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We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More
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Sign in or create a new account.
Upload your prescription.
Complete your purchase by processing the payment.
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Mysimba is a prescription medicine used by adults who are obese or overweight with weight-related health conditions. The medication is a combination of bupropion and naltrexone, available as tablets in 90 mg/8 mg strengths. It is used along with a reduced-calorie diet and increased physical activity to support weight loss.
| Product Name | Mysimba |
|---|---|
| Active Ingredient | Bupropion hydrochloride and Naltrexone hydrochloride |
| Drug Class | Anti-obesity medication |
| Available Forms | Oral tablets |
| Strengths Available | 90 mg/8 mg |
| Routes of Administration | Taken by mouth |
| Mysimba Uses | Helps in weight management in adults (18+) with: Obesity (BMI ≥30) or overweight (BMI ≥27) Overweight with a weight-related condition (e.g., Type 2 diabetes) |
| Mysimba Storage | Store at 20°C to 25°C (68°F to 77°F), excursions permitted up to 30 °C. |
| Pregnancy and Breastfeeding | Consult a doctor |
| Legal Status | Rx only |
| Black Box Warning | Suicidal thoughts and reactions Neuropsychiatric reactions |
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Information: Mysimba is an FDA-approved medicine under the brand name Contrave in the United States. Both brands contain the same ingredients: Bupropion hydrochloride and Naltrexone hydrochloride, used in weight management.
Mysimba, a combination of bupropion and naltrexone, acts on brain centers involved in hunger and reward. The components influence the brain’s reward system, which is associated with the pleasurable effects of eating. When used together, Mysimba helps reduce hunger and decrease the amount of food patients eat. It may help improve energy levels, making it easier to follow a calorie-controlled diet.
Mysimba contains bupropion and naltrexone, a combination that helps manage body weight in adults. Mysimba uses are as follows:
The medication may cause some unwanted effects that require emergency help. Mysimba side effects: less common, more common, rare, and Frequency unknown are as follows:
| Less Common Side Effects | More Common Side Effects | Serious Side Effects | Frequency Unknown |
|---|---|---|---|
| Frequent urge to urinate | Dizziness | Nausea | Chills |
| Bladder pain | Blurred vision | Discomfort or chest pain | Anxiety |
| Lower back or side pain | Headache | Vomiting | Aggression |
| Cloudy or bloody urine | Nervousness or fear | Sweating | Loosening or blistering of the skin |
| Trembling of hands or feet | Loss of interest or pleasure | Pain or discomfort in the arms, jaw, neck, or back | Diarrhea |
| Burning, difficult, or painful urination | Pounding in the ears | Suicidal thoughts | Dry mouth |
| Irregular or pounding heartbeat | Trouble concentrating | Behavioral changes | Hives or itching |
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It is crucial that your doctor check your progress at regular visits to ensure that the medicine is working properly without causing unnecessary side effects. Keep the following Mysimba precautions in mind before taking the medication.
Mysimba box warning - Mysimba tablets have an increased risk of:
Patients who are obese or overweight with weight-related health conditions should keep the following Mysimba dosage guide in mind.
| Week | Morning Dose | Evening Dose | Total Tablets Per Day |
|---|---|---|---|
| Week 1 | 1 | - | 1 |
| Week 2 | 1 | 1 | 2 |
| Week 3 | 2 | 1 | 3 |
| Week 4 onwards | 2 | 2 | 4 |
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Information: Your doctor should be aware of your dosing schedule. Do not change your dose unless your doctor directs you to do so.
Use the following Mysimba alternatives for weight management only under your healthcare professional's supervision.
The above substitutes are approved along with the calorie-controlled diet and increased physical activity. Continue regular follow-up visits with your doctor.
Seek emergency medical help in case of Mysimba overdose.
Mysimba may not be suitable for certain patients due to increased health risks. The following are Mysimba contraindications:
Mysimba storage guidelines are important to understand for your safety.
There are several medicines that should not be used together to avoid serious complications. The following list of Mysimba interactions is not complete. Consult your doctor for the full list of interactions.
Mysimba blocks opioid receptors; opioid use may cause withdrawal.
Obesity or body weight management medications may be costly when purchased from local U.S. pharmacies. At Polar Bear Meds, we help you access your prescribed medications at more affordable prices by sourcing them through fully licensed Canadian and international pharmacy partners.
When you choose to buy Mysimba online from Polar Bear Meds, you may benefit from significantly lower pricing than at many U.S. retail pharmacies.
Here’s why patients trust Polar Bear Meds for their Mysimba prescription:
At Polar Bear Meds, your safety and satisfaction come first. Every order is processed through licensed pharmacy partners to ensure you receive authentic Mysimba medicine as prescribed by your healthcare professional. If you are seeking a trusted, affordable way to buy Mysimba online, Polar Bear Meds offers a secure and cost-effective solution according to your needs.
The information provided about Mysimba (bupropion/naltrexone) is for informational and educational purposes only and is not intended to replace professional medical advice, treatment, or diagnosis. Mysimba is a prescription-based medicine and should be used only under the supervision of a pharmacist, healthcare provider, or doctor. Always consult your doctor before changing or stopping your Mysimba dosage.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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