Rotigotine

Neupro Transdermal Patch

Neupro is a prescription transdermal patch that delivers rotigotine to treat Parkinson’s disease and Restless Legs Syndrome (RLS). Approved by the FDA, it helps manage symptoms like muscle spasms and tremors by mimicking dopamine, a crucial neurotransmitter. Available in various strengths, it ensures adaptable dosing. Common side effects include nausea, headache, and skin reactions, with serious side effects like increased heart rate and blood pressure changes needing urgent care. You may buy Neupro patch online from Canada easily with a doctor’s prescription.

Product Overview

Neupro (rotigotine) is a medicated patch prescribed primarily for treating Parkinson’s disease and moderate to severe Restless Legs Syndrome (RLS) in adults. This FDA-approved medication works as a dopamine agonist, which means it mimics the action of dopamine, a neurotransmitter vital for controlling movement and coordination. By boosting dopamine levels, Neupro effectively reduces symptoms such as stiffness, tremors, and involuntary muscle movements associated with these neurological conditions.

The medication is applied through a skin patch, making it convenient for daily use while ensuring steady medication levels throughout the day. Neupro patch for restless legs are available in strengths ranging from 1 mg to 8 mg per 24 hours, accommodating varying medical needs and allowing for dosage adjustments based on individual responses and tolerability.

Patients using Neupro may experience common side effects like sleep disturbances, headaches, and localized skin reactions. However, they must monitor for severe side effects such as hallucinations, significant blood pressure changes, or severe allergic reactions, which require immediate medical attention. Discussing potential interactions with other medications and existing health conditions with a healthcare provider is crucial to ensure safety and efficacy.

What Is the Drug Neupro Used For?

Nuepro is primarily used for these following conditions:

• Parkinson’s disease (like stiffness, poor muscle control, muscle spasms, and tremors)
• Moderate-to-severe Restless legs syndrome (RLS)

[Note: Do not take Neupro without consulting your doctor. They will determine whether you need this medication based on your conditions.]

What Strength Is the Neupro Patch?

Neupro is available as a transdermal system, which means it comes in the form of a patch that you apply to your skin. These patches are available in the six following strengths:

• 1 mg/24 hours
• 2 mg/24 hours
• 3 mg/24 hours
• 4 mg/24 hours
• 6 mg/24 hours
• 8 mg/24 hours

What Is the Typical Dosage of Neupro?

The typical dosage of Neupro varies for each person, depending on your age, the specific health condition being treated, and how your body responds to the medication. It’s important to take a Neupro patch for restless legs exactly as your doctor prescribes. You should also read and follow the directions on the patient information leaflet and the medication guide that comes with the medicine, provided by your pharmacist or healthcare provider.

The dose you’ll need depends on the strength of the patch and the form of the medication. It also varies based on how many doses you take each day, how long you wait between each dose, and how long you need to be on the medication. Always stick to your prescribed schedule to make sure the treatment is effective and safe.

Dosage for Parkinson’s Disease

• Adults: Initially, use a 2-mg patch every 24 hours if you’re in the early stages of the disease or a 4-mg patch every 24 hours for more advanced stages. Your doctor may increase the dose gradually, depending on how well you tolerate it, but it typically doesn’t exceed 6 to 8 mg every 24 hours.
• Children: The dosage and usage should be determined by a pediatrician.

Dosage for Restless Legs Syndrome (RLS)

• Adults: Start with a 1-mg patch applied every 24 hours. If necessary and tolerated, your doctor may gradually increase the dose, but it usually doesn’t exceed 3 mg every 24 hours.
• Children: The dosage and usage should be determined by a pediatrician.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Neupro Patches?

This medication comes with instructions for patients. Please read and follow these instructions carefully. If you have any questions, don’t hesitate to ask your doctor. Here’s how to use the medicine:

Using the Skin Patch:

• You can place the patch on your belly, side of your body (between your ribs and pelvis), shoulder, hip, upper arm, or thigh.
• After taking the patch out of its protective pouch, apply it immediately. Do not cut it into smaller pieces. Avoid touching the side of the patch that is sticky.
• Stick the patch on a clean, dry, unbroken, and healthy area of your skin. Choose a spot that is not too oily, has little or no hair, and doesn’t have scars, cuts, burns, or any other skin problems. If you need to put the patch on a hairy area, you have to shave the area at least three days before applying the patch. Try to avoid placing the patch on skin folds, under waistbands, or in areas where tight clothing might rub against it.

Here’s how to apply the patch properly:

• Press the Patch: Hold the patch firmly against your skin using the palm of your hand for about 30 seconds. Ensure it sticks well, especially around the edges.
• Keep It On: The patch should stay on during activities like showering, bathing, or swimming. If it falls off, apply a new one.
• Change the Patch: After 24 hours, remove the old patch and place a new one on a different part of your skin. Avoid using the same spot for at least 14 days. Don’t wear a patch for more than 24 hours, as it may lose effectiveness and irritate your skin.
• Dispose of the Patch: Fold the used patch in half with the sticky sides together, place it in its protective pouch or aluminum foil, and dispose of it safely away from children and pets. Wash the area where the patch was applied with soap and water to remove any residue. You can also use baby or mineral oil to clean the area. Avoid using alcohol or other solvents to prevent skin irritation.
• Apply at the Same Time: Try to change the patch at the same time each day. If you forget, replace the old patch with a new one and resume your regular schedule the next day.
• Prepare the Skin: Do not apply cream, lotion, ointment, oil, or powder on the area where you’ll place the patch.
• Wash Your Hands: Always wash your hands before and after applying the patch.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Neupro Patch Work?

Neupro contains rotigotine, a type of drug known as a dopamine agonist. It’s used to help manage symptoms of Parkinson’s disease, either on its own or alongside another medication called levodopa. Parkinson’s disease symptoms occur because there’s not enough dopamine, a chemical messenger, in the brain. Rotigotine works by helping to balance the levels of dopamine, which can reduce these symptoms. 

In addition to Parkinson’s disease, rotigotine is also used to treat moderate-to-severe restless legs syndrome in adults. The medication is in the form of a patch that you apply to your skin. It takes some time for your body to absorb the drug from the patch. Usually, the drug can be detected in your blood about 3 hours after you apply the patch. It may take just over 24 hours for your body to completely absorb the drug, especially after the first dose.

What Are the Important Safety Information for Using Neupro?

What Are the Side Effects of Neupro?

Common Neupro Side Effects: Neupro, like any medication, can cause side effects that usually last for only a short time—from a few days to weeks. Most of these effects are mild and will go away as your body adjusts to the medication. However, if they continue for a longer period, become bothersome, or intensify, it’s important to speak with your doctor or pharmacist to ensure your safety. Here are some of the common side effects you might experience while taking Neupro:

• Headache: You may feel a persistent pain or pressure in your head. This is one of the most common reactions your body may have to the medication.
• Nausea: You might feel an uneasy sensation in your stomach that often comes with an urge to vomit. This is another frequent side effect that people experience.
• Sleepiness: You may feel unusually drowsy or tired during the day. This can happen as your body adjusts to the medication.
• Staying Asleep or Having Trouble Falling Asleep: You may find it difficult to fall asleep, or you might wake up frequently during the night and have trouble going back to sleep.

Mild Neupro Side Effects: Neupro is used in treating Parkinson’s disease and can cause some mild side effects that are generally temporary. Your body may adjust to them over time. If these side effects persist or start to bother you, it’s important to discuss them with your primary healthcare provider. Here are some mild side effects that you may experience while using Neupro:

• Dizziness: You might feel unsteady or as if the room is spinning, making it hard to balance.
• Excessive Sweating: You could find yourself sweating more than usual, even without physical exertion.
• Vision Problems: You may notice changes in your vision, such as blurred or double vision.
• Swelling in Your Ankles, Hands, or Feet: This is often a buildup of fluid, which can cause swelling in these areas.
• Nausea: This is a feeling of discomfort in your stomach, often with the urge to vomit.
• Vomiting: This involves expelling the contents of your stomach through your mouth.
• Trouble Falling or Staying Asleep: You may find it difficult to fall asleep, or you might wake up during the night and have trouble going back to sleep.
• Sleepiness: You may feel unusually sleepy or drowsy during the day, which can interfere with daily activities.
• Loss of Appetite: You might notice a decrease in your desire to eat, which could affect your nutritional intake.

Serious Neupro Side Effects: While Neupro is effective for treating conditions like Parkinson’s disease and Restless Legs Syndrome (RLS), it can sometimes cause serious side effects. If you experience any of the following, it’s important to contact your doctor immediately. For life-threatening symptoms or if you believe you’re having a medical emergency, call your local emergency services or 911 right away.

• Increased Heart Rate: Be alert for signs like:
  • Lightheadedness: Feeling faint or dizzy, especially when you stand up.
  • Shortness of Breath: Difficulty breathing or catching your breath.
  • Fast Pulse: Your heart beats unusually quickly.
• Changes in Blood Pressure: Symptoms may include:
  • Fainting when Standing Up: Losing consciousness briefly when you get up.
  • Feeling Nauseous, Sweaty, or Dizzy when Standing Up: These can be signs that your blood pressure is dropping suddenly.
• Severe Fluid Retention and Weight Gain: Watch for:
  • Sudden Increases in Weight: Rapid weight gain without a clear reason.
  • Swelling: Noticeable puffiness or swelling in your legs or ankles, which can indicate fluid retention.
• Worsening Dyskinesia: For those with Parkinson’s, this can manifest as:
  • Worsening of Existing Abnormal Movements: Movements may become more pronounced or severe.
  • Sudden or Uncontrolled Movements: These might be new and unexpected movements.
• Augmentation and Rebound in RLS: If you are being treated for Restless Legs Syndrome, be aware of:
  • Worsening Severity of RLS Symptoms: Symptoms become more intense than before.
  • Symptoms of RLS Manifesting Earlier in the Day: Symptoms start occurring sooner than they did before beginning Neupro treatment.
• Confusion and High Fever in Parkinson’s Disease: If you suddenly stop taking Neupro, you may experience:
  • Rigid Muscles: Muscles that are stiff and hard to move.
  • Changes in Consciousness: Unusual sleepiness or unresponsiveness.
  • Elevated Body Temperature: A high fever that develops quickly.

Other serious side effects to monitor include:

• Rhabdomyolysis: A severe breakdown of muscle tissue leading to kidney damage.
• Application Site Reactions: Severe irritation, redness, or pain at the patch application site.
• Changes in Mental Health or Behaviors: New or worsening mood swings, depression, or unusual behaviors.
• Sleep Problems: Severe or worsening trouble sleeping.
• Severe Allergic Reactions: Symptoms may include extreme swelling, difficulty breathing, or a severe rash.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Using Neupro?

Before using Neupro patch for restless legs, discussing your medical history with your doctor is important. Neupro might not be suitable for you if you have certain health conditions or other factors that could affect your well-being. Some of these conditions include:

• Daytime Sleepiness (Due to Unpredictable Periods of Sleep or Sleep Disorder): Neupro can cause sleep problems such as feeling sleepy during the day and sudden “sleep attacks,” where you might fall asleep unexpectedly while doing everyday activities. Before starting Neupro, your doctor will check if you have any risk factors for sleep issues. If you already have problems sleeping, your doctor might suggest trying a different medication for your condition.
• High or Low Blood Pressure: Neupro can affect your blood pressure, causing it to either increase or decrease. Although it’s uncommon, these fluctuations can be severe. If you already have issues with high or low blood pressure, make sure to inform your doctor before starting Neupro. 
• Heart Problems: Although uncommon, this medication can cause a faster heart rate and changes in blood pressure. If you already have heart problems, you might be more likely to experience these side effects. It’s essential to inform your primary healthcare giver about any heart conditions you have before starting Neupro patches.
• Orthostatic Hypotension: Neupro can cause a condition called orthostatic hypotension that causes your blood pressure to drop whenever you stand up. If you already have this condition, taking Neupro might make it worse. It’s important to discuss this with your doctor before starting Neupro if you have orthostatic hypotension. 
• Allergic Reaction: Should you have previously experienced an allergic reaction to Neupro or any of its components, your doctor will probably suggest an alternative medication. Talk to your doctor about other medications that might be a better fit for you. If you have an allergy or sensitivity to sulfites, taking Neupro could make it worse. It is although rare, but a severe allergic reaction is possible. Both mild and severe allergic reactions can occur. They include
  • Trouble breathing
  • Swelling of your mouth, throat, or tongue
  • Swelling under your skin, typically in your feet, eyelids, lips, or hands
  • Skin rash
  • Itchiness
  • Flushing (temporary deepening of skin color, warmth, or redness)
• Conditions Related to Mental Health (Including Schizophrenia or Bipolar Disorder): If you have mental health conditions like bipolar disorder or schizophrenia, Neupro may affect them. The medication can sometimes cause these conditions or make existing ones worse. It’s important to tell your doctor about any mental health issues you have before starting Neupro. This will help them decide if it’s a suitable treatment for you.

What Precautions Should You Take While Using Neupro Patches?

When considering whether to take a medication, Weighing the potential risks against the benefits it may offer is crucial. This decision should be made in consultation with your healthcare provider. For this medication, certain factors should be taken into account, including:

• Allergies:  Inform your doctor about any past allergic reactions to this medication or other drugs. It’s also important to mention any other allergies you have, such as to foods, dyes, preservatives, or animals. If you’re using a non-prescription product, make sure to read the label & package ingredients carefully.
• Pediatric: Studies to understand the effects of the rotigotine transdermal patch on children have not been conducted. Therefore, its safety and effectiveness in the pediatric population have not been established.
• Geriatric: Studies conducted so far have not shown any specific problems related to the use of the rotigotine transdermal patch in older adults that would limit its effectiveness. However, it’s important to note that older patients may be more prone to experiencing hallucinations (hearing, seeing, or feeling things that aren’t real) while using this medication. As a result, doctors may need to be cautious when prescribing this medicine to elderly individuals. 
• Pregnancy: The safety of using Neupro during pregnancy is currently unknown, as there have not been studies conducted on its use in pregnant women. However, in animal studies, the drug has been associated with birth defects & pregnancy loss when administered to pregnant animals. It’s important to note that the results from animal studies may not always directly apply to humans. If you’re pregnant and have concerns about managing your condition with Neupro, it’s crucial to discuss your options with your doctor. 
• Birth Control: It’s not clear whether Neupro is safe for use during pregnancy. If you are sexually active and there is a chance of pregnancy for you or your partner, you should discuss your birth control options with your doctor while using Neupro.  
• Breastfeeding: It is currently unclear if Neupro is safe to use while breastfeeding. Specifically, we don’t know if the rotigotine passes into human breast milk or how it might affect a breastfed baby. Rotigotine may reduce prolactin levels, a hormone that aids in milk production, but there isn’t enough data to confirm this. In animal studies, the drug was found in the milk of lactating females, but these results may not apply to humans. If you’re breastfeeding and have questions about managing your condition, it’s important to discuss your options with your doctor.

What Are the Contraindications for Neupro?

Neupro may not be suitable for you if you are having any of the following:

• Breastfeeding
• Mental problems
• Plan to become pregnant.
• High or low blood pressure
• Pregnant
• A sleep disorder
• Heart problems
• Breathing problems
• Plan to breastfeed

What If I Forget to Put on My Neupro Patch?

If you forget to apply your Neupro patch on time, here’s what you should do:

• As soon as you realize you’ve missed it, put on a new patch immediately. Then, continue with your regular schedule by replacing the patch at the usual time the next day, even if it hasn’t been a full 24 hours since you applied the missed dose.
• It’s important to keep your treatment consistent, so try to apply your patches at the same time each day. If you often forget doses, consider setting an alarm or using a reminder app to help you remember.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What to Do If You Use Too Much Neupro Patches?

If you use too much of Neupro patches, seek emergency assistance right away if you notice any of the following symptoms:

• Confusion or disorientation
• Dizziness, faintness, or lightheadedness, especially when standing up quickly from a lying or sitting position
• Nausea or feeling sick to your stomach
• Seizures or convulsions
• Sweating more than usual
• Unusual tiredness or weakness that is not normal for you
• Vomiting or throwing up

These signs indicate a serious condition that needs prompt medical attention.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How Do You Store Neupro Patches?

Patients should always adhere to the proper storage guidelines when you buy Neupro patch online, so that you can ensure the medication is safe and effective for use. Here’s how you can store these transdermal patches:

• Keep the patches at normal room temperature in a container that is tightly closed away from moisture, heat, and direct light. 
• Store them in a place where children cannot access them. 
• Discard any outdated medicine or medicine that is no longer needed. 
• Consult your primary healthcare provider for advice on how to dispose of any unused medicine properly. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Drugs Interact with Neupro?

Like many medications, Neupro patch for restless legs can interact with other drugs, which may affect how well it works or increase the risk of side effects. Here’s a straightforward explanation of how Neupro interacts with some specific medications:

• • Sulpiride: It’s usually not safe to use Neupro with sulpiride, which is another medication used for psychiatric conditions. This combination can lead to increased side effects or reduce the effectiveness of either drug. Because of this, your doctor might decide not to prescribe Neupro if you’re taking sulpiride or may adjust your other medications.

• Medications That May Require Caution:

• • Haloperidol: This is an antipsychotic medication. Using it with Neupro can affect neurological functions and might require careful monitoring and possible dosage adjustments.
  • Metoclopramide: Often used to treat nausea and gastroparesis, combining this with Neupro could enhance its effects on the nervous system, requiring dose adjustments.
  • Olanzapine: Another antipsychotic that, when used with Neupro, might influence the control of Parkinson’s symptoms or side effects related to nervous system functions.
  • Risperidone: Similar to olanzapine, risperidone used with Neupro can also necessitate modifications in dosing to manage side effects or effectiveness.

When Neupro is prescribed along with any of these medications, your doctor may need to adjust the dosage or how often you use one or both of the medicines.

What Are the Other Interactions of Nuepro?

Neupro can interact not just with other drugs but also with food, alcohol, and tobacco. It’s important to understand how these can affect your medication:

• Food Interactions: Some medications can interact with certain foods. For Neupro, your healthcare provider might advise you on specific dietary considerations that can either enhance the effectiveness of the medication or prevent potential side effects. For example, certain foods might affect how quickly the medication is absorbed into your bloodstream.
• Alcohol Interactions: Consuming alcohol while on Neupro might affect how the medication works. Alcohol can also increase the side effects of Neupro, such as dizziness or drowsiness. It’s generally wise to limit or avoid alcohol while using this medication to ensure it works effectively without unnecessary complications.
• Tobacco Interactions: Smoking tobacco can affect how your body processes Neupro. Tobacco use may alter the effectiveness of the medication, potentially requiring adjustments in dosage. Smoking can also exacerbate side effects.

[Note: This isn’t a complete list, and there could be other drugs that interact with Neupro. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Alternatives to Neupro?

If Neupro patch for restless legs aren’t right for you or don’t give you the results you need, there are several other medications you might consider. It’s important to choose an alternative that fits well with your specific health needs and conditions. Always discuss any changes in your treatment with your doctor. They can help you find the best alternative based on your age, medical history, and specific health requirements. Here are some commonly used alternatives to Neupro that your doctor might suggest:

• Benztropine
• Pramipexole
• Ropinirole (Ropinirole Hydrochloride)
• Amantadine (Amantadine Hydrochloride)
• Neurontin (gabapentin)
• Sinemet (carbidopa/levodopa)
• Mirapex ER (pramipexole extended release)
• Trihexyphenidyl
• Horizant (gabapentin enacarbil)
• Lyrica (pregabalin)
• Carbidopa/levodopa ER (extended release)
• Azilect (rasagiline)
• Zelapar (selegiline)
• Xadago (safinamide)
• Ropinirole XR (ropinirole extended release)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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Frequently Asked Questions

Is Neupro addictive?

Yes, there is a potential for withdrawal symptoms if you stop using the Neupro patch for restless legs suddenly or even if you gradually decrease the dose. These withdrawal symptoms can include feelings of anxiety. It’s important to follow your doctor’s instructions carefully when changing how you use this medication to minimize any uncomfortable symptoms.

What should you avoid when applying Neupro patches?

When applying Neupro patches, avoid placing them over joint areas like the knees, hands, or elbows, as movement can dislodge or irritate the patch. Also, avoid areas where the skin folds, such as under clothing that may rub against it. Do not apply the patch to skin that is scarred, irritated, or damaged in any way to ensure it sticks properly and provides the intended dosage.

Does the Neupro patch cause weight gain?

Using the Neupro patch can lead to weight gain and fluid retention. This happens because Neupro can cause your body to retain extra fluid, leading to swelling and weight gain, particularly noticeable in the ankles or legs. If you notice swelling or a rapid increase in weight, it’s important to discuss this with your doctor, as it may require adjustments to your treatment.

How does Neupro make you feel?

People taking Neupro for Restless Legs Syndrome commonly experience side effects like reactions at the site where the patch is applied, nausea, trouble falling and staying asleep, feeling sleepy, and headaches. However, these are not all the possible side effects. For more detailed information, it’s best to consult your doctor or pharmacist.

How long does it take Neupro to start working?

Neupro might take some time to start working because your skin does not immediately absorb it. Usually, the medication won’t show up in blood tests until at least 3 hours after you’ve applied a patch. It can take up to 24 hours or even more for your body to completely absorb the medication, especially after your first dose. 

When is the best time to put the Neupro patch on?

As soon as you take the Neupro patch for restless legs out of its protective pouch, you should apply it to your skin. Do not cut or alter the patch in any way. Decide on a time that suits you best, either during the day or night, to put on your Neupro patch. Make sure to apply it at the same time every day for consistency.

Can Neupro cause hallucinations?

Yes, Neupro can cause hallucinations. People with Parkinson’s disease who are older, taking Neupro, or taking higher doses of Neupro have a higher risk of experiencing hallucinations or other psychotic-like symptoms. If you notice any hallucinations or similar changes, it’s essential to discuss this with your doctor.

Where is the best place to put a Neupro patch?

The best place to apply a Neupro patch is on a clean, dry, and healthy area of your skin. Suitable locations include your stomach, thigh, hip, flank (the side of your body between the ribs and pelvis), shoulder, or upper arm. Select a spot that isn’t too oily, has minimal or no hair, and is free of scars, cuts, burns, or any skin irritations. 

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