Edoxaban

Lixiana

Lixiana is a prescription medication used to treat and prevent blood clots. Its active ingredient is edoxaban, a direct factor Xa inhibitor. It is available in the form of a tablet with strengths of 15 mg, 30 mg, and 60 mg, to be taken once daily, orally by mouth, with or without food. It works by inhibiting factor Xa, an enzyme crucial in blood clotting, effectively reducing clotting formation. For personalized guidance and advice for the safe and efficient use of the medication, you should consult a licensed healthcare professional. You can buy Lixiana online from Canada with a valid prescription from a doctor. 

Product Overview

Lixiana, containing the active ingredient edoxaban, is a potent anticoagulant used to prevent and treat blood clots. Edoxaban is a direct factor Xa inhibitor, meaning it selectively blocks factor Xa, an enzyme crucial in the blood clotting process. By inhibiting this enzyme, Lixiana effectively reduces the formation of blood clots.

Available in strengths of 15, 30, and 60 mg, Lixiana for atrial fibrillation management is typically taken orally once daily, with or without food. This simple dosing regimen enhances patient adherence to treatment. Lixiana is suitable for adults who require anticoagulation for conditions such as atrial fibrillation or venous thromboembolism. It provides reliable anticoagulation without the need for routine blood monitoring, offering a convenient alternative to traditional medications like warfarin.

Common side effects of Lixiana include bleeding complications, which can range from minor to severe. Patients should be carefully monitored for signs & symptoms of bleeding & seek immediate medical attention if they experience unusual bleeding or bruising. It is crucial to inform medical providers about any other medications being taken, as drug interactions can affect the efficacy and safety of Lixiana. You can get affordable Lixiana for stroke prevention online from Canada with a prescription.

What Is Lixiana Used For?

Lixiana is used in adults for:

• Preventing stroke and systemic embolism 
• Deep vein thrombosis and pulmonary embolism

What Strength Is Lixiana?

This medicine is available in the form of an oral tablet with the following strengths:

• Lixiana 15 mg tablet
• Lixiana 30 mg tablet
• Lixiana 60 mg tablet

What Is the Typical Dosage of Lixiana?

The typical dosage of Lixiana (edoxaban) can vary depending on your health condition and your doctor’s recommendations. Healthcare providers generally start with a standard dose and may adjust it over time to meet your specific needs. Here’s a general guide:

Dosage for Atrial Fibrillation

• 60 mg once daily to be taken by mouth. 

Dosage for Deep Vein Thrombosis

• 60 mg taken once daily following five to ten days of initial therapy with parenteral anticoagulant therapy. 

Dosage for Pulmonary Embolism

• 60 mg to be taken orally once daily following five to ten days of initial therapy with a parental anticoagulant.

It’s essential to follow the dose prescribed by your doctor. Do not change your dose or stop taking the medication without consulting your healthcare provider.

[Note: These recommendations may vary from person to person. Discuss them with your doctor; they’ll customize your dosage accordingly.]

How to Take Lixiana?

It’s important to take Lixiana exactly as prescribed by your healthcare provider. Follow the instructions on your prescription label and make sure you understand how to use the medication properly. Here are some simple steps to follow for the correct usage:

• Before taking this medication, carefully read and follow the directions for use that came along with this prescription. If you have any questions or concerns or do not understand any part of the leaflet, ask your doctor or pharmacist. 
• Use Lixiana exactly as prescribed by your doctor. Do not use more or less of it, in large quantities or for longer than prescribed. 
• This medication is available as tablets, which can only be obtained with a prescription.
• To prevent the first stroke in patients with atrial fibrillation, the recommended dosage is 60 mg, taken orally by mouth once every day. 
• Swallow the tablet as a whole with a full glass of water. Do not break, crush, or chew it. 
• If you have difficulty swallowing the tablets as a whole, you should discuss other ways of taking this medication. Your doctor may recommend crushing and breaking the tablets and mixing them with water or apple juice immediately before swallowing them. Your doctor may also give you the crushed tablets through a tube in the nose or stomach. 
• This medication may be taken with or without food, but it is best recommended to take it around the same time every day. 
• You should not stop taking this medication abruptly without consulting a licensed healthcare professional, as it can lead to unwanted health problems caused by blood clots. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Lixiana Work?

Lixiana, also known by its generic name edoxaban, is an anticoagulant medication that belongs to a class of drugs known as direct factor Xa inhibitors. It works by selectively blocking the action of factor Xa which is a critical enzyme in the blood clotting cascade. By inhibiting factor Xa, Lixiana effectively reduces the body’s ability to form blood clots. This mechanism of action interrupts both the intrinsic and extrinsic pathways of coagulation, leading to a decreased production of thrombin and, consequently, less fibrin formation. 

What Are the Important Safety Information for Using Lixiana?

What Are the Side Effects of Lixiana?

Common Side Effects of Lixiana: Like many medications, Lixiana for preventing blood clots can cause some side effects, though not everyone will experience them. It’s important to remember that most of the side effects caused by Lixiana are mild and will usually go away after a few days or weeks as your body adjusts to the medication. Here are some common side effects you might encounter while taking Lixiana:

• Bleeding (various types): Lixiana can increase the risk of bleeding. This might include nosebleeds, bleeding gums, or easy bruising. If you notice unusual bleeding or find it difficult to stop bleeding, it’s important to contact your doctor right away.
• Anemia: Some people may experience a drop in their red blood cell count, leading to anemia. This can cause symptoms like feeling tired, weak, or short of breath. If you feel unusually fatigued, speak with your healthcare provider.
• Nausea: You might feel queasy or have an upset stomach while taking Lixiana. This is common and often goes away after a few days. If nausea becomes persistent, let your doctor know.
• Rash: A rash may appear on your skin as a side effect of Lixiana. If you notice redness, itching, or any changes to your skin, it’s a good idea to mention it to your healthcare provider, especially if the rash becomes uncomfortable or spreads.

Mild Side Effects of Lixiana: Mild side effects caused by Lixiana are not usually a cause for concern and typically go away on their own as your body adjusts to the medication. These side effects don’t typically require medical attention, but if they persist or become bothersome, it’s always a good idea to check in with your doctor. Here are some of the mild side effects you may experience:

• Dizziness: You may feel lightheaded or unsteady, especially when standing up quickly. This is fairly common but should pass once your body gets used to the medication.
• Headache: Some people might experience headaches. If this happens, it’s usually mild and goes away after a short period of time. Drinking plenty of water and resting can help ease the discomfort.
• Abdominal pain: You may feel some discomfort or mild pain in your stomach area. This is usually temporary and will go away as your body adapts.
• Fatigue: Feeling tired or lacking energy is another common side effect. If you find yourself feeling more tired than usual, try to get enough rest, and it should improve over time.
• Abnormal liver function tests: Sometimes, blood tests may show that your liver is not functioning as expected. This is something your doctor will monitor, but it usually doesn’t cause any noticeable symptoms. If the results are concerning, your doctor will guide you on the next steps.

Serious Side Effects of Lixiana: In rare cases, Lixiana for atrial fibrillation management can cause serious side effects that require immediate medical attention. These side effects can be severe and, if not treated promptly, may even be life-threatening. If you notice any new or worsening symptoms, it’s crucial to contact your healthcare provider right away. If you’re concerned about any side effects or need advice on how to manage them, always consult with your doctor. Serious side effects of Lixiana may include:

• Major bleeding events: Lixiana can increase the risk of bleeding, and in some cases, this can be severe, requiring hospitalization, blood transfusions, or emergency treatment. If you experience significant bleeding, seek medical help immediately.
• Spinal/epidural hematoma: This is a condition where blood collects in the spine, which can cause symptoms like back pain, numbness, muscle weakness, or even loss of control over bladder or bowel function (incontinence). If you notice these symptoms, get medical help right away.
• Increased risk of thrombotic events if discontinued abruptly: If Lixiana is stopped suddenly, there’s an increased risk of blood clots. If you need to stop the medication, your doctor will help you do so safely.
• Severe allergic reactions: A severe allergic reaction to Lixiana can cause difficulty breathing, swelling of the face or throat, and a severe rash. If you notice any of these symptoms, seek emergency medical attention immediately.
• Liver injury: Lixiana can sometimes affect liver function. Symptoms of liver injury may include yellowing of the skin or eyes (jaundice), dark urine, or unusual tiredness. If you experience any of these, contact your doctor right away.
• Increased bleeding risk in specific populations: Certain groups, such as elderly patients, those with kidney problems, or people with low body weight, may be at a higher risk of bleeding while taking Lixiana. These individuals should be monitored closely by their healthcare provider.

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]

Are There Any Warnings for Lixiana?

Lixiana (edoxaban) can have certain warnings and side effects that are important to consider, particularly for individuals at higher risk. If you fall into any of the following categories, it’s crucial to be aware of potential risks:

• Lixiana is designed to reduce dangerous clotting, but it can also increase the risk of serious and potentially fatal bleeding. Contact your doctor immediately if you experience more frequent bruising, difficulty stopping bleeding from cuts, or more frequent nosebleeds. Seek urgent medical help if you experience stomach bleeding symptoms, such as passing blood in the stool, vomiting that looks like coffee, or coughing up blood.
• If you have decreased renal function or kidney disease, Lixiana may accumulate in your body, raising the risk of side effects. Discuss with your doctor how this medication might impact your kidney condition, whether dosage adjustments are necessary, and if any special monitoring is required.
• The safety and efficacy of Lixiana in patients with severe liver impairment have not been established. For those with liver dysfunction or liver disease, it is essential to consult with your doctor regarding how this medication may affect your liver condition, dosing adjustments, and the need for specific monitoring. Lixiana is not recommended for individuals with severe liver dysfunction.
• Lixiana should not be taken by individuals with spinal or epidural catheters in place or within 5 hours of their removal. It is also not recommended for those receiving pain medication through an epidural catheter.
• Do not discontinue Lixiana without consulting your doctor. Premature cessation of Lixiana increases the risk of severe blood clots.
• If you plan to have surgery, including a dental procedure, tell your doctor, dentist, or surgeon about all your medications, including Lixiana for preventing blood clots. Your doctor may advise stopping the medication temporarily to minimize the risk of extreme bleeding during surgery and delayed healing afterward.
• It is unknown if Lixiana passes into breast milk. If you are breastfeeding, discuss with your doctor whether you should continue taking Lixiana and the potential impact on your baby. 
• Lixiana should only be used during pregnancy if the potential benefits justify the risks. If you get pregnant while taking this medication, contact your doctor immediately.

What Are the FDA Boxed Warning for Lixiana?

A boxed warning for Lixiana for atrial fibrillation management has been issued by the FDA due to certain risks associated with its use. 

• Decreased Effectiveness in People with Atrial Fibrillation & Good Kidney Function: Before starting Lixiana, your doctor will test your kidney function with a creatinine clearance (CrCl) test. If your kidneys work very well (CrCl greater than 95 mL/min) and you have atrial fibrillation, Lixiana might not be effective in preventing strokes.
• Warning for Stopping Treatment Early: Do not stop taking Lixiana without consulting your doctor. Stopping it too soon increases the risk of blood clots, which can cause a stroke. Your doctor might stop the medication temporarily before surgery or a medical/dental procedure and will tell you when to start it again. If you must stop taking Lixiana, your doctor might prescribe another medication to prevent blood clots.
• Risk of Spinal or Epidural Blood Clots (Hematomas): Lixiana can increase the risk of serious blood clots in the spine, which can cause permanent paralysis. You are at higher risk if you have an epidural catheter, take NSAIDs or other blood thinners, have had spinal surgery, or have spine problems. Your physician will monitor you carefully if you have any of these risk factors. Inform your doctor immediately if you experience tingling or numbness in your legs and feet, incontinence, back pain, or muscle weakness in your legs and feet.

What Are the Precautions for Edoxaban?

When using Lixiana (edoxaban), it’s important to take certain precautions to ensure it works safely and effectively. Here are some key things to keep in mind:

• Before you start taking Lixiana, you should share your complete medical history with your doctor. Especially if you have the following conditions:
  • Stomach ulcer or recent stroke
  • Have a liver disease that also affects your clotting ability
  • Pregnant 
  • Breastfeeding 
  • Currently experiencing severe or dangerous bleeding. 
  • Are taking certain medications to reduce the risk of bleeding, such as warfarin, apixaban, dabigatran, and heparin. 
• Before taking this medication, tell your doctor if you have an allergy to it, edoxaban, or any other medications. Also, tell your doctor if you have an allergy to any of the ingredients present in the product. Ask your doctor or pharmacist for the full list of ingredients. 
• It is crucial that you visit your doctor on a regular basis while using this medication to ensure that it is working properly and to determine whether you should continue taking it. Your doctor may also recommend that you take certain tests, such as blood & urine tests, to check for unwanted side effects. 
• Do not take other medications without consulting your doctor. 
• Contact your physician immediately if you have unusual bruising, bleeding, abnormal vaginal bleeding, tarry, black stools, headache, dizziness, swelling, or unusual nosebleeds. These may be signs of bleeding problems.  
• This medication may increase your risk of forming blood clots in the epidural area or spine, which may cause long-term or permanent paralysis. 

What Are the Contraindications for Lixiana?

Lixiana for stroke prevention is contraindicated for use in patients who have/are:

• A hypersensitivity to Lixiana or any of the ingredients in the medication. 
• Existing severe or existing bleeding
• Taking certain medications, such as apixaban, heparin, dabigatran, warfarin, tinzaparin, and enoxaparin, reduces the risk of clotting.  
• Have a condition that increases the risk of experiencing dangerous or severe bleeding, such as a stomach ulcer or stroke. 
• Have liver disease that affects clotting ability
• Pregnant or suspected pregnancy
• Breast-feeding 

What If You Miss a Dose of Lixiana?

Here’s what you can do when you skip or miss a dose of Lixiana for atrial fibrillation management:

• If you have missed a dose of Lixiana to prevent blood clots, you should take it as soon as you remember and return to your regular medication dosage schedule. 
• However, if it is almost time to take your next dose, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• Do not take double or extra doses of the same medication to compensate for the missed dose, as it can cause undesirable side effects. 
• You can set a reminder on your phone to prevent missed doses further.

[Note: If you have missed a medication dose and are still determining when to take the next one, consult your doctor or pharmacist immediately.]

What Happens If I Take Too Much Edoxaban?

Lixiana overdose may lead to hemorrhage. If you suspect an overdose, you should immediately call your doctor, 911, or the poison control helpline. You can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How Do You Store Lixiana?

To keep Lixiana for atrial fibrillation management effective and safe, it’s important to store it properly. Here are some simple guidelines for storing Lixiana tablets:

• You should store Lixiana tablets in their original container, tightly closed away from excess heat, direct sunlight, and moisture. 
• Do not keep it in the bathroom or near the sink. 
• Keep all medications, including Lixiana, in a safe place, away from the sight and reach of children and pets. 
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• Do not pour them in wastewater, flush them down the toilet or throw them in the household garbage bin. 
• You should dispose of Lixiana to prevent blood clots in such a way that prevents animals, children, and others from consuming it.
• For more information on properly disposing of unwanted medications, you can consult your pharmacist, healthcare provider, or local waste disposal company. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Drugs Should Not Be Taken with Edoxaban?

Certain medications can interact with Lixiana and affect how it works, either increasing the risk of side effects or reducing its effectiveness. It’s important to inform your doctor or healthcare provider about all the medications, including prescription, over-the-counter drugs, herbal supplements, and vitamins you’re taking before starting Lixiana. Here are some medications that may interact with Lixiana and how they might affect the medication:

• Warfarin: It is a blood thinner, and when taken with Lixiana, it can increase the risk of bleeding. Both medications affect blood clotting, so your doctor may monitor you closely for any signs of bleeding and adjust your doses as needed.
• Enoxaparin: It is also a blood thinner. Using it together with Lixiana can increase the risk of bleeding. Your doctor will need to carefully manage the combination of these medications.
• Fluconazole: It is an antifungal medication that can increase the levels of Lixiana in your blood, potentially leading to more side effects. Your doctor may adjust your Lixiana dose or monitor you more closely.
• Erythromycin and Clarithromycin: Both of these antibiotics can raise the levels of Lixiana in your bloodstream, increasing the risk of side effects, especially bleeding. Your healthcare provider may need to adjust your medications or monitor you more carefully.
• Rifampicin: It is an antibiotic that can reduce the effectiveness of Lixiana by lowering its levels in the blood. This could make Lixiana less effective at preventing blood clots, so your doctor might suggest a different treatment or adjust the dose.
• Dronedarone: It is used to treat heart rhythm problems and can increase the risk of bleeding when combined with Lixiana. Your doctor may need to monitor you closely for any signs of bleeding or other side effects.
• Quinidine: It is a medication used for heart rhythm issues, and when taken with Lixiana, it can increase the risk of serious bleeding problems. Your doctor may avoid this combination or adjust the dosage of either medication.
• Verapamil: It is a calcium channel blocker used to treat high blood pressure and heart conditions. It can increase the levels of Lixiana in your blood, which may increase the risk of bleeding or other side effects. Your doctor may adjust your dosage accordingly.
• Ciclosporin: It is an immunosuppressive drug that can increase the concentration of Lixiana in the blood, raising the risk of bleeding. Your doctor will closely monitor you and may adjust the doses of both medications.
• Carbamazepine, Phenytoin, and Phenobarbital: These are anticonvulsant medications used to control seizures. They can lower the levels of Lixiana in your blood, making it less effective. If you’re taking any of these medications, your doctor may monitor your condition more closely or adjust your treatment plan.
• Ibuprofen and Aspirin: These nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of bleeding when taken with Lixiana. Your doctor may recommend avoiding these medications, or using them with caution, especially for long periods.

What Are the Other Lixiana Interactions?

In addition to medications, certain herbs, foods, beverages, and supplements can interact with Lixiana for stroke prevention and may affect how well it works or increase the risk of side effects. If you’re concerned about any of these interactions, it’s important to speak with your healthcare provider to ensure your treatment is safe and effective. Here’s how some of these interactions work:

• St John’s Wort: It is an herbal supplement often used for mood enhancement. However, it can lower the effectiveness of Lixiana by speeding up how your body breaks it down. This means Lixiana may not work as well to prevent blood clots if you’re also taking St. John’s Wort. Your doctor may advise against using this herbal supplement while on Lixiana.
• Grapefruit: It can affect the way your body metabolizes certain medications, including Lixiana. Eating grapefruit or drinking grapefruit juice can increase the levels of Lixiana in your bloodstream, raising the risk of bleeding and other side effects. It’s best to limit or avoid grapefruit products while taking Lixiana.
• Alcohol: Drinking alcohol while taking Lixiana can increase the risk of certain side effects, such as bleeding or low blood pressure. Alcohol can also affect your balance and cause dizziness, which may be more pronounced when combined with Lixiana. It’s a good idea to limit alcohol intake or avoid it entirely while on this medication.
• Coenzyme Q10: It is a supplement commonly used for heart health and energy. While not a major interaction, CoQ10 may affect the way your body processes Lixiana, potentially reducing its effectiveness. If you are taking CoQ10, let your doctor know so they can monitor your treatment closely.

[Note: This isn’t a complete list, and there could be other drugs that interact with Lixiana. Tell your doctor about any prescription, over-the-counter medicines, and herbal products.]

Is There an Alternative to Lixiana?

People look for alternative medicines to Lixiana for stroke prevention when they do not suit them or do not get the desired results. There are many effective alternative medicines to Lixiana present in the market. However, you should not use any substitute medicines without consulting your healthcare provider. Let your doctor know if you plan to change or start a new medication. They will help you determine the medication that works best for you. Some alternatives for Lixiana to prevent blood clots are as follows:

• Xarelto (rivaroxaban)
• Pradaxa (dabigatran)
• Eliquis (apixaban)
• Carvedilol (carvedilol)
• Digoxin (digoxin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Lixiana Coupons & Cost

The cost of Lixiana for stroke prevention and options for obtaining it at a lower price are influenced by various factors, including health insurance coverage. Many Americans find their health insurance does not cover medications like affordable Lixiana for preventing blood clots, leading to high out-of-pocket expenses- often more than $1000 per month. To manage these costs, some Americans turn to services like Polar Bear Meds, where they can buy Lixiana online from Canada in the USA at a reduced price. Additionally, customers can use the Lixiana coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

What foods should I avoid when taking Lixiana?

When taking Lixiana (edoxaban), there are no specific foods you need to avoid. However, it’s important to be cautious with alcohol, particularly binge drinking or consuming large amounts of alcohol in one go. Drinking heavily while on Lixiana can increase the risk of bleeding. Otherwise, there are no restrictions on foods or drinks, but always follow your healthcare provider’s advice.

When is the best time of day to take Lixiana?

Lixiana can be taken at any time of day, with or without food, but it’s best to take it at the same time each day to help you remember. Taking it consistently at the same time can help you stay on track with your treatment. Be sure to follow your doctor’s instructions and take it with a full glass of water.

How long is Lixiana given for?

Lixiana is typically taken once daily. For certain conditions, like non-valvular atrial fibrillation (NVAF), Lixiana is often used long-term to reduce the risk of blood clots and stroke. In some cases, after starting Lixiana, it may be combined with another medication (like a Vitamin K antagonist, or VKA) for a short period before stopping Lixiana. Your doctor will guide you on how long you should continue treatment based on your specific condition.

Is Lixiana used for atrial fibrillation?

Yes, Lixiana (edoxaban) is commonly used to reduce the risk of stroke and blood clots in people with atrial fibrillation (AFib), a condition where the heart beats irregularly. It helps prevent the formation of dangerous blood clots that can lead to strokes. If you have AFib and are at risk for stroke, your doctor may recommend Lixiana as part of your treatment plan.

Does Lixiana cause joint pain?

In some cases, Lixiana may cause joint pain. If you experience stiff, sore, hot, or painful joints while taking this medication, contact your doctor right away. These could be signs of an issue that needs attention. While joint pain is not common, it’s important to report any unusual symptoms to your healthcare provider.

How does Lixiana interact with other medications?

Lixiana may interact with certain medications, including other anticoagulants, antiplatelet drugs, and some antifungals. These interactions can affect its efficacy and increase the risk of bleeding. It’s crucial to tell your healthcare provider of all medications you are currently taking or plan to take to manage potential interactions effectively.

Can Lixiana be used in patients with renal impairment?

Lixiana dosage may need adjustment in patients with renal impairment. The medicine is primarily eliminated by the kidneys, so impaired kidney function can affect its clearance. Patients with significant renal issues should consult their healthcare provider for appropriate dosing and monitoring.

How should Lixiana be discontinued?

Lixiana should not be stopped abruptly without medical guidance. If discontinuation is necessary, your healthcare provider will provide a tapering plan or alternative management to minimize the risk of thrombotic events. Always follow professional advice to ensure safety.

What is the impact of liver disease on Lixiana use?

Patients with severe liver disease should avoid using Lixiana for stroke prevention due to the risk of increased bleeding and impaired drug metabolism. Moderate liver impairment requires careful monitoring and potential dose adjustments. Ask your healthcare provider for personalized guidance if you have liver conditions.

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