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Naltrexone Hydrochloride

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Product Details

What Is Naltrexone Hydrochloride?

What Is Naltrexone Hydrochloride?

Naltrexone Hydrochloride is a prescription medication used to treat OUD (Opioid Use Disorder) and AUD (Alcohol Use Disorder) in adults. It works as an opioid receptor antagonist, which means it blocks the effects of opioids in the brain and may help reduce alcohol cravings.

Naltrexone tablets do not produce opioid-like effects and are not habit-forming. This medication should be taken under medical supervision as part of a comprehensive treatment program that includes behavioral support and counseling.

Naltrexone is available in tablet and injection forms. Currently, our pharmacy provides only a 50 mg oral tablet. Many patients purchase this medication from licensed Canadian pharmacies to save on costs with a valid prescription.

Quick Facts About Naltrexone Hydrochloride

Quick Facts About Naltrexone Hydrochloride

CategoryDetails
Brand NamesRevia (oral tablets), Vivitrol (extended‑release injection)
Generic NameNaltrexone Hydrochloride
Drug ClassOpioid antagonist
Prescription RequiredYes, must be prescribed by a licensed healthcare provider
FDA‑Approved IndicationsOUD (Opioid Use Disorder); AUD (Alcohol Use Disorder)
Dosage FormsOral tablet: 50 mg; Injectable suspension: 380 mg (monthly intramuscular injection)
Important Safety NotesPatient must be opioid‑free for 7–10 days before starting; risk of hepatotoxicity at high doses; not for patients with liver failure or acute hepatitis
Common Side EffectsNausea, headache, dizziness, fatigue, insomnia, anxiety
MonitoringLiver function tests before and during treatment; confirm opioid abstinence prior to initiation

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What Is Naltrexone Hydrochloride Used For?

What Is Naltrexone Hydrochloride Used For?

Naltrexone Hydrochloride 50 mg tablets are FDA-approved for:

  • Alcohol Use Disorder (AUD)
  • Opioid Use Disorder (OUD)
What Are the Risks of Taking Naltrexone?

What Are the Risks of Taking Naltrexone?

Naltrexone Hydrochloride can cause side effects and may not be appropriate for everyone. Important risks include:

  • Opioid withdrawal: Naltrexone can cause severe and sudden withdrawal symptoms in patients who are physically dependent on opioids. People must be opioid‑free for 7-10 days before starting treatment.
  • Liver injury: Cases of liver damage have been reported, particularly at higher doses. Symptoms may include dark urine, abdominal pain, and yellowing of the skin or eyes.
  • Reduced opioid tolerance: After stopping Naltrexone, patients might be more sensitive to opioids, raising the risk of overdose if opioids are used again.
What Are the Precautions for Naltrexone?

What Are the Precautions for Naltrexone?

Before taking Naltrexone, inform your healthcare provider about your medical history and all medications you use. Important precautions include:

  • Liver disease: Use with caution in people with liver conditions. Baseline and periodic liver function tests may be required.
  • Surgery or pain treatment: Inform healthcare providers you are taking Naltrexone, as opioid pain medications will be ineffective. Non‑opioid alternatives must be considered.
  • Opioid use: Do not take Naltrexone if you are currently using opioids or have not completed opioid withdrawal.
  • Pregnancy and breastfeeding: Use only if clearly needed and under the guidance of a healthcare provider.
  • Alcohol use disorder treatment: Naltrexone should be used as part of a comprehensive treatment program, including counseling and psychosocial support.
What Are the Side Effects of Naltrexone Tablets?

What Are the Side Effects of Naltrexone Tablets?

Naltrexone Hydrochloride may cause side effects, which can vary by individual. Most of them are mild, but some are serious and require medical attention. Below are some of the Naltrexone side effects:

Common Side Effects of Naltrexone tabletsRare or Serious Side Effects of Naltrexone tablets
Nausea or vomitingLiver injury or hepatitis (yellowing of skin/eyes, dark urine)
Diarrhea or abdominal painSevere allergic reactions (rash, itching, swelling of face or throat)
HeadacheSevere depression or suicidal thoughts
DizzinessSevere abdominal pain
Fatigue or weaknessSigns of opioid withdrawal if opioids are taken
Anxiety or nervousnessAbnormal liver function tests
Sleep problems (insomnia)
Muscle or joint pain

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This is not a complete list of side effects. If you experience any unusual or severe symptoms, contact your provider immediately.

How Does Naltrexone HCl Work?

How Does Naltrexone HCl Work?

Naltrexone Hydrochloride (HCl) blocks the effects of opioids in the brain, including feelings of euphoria or pain relief.

  • By blocking these receptors, Naltrexone helps reduce the desire to use opioids in people being treated for opioid dependence.
  • It may also help reduce alcohol cravings by affecting the brain’s reward pathways.
  • Naltrexone does not produce a “high” and is not addictive.

Naltrexone works by preventing the pleasurable effects of certain substances, supporting recovery, and helping patients maintain abstinence.

What's the Best Way to Take Naltrexone?

What's the Best Way to Take Naltrexone?

  • Take Naltrexone exactly as prescribed by your healthcare provider.
  • Swallow the tablet whole with water; do not crush, chew, or split it.
  • Try to take it at the same time each day to maintain consistent medication levels.
  • It can be taken with or without food.
  • Do not stop taking Naltrexone or change your dose without consulting your doctor.

Following these instructions helps ensure you are taking Naltrexone correctly for its intended use.

Naltrexone HCl Tablets Dosage Guide

Naltrexone HCl Tablets Dosage Guide

Follow this Naltrexone Hydrochloride dosing schedule for different medical conditions:

IndicationInitial DoseMaintenance DoseKey Notes
Alcohol DependenceNo initial dose required50 mg once dailyUsed as part of a comprehensive treatment program for alcohol dependence
Opioid Dependence25 mg once daily (initial test dose)50 mg once dailyPatient must be opioid‑free for 7–10 days to avoid precipitated withdrawal

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Always follow the exact Naltrexone dosage prescribed by your healthcare professional.

What Happens If You Overdose on Naltrexone?

What Happens If You Overdose on Naltrexone?

Taking more Naltrexone than prescribed may increase the risk of side effects and require medical attention.

Possible effects of a Naltrexone overdose may include:

  • Nausea or vomiting
  • Dizziness or lightheadedness
  • Abdominal pain
  • Fatigue or weakness
  • Headache

There is limited experience with Naltrexone overdose in humans, and no specific antidote is available. Treatment focuses on monitoring symptoms and providing supportive medical care as needed. If you suspect a Naltrexone overdose, contact your provider or a poison control center immediately.

How Do I Store Naltrexone Properly?

How Do I Store Naltrexone Properly?

Follow these Naltrexone Hydrochloride storage guidelines to maintain the medication’s effectiveness and safety:

  • Store Naltrexone HCl tablets at room temperature, between 20°C-25°C (68°F-77°F).
  • It must be stored in a dry place, away from bathrooms and other damp areas.
  • Keep Naltrexone 50 mg in its original container, tightly closed, and away from moisture.
  • Store it out of reach of both children and pets. This will prevent accidental ingestion.
  • Dispose of any expired medication safely, following local guidelines or pharmacy instructions.
What Is the Alternative to Naltrexone Hydrochloride?

What Is the Alternative to Naltrexone Hydrochloride?

If Naltrexone Hydrochloride 50 mg is unavailable, other brand medications may be used under medical supervision. The alternatives to Naltrexone Hydrochloride tablets include:

  • Revia (Naltrexone Hydrochloride)
  • Vivitrol (Naltrexone Hydrochloride)

Other Naltrexone Hydrochloride Alternatives for Opioid Use Disorder (OUD)

  • Suboxone (Buprenorphine/Naloxone)
  • Subutex (Buprenorphine)
  • Methadose (Methadone Hydrochloride)

Other Naltrexone Hydrochloride Alternatives for Alcohol Use Disorder (AUD)

  • Antabuse (Disulfiram)
  • Campral (Acamprosate Calcium)
What Drugs Should Not Be Taken with Naltrexone?

What Drugs Should Not Be Taken with Naltrexone?

Naltrexone Hydrochloride may interact with other medicines. You should always tell your doctor about all drugs or supplements you are taking.

Drug CategoryDrug ExamplesNaltrexone Interaction Note
Opioid AnalgesicsMorphine, Oxycodone, Hydrocodone, Codeine, Fentanyl, Tramadol, MethadoneNaltrexone blocks opioid receptors, making these drugs ineffective and causing sudden, severe withdrawal if opioids are present.
Opioid‑Containing Cough/Cold PreparationsCodeine‑based syrupsIneffective for cough relief; risk of withdrawal symptoms.
Opioid Dependence TreatmentsBuprenorphine, MethadoneNaltrexone antagonizes their effects; it can precipitate withdrawal.
Hepatotoxic DrugsIsoniazid, Acetaminophen (high doses), AmiodaroneIncreased risk of liver injury when combined with Naltrexone.
Other CNS DepressantsAlcohol, Sedatives, BenzodiazepinesMay increase dizziness or drowsiness; caution advised

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Why Buy Naltrexone Hydrochloride Online from Polar Bear Meds?

Why Buy Naltrexone Hydrochloride Online from Polar Bear Meds?

Many patients choose to order Naltrexone Hydrochloride from Canada because the cost is often much lower than U.S. retail prices. At Polar Bear Meds, we source Naltrexone Hydrochloride 50 mg tablets from a trusted network of licensed Canadian and international pharmacies that comply with strict safety regulations. When you buy Naltrexone Hydrochloride online from our pharmacy, you save up to 80% compared with U.S. retail rates.

Plus, if you are a first-time buyer on our website, you can apply our Naltrexone Hydrochloride coupon code “WELCOMEPB10” to get 10% more discount. You can also expect your Naltrexone Hydrochloride delivery within 3-5 business days via our Xpress Post.

Important Disclaimer

Important Disclaimer

The information provided above about Naltrexone Hydrochloride is for general educational purposes only. The content on this page is not intended to replace any kind of professional advice, diagnosis, or treatment. Naltrexone Hydrochloride is a prescription-only medicine and should be used strictly under the guidance of a licensed healthcare professional. Do not start, stop, or change the dosage of this medication without consulting your doctor. Reliance on this information is solely at your own risk.

Naltrexone Hydrochloride FAQs

Naltrexone Hydrochloride FAQs

If you are looking for a more affordable option, some patients choose to order prescription medications from licensed Canadian pharmacies, such as Polar Bear Meds, with a valid prescription. Canadian pharmacies may offer lower prices while still requiring proper medical authorization.

Learn more about Naltrexone Hydrochloride and related topics

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