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Loteprednol Etabonate

Lotemax Ophthalmic Gel

Lotemax Ophthalmic Gel is a topical medicine containing Loteprednol Etabonate, an FDA-approved corticosteroid. Loteprednol Etabonate reduces inflammation, redness, and discomfort in eye conditions like allergic conjunctivitis and postoperative inflammation. It works by inhibiting inflammatory mediators and immune cell activity. It is available in a strength of 0.5%. It is suitable for adults and children (6 years and older). Your doctor may prescribe that you apply a small amount four times daily initially, then reduce it gradually. Side effects may include temporary stinging, blurred vision, or light sensitivity. Follow your healthcare provider’s instructions carefully, avoiding missed doses and excessive use. Store at room temperature, tightly closed. You should consult your healthcare providers for specific guidance.

Product Overview

Lotemax Ophthalmic Gel is an FDA-approved topical medication containing the active ingredient of Loteprednol Etabonate, a corticosteroid. Loteprednol is a potent anti-inflammatory agent that reduces swelling, redness, itching, and discomfort associated with certain eye conditions such as allergic conjunctivitis, postoperative inflammation following eye surgery, and anterior uveitis. These conditions involve inflammation of the eye tissues, leading to symptoms such as rashes, irritation, and blurred vision. Lotemax Ophthalmic Gel works by stopping the production of inflammatory mediators and lowering the activity of immune cells in the eye, thereby alleviating the symptoms.

Lotemax Gel typically comes in a strength of 0.5%, indicating that each gram of gel contains 5 milligrams of Loteprednol Etabonate. For adults and children older than 6 years, the gel is applied four times daily to the conjunctival sac of the eye in a small amount (approximately half-inch ribbon). This dosage schedule is often prescribed for the first 2 days, and then the frequency is reduced gradually. 

Lotemax Gel may cause side effects such as transient stinging or burning upon application, blurred vision, or sensitivity to light. It is essential to follow the advice of a healthcare professional regarding its usage, including proper application techniques and dosage frequency. Avoid missing doses and applying more than the prescribed dose. It should be kept at room temperature, away from moisture and heat, and the container should be tightly closed when not in use. You should consult your healthcare professional for specific guidance for safe use.

Uses of Lotemax Ophthalmic Gel

It is used for the treatment of:

  • Allergic conjunctivitis
  • Postoperative inflammation after eye surgery
  • Anterior uveitis

How to Use Lotemax Ophthalmic Gel?


Strengths and Forms

Lotemax Ophthalmic Gel typically comes in a 0.5% strength.

Recommended Dosage for Lotemax Ophthalmic Gel

Apply 1-2 drops of Lotemax Gel into the conjunctival sac of your eye four times daily. The amount may be increased up to 1 drop every hour initially. Continue it throughout the first 2 weeks of the postoperative period.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Lotemax Ophthalmic Gel dosage accordingly.]

How to Take It?

To properly administer Lotemax ophthalmic gel, follow these steps:

  • Using soap and water, thoroughly wash your hands.
  • Tilt your head back or lie down and look up towards the ceiling.
  • Create a small pocket by gently pulling down your lower eyelid.
  • Hold the tube of gel upside down with the tip pointing towards your eye.
  • In the pocket formed by your lower eyelid, squeeze a small amount of gel (usually one or two drops). Avoid touching your eye with the tube’s tip.
  • Gently close your eyes after releasing your lower eyelid.
  • For about a minute, lightly press your finger to the inner corner of the eye (near your nose). As a result, the medication does not drain into your tear ducts.
  • If you need to apply the gel to both eyes, repeat the process for the other eye.
  • Recap the tube securely to prevent contamination.
  • Rewash your hands to remove any residue.

[Note: Your doctor will decide the right amount of Lotemax Ophthalmic Gel for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Lotemax Gel Work?

Lotemax ophthalmic gel contains loteprednol etabonate, a corticosteroid that works by decreasing inflammation in the eye. It hinders the production of inflammatory mediators and suppresses the immune response, thereby alleviating symptoms such as redness, swelling, and discomfort associated with various eye conditions, including postoperative inflammation and allergic conjunctivitis. Lotemax Gel is formulated to provide sustained release and prolonged contact time on the ocular surface, enhancing its therapeutic effectiveness.

Important Safety Information

Side Effects

Common side effects of Lotemax Ophthalmic Gel may include:

  • Eye inflammation
  • Eye pain
  • Eye sensitivity to light
  • Headache
  • Runny nose
  • Red or itchy eyes
  • Sore throat
  • Sensation in the eye
  • Burning sensation in eyes
  • Dry or watery eyes
  • Delayed healing
  • Cataracts

Mild side effects of Lotemax Ophthalmic Gel may include:

  • Headache
  • Dry eye
  • Eye discomfort or itching
  • Redness of the eyes
  • Foreign body sensation in the eye

Serious side effects of Lotemax Ophthalmic Gel may include:

  • Sudden vision loss
  • Increased intraocular pressure (leading to glaucoma)
  • Cataract formation
  • Delayed wound healing
  • Eye pain
  • Vision changes
  • Eye infections (such as fungal or bacterial keratitis)
  • Allergic reactions (severe inflammation, redness, or burning)

[Note: Remember, this list may not cover all possible side effects of Lotemax Ophthalmic Gel. Always consult with your healthcare giver for medical advice about side effects.]


For Ophthalmic Use Only: Lotemax Ophthalmic Gel is intended for use in the eye(s) only. Avoid contact with other parts of the body to prevent adverse reactions.

Contact Lens Usage: Remove contact lenses before applying Lotemax Ophthalmic Gel. Contact lenses can soak the medicine and may irritate reinsertion.

Risk of Glaucoma: Prolonged use of corticosteroids such as Lotemax Ophthalmic Gel may result in increased intraocular pressure, leading to glaucoma. Regular monitoring of intraocular pressure is recommended during prolonged therapy.

Cataract Formation: Corticosteroid use may promote the development of cataracts. Your healthcare professional should monitor the signs and symptoms of cataract formation during treatment.

Delayed Healing: Corticosteroids may delay wound healing. Patients with ocular diseases characterized by thinning of the cornea or sclera may be at increased risk of perforation with prolonged corticosteroid use.

Immunosuppression: Corticosteroids may suppress the immune response, increasing the risk of ocular infections. You should be monitored for signs of bacterial, fungal, or viral infections, and appropriate antimicrobial therapy should be initiated if an infection occurs.

Concomitant Therapy: If you are using other ophthalmic medications, you should be administered at least 10 minutes apart from Lotemax Ophthalmic Gel to prevent dilution and washout of the medication.

Systemic Effects: Systemic absorption of corticosteroids may occur with ophthalmic administration. Patients with a history of systemic corticosteroid use may have an increased chance of systemic effects.

Pediatric Use: The safety and efficacy of Lotemax Ophthalmic Gel in pediatric patients have not been established. Use in pediatric patients should be under the supervision of a healthcare professional.

Geriatric Use: Older patients may be more susceptible to the systemic and ocular effects of corticosteroids. Caution is advised when using Lotemax Ophthalmic Gel in this population.

Allergic Reactions: You should be monitored for signs of allergic reactions, including rash, itching, swelling, or difficulty breathing. Stop using the gel and consult your healthcare provider if an allergic reaction occurs.


  • Do not use Lotemax Gel if you have an eye infection.
  • Before using, shake the closed bottle once while it’s upside down. This helps to fill the bottle tip with the gel.
  • Keep the dropper tip clean. Avoid touching it to any surface to prevent contamination.
  • If you use contact lenses, remove them prior to using Lotemax Gel.
  • Contact your doctor if you experience any of these symptoms worsening or not improving:
  • Pain in the eye.
  • Increased redness, itching, or inflammation.
  • If you use Lotemax Gel for more than 10 days, your doctor might need to check your eye pressure.
  • Using Lotemax Gel may increase the risk of developing cataracts.
  • It might also slow down the healing process after cataract surgery.

Lotemax Gel Contraindications

  • Hypersensitivity to Loteprednol Etabonate or any other ingredient.
  • In viral infections of the cornea and conjunctiva, such as dendritic keratitis, varicella, and vaccinia.
  • Mycobacterial eye infections.
  • Fungal diseases of ocular structures.

Missed Dose

If you forget to apply a dose of Lotemax Ophthalmic Gel, use it as soon as you remember unless it’s close to the time for your next dose. If it’s nearing the next planned dose, ignore the missed one and resume with your regular dosing schedule. Avoid applying two doses to compensate for the missed one.

[Note: If you have missed a dose of Lotemax Ophthalmic Gel and are still determining when to take the next one, immediately consult your doctor or pharmacist.]


Apply only the recommended dosage as instructed by your healthcare provider. Overdose may lead to symptoms like increased eye redness, itching, or swelling.

[Note: If you consumed more than the recommended dose of Lotemax Ophthalmic Gel, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Store Lotemax Ophthalmic Gel at room temperature (15°C to 25°C).
  • Keep the tube tightly closed and protect it from light.
  • Do not freeze the medication.
  • Store out of reach of children and pets.
  • Do not share with others.
  • Check the expiration date and discard expired medication.
  • Dispose of unused gel properly.

[Note: Discuss with your healthcare professional about the proper disposal of unused Lotemax Ophthalmic Gel and any questions you may have regarding its storage.]

Lotemax Gel Interactions

  • Amlodipine
  • Albuterol
  • Aspirin
  • Tramadol
  • Trazodone
  • Tylenol (acetaminophen)
  • Statins (Atorvastatin, Simvastatin)
  • Doxycycline
  • Fluticasone nasal
  • Diuretics (Furosemide, Hydrochlorothiazide)
  • Gabapentin
  • Levothyroxine (Synthroid)
  • Lisinopril
  • Losartan
  • NSAIDs (Meloxicam, Ibuprofen)
  • Metformin
  • Proton Pump Inhibitors (Omeprazole, Pantoprazole)
  • Prednisone
  • Restasis (cyclosporine ophthalmic)
  • Zyrtec (cetirizine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Multivitamin
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)

[Note: This isn’t a complete list, and there could be other drugs that interact with Lotemax Ophthalmic Gel. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Lotemax Gel Alternatives

[Note: Your doctor will choose the best alternative of Lotemax Ophthalmic Gel for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How long does it take Lotemax Gel to work?

Lotemax Gel usually starts working within two days, helping to ease symptoms. If you don’t notice any improvement after two days, consult with your healthcare provider for further advice.

How do I apply Lotemax Gel to my eyes?

  • First, turn the bottle upside down and give it one shake. This helps get the gel into the tip of the bottle.
  • Carefully pull down your lower eyelid. This creates a little pocket or pouch.
  • Now, drop the amount of gel your doctor told you to use into that pouch.
  • Finally, close your eyes softly and move your eyeballs around in different directions. This helps to distribute the medication across your eye evenly.

Always handle your eye and the medication carefully to avoid any discomfort or injury.

How often should I use Lotemax Ophthalmic Gel?

Lotemax Ophthalmic Gel should be used four times a day for optimal results. Remember to follow your healthcare provider’s instructions carefully and continue using it as prescribed. If you have any concerns or experience side effects, consult your doctor promptly.

Can I apply Lotemax Ophthalmic Gel with other eye drops?

It’s crucial to discuss with your healthcare professional or pharmacist before combining Lotemax Ophthalmic Gel with other eye drops. If you are using other eye medicines (such as drops, ointments, or gels), wait at least 5 to 10 minutes before applying them after using Lotemax.

Our Guarantee

At, we assure you the most affordable price to buy Lotemax Ophthalmic Gel from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Lotemax Gel at a substantial cost, call us at 1-888-779-2193 toll-free.


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