation and Associated Risks: Ivabradine may cause an irregular heartbeat, known as QT prolongation. This condition is serious and can lead to:
  • Fainting
  • Seizures
  • Sudden death

Those at higher risk for heart rhythm issues, such as individuals with angina, heart failure, or low magnesium or potassium levels, should discuss with their doctor how ivabradine might impact their health. Your doctor will consider these factors to determine the appropriate dosage and whether special monitoring is required. 

• Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Lancora may affect your health condition, dosing, effectiveness, or whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
• Vision changes: The medication Lancora, containing ivabradine, has been reported to potentially influence your vision. You may experience symptoms such as the appearance of spots or a general blurring of light. It is essential to monitor for any alterations in your vision while on this medication. Should you observe any changes, such as increased blurriness or spots, it is crucial to promptly contact your healthcare provider or doctor for advice and potential adjustments to your treatment plan.
• Pregnancy: Ivabradine is generally advised against during pregnancy unless the anticipated benefits significantly surpass the potential risks involved. If you become pregnant while undergoing treatment with this medication, it is important to inform your doctor immediately. Additionally, individuals who are of childbearing potential are advised to employ reliable methods of contraception throughout the duration of treatment with ivabradine to prevent pregnancy.
• Breast-feeding: The excretion of ivabradine into breast milk remains uncertain. Therefore, if you are breastfeeding and taking this medication, there could be implications for your child’s health. It is important to discuss with your doctor whether continuing breastfeeding is advisable under these circumstances. They can provide guidance on whether the benefits of breastfeeding might outweigh the risks or if alternative feeding solutions should be considered for your child during the course of treatment.
• Children: The effectiveness of this medication for pediatric patients have not yet been conclusively established. Clinical studies assessing its impact on children are limited or inconclusive. As a result, caution is advised when considering this medication for treatment in children. Healthcare providers typically evaluate the potential risks and benefits on a case-by-case basis before prescribing this medication to younger patients.
• Seniors: Individuals who are 75 years of age and older may experience a higher susceptibility to side effects when using this medication. Due to physiological changes that occur with aging, such as alterations in liver and kidney function, older adults may process drugs differently. Consequently, seniors might require adjustments in the dosage to minimize the risk of adverse effects. It is important for healthcare professionals to closely monitor the health and response of elderly patients on this medication and tailor dosages specifically to their needs.

What If You Missed a Dose of Lancora?

• If you miss a dose of Lancora, it is important to assess the timing of your next scheduled dose.
• If your next dose is due in more than 4 hours, take the missed dose as soon as you remember.
• Continue with your regular dosing schedule by taking the subsequent dose at the usual time.
• If it is less than 4 hours until your next dose, skip the missed dose altogether.
• Return to your regular dosing schedule without taking double doses to compensate for the missed one.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Lancora?

If someone takes too much Lancora and experiences severe reactions such as collapsing, having a seizure, struggling to breathe, or becoming unresponsive, it is critical to call emergency services immediately by dialing 911. An overdose of Lancora can lead to a variety of symptoms, which include a significantly slowed heartbeat, feelings of dizziness, extreme fatigue, and a noticeable decrease in energy levels. Immediate and urgent medical attention is essential to address these symptoms effectively and prevent further health complications.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Lancora?

• Securely store Lancora in a closed container positioned at room temperature.
• Ensure the storage area is free from sources of heat, moisture, and direct light exposure.
• Prevent freezing of the medicine.
• Maintain strict accessibility controls, keeping the medicine out of reach of children.
• Tablets should be stored at a stable temperature of 25°C (77°F), with allowances for temperature fluctuations between 15°C and 30°C (59°F to 86°F).
• Oral solution should also be maintained at 25°C (77°F), with the same temperature range permitted as for tablets. Additionally, protect the oral solution ampules from light exposure by storing them in the provided foil pouch until needed.
• Dispose of any outdated or unneeded medication; consult your healthcare professional for proper disposal methods.
• Dispose of any unused oral liquid immediately to ensure safety.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Lancora?

When consulting with your healthcare professional, it is crucial to disclose all substances you are currently using or plan to use. This includes not only prescription medications but also over-the-counter drugs, vitamins, and herbal supplements. Such transparency is essential because various medications can influence how Lancora functions in your body. Specifically, you must inform your doctor if you are taking any of the following:

• • Verapamil or Diltiazem: These drugs, when used in combination with ivabradine (the active ingredient in Lancora), significantly increase systemic exposure to ivabradine. Therefore, their co-administration should be avoided to prevent potential adverse effects.
  • Negative Chronotropes: Medications such as digoxin, amiodarone, and beta-blockers can slow down your heart rate. When these are used with ivabradine, there is a heightened risk of bradycardia (abnormally slow heart rate). It is important to monitor heart rate closely if these medications are taken concurrently with ivabradine.

• CYP3A4 Inhibitors and Inducers:

• • Primarily Metabolized by CYP3A4: Ivabradine is primarily metabolized by the enzyme CYP3A4.
  • CYP3A4 Inhibitors: These inhibitors increase the plasma concentrations of ivabradine, which may exacerbate bradycardia & conduction disturbances. The use of strong CYP3A4 inhibitors is also contraindicated, and even moderate inhibitors should be avoided.
  • CYP3A4 Inducers: These can decrease the plasma concentrations of ivabradine, potentially reducing its effectiveness. Their use should also be avoided.

While certain medications should not be used concurrently under any circumstances, there are instances where two different drugs may be prescribed together despite a possible interaction. In such situations, your doctor might adjust the dosages or take other precautionary measures. It is particularly important that your healthcare provider is aware if you are taking any of the medications mentioned above, as they have been selected based on their potential significance, although this list is not exhaustive. 

• Other Drug Interactions: Using this medicine with any of the following medicines is usually not recommended but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
  • Flucytosine
  • Osimertinib
  • Granisetron
  • Sorafenib
  • Haloperidol
  • Apomorphine
  • Octreotide
  • Vorinostat
  • Goserelin
  • Leuprolide
  • Quinidine
  • Imipramine
  • Lofexidine
  • Fluoxetine
  • Zuclopenthixol
  • Promethazine
  • Citalopram
  • Procainamide
  • Pazopanib
  • Duvelisib
  • Verapamil
  • Aprepitant
  • Dabrafenib
  • Dronedarone
  • Atazanavir
  • Deutetrabenazine
  • Ozanimod
  • Efavirenz
  • Gepirone
  • Clomipramine
  • Perphenazine
  • Panobinostat
  • Netupitant
  • Alfuzosin
  • Ondansetron
  • Lapatinib
  • Ribociclib
  • Quizartinib
  • Levofloxacin
  • Fexinidazole
  • Vinflunine
  • Telavancin
  • Ponesimod
  • Pimavanserin
  • Gatifloxacin
  • Ivabradine
  • Nilotinib
  • Mifepristone
  • Risperidone
  • Clozapine
  • Diltiazem
  • Tacrolimus
  • Dasatinib
  • Eribulin
  • Lumefantrine
  • Halofantrine
  • Rifampin
  • Trimipramine
  • Formoterol
  • Glasdegib
  • Ranolazine
  • Aripiprazole
  • Buserelin
  • Dofetilide
  • Mirtazapine
  • Clofazimine
  • Ebastine
  • Buprenorphine
  • Primidone
  • Pazopanib
  • Mobocertinib
  • Prochlorperazine
  • Fosaprepitant
  • Doxepin
  • Protriptyline
  • Olanzapine
  • Galantamine
  • Methadone
  • Selpercatinib
  • Efavirenz
  • Asenapine
  • Trofinetide
  • Mitotane
  • Azithromycin
  • Chloroquine
  • Sodium Phosphate
  • Tacrolimus
  • Tamoxifen
  • Bedaquiline
  • Fingolimod
  • Delamanid
  • Macimorelin
  • Escitalopram
  • Trazodone
  • Primidone
  • Histrelin
  • Vilanterol
  • Gonadorelin
  • Desipramine
  • Ibutilide
  • Ivosidenib
  • Domperidone
  • Pacritinib
  • Enzalutamide
  • Digoxin
  • Triclabendazole
  • Venlafaxine
  • St John’s Wort
  • Vorinostat
  • Droperidol
  • Mizolastine
  • Sunitinib
  • Vardenafil
  • Venlafaxine
  • Ritonavir
  • Pentamidine
  • Entrectinib
  • Sevoflurane
  • Clozapine
  • Hydroxyzine
  • Siponimod
  • Moxifloxacin
  • Vandetanib
  • Propafenone
  • Metronidazole
  • Ceritinib
  • Sotalol
  • Hydroquinidine
  • Sulpiride
  • Buprenorphine
  • Alpelisib
  • Norfloxacin
  • Lenacapavir
  • Lenvatinib
  • Sodium Phosphate, Monobasic
  • Adagrasib
  • Deslorelin
  • Inotuzumab Ozogamicin
  • Aripiprazole Lauroxil
  • Solifenacin
  • Omaveloxolone
  • Dolasetron
  • Diltiazem
  • Norfloxacin
  • Vemurafenib
  • Fosnetupitant
  • Crizotinib
  • Vincristine
  • Pitolisant
  • Sertraline
  • Encorafenib
  • Relugolix
  • Sodium Phosphate, Dibasic
  • Toremifene
  • Donepezil
  • Voriconazole
  • Carbamazepine
  • Sertindole
  • Felbamate
  • Gemifloxacin
  • Amisulpride
  • Degarelix
  • Lorlatinib
  • Fosphenytoin
  • Anagrelide
  • Tetrabenazine
  • Mavacamten
  • Pirtobrutinib
  • Triptorelin
  • Disopyramide
  • Mefloquine
  • Darolutamide
  • Sodium Phosphate, Monobasic
  • Hydroxychloroquine
  • Quetiapine
  • Letermovir
  • Tolterodine
  • Fedratinib
  • Amiodarone
  • Inotuzumab Ozogamicin
  • Amitriptyline
  • Darunavir
  • Ritlecitinib
  • Foscarnet
  • Lumacaftor
  • Larotrectinib
  • Pitolisant
  • Alprazolam
  • Givinostat
  • Fostemsavir
  • Chlorpromazine
  • Dasatinib
  • Pasireotide
  • Amiodarone
  • Lumefantrine
  • Imatinib
  • Hydroxychloroquine
  • Quizartinib
  • Fosaprepitant

What Are the Other Lancora Interactions?

Certain medications, including Lancora, should not be taken during or close to meal times, particularly with specific types of food, because this can lead to interactions that may affect how the drug works or increase the risk of side effects. Additionally, the consumption of alcohol or the use of tobacco products when taking certain medications can also trigger potentially harmful interactions.

• Interactions with Food: Some medicines may interact with specific components found in foods, altering the medication’s effectiveness or causing adverse effects. For example, high-fiber meals may impede the absorption of certain drugs, while dairy products can interfere with the effectiveness of some antibiotics by binding to the medication and preventing it from being absorbed. Always check with your healthcare provider about any dietary restrictions or guidelines you should follow while taking medication, like Lancora.
• Interactions with Alcohol: Consuming alcohol can intensify the sedative effects of medications like sleeping pills, antianxiety drugs, and some antidepressants, potentially leading to excessive drowsiness or other impairments. Specifically, when taking Lancora, consuming alcohol may exacerbate the medication’s effects on heart rate and blood pressure. Drinking alcohol while on medications can increase the risk of liver damage, while alcohol can exacerbate the risk of stomach bleeding with nonsteroidal anti-inflammatory drugs (NSAIDs). For Lancora users, alcohol may also interfere with its heart rate-regulating effects. It is important to ask your doctor or pharmacist whether it is safe to consume alcohol with any medication you are prescribed, including Lancora.
• Interactions with Tobacco: Tobacco smoke can affect the levels of various drugs in the bloodstream, potentially making them less effective. For instance, smoking can accelerate the metabolism of drugs processed by certain liver enzymes, decreasing their effectiveness. This includes Lancora, where smoking may alter its effectiveness in managing heart conditions. Smoking while using oral contraceptives increases the risk of cardiovascular problems, such as heart attacks and strokes, especially in women over 35. Discuss with your healthcare provider how smoking might affect the medications you are taking, including Lancora.
• Interactions with Herbal Supplements and Vitamins: Herbal supplements like St. John’s wort can interfere with the effectiveness of prescription medications, including antidepressants and birth control pills. Vitamin supplements, especially in large doses, can also interact with medications. For example, vitamin K can reduce the effectiveness of blood thinners. For those taking Lancora, it’s critical to discuss any herbal or vitamin supplements as they may interact with the medication’s mechanism. Always inform your healthcare provider about any herbal or vitamin supplements you are taking to ensure they do not interfere with your prescribed medications, such as Lancora. 

Do not start taking other medications, whether prescription, over-the-counter, or herbal/vitamin supplements, without discussing them with your doctor. This ensures that all potential interactions are considered and managed appropriately, especially when taking medications like Lancora.

[Note: This isn’t a complete list, and there could be other drugs that interact with Lancora. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Lancora Alternatives?

Lancora (ivabradine) is primarily used to treat certain types of heart failure and angina when beta-blockers cannot be used or are insufficient. Here are some alternatives that might be considered, depending on the specific needs and condition of the patient:

 

• Loop Diuretics: These medications act on the ascending limb of the loop of Henle in the kidney to increase urine production, which helps reduce fluid accumulation associated with heart failure.
  • Lasix (furosemide)

 

• Beta-Blocker with Alpha-Blocking Activity: Beta-blockers reduce the heart rate and the force of the heart muscle contraction, lowering blood pressure and reducing heart workload. Alpha-blocking activity also helps to dilate blood vessels, further helping to lower blood pressure.
  • Coreg (carvedilol)
  • Lopressor (metoprolol)
  • Toprol-XL (metoprolol)

 

• Potassium-Sparing Diuretic: These diuretics prevent potassium loss and are often used to treat fluid retention in patients with heart failure. They act on the kidneys to help the body eliminate sodium and water while conserving potassium.
  • Aldactone (spironolactone)

 

• Angiotensin-Converting Enzyme (ACE) Inhibitor: ACE inhibitors help relax blood vessels and reduce blood pressure by blocking the formation of a natural chemical that narrows blood vessels. This helps improve the efficiency of the heart.
  • Zestril (lisinopril)
  • Prinivil (lisinopril)

 

• Angiotensin Receptor Neprilysin Inhibitor (ARNI): These combine the effects of neprilysin inhibitors (which increase the levels of beneficial body peptides that help control blood pressure and fluid balance) with angiotensin receptor blockers (ARBs, which relax blood vessels). This combination is particularly effective in treating heart failure.
  • Entresto (sacubitril/valsartan)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Lancora Cost & Coupons

In the United States, the price of Lancora fluctuates based on dosage strength, quantity purchased, and insurance specifics. As of 2024, you can expect to pay between $150 and $300 for a 30-day supply of Lancora, available in either 5 mg or 7.5 mg tablets. For the most precise pricing and to investigate available insurance or financial assistance options, patients should speak with their healthcare provider or pharmacist. If you’re looking to buy Lancora online from Canada, Polar Bear Meds is a trusted option known for competitive pricing. Patients in the USA can order Lancora from Canada and use the coupon code “WELCOMEPB10” at checkout to get a 10% discount on their first purchase. For even more benefits, consider joining our referral program to receive a free coupon for your next order.

Frequently Asked Questions

What type of drug is Ivabradine?

Ivabradine is a medication primarily used to manage certain heart conditions. It belongs to a class of drugs known as hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. Ivabradine works by reducing the heart rate, which allows the heart to pump blood more effectively throughout the body with each beat.

Does Ivabradine lower blood pressure?

No, Ivabradine does not lower blood pressure. In fact, one of its common side effects is a temporary increase in blood pressure. This side effect typically does not interfere with the treatment process. However, Ivabradine is not recommended for patients who have significantly low blood pressure (less than 90/50 mmHg).

Is Ivabradine a beta-blocker?

No, Ivabradine is not classified as a beta-blocker. While both Ivabradine and beta-blockers reduce heart rate, Ivabradine achieves this by selectively blocking the sodium channels in the heart’s pacemaker cells, which are responsible for regulating heart rate increases. Beta-blockers, on the other hand, work by blocking the effects of adrenaline on the heart.

How should I take Ivabradine?

Ivabradine should be taken exactly as prescribed by your doctor. It is usually recommended to be taken twice a day with food. Some Ivabradine tablets are scored with a line down the middle to facilitate splitting. If your doctor instructs you to take half a tablet, carefully break it along the line and take the prescribed half, saving the other half for your next dose.

What are the symptoms of an overdose of Ivabradine?

Symptoms of Ivabradine overdose include an abnormally slow heartbeat, dizziness, extreme fatigue, and a lack of energy. If you suspect that you have taken more than the recommended dose or experience any of these symptoms, it is crucial to seek medical attention immediately or consult your doctor.

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