Search for 'Ozempic'
We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More
We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More
Ordering your medication online is simple and convenient.
Select the prescribed dosage and quantity, then proceed to checkout.
Sign in or create a new account.
Upload your prescription.
Complete your purchase by processing the payment.
Select the prescribed dosage and quantity, then proceed to checkout.
Sign in or create a new account.
Upload your prescription.
Complete your purchase by processing the payment.
Shipping takes approximately 3-5 business days.
Methotrexate is a prescription medicine used to treat autoimmune diseases and certain types of cancer. At low doses, it helps control conditions like rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis. It calms an overactive immune system and reduces inflammation. At higher doses, Methotrexate is used as a chemotherapy drug to slow or stop the growth of cancer cells in diseases such as leukemia, lymphoma, and breast cancer. Methotrexate interferes with the body’s use of folic acid, which cells need to grow and repair. This makes it effective for both immune-related conditions and cancer when used under careful medical supervision.
| Product Name | Methotrexate |
|---|---|
| Drug Class | Antimetabolite, Immunosuppressant, Antineoplastic |
| FDA Approval Status | FDA-approved for cancer, rheumatoid arthritis, severe psoriasis, and juvenile idiopathic arthritis |
| Available Forms | Oral tablets |
| Strengths Available | 10 mg |
| Routes of Administration | Orally (by mouth) |
| Administration Frequency | Once weekly for RA, psoriasis, and JIA. Variable schedules for cancer therapy |
| Methotrexate Uses | Rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, cancers (ALL, lymphoma, osteosarcoma, breast, head/neck, uterus) |
| Methotrexate Contraindications | Pregnancy, breastfeeding, severe liver disease, alcoholism, blood disorders, active infections |
| Methotrexate Storage | Store at room temperature (20°C-25°C) |
| Prescription Required | Rx only |
| Elimination Half-Life | 3-10 hours (low-dose) 8-15 hours (high-dose) |
← Swipe to see more →
Methotrexate is FDA-approved for:
If you are prescribed to use Methotrexate for psoriasis, rheumatoid arthritis, or cancer treatment, follow these administration guidelines:
Follow this Methotrexate 10 mg dosing schedule to treat your condition effectively:
| Condition | Starting Dose | Usual Dose Range | Frequency | Important Notes |
|---|---|---|---|---|
| Methotrexate for Rheumatoid Arthritis (RA) | 7.5-10 mg orally | 10-25 mg/week | Once weekly only | May be given as a single weekly dose or split into 2-3 doses over 24 hours. Folic acid supplementation is required. |
| Methotrexate for Psoriasis (severe) | 7.5-15 mg orally | 10-30 mg/week | Once weekly only | Adjust based on response and tolerance. Folic acid is required. |
| Methotrexate for Polyarticular Juvenile Idiopathic Arthritis (pJIA) | 10 mg/m² orally | 10-30 mg/m²/week | Once weekly only | Dose calculated by body surface area. Specialist supervision required. |
| Methotrexate for Cancer Regimens | Highly variable | Protocol dependent | Weekly or cyclic | Requires oncology supervision, hydration, monitoring, and leucovorin rescue. |
← Swipe to see more →
Methotrexate 10 mg tablets work by blocking the body’s use of folic acid, which is a vitamin needed for cells to make DNA and grow. However, Methotrexate looks very similar to folate because it tricks the enzymes that normally use folate and prevents them from working. This slows the growth of rapidly dividing cells (such as cancer cells, skin cells in psoriasis, or immune cells in rheumatoid arthritis). In simple terms, Methotrexate calms an overactive immune system, reduces inflammation, and stops abnormal cell growth. That’s why it’s used both for autoimmune diseases and certain cancers.
Missing one weekly dose of Methotrexate is usually not dangerous. However, you may notice your symptoms (like joint pain or skin flare-ups) creeping back. The important thing is not to double the Methotrexate dose next week. Just take your regular Methotrexate 10 mg dose on your usual day and continue as normal. If you missed a Methotrexate dose for more than one week, let your doctor know. However, there are various side effects of stopping Methotrexate suddenly.
Taking an extra dose can be serious because Methotrexate builds up in the body and can cause harmful side effects like mouth ulcers, nausea, liver problems, or low blood counts. If you suspect a Methotrexate overdose, contact the poison control center or your healthcare provider immediately. Do not wait for Methotrexate overdosing symptoms to appear.
| Common Side Effects of Methotrexate | Rare or Serious Side Effects of Methotrexate |
|---|---|
| Gastrointestinal issues like diarrhea, nausea, vomiting, appetite loss, and abdominal pain | Liver damage |
| Mouth sores | Lung damage |
| Fatigue | Blood disorders |
| Skin issues | Signs of infection |
| Hair loss | Kidney damage |
| Sensitivity to sunlight | Confusion, seizures, or neurological changes |
← Swipe to see more →
Methotrexate Boxed Warning
Methotrexate carries a black box warning because it can cause very serious and sometimes life‑threatening side effects. The strongest warnings highlight that Methotrexate may lead to severe liver damage (including cirrhosis), serious lung problems, and dangerous infections. It can also cause embryo‑fetal toxicity (harm to an unborn baby), meaning it should never be used during pregnancy for non‑cancer conditions. It may result in miscarriage or birth defects. Methotrexate is contraindicated in patients with a history of serious hypersensitivity reactions, including anaphylaxis.
Follow these Methotrexate precautions if you are considering this medication for psoriasis, rheumatoid arthritis, and cancer treatment:
Here are the Methotrexate interactions you should know before starting treatment. These are medications that should generally be avoided while taking Methotrexate:
Consider the following Methotrexate alternatives if this medication doesn’t suit your condition:
A high Methotrexate cost makes the treatment difficult for many patients. That is why people choose Polar Bear Meds. When you buy Methotrexate online from Canada with us, you can save a lot compared to U.S. pharmacy prices. We offer Methotrexate 10 mg tablets at prices up to 80% lower, making treatment more affordable.
We source Methotrexate from licensed Canadian pharmacies. New customers can save more with our Methotrexate coupon code “WELCOMEPB10” to get 10% off. Methotrexate orders arrive within 3-5 business days through our Xpress Post. Get a Methotrexate prescription from your doctor today to buy with us.
This content is for general information only. It does not replace professional medical advice. Methotrexate is a strong prescription medicine. It must be used only under a doctor’s supervision. Do not start, stop, or change the Methotrexate dose without medical guidance. If you experience side effects, signs of infection, allergic reactions, or worsening symptoms, seek immediate medical attention. Always discuss your full medical history, current medications, and health concerns with your doctor or healthcare provider before using Methotrexate.
Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
Learn more about Methotrexate and related topics
