Mesalamine 

Mesalamine DR

Mesalamine, also known as 5-ASA or 5-aminosalicylic acid, is an FDA-approved anti-inflammatory medication used to treat inflammatory bowel diseases (IBD), such as Crohn’s disease & ulcerative colitis. It functions by reducing inflammation in the colon, which helps manage and improve symptoms of IBD. It is available in different forms, with strengths ranging from 800 mg to 1.2 grams per tablet. It is typically taken orally by mouth with or without food. You can consult a licensed healthcare provider for personalized guidance and advice regarding storage, dosage, usage of Mesalamine for ulcerative colitis. You can buy Mesalamine DR online from Canada from the convenience of your home.  

Product Overview

Mesalamine DR is an anti-inflammatory medication and is typically used to treat inflammatory bowel diseases (IBD), such as ulcerative colitis. It functions by reducing inflammation in the colon, thus helping to alleviate symptoms like abdominal pain, diarrhea, and rectal bleeding. Available in various strengths, Mesalamine DR is typically taken in dosages prescribed by a healthcare provider, ranging from 800 mg to 1.2 grams per tablet. 

It is necessary to follow the prescribed dosage instructions strictly. Based on the specific product instructions, it is usually taken with or without food. Mesalamine DR is suitable for adults and children over a certain age, as determined by a healthcare provider. It works by directly targeting and reducing inflammation in the colon, which helps manage and improve symptoms of IBD. Potential side effects of Mesalamine DR include headaches, nausea, vomiting, and abdominal pain. 

Patients should seek medical guidance if they experience severe or persistent side effects. It is important to inform the healthcare provider of any other medications being taken to avoid adverse interactions. In case of a missed dose, take it as soon as possible. In the event of a Mesalamine overdose, seek immediate medical attention. Always follow the advice of a medical provider when you buy Mesalamine DR online or start using it to ensure safe and effective treatment.

What Is Mesalamine DR Used For?

It is used to treat the following medical condition:

• Ulcerative colitis
• Crohn’s disease 

What Forms & Strengths Does Mesalamine Come In?

It is available in the following forms and strengths:

• Oral Forms:

• • • Delayed-Release Capsules: 400 mg (such as Delzicol)
    • Extended-Release Capsules: 0.375 g, 500 mg (such as Apriso, Pentasa)
    • Delayed-Release Tablets: 800 mg, 1.2 g (such as Asacol HD, Lialda)

• Rectal Forms:

• • Enemas: 4g (such as Rowasa)
  • Suppositories: 1g (such as Canasa)

What Is the Typical Dosage of Mesalamine DR?

The correct dosage of Mesalamine for ulcerative colitis varies for each person and is determined by factors like your age, your specific health condition, and how you respond to the treatment. It’s important to use this medication exactly as your doctor prescribes. Always follow the instructions provided by your doctor, as well as the guidelines in the patient information leaflet and medication guide that comes with the medicine. The amount of Mesalamine DR you need, how often you take it, and for how long, depend on the strength of the medicine and the form it comes in (like tablets or capsules).

Dosage for the Treatment of Ulcerative Colitis 

• Oral Capsules

• • • Adults should take 800 mg thrice daily
    • Children aged five years or more: Your doctor should determine the medication dosage based on body weight. The maximum dosage is 2400 mg daily, in divided doses. 
    • Children less than five years of age: The Doctor should determine the usage and dosage.

• Oral Tablets

• • Adults should take 800 mg thrice daily for six weeks
  • Children aged five years and above: Medication dosage is based on the body weight and should be determined by your doctor.
    • Weighing 54 kg-90 kg: 1200 mg in the morning and 1200 mg in the afternoon for six weeks. 
    • Weighing 33 kg- 54 kg: 1200 mg in the morning and 800 mg in the afternoon for six weeks.
    • Weighing 17 kg-33 kg: 800 mg in the morning & 400 mg in the afternoon for six weeks. 

Dosage for Prevention of Ulcerative Colitis

• Adults: 1600 mg daily, in divided dosage.
• Children: Medication dosage should be determined by your doctor. 

[Note: These recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Do You Use Mesalamine DR?

Always take Mesalamine for ulcerative colitis precisely as your healthcare provider prescribes it. Do not change the dose or frequency without first consulting your doctor. Here are some guidelines you may follow to take your Mesalamine DR properly:

• Before using this medication, carefully read and follow the instructions for use given in the patient information leaflet and medication guide provided by your pharmacist or healthcare provider. Ask a licensed healthcare professional if you do not understand any part of this leaflet. 
• Your doctor may monitor your kidney & liver functions carefully before you start taking this medication and thereafter on a regular basis.
• Use this medicine exactly as directed by your physician, usually once daily, with or without food. Do not take it more or less than prescribed, in large quantities, or more frequently. 
• Take this medication orally by mouth, usually once daily. 
• Drink plenty of water and other fluids while receiving treatment with this medication unless instructed otherwise by your doctor. This will help prevent kidney stones. 
• Swallow the tablets and capsules whole. Do not crush, break, chew, or open them. Doing so may keep the medication from being properly released into the colon. 
• The medication dosage is based on the condition being treated and the body’s response to treatment. For pediatric patients, the dosage is also based on their weight. 
• Continue using Mesalamine even if you feel well after a few days. You should not discontinue using this medication abruptly without consulting your physician, as it can cause undesirable side effects. 
• Use your medication regularly, and take it around the same time every day to help you remember. 
• Inform your doctor if your condition does not get better or if it worsens. 
• You may sometimes see partial or whole tablets or capsules in your stool after your body has absorbed this medication. If this occurs frequently, inform your doctor. You may not be absorbing enough of this medication.  

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Mesalamine DR Work?

While the exact mechanism of Mesalamine DR isn’t fully understood, it appears to work within the bowels to reduce inflammation. It may help regulate the inflammatory response from the cyclooxygenase and lipoxygenase pathways. By affecting these enzyme pathways, it could decrease the production of prostaglandins and leukotrienes. Overall, Mesalamine helps manage UC symptoms by reducing gut inflammation. 

What Are the Important Safety Information for Using Mesalamine DR?

What Are the Side Effects of Using Mesalamine DR?

Common Side Effects of Mesalamine DR: Mesalamine DR, like many medications, can cause some side effects as your body adjusts to it. These are usually not serious and often go away after a short period. If these side effects become bothersome or if you have questions about them, it’s a good idea to talk to your doctor or healthcare provider. They can offer advice on how to manage these effects. Here are the common Mesalamine DR side effects you might experience:

• Headache: You may feel pain or discomfort in your head.
• Nausea: You might feel like you are going to vomit.
• Abdominal Pain or Cramps: You could experience pain or uncomfortable cramps in your stomach area.
• Diarrhea: You may have loose, watery stools more frequently than usual.
• Gas (Flatulence): You might notice more gas or bloating in your stomach.
• Constipation: You could find it difficult to pass stools due to them being hard or infrequent.
• Mild Rash: You may notice small red spots or slightly irritated skin.

Mild Side Effects of Mesalamine DR: Mesalamine DR can cause some mild side effects, which usually aren’t severe and often don’t need special medical treatment. However, it’s important to keep your doctor informed if these symptoms start, get worse, or bother you over time. Here’s what you might experience while taking this medication:

• Fatigue: You may feel unusually tired or low on energy.
• Loss of Appetite: You might not feel like eating as much as usual.
• Mild Fever: You could experience a low-grade fever.
• Muscle or Joint Pain: You may feel discomfort or pain in your muscles or joints.
• Hair Loss: You might notice that you are losing more hair than normal.
• Acne: You could develop spots or pimples on your skin.
• Mild Itching: You might feel a slight itchy sensation on your skin.

Serious Side Effects of Mesalamine DR: Mesalamine for ulcerative colitis is generally safe for most people, but like all medications, it can cause serious side effects in rare cases. While these severe reactions are uncommon, they require immediate medical attention as they can be life-threatening if untreated. Here are the serious Mesalamine DR side effects:

• Severe Allergic Reactions (Anaphylaxis): Watch for trouble breathing, swelling around your face or throat, intense skin rash, or hives. These are signs of a potentially life-threatening allergic reaction.
• Kidney Problems: If you notice reduced urine output, swelling in your legs or feet, or feel unusually tired, these could be signs of kidney issues.
• Liver Problems: Symptoms like yellowing of your skin or the whites of your eyes, dark-colored urine, or pain in your abdomen may indicate liver issues.
• Severe Skin Reactions: Look out for severe skin conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, which involve blistering or peeling skin.
• Pancreatitis: This is characterized by severe abdominal pain accompanied by nausea and vomiting.
• Pericarditis/Myocarditis: These are heart conditions that may cause chest pain and difficulty breathing.
• Worsening of Colitis Symptoms: If your abdominal pain increases or you experience bloody diarrhea, your colitis might be getting worse.
• Blood Disorders: Symptoms like fatigue or frequent infections could be due to a decrease in white blood cells or other changes in your blood.

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Using Mesalamine DR?

There are certain warnings that you should take into consideration while using this medication or even before you order Mesalamine delayed-release tablets online:

• This medication may cause hypersensitivity reactions in some people, including anaphylaxis. It should not be taken by patients with a known or suspected hypersensitivity to Mesalamine, salicylates, aminosalicylates, or any of the inactive ingredients present in the medication. Discontinue taking the medication immediately and call your doctor if you experience signs and symptoms of a severe hypersensitivity reaction, including hives, difficulty breathing, or swelling of your throat, lips, face, or tongue.   
• Kidney problems have been reported in people taking this medication. Your healthcare provider will carefully monitor your kidney function before you start taking this medication and thereafter on a regular basis. This medication is not recommended for use in people with pre-existing kidney problems or who are also taking other medications that may affect kidney function. 
• This medication has also been linked with an acute intolerance syndrome that may be hard to differentiate from an exacerbation of ulcerative colitis. Inform your healthcare provider if your symptoms worsen while using this medication, discontinue taking this medication, or if you suspect AIS. 
• This medication may not be suitable for use in patients with pre-existing liver disease. 
• This medication may cause blood disorders, and elderly patients using azathioprine or 6-mercaptopurine are at an increased risk. Your physician will closely monitor you for these risks. 

What Precautions Should Be Taken While Taking Mesalamine?

When deciding to start your treatment with Mesalamine for ulcerative colitis, you should consult a licensed primary health care professional, discuss with them in detail, and weigh the risks associated with the use of the medication and its benefits. For Mesalamine, you should consider the following precautions:

• Before taking this medication, tell your doctor if you have an allergy to it, other aminosalicylates, salicylates, or sulfasalazine, or if you have any other allergies. This product contains certain inactive ingredients that may cause allergic reactions or other problems. Consult your medical provider for more information.
• Before using this medication, share your medical history with your doctor, especially if you have stomach blockage, kidney disease, or liver disease. 
• This medication may make you more sensitive to sunlight, especially if you have skin problems such as eczema and atopic dermatitis. You should limit your time in the sun and avoid sunlamps and tanning booths. Use sunscreen & wear protective clothing when you are outdoors. Inform your doctor immediately if you get sunburn or have redness or skin blisters. 
• If you plan to have surgery, including a dental procedure, tell your surgeon, dentist, or doctor about all the medications you are using, including all prescription, non-prescription, over-the-counter drugs, and herbal supplements. 
• Mesalamine is similar to aspirin. Children and teenagers under 18 should not take aspirin or aspirin-related medications if they have flu, chicken pox, or any undiagnosed illness or have recently received a vaccine. In such cases, taking aspirin increases the risk of developing a rare but severe illness known as Reye’s syndrome. 

Who Shouldn’t Take Mesalamine?

Mesalamine for ulcerative colitis is contraindicated for use in patients who have/are:

• Hypersensitivity to 5-ASA, salicylates, or aminosalicylates. 
• Severe renal or hepatic impairment
• Urinary tract obstruction
• Existing gastric or duodenal ulcers
• Breastfeeding 
• Infants
• Children with chickenpox or flu-like symptoms 

What to Do If You Miss a Dose of Mesalamine DR?

If you think that you have missed a dose of Mesalamine for ulcerative colitis or forget to take it on time, below are some instructions of what you can do:

• If you have missed a dose of Mesalamine DR, you should take it as soon as you remember. 
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose. 
• You can set a reminder on your phone to prevent missing your doses. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What to Do If You Take Too Much Mesalamine DR?

Mesalamine overdose symptoms may include vomiting, abdominal pain, tinnitus, headache, dizziness, confusion, nausea, and seizures. If you suspect an overdose of the medication, immediately seek medical attention. If someone is experiencing severe overdose symptoms such as passing out, difficulty breathing, and seizures, you should contact your doctor, 911, or poison control helpline. You can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How Do You Store Mesalamine DR?

When you buy Mesalamine DR online to treat ulcerative colitis, you should know how to store this medication. Here are the storage guidelines:

• You should keep Mesalamine in its original container tightly closed at room temperature between 20-25°C or 68-77°F, away from moisture, direct sunlight, and heat. 
• Do not keep it in the bathroom or near the sink.
• Keep all medications, including Mesalamine, in a safe place, away from the sight and reach of children and pets. 
• Don’t keep medications that are outdated or no longer needed. Discard them safely. 
• You should not dispose of unwanted medications by pouring them into the drain, flushing them down the toilet, or throwing them into the household garbage bin.
• You should eliminate unwanted medications in such a way that prevents children, animals, and others from consuming them.
• To learn more about how to dispose of unwanted medications, consult your pharmacist, healthcare provider, or local waste disposal company. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Drugs Interact with Mesalamine DR?

Mesalamine DR is used to treat inflammatory bowel diseases, and it’s important to manage its interactions with other medications to avoid complications. Here’s how these interactions can impact your treatment:

• Pain Relievers and Anti-inflammatory Drugs: Many drugs listed, like ibuprofen, naproxen, and celecoxib, are non-steroidal anti-inflammatory drugs (NSAIDs). Combining these with Mesalamine can increase your risk of kidney problems and stomach or intestinal irritation.
• Salicylates: Drugs like sodium salicylate, salsalate, and aspirin (salicylic acid) are similar to Mesalamine and can lead to an overdose effect, increasing the risk of gastrointestinal side effects like stomach pain, bleeding, and ulcers.
• Immunosuppressants: Medications like methotrexate and mercaptopurine suppress the immune system. When used with Mesalamine, there might be an increased risk of infection or interaction that could affect how your medications work.
• Blood Thinners: Warfarin, used to prevent blood clots, can interact with Mesalamine, potentially increasing the risk of bleeding.
• Diuretics: Drugs like furosemide can interact with Mesalamine, potentially leading to kidney issues or changes in how the drug works.
• Other Digestive Tract Medications: Medicines like olsalazine and sulfasalazine are also used to treat similar conditions as Mesalamine. Using them together can amplify effects and side effects.
• Live Vaccines: The live varicella virus vaccine interaction could be problematic, as immune response might be altered by Mesalamine.

It’s crucial to provide your doctor with a complete list of medications you are taking to ensure they can manage any interactions effectively. Adjusting doses or changing medications might be necessary to keep your treatment safe and effective.

What Are the Other Mesalamine DR Interactions?

When using Mesalamine DRMesalamine for ulcerative colitis, which is commonly prescribed for ulcerative colitis, it’s important to consider how different factors might interact with the medication:

• Disease Interactions: If you have conditions like liver disease, kidney disease, or a history of heart conditions, Mesalamine may affect these conditions. For instance, it can potentially worsen kidney problems or interact with liver function, so your doctor may need to adjust your dosage or monitor you more closely.
• Food and Beverage Interactions: While Mesalamine generally does not have many dietary restrictions, it’s always good practice to discuss your diet with your healthcare provider. In some cases, certain foods might exacerbate symptoms of ulcerative colitis, so dietary adjustments could be recommended.
• Herbal Remedies: Some herbal supplements might interact with Mesalamine. For example, herbs that affect kidney function or those that have anti-inflammatory properties might interfere with the medication’s mechanism.
• Alcohol and Tobacco Use: Alcohol can irritate the gut and might worsen the symptoms of ulcerative colitis, potentially making Mesalamine less effective. Smoking, on the other hand, is generally harmful to gut health and can exacerbate symptoms of inflammatory bowel diseases. Your doctor might advise you to limit or avoid alcohol and quit smoking if you are using Mesalamine.

[Note: This isn’t a complete list, and there could be other drugs that interact with Mesalamine DR. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Is An Alternative to Mesalamine?

People look for alternative medications to Mesalamine for ulcerative colitis when it does not suit them or they do not get the desired results from it. There are many effective alternative medicines available on the market for Mesalamine DR. You should not change your medication or start a new one without consulting your doctor, as it may cause unwanted side effects. Discuss with them, and they will help you determine the best medication for you based on your condition and needs. Given below is a list of alternative medicines for Mesalamine DR.

• Colazal (balsalazide)
• Azulfidine (sulfasalazine)
• Canasa (Mesalamine)
• Rayos (prednisone)
• Uceris (budesonide)
• Cortef (hydrocortisone)
• Medrol (methylprednisolone)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Mesalamine DR Coupons & Cost

The cost of Mesalamine for ulcerative colitis can vary widely based on factors like health insurance coverage and pharmacy pricing. Many Americans face high out-of-pocket expenses for this medication, as it is often not covered by health insurance for weight loss purposes. To help manage these costs, some turn to services like Polar Bear Meds, which offer the option to order Mesalamine delayed-release tablets online from Canada at a lower price. Customers can also benefit from the Mesalamine DR coupon code WELCOMEPB10 for a 10% discount on their first order, making it more affordable for those in need of this medication.

Frequently Asked Questions

What does Mesalamine do to your body?

Mesalamine is used to manage and prevent flare-ups of ulcerative colitis, which is a type of inflammatory bowel disease. It acts directly in the bowels to reduce inflammation and ease symptoms associated with the condition. This medication must be prescribed by a doctor.

How long does it take for Mesalamine DR to work?

Mesalamine, when taken as directed, can start showing results in about 2 to 4 weeks. It’s known for being well tolerated by most people and does not increase the risk of infections or cancer, making it a preferred option for many patients.

Is Mesalamine DR the same as Lialda?

Mesalamine DR, known under the brand name Lialda, is a medication used to treat mild to moderate ulcerative colitis in both adults and children. It is a delayed-release tablet designed to be taken once daily with food to manage symptoms effectively.

Can I drink alcohol with Mesalamine?

Drinking alcohol while taking Mesalamine for ulcerative colitis is generally considered safe. However, if you experience side effects like headaches or nausea from the medication, consuming alcohol may worsen these symptoms. Additionally, alcohol can trigger a flare-up of ulcerative colitis in some individuals.

Does Mesalamine get rid of inflammation?

Mesalamine belongs to a class of drugs known as anti-inflammatory agents. It helps reduce inflammation by blocking the production of certain substances in the body that can lead to inflammation, providing relief from symptoms of diseases like ulcerative colitis.

What is the brand name for Mesalamine DR 1.2 gm?

Mesalamine DR 1.2 gm is commonly marketed under the brand name Lialda. This formulation is designed for delayed release to treat inflammatory bowel diseases like ulcerative colitis. Lialda targets inflammation directly in the colon, which helps manage symptoms such as diarrhea, abdominal pain, and rectal bleeding. It is essential to follow the recommended medication dosage & instructions a healthcare provider provides to ensure the medication’s effectiveness and safety.

When is the best time to take Mesalamine DR?

The best time to take Mesalamine for ulcerative colitis varies depending on individual needs & the specific product instructions. Generally, it is taken once daily, either in the morning or the evening, with or without food. Following your healthcare provider’s instructions regarding timing and dosage is crucial to maximize the medication’s benefits. Consistency in taking the medication simultaneously daily can help improve its efficacy and ensure better management of inflammatory bowel disease symptoms.

Can Mesalamine be taken long-term?

Yes, Mesalamine can be taken long-term to manage chronic conditions like ulcerative colitis. Long-term use is often necessary to maintain remission and prevent flare-ups of the disease. Regular monitoring by a medical provider is crucial to manage any potential side effects & adjust the dosage as needed. Patients should stick to their prescribed regimen and consult their healthcare provider regularly to ensure the medication continues to be effective and safe over the long term.

How do you take Mesalamine 1.2 gm tablets?

Mesalamine 1.2 gm tablets should be taken exactly as your healthcare provider prescribes. Typically, these tablets are taken once daily with a full glass of water. It is important to swallow the tablets whole without crushing, chewing, or breaking them, as this ensures the medication is properly released into the colon. Follow your healthcare provider’s instructions regarding the timing and dosage, and maintain consistent use to effectively manage symptoms of inflammatory bowel disease.

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