Moclobemide

Moclobemide 

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), used primarily to treat depression and social anxiety disorders. It enhances mood by increasing levels of neurotransmitters like norepinephrine, serotonin, and dopamine in the brain. Suitable for adults, it comes in tablet form with doses typically ranging from 150 mg to 300 mg. Common side effects include dizziness and nausea, with serious side effects requiring immediate medical attention. You need to get a prescription from your doctor before you order Moclobemide tablets online, as it is a prescription-based and FDA-approved medication for these mentioned uses.

Product Overview

Moclobemide is a prescription medication commonly used to treat depression and social anxiety disorders. It belongs to a class of drugs known as reversible inhibitors of monoamine oxidase A (RIMA). This medicine works by increasing the levels of specific neurotransmitters, such as norepinephrine, serotonin & dopamine, which are essential for improving mood. Moclobemide is not a controlled substance and is approved by the FDA for its intended uses. 

This medication is available in tablet form, typically in strengths of 150 mg & 300 mg. The medication is taken orally, usually daily after meals in divided doses, to ensure optimal absorption. It is suitable for adults but should not be used in children or adolescents without proper medical advice. It works by selectively restricting the enzyme monoamine oxidase A, which helps increase the availability of mood-enhancing neurotransmitters in the brain.

Common side effects of this medication may include dizziness, nausea, and insomnia. To minimize these reactions, avoid alcohol and certain foods high in tyramine. In case of a missed dose, take it as soon as possible. Do not double the dose to compensate. Overdose requires immediate medical attention. Store Moclobemide at room temperature. You may need to get a prescription from your doctor to buy Moclobemide online from Canada.

What Is Moclobemide Used to Treat?

This medication is used for the following purposes:

• Treatment of Depression: It helps manage major depressive disorder by re-establishing the balance of neurotransmitters in the brain.
• Bipolar Disorder: Moclobemide can also be used to treat depressive episodes of bipolar disorder.
• Social Anxiety Disorder: Moclobemide aids in reducing the symptoms of social anxiety.
• Improves Mood and Well-Being: It helps uplift mood and overall well-being.    

What Strengths Does Moclobemide Come In?

It is available in the form of tablets with the following strengths:

• Moclobemide 150 mg tablet
• Moclobemide 300 mg tablet

What Is the Typical Dosage for Moclobemide?

The dosage recommendations for Moclobemide for depression treatment depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.

Dosage for Major Depression

• Adults: Take 300 mg of Moclobemide once daily in divided doses after having a meal. Your doctor may increase the dosage up to 600 mg per day based on your depression severity. The dose may be reduced to 150 mg as per the individual’s response to the treatment.
• Children (Below 18 Years of Age): Talk to a medical professional; a professional must determine the use and dose.

Dosage for Social Phobia or Anxiety

• Adults: Start the treatment by taking 300 mg once daily, and on day 4, increase the dosage to 600 mg per day divided into two doses. Moreover, it is not recommended to keep taking 300 mg per day for more than three days because the effective dose is 600 mg per day. You should take 600 mg daily for 8 to 12 weeks to see if the medicine works. If it helps, you can keep taking it. The doctor will check you regularly to see if you need to continue the treatment. 
• Children (Below 18 Years of Age): Talk to a medical professional; a professional must determine the use and dose.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Do You Take Moclobemide? 

Before using Moclobemide for depression treatment, you should carefully read and follow the instructions for use in the patient information leaflet and medication guide. Here are some of the instructions that you may follow to use Moclobemide properly:

• Follow the dosage recommendations exactly as mentioned on the prescription label.
• Do not exceed or subceed the doses without consulting a medical expert. Doing so may increase the risk of side effects.
• Take the medication orally with a glass of water.
• Swallow the tablets as a whole.
• You can take the medication with food unless your doctor advises otherwise.
• Avoid chewing, crushing, splitting, or breaking the tablets. Doing so may release the drug at once. 
• If you are unable to swallow the medicine, consult your healthcare practitioner. They will suggest alternate options that suit your body’s needs.
• Take the medicines at the same time each day to get the most benefit out of it.
• Do not abruptly stop taking your medication without consulting a medical provider. This may cause serious complications in the future. So, complete your course of treatment till the days your doctor has advised.  

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Moclobemide Help Cure Depression?

Moclobemide for depression treatment works by restricting an enzyme called monoamine oxidase A (MAO-A) in the brain. This enzyme typically breaks down neurotransmitters such as serotonin, norepinephrine & dopamine, which are chemicals that help control mood. By blocking MAO-A, the medication increases the levels of these neurotransmitters, leading to enhanced mood and reduced symptoms of depression and anxiety. Unlike some older antidepressants, Moclobemide is selective and reversible, meaning it targets MAO-A specifically, and its effects can be quickly reversed if needed. This makes it a safer and more targeted option for treating mood disorders.

What Are the Important Safety Information for Moclobemide?

What Are the Side Effects of Moclobemide?

Common Side Effects of Moclobemide: Moclobemide is a medication that helps manage certain mood disorders, but like all medicines, it can cause side effects. These reactions usually aren’t serious and often go away as your body adjusts to the medication. Here’s a simple breakdown of the common side effects:

• Mild Headache: You might experience headaches that are generally mild.
• Dizziness or Lightheadedness: This can happen, especially when you stand up quickly from sitting or lying down.
• Nervousness: You may feel unusually anxious or uneasy.
• Restlessness: A feeling of needing to move around or being unable to stay still.
• Unusual Tiredness/Weakness: You might feel more tired or weaker than usual without a clear reason.
• Nausea and Vomiting: Feeling sick to your stomach or actually vomiting can occur.
• Insomnia: Difficulty falling asleep or staying asleep might happen.
• Mouth Dryness: Your mouth may feel unusually dry.
• Constipation and Diarrhea: You could experience changes in your bowel habits, including having hard stools or loose stools.
• Aggressive Behavior: There may be times when you feel unusually aggressive.
• Feeling Sick: General feeling of being unwell.

Serious Side Effects of Moclobemide for Depression Treatment: Moclobemide can sometimes cause serious side effects that may require immediate medical attention. If you experience any of these symptoms, it’s crucial to seek medical help immediately. These side effects can be serious and need prompt attention from a healthcare professional. Here’s an explanation of these serious reactions:

• • Rapid or Irregular Heartbeats: Your heart might beat unusually fast or irregularly.
  • Neck Stiffness: You may experience unusual stiffness in your neck, which can be uncomfortable.
  • Extreme Headaches: Severe headaches that start at the back and move to the front of the head.
  • Slow Heartbeat: A noticeable decrease in the rate of your heartbeat.
  • Anxiety: Feelings of intense worry or fear that can be overwhelming.
  • Blurred Vision: Your sight might become unclear, making it hard to see details.
  • High Blood Pressure: An increase in blood pressure which can be dangerous.
  • Chest Pain: Pain in the chest area, which can be a sign of serious heart problems.
  • Confusion: Difficulty in thinking clearly or understanding what’s happening.
  • Suicidal Thoughts: Thoughts about harming yourself or ending your life.
  • Loss of Taste: You might notice a decrease or loss in your sense of taste.
  • Swelling: Unusual puffiness or swelling in parts of your body.
  • Not Feeling Hungry: A decrease in appetite or interest in eating.

• Low Sodium Levels in the Blood:

• • • Sleepiness: Feeling unusually sleepy or drowsy.
    • Confusion: More difficulty in thinking clearly.
    • Seizures: Episodes of uncontrolled electrical activity in the brain, which can cause convulsions.

• Serotonin Syndrome (a potentially life-threatening condition caused by too much serotonin in the brain):

• • Involuntary or Rhythmic Muscle Contractions: Muscles twitching or spasms that you can’t control.
  • Coma: A deep state of unconsciousness.
  • Excessive Sweating: Sweating much more than usual.
  • Tremor: Shaking or trembling that you can’t control.
  • Increased Muscle Tension: Muscles feeling unusually tight.
  • Losing Consciousness: Brief periods where you pass out or faint.
  • Skin Reactions: Rashes, hives, or other skin abnormalities.
  • Delusion: Strong beliefs in things that are not true or based on reality.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Using Moclobemide?

Moclobemide for depression treatment can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious as it has several warnings, which are as follows:

• Risk of Suicidal Thoughts: It is not clear if older antidepressants increase the risk of suicidal thoughts and behavioral problems in adults or children. However, recent studies have observed changes in the behavior and emotions of patients taking newer antidepressants. Therefore, it’s important to closely monitor anyone taking any antidepressant for signs of suicidal thoughts or other changes in behavior and emotions.
• Hepatic Impairment: Patients with severe liver problems should consult a medical practitioner before taking this medication. The doctor will decide the accurate dose suiting the patient’s body needs. These doses are usually lower than the actual adult dose.
• Angle-Closure Glaucoma: Moclobemide may cause an acute attack of glaucoma. Therefore, if you are experiencing vision changes, eye pain, swelling, or redness around the eye, seek medical attention.

Does Moclobemide Have an FDA Boxed Warning?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Moclobemide does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or notice any unusual symptoms, it’s best to consult with an expert.

What Are the Precautions for Moclobemide?

When considering treatment with Moclobemide for depression treatment, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Moclobemide for depression problems:

• Before using this medication, tell your doctor if you have any allergies or are even allergic to Moclobemide or any of the ingredients used in its formulation. The product may contain certain inactive components that can cause allergic reactions. 
• When considering treatment with Moclobemide, tell your doctor about your or your family’s medical history.
• Taking this medicine with certain drinks or other drugs can cause serious reactions like high blood pressure. To avoid this life-threatening reaction, avoid drinking excessive alcohol. 
• If you are undergoing surgery or any medical procedure, inform your healthcare provider about the products you are taking. This includes all prescription medications, over-the-counter drugs, and herbal products. Some of the examples are:
  • Dextromethorphan (found in cough medicines)
  • Buprenorphine
  • Fluoxetine
  • Bupropion
  • Paroxetine
  • Clomipramine
  • Pethidine (for pain relief)
  • Selegiline (for Parkinson’s disease)
  • Linezolid (for the treatment of infections)
  • St John’s Wort (for anxiety)
  • Triptans (for migraines)
  • Tramadol (for pain relief)
• It is advised not to eat large amounts of tyramine during your treatment with Moclobemide. Ask your medical practitioner about any diet changes that you should take. Some of the foods containing tyramine are:
  • Yeast extract
  • Mature cheese
  • Fermented soya bean products 
• Sometimes, you may feel better, but you must continue taking the medicine for several weeks or as your doctor advises. 
• Make frequent doctor visits, as they will monitor your progress reports, especially during the initial stages of treatment. This will prevent you from any serious effects and ensure that the medicine is working properly.
• Moclobemide may cause blurred vision or make you drowsy, so avoid driving or using any heavy machinery that requires alertness. 
• If your course is completed or you have stopped using this medication, you must exercise caution for at least two weeks while taking any food, drink, or other medicines.
• If you have suicidal thoughts or thoughts of killing someone, get medical assistance right away.
• If you are pregnant or planning to have a baby, avoid using this medication unless advised by your doctor. Discuss every risk and benefit with your medical provider before making any decision.
• If you are intolerant to some sugars, talk to a medical expert to avoid any serious side effects. 
• This medicine is not intended for use in children under 18 years of age.
• If you are experiencing psychotic symptoms or any antipsychotic medications, talk to your medical professional.

What Are Contraindications with MAOIs Like Moclobemide?

Moclobemide for depression treatment is contraindicated in the following conditions:

• Patients with hypersensitivity reactions to Moclobemide or any of the ingredients present in its formulation.
• Patients who have an acute confusional state.
• Co-administration with bupropion, tramadol, and triptans.
• Using Moclobemide in combination with thioridazine and dextromethorphan.
• Patients with phaeochromocytoma (tumor on one of the adrenal glands).
• Taking pethidine or selegiline.

What If You Miss a Dose of Moclobemide?

Generally, it is advisable not to miss any doses of Moclobemide, but if someone forgets, they should:

• Take the tablets as soon as possible or whenever they remember.
• If it is almost time for the next dose, omit the missed dose and follow the regular dosing schedule as a medical professional instructed.
• Remember not to take double doses of the prescribed medication just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your mobile phone to avoid skipping any doses.
• Take each dose at the same time every day to get the most benefit out of it.
• If patients are still unsure about the missed doses, talk to an expert physician. They will guide each patient and suggest alternate options suiting their body needs.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Accidentally Take Too Much Moclobemide?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly take an excessive amount of Moclobemide for depression treatment. In such cases, patients are advised not to panic and instead look for unusual signs like:

• Vomiting
• Nausea
• Disorientation
• Slurred speech
• Drowsiness
• Reduced reflexes
• Hypertension
• Agitation
• Amnesia
• Convulsions

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How Do You Store Moclobemide?

Following the proper storage guidelines is essential, when you order Moclobemide tablets online, for the safe and efficient use. Here’s how you can store your medication:

• Store the medication at a room temperature of 15-30°C.
• Keep the tablets in a closed container and place a safety lock to avoid poisoning your child. There are many products in the market that are not child-resistant. 
• Keep the medicine protected from heat, direct light, and moisture. 
• Ensure that tablets are kept somewhere safe, away from the reach and sight of children and pets.
• Do not flush the medication down the toilet. 
• Avoid keeping them in moist or damp areas like the bathroom or near the sink.
• Discard the product when not in use.
• Keep the tablets in a dry place.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• Ask a medical professional how to dispose of the product properly without damaging the environment.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Drugs Interact with Moclobemide?

Moclobemide interacts with a variety of medications, which can lead to increased side effects or reduce the effectiveness of the treatments. Here’s how these interactions can affect your body when Moclobemide is taken with certain drugs:

• Blood Pressure Medications and Sympathomimetic Drugs (such as Pseudoephedrine, Phenylalanine, Methyldopa): These can lead to dangerously high blood pressure or enhance the effects of each other, increasing the risk of side effects.
• Antidepressants (such as Amitriptyline, Trazodone, Nortriptyline): Using Moclobemide with other antidepressants can increase the risk of serotonin syndrome, a serious condition characterized by high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea.
• Opioids (such as Codeine, Tramadol): Combining these with Moclobemide may increase the risk of serotonin syndrome.
• Diet Pills and Stimulants (such as Phentermine, Methamphetamine): These can raise blood pressure and heart rate, which can be dangerous when combined with Moclobemide.
• MAO Inhibitors (such as Tranylcypromine, Selegiline): Taking Moclobemide with other MAO inhibitors can greatly increase the risk of a hypertensive crisis (a dangerous increase in blood pressure).
• Triptans (such as Sumatriptan): Used for migraines, when combined with Moclobemide, can also lead to serotonin syndrome.
• Certain Pain Relievers (such as Cyclobenzaprine, Methotrimeprazine): These can interact with Moclobemide to increase serotonin levels, potentially leading to serotonin syndrome.

What Are the Other Moclobemide Interactions?

When using Moclobemide, it’s essential to consider how various non-drug factors might interact with your treatment:

• Foods High in Tyramine: Foods like aged cheeses, cured meats, and certain soy products contain tyramine, which can interact with Moclobemide to potentially cause high blood pressure. It’s best to avoid these foods or consume them in very small amounts.
• Alcohol: Drinking alcohol while taking Moclobemide may increase the risk of side effects like dizziness and can also intensify feelings of depression or anxiety. Moderate alcohol consumption might be safe for some people, but it’s important to consult your doctor first.
• Herbal Remedies: Certain herbs, like St. John’s Wort, can interfere with how Moclobemide works in your body. St. John’s Wort, for example, may lead to an increase in serotonin levels and contribute to serotonin syndrome, a potentially dangerous condition.
• Tobacco: Smoking can affect how Moclobemide is metabolized (broken down) in your body, potentially decreasing its effectiveness or altering side effects.
• Caffeine: Caffeine can increase the stimulating effects of Moclobemide, leading to increased heart rate and blood pressure. If you consume caffeine, it may be best to limit the amount.

[Note: This isn’t a complete list, and there could be other drugs that interact with Moclobemide. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Is An Alternative to Moclobemide?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to Moclobemide for depression treatment are as follows:

• Selective Serotonin Reuptake Inhibitors. Examples are:
  • Fluoxetine (Prozac)
  • Sertraline (Zoloft)
  • Citalopram (Celexa)
• Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). For example:
  • Venlafaxine (Effexor)
  • Duloxetine (Cymbalta)
• Tricyclic Antidepressants. Some of its examples are:
  • Amitriptyline
  • Nortriptyline (Pamelor)
• Atypical Antidepressants. Examples are:
  • Bupropion (Wellbutrin)
  • Mirtazapine (Remeron)
• Monoamine Oxidase Inhibitors (MAOIs). For example:
  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Moclobemide Coupons & Cost

Moclobemide for depression treatment can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here, you can buy Moclobemide online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Moclobemide coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

What should you avoid while taking Moclobemide?

While on Moclobemide, it’s important to avoid foods high in tyramine due to the risk of sensitivity reactions. Such foods include aged cheeses, cured meats, broad bean pods, yeast-extract spreads, and soy products. These could trigger adverse effects when combined with the medication.

When is the best time to take Moclobemide?

Moclobemide is typically prescribed in doses ranging from 300 mg to 600 mg daily. You should take the tablets whole with a full glass of water and after meals to ensure the best absorption and to reduce stomach upset.

What food to avoid with Moclobemide?

Even though Moclobemide is less likely to interact with tyramine compared to other MAO inhibitors, it’s wise to avoid large amounts of tyramine-rich foods. These include mature cheeses, yeast extracts, and fermented soy products, as they can still pose risks.

Does Moclobemide increase blood pressure?

Yes, Moclobemide can lead to a dangerous increase in blood pressure if combined with certain other medications or specific types of food and drink. This condition, known as a hypertensive crisis, requires immediate medical attention.

How quickly does Moclobemide work?

Moclobemide typically starts to show effects within 1 to 2 weeks of consistent use, but it may take up to 4 weeks for the full therapeutic benefits to become noticeable. The time it takes to work can vary based on the individual & the severity of symptoms. It’s important to continue taking the medication as directed, even if you don’t feel immediate improvement, and to discuss any concerns, consult your medical provider.

Does Moclobemide make you sleepy?

Moclobemide is generally not known to cause drowsiness or sleepiness, which is a common side effect of many other antidepressants. In fact, some individuals may experience increased alertness or insomnia, particularly when first starting the medication. However, as with any medication, reactions can vary, so it’s important to monitor how you feel and discuss any sleep-related issues with your healthcare provider to ensure proper management.

Is Moclobemide an addictive drug?

Moclobemide for depression treatment is not considered an addictive drug. It does not have the potential for abuse or physical dependence that some other medications, particularly certain types of antidepressants or anxiolytics, may have. This makes it a safer option for long-term use in treating depression and anxiety disorders. However, it should still be used under the guidance of a healthcare provider, and any discontinuation should be done gradually to avoid potential withdrawal symptoms.

Does Moclobemide affect dopamine levels?

Yes, Moclobemide affects dopamine levels by suppressing the enzyme monoamine oxidase A (MAO-A), which breaks down dopamine in the brain. By preventing this breakdown, Moclobemide increases the availability of dopamine, along with other neurotransmitters like serotonin and norepinephrine. This action helps improve mood and alleviate symptoms of depression and anxiety. The selective nature of Moclobemide means it specifically targets MAO-A, leading to a more balanced increase in neurotransmitter levels.

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